Sökning: WFRF:(Eklund Lauri)
> (2020) >
EphrinB2-EphB4 sign...
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity
-
- Frye, Maike (författare)
- Uppsala universitet,Vaskulärbiologi,Univ Med Ctr Hamburg Eppendorf, Inst Clin Chem & Lab Med, Hamburg, Germany.
-
- Stritt, Simon (författare)
- Uppsala universitet,Vaskulärbiologi
-
- Ortsäter, Henrik (författare)
- Uppsala universitet,Vaskulärbiologi
-
visa fler...
-
- Hernandez Vasquez, Magda (författare)
- Uppsala universitet,Vaskulärbiologi
-
- Kaakinen, Mika (författare)
- Univ Oulu, Bioctr Oulu, Oulu, Finland.
-
- Vicente, Andres (författare)
- Canc Res UK London Res Inst, Lymphat Dev Lab, London, England.;UCL, Inst Global Prosper, London, England.
-
- Wiseman, John (författare)
- AstraZeneca, Discovery Biol Discovery Sci, Biopharmaceut R&D, Gothenburg, Sweden.
-
- Eklund, Lauri (författare)
- Univ Oulu, Bioctr Oulu, Oulu, Finland.;Univ Oulu, Fac Biochem & Mol Med, Oulu Ctr Cell Matrix Res, Oulu, Finland.
-
- Martinez-Torrecuadrada, Jorge L. (författare)
- Spanish Natl Canc Res Ctr CNIO, Crystallog & Prot Engn Unit, Madrid, Spain.
-
- Vestweber, Dietmar (författare)
- Max Planck Inst Mol Biomed, Munster, Germany.
-
- Mäkinen, Taija (författare)
- Uppsala universitet,Vaskulärbiologi
-
visa färre...
-
(creator_code:org_t)
- eLife Sciences Publications, Ltd, 2020
- 2020
- Engelska.
-
Ingår i: eLIFE. - : eLife Sciences Publications, Ltd. - 2050-084X. ; 9
- Relaterad länk:
-
https://doi.org/10.7...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.7...
-
visa färre...
Abstract
Ämnesord
Stäng
- Endothelial integrity is vital for homeostasis and adjusted to tissue demands. Although fluid uptake by lymphatic capillaries is a critical attribute of the lymphatic vasculature, the barrier function of collecting lymphatic vessels is also important by ensuring efficient fluid drainage as well as lymph node delivery of antigens and immune cells. Here, we identified the transmembrane ligand EphrinB2 and its receptor EphB4 as critical homeostatic regulators of collecting lymphatic vessel integrity. Conditional gene deletion in mice revealed that EphrinB2/EphB4 signalling is dispensable for blood endothelial barrier function, but required for stabilization of lymphatic endothelial cell (LEC) junctions in different organs of juvenile and adult mice. Studies in primary human LECs further showed that basal EphrinB2/EphB4 signalling controls junctional localisation of the tight junction protein CLDN5 and junction stability via Rac1/Rho-mediated regulation of cytoskeletal contractility. EphrinB2/EphB4 signalling therefore provides a potential therapeutic target to selectively modulate lymphatic vessel permeability and function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
eLIFE
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas