SwePub - search: WFRF:(Eliasson M)

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1.	SCHMALIX, WA, et al. (author) Stable expression of human cytochrome P450 2E1 in V79 Chinese hamster cells 1995 In: European journal of pharmacology. - 0014-2999. ; 293:2, s. 123-131 Journal article (peer-reviewed)
2.	Barg, Sebastian, et al. (author) The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein 1999 In: Proceedings of the National Academy of Sciences. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 96:10, s. 5539-5544 Journal article (peer-reviewed)abstract Intracellular application of the sulfonylurea tolbutamide during whole-cell patch-clamp recordings stimulated exocytosis >5-fold when applied at a cytoplasmic Ca2+ concentration of 0.17 microM. This effect was not detectable in the complete absence of cytoplasmic Ca2+ and when exocytosis was elicited by guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS). The stimulatory action could be antagonized by the sulfonamide diazoxide, by the Cl--channel blocker 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), by intracellular application of the antibody JSB1 [originally raised against a 170-kDa multidrug resistance (mdr) protein], and by tamoxifen (an inhibitor of the mdr- and volume-regulated Cl- channels). Immunocytochemistry and Western blot analyses revealed that JSB1 recognizes a 65-kDa protein in the secretory granules. This protein exhibited no detectable binding of sulfonylureas and is distinct from the 140-kDa sulfonylurea high-affinity sulfonylurea receptors also present in the granules. We conclude that (i) tolbutamide stimulates Ca2+-dependent exocytosis secondary to its binding to a 140-kDa high-affinity sulfonylurea receptor in the secretory granules; and (ii) a granular 65-kDa mdr-like protein mediates the action. The processes thus initiated culminate in the activation of a granular Cl- conductance. We speculate that the activation of granular Cl- fluxes promotes exocytosis (possibly by providing the energy required for membrane fusion) by inducing water uptake and an increased intragranular hydrostatic pressure.
3.	Clot, P, et al. (author) Cytochrome P4502E1 hydroxyethyl radical adducts as the major antigen in autoantibody formation among alcoholics 1996 In: Gastroenterology. - : Elsevier BV. - 0016-5085. ; 111:1, s. 206-216 Journal article (peer-reviewed)
4.	Ding, M, et al. (author) Altered taurine release following hypotonic stress in astrocytes from mice deficient for GFAP and vimentin 1998 In: Brain research. Molecular brain research. - 0169-328X. ; 62:1, s. 77-81 Journal article (peer-reviewed)
5.	Mero, N., et al. (author) Postprandial elevation of ApoB-48-containing triglyceride-rich particles and retinyl esters in normolipemic males who smoke 1997 In: Arterioscler Thromb Vasc Biol. - 1079-5642. ; 17:10, s. 2096-102 Journal article (peer-reviewed)abstract Smokers have an increased risk for coronary artery disease (CAD), which can only partly be explained by fasting lipoprotein changes. Recent studies have indicated that smokers express metabolic abnormalities characteristic of insulin resistance syndrome. A preliminary study reported an increased postprandial triglyceride (TG) response in smokers compared with nonsmokers. To investigate the effect of smoking on postprandial lipemia, a fat-rich mixed meal (837 kcal, 63 g of fat) was served to 12 healthy smokers and 12 controls with similar fasting lipoprotein profiles, body composition, and lifestyles. Blood was drawn before and 3, 4, 6, and 8 hours postprandially, and triglyceride-rich lipoprotein (TRL) fractions (chylomicrons, VLDL1, VLDL2, and IDL) were separated with density gradient ultracentrifugation. Pre- and postprandial TG, retinyl esters (RE), apolipoprotein B-48 (apoB-48) and B-100 (apoB-100) were measured in each fraction. Smokers showed a significantly increased postprandial TG response in chylomicrons, VLDL1, and VLDL2. The areas under the incremental curve (AUIC) of apoB-48 in chylomicrons (2.83 +/- 0.84 versus 0.56 +/- 0.17; P < .05) and VLDL1 (10.17 +/- 1.96 versus 2.95 +/- 2.44; P = < .01) were markedly higher in smokers than in controls. Changes of RE responses of all TRL fractions were consistent with those of apoB-48. Postprandial apoB-100 concentrations and lipolytic enzymes were similar between the two groups. In conclusion, smokers have the syndrome of impaired TG tolerance because of defective clearance of chylomicrons and their remnants. Prolonged residence time of atherogenic remnant particles may constitute a significant risk factor for CAD in smokers.
6.	Pekny, M, et al. (author) Mice lacking glial fibrillary acidic protein 1995 In: EMBO J. ; 14, s. 1590- Journal article (peer-reviewed)
7.	PEKNY, M, et al. (author) Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally 1995 In: The EMBO journal. - 0261-4189. ; 14:8, s. 1590-1598 Journal article (peer-reviewed)
8.	Sun, XY, et al. (author) The free radical of the anaerobic ribonucleotide reductase from Escherichia coli is at glycine 681 1996 In: The Journal of biological chemistry. - : Elsevier BV. - 0021-9258. ; 271:12, s. 6827-6831 Journal article (peer-reviewed)
9.	Yamauchi, M, et al. (author) Dynamic response of the cusp morphology to the solar wind : A case study during passage of the solar wind plasma cloud on February 21, 1994 1996 In: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 101:A11, s. 24675-24687 Journal article (peer-reviewed)abstract On February 21, 1994, both Geotail and LMP 8 satellites detected an interplanetary plasma cloud with intense interplanetary magnetic field (IMF>50 nT) and high dynamic pressure (> 50 nPa). During this interval the Freja satellite detected intense cusp-like plasma injections in four out of six dayside traversals. The first two traversals are carefully studied, During the first traversal the overall morphology of the ion injection is characterized by a ''multiple-injection'' signature over a wide magnetic local time (MLT) range, whereas it is characterized by a ''single-injection'' signature with narrow injection region at 8 MLT in the second traversal, The solar wind conditions were also quite different between these two periods: while both dynamic and magnetic pressures stayed high during entire period, the dynamic beta was much higher during the first Freja traversal than during the second traversal. Between these two traversals, the cusp plasma injection is detected by the Sondre Stromfjord radar. The radar signature of the plasma injection is identified using the satellite particle data when the satellite and the radar were conjugate (the satellite's footprint was in the radar's field of view.) The cusp position and dynamics observed by the Sondre Stromfjord radar again show a very good correlation to the solar wind condition, especially to the dynamic pressure. The result indicates the following. (1) During southward IMF the cusp morphology differs for conditions of high or low solar wind dynamic pressure. High dynamic pressure widens the cusp (with multiple injections), whereas high magnetic pressure narrows it (with single injection), The effect of the IMF on the cusp locations and morphology becomes dominant only when the dynamic pressure is not very high, (2) Such a morphological difference reflects dynamic pressure more than dynamic beta during southward IMF at least during times of high solar wind dynamic pressure. (3) The cusp morphology responds very quickly to the changes in the solar wind conditions.
10.	Andre, M, et al. (author) Ion energization mechanisms at 1700 km in the auroral region 1998 In: JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. - 0148-0227. ; 103:A3, s. 4199-4222 Journal article (peer-reviewed)abstract Observations obtained by the Freja satellite at altitudes around 1700 km in the high-latitude magnetosphere are used to study ion energization perpendicular to the geomagnetic field. Investigations of ions, electrons, plasma densities, electric and magnetic wave fields, and field-aligned currents are used to study O+ heating mechanisms. Three ion heating events are studied in detail, and 20 events are used in a detailed statistical study. More than 200 events are classified as belonging to one of four major types of ion heating and are ordered as a function of magnetic local time. The most common types of ion heating are associated with broadband low-frequency electric wave fields occurring at all local times. These waves cover frequencies from below one up to several hundred hertz and correspond to the most intense O+ energization. Heating by these waves at frequencies of the order of the O+ gyrofrequency at 25 Hz seems to be the important energization mechanism, causing O+ ion mean energies up to hundreds of eV. The broadband waves are associated with Alfven waves with frequencies up to at least a few hertz and with field-aligned currents. Other types of O+ energization events are less common. During these events the ions are heated by waves near the lower hybrid frequency or near half the proton gyrofrequency. These waves are generated by auroral electrons or in a few cases by precipitating ions.
11.	Andre, M, et al. (author) Ion energization mechanisms at 1700 km in the auroral region 1998 In: JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. - : AMER GEOPHYSICAL UNION. ; 103:A3, s. 4199-4222 Journal article (other academic/artistic)abstract Observations obtained by the Freja satellite at altitudes around 1700 km in the high-latitude magnetosphere are used to study ion energization perpendicular to the geomagnetic field. Investigations of ions, electrons, plasma densities, electric and magnet
12.	Asp, N-G, et al. (author) Mat vid Diabetes. Bra mat för barn mellan 1 och 14 år 1996 Other publication (other academic/artistic)
13.	Axelsen, Mette, 1965, et al. (author) Lipid intolerance in smokers 1995 In: J Intern Med. - 0954-6820. ; 237:5, s. 449-55 Journal article (peer-reviewed)abstract OBJECTIVES. Smokers have recently been shown to be insulin resistant and to exhibit several characteristics of the insulin resistance syndrome (IRS). In this study, we assessed fasting and postprandial lipid levels in healthy, normolipidaemic, chronic smokers and a matched group of non-smoking individuals. DESIGN. A standardized mixed meal (containing 3.78 MJ and 51 g of fat) was given in the morning after an overnight fast. The smokers were either abstinent from tobacco for 48 h or were allowed to smoke freely, including being allowed to smoke six cigarettes during the study. SUBJECTS. Twenty-two middle-aged, healthy male subjects, nine habitual smokers and 13 non-smoking control subjects, were recruited to the study. The smokers had all been smoking at least 10 cigarettes per day for at least 10 years. RESULTS. The smokers exhibited a lipid intolerance in that their postprandial increase in triglyceride levels was more than 50% higher than in the non-smokers' group. This lipid intolerance could not be discerned in the postabsorptive state because the fasting triglyceride levels were the same in both groups, while the smokers had significantly lower high-density lipoprotein (HDL) cholesterol. The peak postprandial triglyceride level correlated closely and negatively with fasting HDL cholesterol, indicating an impaired lipolytic removal capacity in smokers. CONCLUSIONS. Healthy, normotriglyceridaemic smokers exhibit an abnormal postprandial lipid metabolism consistent with lipid intolerance. It is suggested that postprandial hyperlipidaemia is a characteristic trait of the insulin resistance syndrome and that the defect in lipid removal is related to the low HDL cholesterol in this syndrome. The insulin resistance syndrome is likely to be an important reason for the increased propensity for cardiovascular disease in smokers.
14.	Boehm, M. H., et al. (author) Observations of an upward-directed electron beam with the perpendicular temperature of the cold ionosphere 1995 In: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 22, s. 2103-2106 Journal article (peer-reviewed)abstract The Freja TESP electron spectrometer has repeatedly observed similar to 100 eV - 1 keV upward-directed, anti-field-aligned electron beams near 1700 km altitude in the auroral zone. A particularly intense event, at energies up to 2 keV, is described. The beam perpendicular temperature T perpendicular to(e)), was as low as 0.1-0.2 eV at 100-200 eV parallel energy. The 10-15 s period of upward fluxes was coincident with a low density (similar to 10 cm(-3)) period and a similar to 5 keV ion conic. Strong low frequency waves and the lack of any downward motion in the simultaneously observed ion conic suggest a strong element of wave acceleration, while electric field and ion loss cone measurements provide limited evidence of potential acceleration to a fraction of the observed energies.
15.	Bolin, A, et al. (author) Radiographic evaluation of mandibular posterior implant sites: correlation between panoramic and tomographic determinations 1996 In: Clinical oral implants research. - : Wiley. - 0905-7161. ; 7:4, s. 354-359 Journal article (peer-reviewed)
16.	Bolmsjo, M, et al. (author) The heat is on--but how? A comparison of TUMT devices 1996 In: British journal of urology. - : Wiley. - 0007-1331. ; 78:4, s. 564-572 Journal article (peer-reviewed)
17.	Dovner, PO, et al. (author) The occurrence of lower hybrid cavities in the upper ionosphere 1997 In: GEOPHYSICAL RESEARCH LETTERS. - : AMER GEOPHYSICAL UNION. - 0094-8276. ; 24:5, s. 619-622 Journal article (other academic/artistic)abstract Lower hybrid cavities (LHC), i. e., small-scale density depletions coinciding with enhanced lower hybrid waves, are frequent in the upper ionosphere. It is found that they exist in all regions the Freja satellite has scanned, as long as lower hybrid waves
18.	Eliasson, Björn, 1959, et al. (author) Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance 1996 In: Circulation. - 0009-7322. ; 94:5, s. 878-81 Journal article (peer-reviewed)abstract BACKGROUND: Insulin sensitivity and cardiovascular risk profile were examined in 20 healthy, nonobese, middle-aged men who were long-term users of nicotine-containing chewing gum and in 20 matched control subjects who did not use nicotine. METHODS AND RESULTS: Long-term use of nicotine-containing chewing gum was associated with insulin resistance and hyperinsulinemia. The degree of insulin sensitivity correlated negatively to the extent of nicotine use measured as plasma cotinine levels. CONCLUSIONS: These findings suggest that nicotine is the major constituent in cigarette smoke that leads to insulin resistance, metabolic abnormalities associated with the insulin resistance syndrome, and increased cardiovascular morbidity. Thus, the use of nicotine replacement therapy during smoking cessation should be transient and limited.
