| 1. |
- Samnegård, Björn, et al.
(författare)
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C-peptide and captopril are equally effective in lowering glomerular hyperfiltration in diabetic rats.
- 2004
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Ingår i: Nephrol Dial Transplant. - : Oxford University Press (OUP). - 0931-0509. ; 19:6, s. 1385-91
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- 150042582004051920040921200611150931-05091962004JunNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal AssociationNephrol. Dial. Transplant.C-peptide and captopril are equally effective in lowering glomerular hyperfiltration in diabetic rats.1385-91BACKGROUND: C-peptide has been shown to reduce glomerular hyperfiltration, glomerular hypertrophy and urinary albumin excretion in type 1 diabetes, but its effect has not been compared with that of an angiotensin-converting enzyme inhibitor (ACEI) in the early stage of renal involvement in diabetes. METHODS: Glomerular filtration rate (GFR) was measured in terms of inulin clearance and renal blood flow, using ultrasound technique, in four groups of streptozotocin-induced diabetic rats before and after a 60 min infusion of C-peptide (D-Cp), captopril (D-ACEI), C-peptide and captopril (D-Cp-ACEI) or placebo (D-placebo). In addition, a non-diabetic control group was studied before and after captopril infusion (C-ACEI). RESULTS: GFR was 37-51% higher in the diabetic groups than in the control animals. GFR decreased after treatment in the D-Cp, D-ACEI and D-Cp-ACEI groups, but did not change in the D-placebo group. Blood flow increased by 26-32% in the three groups receiving captopril and by 5% in the diabetic groups treated with C-peptide alone or placebo. The increase in blood flow in the three ACEI-treated groups was significantly greater than in the D-placebo group. Filtration fraction fell significantly in all groups, but only in the combined D-Cp-ACEI group did it fall significantly more than in the D-placebo group. CONCLUSIONS: C-peptide and captopril lower diabetes-induced glomerular hyperfiltration to a similar extent, but the influence of captopril on blood flow is greater than that of C-peptide, suggesting different mechanisms of action. No statistically significant additive effects of C-peptide and captopril were shown in this acute infusion study.Department of Nephrology, Danderyd Hospital, SE-182 88 Stockholm, Sweden. bjorn.samnegard@medks.ki.seSamnegårdBjörnBJacobsonStefan HSHJohanssonBo-LennartBLEkbergKarinKIsakssonBrittaBWahrenJohnJSjöquistMatsMengComparative StudyJournal Article20040305EnglandNephrol Dial Transplant87064020Angiotensin-Converting Enzyme Inhibitors0C-Peptide62571-86-2CaptoprilIMAngiotensin-Converting Enzyme InhibitorspharmacologyAnimalsC-PeptidepharmacologyCaptoprilpharmacologyDiabetes Mellitus, ExperimentalphysiopathologyGlomerular Filtration Ratedrug effectsKidney Glomerulusdrug effectsphysiopathologyMaleRatsRats, Sprague-DawleyRegional Blood Flowdrug effects200439502004924502004Mar5ppublish1500425810.1093/ndt/gfh163gfh163
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| 2. |
- Sjödin, Kristina, et al.
(författare)
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Occurrence and correlations of monoterpene hydrocarbon enantiomers in Pinus sylvestris and Picea abies
- 2000
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Ingår i: Journal of Chemical Ecology. - 0098-0331 .- 1573-1561. ; 26:7, s. 1701-1720
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Tidskriftsartikel (refereegranskat)abstract
- The relative amounts and enantiomeric compositions of monoterpene hydrocarbons in branch and trunk xylem, in needles, and in resin from apical buds in 18 Pinus sylvestris trees have been determined and compared with the terpene content in branch xylem and needles of Picea abies. Besides the high amount of (+)-3-carene, an excess of (+)-alpha-pinene has been found in P. sylvestris, whereas in P. abies (-)-alpha-pinene dominates over (+)-alpha-pinene. In P. sylvestris, clear positive correlations were found between (+)-alpha-pinene and (+)-camphene in the four tissues analyzed. Good positive correlations were also observed between (-)-alpha-pinene and (-)-camphene in the two types of xylem, between (+)-alpha-pinene and (+)-beta-pinene in the resin, and between tricyclene and (-)-camphene in resin and needles. In P. abies, positive correlations were found between (+)-alpha-pinene and (+)-camphene in the branch xylem and between tricyclene and (-)-camphene as well as between (-)-alpha-pinene and (-)-camphene in the needles. Complex relationships between (-)-alpha-pinene and (-)-beta-pinene were found both in the P. abies and in the P. sylvestris tissues. The importance of the enantiomeric composition of alpha-pinene for the host selection of Ips typographus, Tomicus piniperda, and Hylobius abietis is discussed.
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| 3. |
- Sparring Björkstén, Karin, et al.
(författare)
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A computerized human reference brain for rCBF/SPET technetium-99m exametazime (HMPAO) investigation of elderly
- 2004
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Ingår i: Clinical Physiology and Functional Imaging. - 1475-0961 .- 1475-097X. ; 24:4, s. 196-204
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Tidskriftsartikel (refereegranskat)abstract
- Using the bull's eye approach, a reference brain from the single photon emission tomography (SPET) images of 10 subjects aged 62-81 years with excellent mental and physical health was constructed. SPET images were acquired twice, 1 week apart, using a single detector rotating gamma camera collecting 64 planar images over a 360° orbit. The centre of each transaxial slice was first defined with an automatic edge detecting algorithm applied to an anterior-posterior and a side profile of the brain. Each slice was divided into 40 sectors. Maximum counts/pixel in each sector was picked. The 40 maximum count values from one transaxial slice were allowed to form a horizontal row in a new parametric image on the x-axis and slice number from the vertex to the basal parts of the brain on the y-axis. This new image was scaled to a 64 × 16 pixel matrix by interpolation, which meant a normalization of all studies to the same size. The parametric image in each subject was scaled with regard to intensity by a factor calculated by a normalization procedure using the least squares analysis. Mean and SD for each pixel were calculated, thereby constructing a 'mean parametric image', and a 'SD parametric image'. These two images are meant to be used as the reference brain for evaluation of patient studies. This method can be used for objective measurements of diffuse brain changes and for pattern recognition in larger groups of patients. Statistical multifactorial analysis of parameters used for acquisition and data processing is possible. © 2004 Blackwell Publishing Ltd.
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