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Sökning: WFRF:(El Shabasy R. M.)

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1.
  • El-Seedi, Hesham R., et al. (författare)
  • Anti-schistosomiasis triterpene glycoside from the Egyptian medicinal plant Asparagus stipularis
  • 2011
  • Ingår i: REV BRAS FARMACOGN. - : SOC BRASILEIRA FARMACOGNOSIA. - 0102-695X. ; 22:2, s. 314-318
  • Tidskriftsartikel (refereegranskat)abstract
    • Bioassay-guided isolation using an in vitro assay testing for anti-schistosomiasis yielded a novel triterpene saponin, asparagalin A, from the n-butanol extract of the roots of Asparagus stipularis Forssk., Asparagaceae. The structure was elucidated by spectroscopic analysis and chemical transformations. Administration of asparagalin A resulted in a retardation of worm growth and locomotion at the first day and showed a significant activity of egg-laying suppression at 200 mu g/mL concentration.
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2.
  • Saifullah, S., et al. (författare)
  • Surface functionalized magnetic nanoparticles for targeted cancer therapy and diagnosis
  • 2019
  • Ingår i: Metal Nanoparticles for Drug Delivery and Diagnostic Applications. - : Elsevier Inc.. ; , s. 215-236
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • In the last few decades, magnetic nanoparticles (MNPs) have had significant interest and became more remarkable in the field of oncology. MNPs has been proven to be the most suitable and promising nanomaterials for tumor targeting. This is mainly due to its intrinsic magnetic property which makes them characteristic agents to inducing magnetic hyperthermia and magnetic resonance imaging. The MNPs have usually been employed for cancer imaging through a passive approach. The modern techniques have enabled multimodal imaging, drug delivery, and specific cells targeting by MNPs. To synthesize more extravagant MNPs, the design criteria considerations, such as core metal, hydrodynamic size, shape, surface coating, and molecular functionalization, become very essential. In this chapter, the design parameters of MNPs including surface functionalization and physiochemical properties are summarized to overcome biological barriers. Furthermore, the chemistry of MNPs surface modification is discussed in detail to describe its nature and binding type.
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