19.	Eliasson, Björn, 1959, et al. (author) Smoking cessation improves insulin sensitivity in healthy middle-aged men 1997 In: Eur J Clin Invest. - 0014-2972. ; 27:5, s. 450-6 Journal article (peer-reviewed)abstract Cigarette smokers have recently been shown to exhibit insulin resistance, dyslipidaemia and markers of the insulin resistance syndrome (IRS). The aim of this study was to examine the effects of smoking cessation on insulin sensitivity and IRS. Forty male, non-obese healthy smokers participated in this open parallel study with 8 weeks of follow-up. Seventeen subjects were able to stop smoking, while 23 subjects continued to smoke and served as a controls group. Anthropometric and metabolic data were measured. Degree of insulin sensitivity was determined with the euglycaemic hyperinsulinaemic clamp technique. Smoking cessation increased insulin sensitivity and improved the lipoprotein profile in spite of a modest increase in body weight. Initial smoking habits correlated positively with the increase in BMI as well as the improvements in the metabolic variables after smoking cessation. These data support the view that smoking causes insulin resistance and IRS, and also demonstrate that the beneficial metabolic effects of smoking cessation override the effects of an accompanying modest increase in body weight.
20.	Eliasson, Björn, 1959, et al. (author) The insulin resistance syndrome and postprandial lipid intolerance in smokers 1997 In: Atherosclerosis. - 0021-9150. ; 129:1, s. 79-88 Journal article (peer-reviewed)abstract BACKGROUND: The effects of cigarette smoking on insulin resistance, postprandial lipemia following a mixed meal, lipoproteins and other aspects of the insulin resistance syndrome (IRS) were investigated in healthy middle-aged men. METHODS: 36 smoking and 25 age- and body mass index (BMI)-matched non-smoking men participated. They were non-obese (BMI < 27), healthy and without any medication. The smokers had been smoking more than 10 cigarettes per day for more than 20 years; the non-smokers had never been habitual smokers. Body composition and several metabolic and cardiovascular risk factors were studied, including the prevalence of small dense LDL-particles, lipoprotein and hepatic lipase activity and triglyceride levels after a mixed test meal. For determination of degree of insulin sensitivity the euglycemic hyperinsulinemic clamp technique was used. RESULTS: The smokers had lower HDL-cholesterol and lipoprotein A-I levels but higher fasting triglycerides, as well as an increased proportion of small dense LDL-particles and higher postheparin hepatic lipase activity. They also had higher levels of fibrinogen, plasminogen activator inhibitor 1 (PAI-1) activity and fasting and steady-state C-peptide levels during the clamp. The smokers were insulin resistant and lipid intolerant with an impaired triglyceride clearance after a mixed test meal. This lipid intolerance was not mirrored by fasting hypertriglyceridemia. CONCLUSIONS: This study, using the euglycemic hyperinsulinemic clamp technique, shows that smokers are both insulin resistant and lipid intolerant. The postprandial lipid intolerance is also seen in individuals with normal fasting triglyceride levels and is related to an increased prevalence of atherogenic small dense LDL. IRS is likely to be an important reason for the increased cardiovascular morbidity in smokers.
