| 1. |
- Baud, Maxime O, et al.
(author)
-
European trends in epilepsy surgery.
- 2018
-
In: Neurology. - 1526-632X. ; 91:2
-
Journal article (peer-reviewed)abstract
- Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart.Sixteen European centers retrospectively identified 2 cohorts of children and adults who underwent epilepsy surgery in the period of 1997 to 1998 (n = 562) or 2012 to 2013 (n = 736). Data collected included patient (sex, age) and disease (duration, localization and diagnosis) characteristics, type of surgery, histopathology, Engel postsurgical outcome, and complications, as well as imaging and electrophysiologic tests performed for each case. Postsurgical outcome predictors were included in a multivariate logistic regression to assess the strength of date of surgery as an independent predictor.Over time, the number of operated cases per center increased from a median of 31 to 50 per 2-year period (p = 0.02). Mean disease duration at surgery decreased by 5.2 years (p < 0.001). Overall seizure freedom (Engel class 1) increased from 66.7% to 70.9% (adjusted p = 0.04), despite an increase in complex surgeries (extratemporal and/or MRI negative). Surgeries performed during the later period were 1.34 times (adjusted odds ratio; 95% confidence interval 1.02-1.77) more likely to yield a favorable outcome (Engel class I) than earlier surgeries, and improvement was more marked in extratemporal and MRI-negative temporal epilepsy. The rate of persistent neurologic complications remained stable (4.6%-5.3%, p = 0.7).Improvements in European epilepsy surgery over time are modest but significant, including higher surgical volume, shorter disease duration, and improved postsurgical seizure outcomes. Early referral for evaluation is required to continue on this encouraging trend.
|
|
| 2. |
- Conze, Ronald, et al.
(author)
-
Utilizing the International Geo Sample Number Concept in Continental Scientific Drilling During ICDP Expedition COSC-1
- 2017
-
In: Data Science Journal. - : Ubiquity Press. - 1683-1470. ; 1:1, s. 1-8
-
Journal article (peer-reviewed)abstract
- The International Geo Sample Number (IGSN) is a globally unique persistent identifier (PID) for physical samples that provides discovery functionality of digital sample descriptions via the internet. In this article we describe the implementation of a registration service for IGSNs of the Helmholtz Centre Potsdam – GFZ German Research Centre for Geosciences. This includes the adaption of the metadata schema developed within the context of the System for Earth Sample Registration (SESAR1) to better describe the complex sample hierarchy of drilling cores, core sections and samples of scientific drilling projects. Our case study is the COSC-1 expedition2 (Collisional Orogeny in the Scandinavian Caledonides) supported by the International Continental Scientific Drilling Program3 (ICDP). COSC-1 prompted for the first time in ICDP’s history to assign and register IGSNs during an on-going drilling campaign preserving the original parent-child relationship of the sample objects. IGSN-associated data and metadata are distributed and shared with the world wide community through novel web portals, one of which is currently evolving as part of ICDP’s collaborative efforts within the GFZ Potsdam and researchers from ICDP’s COSC clientele. Thus, COSC-1 can be considered as a ‘Prime-Example’ for ICDP projects to further improve the quality of scientific research output through a transparent process of producing and managing large quantities of data as they are normally acquired during a typical scientific drilling operation. The IGSN is an important new player in the general publication landscape that can be cited in scholarly literature and also cross-referenced in DOI-bearing scholarly and data publications.
|
|