21.	Eliasson, C, et al. (author) Intermediate filament protein partnership in astrocytes 1999 In: The Journal of biological chemistry. - 0021-9258. ; 274:34, s. 23996-24006 Journal article (peer-reviewed)
22.	Eliasson, L, et al. (author) Observations of electron conics by the Viking satellite 1996 In: JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. - : AMER GEOPHYSICAL UNION. - 0148-0227. ; 101:A6, s. 13225-13238 Journal article (other academic/artistic)abstract Electron angular distributions peaked at oblique angles to the magnetic field, electron conics, are frequently found in the Viking data at all magnetic local times, but with a maximum in the dusk sector. Several types of electron conics have been observed
23.	Eliasson, Lena, et al. (author) PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells 1996 In: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 271:5250, s. 813-815 Journal article (peer-reviewed)abstract Hypoglycemic sulfonylureas represent a group of clinically useful antidiabetic compounds that stimulate insulin secretion from pancreatic beta cells. The molecular mechanisms involved are not fully understood but are believed to involve inhibition of potassium channels sensitive to adenosine triphosphate (KATP channels) in the beta cell membrane, causing membrane depolarization, calcium influx, and activation of the secretory machinery. In addition to these effects, sulfonylureas also promoted exocytosis by direct interaction with the secretory machinery not involving closure of the plasma membrane KATP channels. This effect was dependent on protein kinase C (PKC) and was observed at therapeutic concentrations of sulfonylureas, which suggests that it contributes to their hypoglycemic action in diabetics.
24.	Eliasson, M (author) News coverage of violence against women: Engendering blame 1998 In: FEMINISM & PSYCHOLOGY. - : SAGE PUBLICATIONS INC. ; 8:2 Other publication (other academic/artistic)
25.	Eliasson, M (author) Science, men and experiments: Psychology in Sweden 1998 In: FEMINISM & PSYCHOLOGY. - : SAGE PUBLICATIONS INC. ; 8:4:8, s. 552-557 Other publication (other academic/artistic)
26.	Eliasson, M (author) Women and violence: Working for change. 1998 In: FEMINISM & PSYCHOLOGY. - : SAGE PUBLICATIONS INC. ; 8:2 Other publication (other academic/artistic)
27.	Eliasson, M (author) Women, violence and male power: Feminist activism, research and practice. 1998 In: FEMINISM & PSYCHOLOGY. - : SAGE PUBLICATIONS INC. ; 8:2 Other publication (other academic/artistic)
28.	Eliasson, M (author) Women's place in Swedish psychology 1996 In: INTERNATIONAL JOURNAL OF PSYCHOLOGY. - : PSYCHOLOGY PRESS. ; 31:3-4 Other publication (other academic/artistic)
29.	ELIASSON, R, et al. (author) The mechanism of the anaerobic Escherichia coli ribonucleotide reductase investigated with nuclear magnetic resonance spectroscopy 1995 In: Biochemical and biophysical research communications. - : Elsevier BV. - 0006-291X. ; 214:1, s. 28-35 Journal article (peer-reviewed)
30.	Gilljam, H, et al. (author) [Bedside. The portable pencil computer for complete medical history taking in hospitals] 1995 In: Lakartidningen. - 0023-7205. ; 92:22, s. 2293-4 Journal article (peer-reviewed)
31.	Gustafsson, M, et al. (author) Amyloid fibril formation by pulmonary surfactant protein C 1999 In: FEBS letters. - : Wiley. - 0014-5793. ; 464:3, s. 138-142 Journal article (peer-reviewed)
32.	Huque, Y, et al. (author) The metal cofactor in the class Ib RNR from Corynebacterium ammoniagenes 1999 In: JOURNAL OF INORGANIC BIOCHEMISTRY. - 0162-0134. ; 74:1-4, s. 173-173 Conference paper (other academic/artistic)
33.	Karlström Brita, Eliasson M, Vessby Bengt, Cedermark G, Nilsson U. (author) A presentation of the new Swedish booklet "Good food for children - Food for children with diabetes" 1997 In: Satellite Symposium on Nutrition, Obesity and Diabetes. July 17-19, 1997, Kuopio, Finland. Kuopio University Publications D. Medical Sciences 128, Kupio 1997:65.. Conference paper (other academic/artistic)
34.	Kjerrulf, Martin, et al. (author) Induction of gut mucosal immune responses: importance of genetic background and Th1/Th2 cross-regulation. 1998 In: Scandinavian journal of immunology. - 0300-9475. ; 47:5, s. 401-7 Journal article (peer-reviewed)abstract The reciprocal regulation of T-helper cell (Th) subsets is widely documented in various animal models of infectious diseases. In this study IFN-gamma/IL-4 double knockout (DKO) mice were used to analyse the role of Th subsets in mucosal immune responses. We found that the DKO mice had normal IgA differentiation but impaired induction of specific gut mucosal antibody responses after oral immunization using cholera toxin adjuvant. Both Th1 and Th2 responses were reduced compared with wild-type mice. Despite the absence of both IFN-gamma and IL-4 in the DKO mice the overall results were similar to previous observations in IFN-gamma receptor-knockout (IFN-gammaR-/-) mice and did not suggest a strict cross-regulation of the two Th subsets in the gut mucosa. To further examine the role of IFN-gamma in mucosal immunity we compared two different mouse strains lacking IFN-gamma, i.e. IFN-gamma-/- (C57BL/6) and IFN-gammaR-/- mice (129/Sv). We found that IFN-gammaR-/- mice exhibited reduced mucosal antibody responses and decreased Th1 and Th2 activity after oral immunization, while IFN-gamma-/- mice had intact antibody responses and increased Th2 responses. Thus, genetic differences were found to critically affect the development of a specific gut mucosal immune response. An enhanced Th2 activity in the Peyer's patches following oral immunization was associated with an ability to mount strong intestinal IgA immunity.
35.	Kjerrulf, Martin, et al. (author) Interferon-gamma receptor-deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance. 1997 In: Immunology. - 0019-2805. ; 92:1, s. 60-8 Journal article (peer-reviewed)abstract Interferon-gamma (IFN-gamma) receptor knock-out (IFN-gamma R -/-) mice were used to analyse the role of IFN-gamma in mucosal immune responses following oral immunization. We found that the IFN-gamma R -/- mice demonstrated 50% reduced spot-forming cell (SFC) responses in the gut lamina propria and spleen after oral immunization with keyhold limpet haemocyanin (KLH) plus cholera toxin (CT) adjuvant. The IFN-gamma R -/- mice exhibited 10-fold reduced total serum KLH-specific antibody levels compared with wild-type mice after oral immunization, while after intravenous immunization, no such difference was seen, suggesting a selective impairment of mucosal immune responses. Moreover, oral immunizations resulted in impaired interleukin-4 (IL-4), IL-10 and IFN-gamma production by spleen T cells from IFN-gamma R -/- mice, indicating that no reciprocal up-regulation of Th2-activities had occurred despite the lack of IFN-gamma R function. No reduction in Th1 or Th2 cytokines was observed following systemic immunizations. Despite potentially strong modulating effects of IFN-gamma on epithelial cell IgA transcytosis and electrolyte barrier functions, CT-immunized IFN-gamma R -/- mice demonstrated unaltered protection against CT in ligated intestinal loops together with normal anti-CT IgA and total IgA levels in gut lavage. Oral feeding with KLH followed by parenteral immunization resulted in strongly suppressed SFC numbers and reduced cell-mediated immunity in both wild-type and IFN-gamma R -/- mice. CT-adjuvant abrogated induction of oral tolerance in both IFN-gamma R -/- and wild-type mice. Collectively, our data argue that the two major response patterns induced by oral administration of protein antigen, i.e. active IgA immunity and oral tolerance, are differently regulated. Thus, IFN-gamma R -/- mice have impaired mucosal immune responses while induction of oral tolerance appears to be unaffected by the lack of IFN-gamma functions.
36.	Makela, JS, et al. (author) Observations of mesoscale auroral plasma cavity crossings with the Freja satellite 1998 In: JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. - : AMER GEOPHYSICAL UNION. ; 103:A5, s. 9391-9404 Journal article (other academic/artistic)abstract We have used data from the Freja satellite, with an apogee of 1700 km over the auroral oval, to make a statistical analysis of mesoscale auroral plasma density cavities. Such cavities are defined to be regions in the auroral zone with size scales between
37.	Mishin, V M, et al. (author) A study of the CDAW 9C substorm of May 3, 1986, using magnetogram inversion technique 2, and a substorm scenario with two active phases 1997 In: JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. - 0148-0227. ; 102:A9, s. 19845-19859 Journal article (peer-reviewed)abstract One of the CDAW 9C substorms is investigated in this paper using the database reported by Hones et al. and supplemented with magnetogram inversion technique (MIT) 2 data. These latter have provided information about the dynamics of the open tail magnetic Aux, current systems in the ionosphere, and the size and dynamics of the current wedge. We have identified the growth: expansion, and recovery phases of this substorm, with characteristics expected from a generally accepted scenario. However, specific signatures were observed in the interval (0919-0935) UTI i.e., between the growth and expansion phases, indicating the concurrent development of the substorm onset and corresponding instabilities in the innermost current sheet, and small-scale cross-tail current disruptions without the open tail reconnection. In addition to signatures of small-scale dipolarization, an increase of the open tail magnetic flux, and a current system of the type close to DP 2 were observed at (0919-0935) UT, which is more likely to suggest predominance of the tail-stretching process than magnetic collapse, This fact was interpreted in tel ms of a relevant simple model as a signature of the growth of the energy input from the solar wind which ensures the observable disturbance power. Hence the disturbance st (0919-0935) UT was more likely a driven one than an unloading one. The aforementioned signatures make it possible to identify the interval (0919-0935) UT as the ''phase of multiple onsets'' or: (equivalently) the ''first active phase,'' which was previously defined by Mishin [1991., and references therein] as one of the four standard phases of a typical substorm (in addition to the expansion phase). Thus the case study supports the substorm scenario with two active phases and, accordingly, with two different kinds of physics, This case study illustrates also the informativity of MIT 2 data and their ability to effectively complement the database traditionally used in substorm studies.
38.	MULLIEZ, E, et al. (author) Formate is the hydrogen donor for the anaerobic ribonucleotide reductase from Escherichia coli 1995 In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 92:19, s. 8759-8762 Journal article (peer-reviewed)abstract During anaerobic growth Escherichia coli uses a specific ribonucleoside-triphosphate reductase (class III enzyme) for the production of deoxyribonucleoside triphosphates. In its active form, the enzyme contains an iron-sulfur center and an oxygen-sensitive glycyl radical (Gly-681). The radical is generated in the inactive protein from S-adenosylmethionine by an auxiliary enzyme system present in E. coli. By modification of the previous purification procedure, we now prepared a glycyl radical-containing reductase, active in the absence of the auxiliary reducing enzyme system. This reductase uses formate as hydrogen donor in the reaction. During catalysis, formate is stoichiometrically oxidized to CO2, and isotope from [3H]formate appears in water. Thus E. coli uses completely different hydrogen donors for the reduction of ribonucleotides during anaerobic and aerobic growth. The aerobic class I reductase employs redox-active thiols from thioredoxin or glutaredoxin to this purpose. The present results strengthen speculations that class III enzymes arose early during the evolution of DNA.
39.	Neve, EPA, et al. (author) Enzyme-specific transport of rat liver cytochrome P450 to the Golgi apparatus 1996 In: Archives of biochemistry and biophysics. - : Elsevier BV. - 0003-9861. ; 333:2, s. 459-465 Journal article (peer-reviewed)
40.	Norqvist, P, et al. (author) Ion cyclotron heating in the dayside magnetosphere 1996 In: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 101:A6, s. 13179-13193 Journal article (peer-reviewed)abstract Observations of waves and particles obtained by the Freja satellite at altitudes around 1700 km in the dayside high-latitude magnetosphere are used to study ion energization. We find that ions, including O+, during several events of intense ion energization can be heated perpendicularly to the geomagnetic field to mean energies df up to about 20 eV via the process of cyclotron resonance by broadband waves around the ion gyrofrequencies. There is a good correlation between such broadband waves and the ion energization. The waves show no spectral features at the O+ gyrofrequency. The observed wave amplitudes are used as an input to a Monte Carlo simulation to obtain the observed ion energies. The waves around the ion gyrofrequencies may be generated either by field-aligned electrons or by nonlinear processes transferring energy from waves with lower frequencies. Not only the mean energy but also the shape of the particle distribution agrees with the cyclotron resonance heating mechanism. Other mechanisms, such as heating by lower hybrid waves or by a slowly varying electric field, are investigated but are found to be less important than cyclotron heating in this region of space.
41.	Norqvist, P, et al. (author) Ion cyclotron heating in the dayside magnetosphere 1996 In: JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. - : AMER GEOPHYSICAL UNION. - 0148-0227. ; 101:A6, s. 13179-13193 Journal article (other academic/artistic)abstract Observations of waves and particles obtained by the Freja satellite at altitudes around 1700 km in the dayside high-latitude magnetosphere are used to study ion energization. We find that ions, including O+, during several events of intense ion energizati
42.	Ollagnier, S, et al. (author) Activation of the anaerobic ribonucleotide reductase from Escherichia coli. The essential role of the iron-sulfur center for S-adenosylmethionine reduction 1997 In: The Journal of biological chemistry. - : Elsevier BV. - 0021-9258. ; 272:39, s. 24216-24223 Journal article (peer-reviewed)
43.	Ollagnier, S, et al. (author) The anaerobic Escherichia coli ribonucleotide reductase. Subunit structure and iron sulfur center 1996 In: The Journal of biological chemistry. - : Elsevier BV. - 0021-9258. ; 271:16, s. 9410-9416 Journal article (peer-reviewed)
44.	Pekny, M, et al. (author) Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin 1999 In: The Journal of cell biology. - : Rockefeller University Press. - 0021-9525 .- 1540-8140. ; 145:3, s. 503-514 Journal article (peer-reviewed)abstract In response to injury of the central nervous system, astrocytes become reactive and express high levels of the intermediate filament (IF) proteins glial fibrillary acidic protein (GFAP), vimentin, and nestin. We have shown that astrocytes in mice deficient for both GFAP and vimentin (GFAP−/−vim−/−) cannot form IFs even when nestin is expressed and are thus devoid of IFs in their reactive state. Here, we have studied the reaction to injury in the central nervous system in GFAP−/−, vimentin−/−, or GFAP−/−vim−/− mice. Glial scar formation appeared normal after spinal cord or brain lesions in GFAP−/− or vimentin−/− mice, but was impaired in GFAP−/−vim−/− mice that developed less dense scars frequently accompanied by bleeding. These results show that GFAP and vimentin are required for proper glial scar formation in the injured central nervous system and that some degree of functional overlap exists between these IF proteins.
45.	Pekny, M, et al. (author) GFAP-deficient astrocytes are capable of stellation in vitro when cocultured with neurons and exhibit a reduced amount of intermediate filaments and an increased cell saturation density 1998 In: Experimental cell research. - 0014-4827. ; 239:2, s. 332-343 Journal article (peer-reviewed)
46.	Pekny, M, et al. (author) Impaired induction of blood-brain barrier properties in aortic endothelial cells by astrocytes from GFAP-deficient mice 1998 In: Glia. - 0894-1491. ; 22:4, s. 390-400 Journal article (peer-reviewed)
47.	Tatzelt, J, et al. (author) Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein 1996 In: Neurology. - 0028-3878. ; 47:2, s. 449-453 Journal article (peer-reviewed)
48.	Wannerberger, Lars, et al. (author) Adsorption of protein fractions from wheat onto methylated silica surfaces 1996 In: Cereal Chemistry. - 0009-0352. ; 73:4, s. 499-505 Journal article (peer-reviewed)abstract The kinetics of the sequential adsorption of gliadins and water-soluble fraction (WSF) from the wheat variety Kosack onto hydrophobic silica (methylated silica) surfaces were studied by in situ ellipsometry. The measurements were made in water and in 0.01M acetate buffer, pH 4.0 and 5.0, with and without 0.1M NaCl. The concentration of gliadins and WSF was 1.7 µg/ml. The adsorption of gliadins in water was investigated at three different protein concentrations (0.17, 1.7, and 17 µg/ml), and the adsorption was found to be very high with regard to the low concentrations of protein in solution. The results of the sequential adsorption in water indicated that the WSF adsorbed to preadsorbed gliadins. When proteins of the WSF were adsorbed first, they blocked further adsorption of gliadins. Measurements in acetate buffer at different pH values showed that the effect of pH was larger in the experiments where the gliadins were adsorbed first, both for the initial adsorption and for the sequential addition of WSF. An increase in ionic strength also increased the amount of WSF adsorbed to preadsorbed gliadins. These results indicate that the sequential adsorption of WSF to gliadins is strongly affected by electrostatic interactions.
49.	Yasar, U, et al. (author) Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population 1999 In: Biochemical and biophysical research communications. - : Elsevier BV. - 0006-291X. ; 254, s. 628- Journal article (peer-reviewed)
50.	ZAPHIROPOULOS, PG, et al. (author) Cytochrome P450 genes expressed in porcine ovaries: identification of novel forms, evidence for gene conversion, and evolutionary relationships 1995 In: Biochemical and biophysical research communications. - : Elsevier BV. - 0006-291X. ; 212:2, s. 433-441 Journal article (peer-reviewed)

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