| 1. |
- Emma, Lindblad, et al.
(author)
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Experiences of the new role of advanced practice nurses in Swedish primary health care--a qualitative study
- 2010
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In: International Journal of Nursing Practice. - 1322-7114. ; 2010:16, s. 69-74
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Journal article (peer-reviewed)abstract
- The aim of this study was to investigate and describe the experiences of the first advanced practice nurses (APNs), a new profession for Swedish health care, and of their supervising general practitioners (GPs), regarding the new role and scope of practice of APNs in primary health care. Individual interviews were conducted with the four first APNs and one focus group interview was conducted with five supervising physicians. The material was transcribed verbatim and analysed using latent content analysis. The respondents expressed confidence and trust in the new role of APNs. Some opposition to this new role from the GPs and other colleagues was observed, but was nonetheless overcome. The experiences of the APN role indicate that the new role is clearly demarcated from the role of physicians. The APNs were considered an extra resource for both the GPs and other nurses, which contributed to an increased availability of care for patients. The APN role requires an explicit definition and demarcation in relation to responsibility and roles among colleagues. Further development of the APN role presupposes the right to prescribe medication and order treatments, as well as an evaluation of patient, organizational and inter-professional perspectives on the matter.
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| 2. |
- Lindblad, Emma, et al.
(author)
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Experiences of the new role of advanced practice nurses in Swedish primary health care - A qualitative study
- 2010
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In: International Journal of Nursing Practice. - : Blackwell Publishing Asia Pty Ltd. - 1322-7114 .- 1440-172X. ; 16:1, s. 69-74
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Journal article (peer-reviewed)abstract
- The aim of this study was to investigate and describe the experiences of the first advanced practice nurses (APNs), a new profession for Swedish health care, and of their supervising general practitioners (GPs), regarding the new role and scope of practice of APNs in primary health care. Individual interviews were conducted with the four first APNs and one focus group interview was conducted with five supervising physicians. The material was transcribed verbatim and analysed using latent content analysis. The respondents expressed confidence and trust in the new role of APNs. Some opposition to this new role from the GPs and other colleagues was observed, but was nonetheless overcome. The experiences of the APN role indicate that the new role is clearly demarcated from the role of physicians. The APNs were considered an extra resource for both the GPs and other nurses, which contributed to an increased availability of care for patients. The APN role requires an explicit definition and demarcation in relation to responsibility and roles among colleagues. Further development of the APN role presupposes the right to prescribe medication and order treatments, as well as an evaluation of patient, organizational and inter-professional perspectives on the matter. © 2010 Blackwell Publishing Asia Pty Ltd.
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| 3. |
- Karlsson, Elinor K, et al.
(author)
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Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B
- 2013
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In: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X .- 1474-7596. ; 14:12
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Journal article (peer-reviewed)abstract
- BACKGROUND: Canine osteosarcoma is clinically nearly identical to the human disease, but is common and highly heritable, making genetic dissection feasible.RESULTS: Through genome-wide association analyses in three breeds (greyhounds, Rottweilers, and Irish wolfhounds), we identify 33 inherited risk loci explaining 55% to 85% of phenotype variance in each breed. The greyhound locus exhibiting the strongest association, located 150 kilobases upstream of the genes CDKN2A/B, is also the most rearranged locus in canine osteosarcoma tumors. The top germline candidate variant is found at a >90% frequency in Rottweilers and Irish wolfhounds, and alters an evolutionarily constrained element that we show has strong enhancer activity in human osteosarcoma cells. In all three breeds, osteosarcoma-associated loci and regions of reduced heterozygosity are enriched for genes in pathways connected to bone differentiation and growth. Several pathways, including one of genes regulated by miR124, are also enriched for somatic copy-number changes in tumors.CONCLUSIONS: Mapping a complex cancer in multiple dog breeds reveals a polygenic spectrum of germline risk factors pointing to specific pathways as drivers of disease.
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| 4. |
- Lindblad, Emma, 1981-, et al.
(author)
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The Cultural Role of Stigmatized Youth Groups : The Case of the Partille Johnnys of Sweden
- 2011
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In: Research in Consumer Behavior. - : Emerald Group Publishing Limited. - 9781780521169 - 9781780521176 ; , s. 127-143
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Book chapter (peer-reviewed)abstract
- Purpose: This paper aims to contribute to the theoretical domain of identity construction by discussing an aspect of identity-not, i.e. how identity is largely formed by delimitations of what one does not identify with. We do this by analyzing the reactions of mainstream youth to the stylistic expressions of one particular youth group—the so-called Partille Johnnys (PJs) of Sweden—who in certain ways breaks with conventions of how to relate to the globally available canon of culturally sanctioned styles which places them in a position as stigmatized. The purpose of the paper is to further the understanding of how stigma gets orchestrated in consumer culture and what cultural role stigmatized groups might play.Methodology: The empirical material for this paper has been collected using various qualitative research techniques. Initially the phenomenon was discovered and explored during ethnographic observations and interviews. In addition online research was carried out.Findings: The PJ style functions as a mirror for reflecting on transgressions of what is considered normal in terms of style and bodily practices for contemporary Swedish youth. Our conclusion suggests that the cultural function of the stigmatized group PJ is to serve as a reminder of what the mainstream is not.Originality/value of paper: A phenomenon previously not studied, part of the value lies in the ethnographic descriptions capturing the PJ phenomenon. With these empirical descriptions we wish to add to discussions of how the stigmatized groups gets orchestrated as well as the role that stigmatized groups can play at a cultural level.
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| 5. |
- Olsson, Mia, et al.
(author)
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The dog as a genetic model for immunoglobulin A (IgA) deficiency : Identification of several breeds with low serum IgA concentrations
- 2014
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In: Veterinary Immunology and Immunopathology. - : Elsevier BV. - 0165-2427 .- 1873-2534. ; 60:3-4, s. 255-259
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Journal article (peer-reviewed)abstract
- Immunoglobulin A (IgA) serves as the basis of the secretory immune system by protecting the lining of mucosal sites from pathogens. In both humans and dogs, IgA deficiency (IgAD) is associated with recurrent infections of mucosal sites and immune-mediated diseases. Low concentrations of serum IgA have previously been reported to occur in a number of dog breeds but no generally accepted cut-off value has been established for canine IgAD. The current study represents the largest screening to date of IgA in dogs in terms of both number of dogs (n = 1267) and number of breeds studied (n = 22). Serum IgA concentrations were quantified by using capture ELISA and were found to vary widely between breeds. We also found IgA to be positively correlated with age (p < 0.0001). Apart from the two breeds previously reported as predisposed to low IgA (Shar-Pei and German shepherd), we identified six additional breeds in which > 10% of all tested dogs had very low (<0.07 g/l) IgA concentrations (Hovawart, Norwegian elkhound, Nova Scotia duck tolling retriever, Bullterrier, Golden retriever and Labrador retriever). In addition, we discovered low IgA concentrations to be significantly associated with canine atopic dermatitis (CAD, p < 0.0001) and pancreatic acinar atrophy (PAA, p = 0.04) in German shepherds.
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| 6. |
- Zeng, R., et al.
(author)
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Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy
- 2014
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In: Journal of Veterinary Internal Medicine. - : Wiley. - 0891-6640 .- 1939-1676. ; 28:2, s. 515-521
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Journal article (peer-reviewed)abstract
- Background Previous reports associated 2 mutant SOD1 alleles (SOD1:c.118A and SOD1:c.52T) with degenerative myelopathy in 6 canine breeds. The distribution of these alleles in other breeds has not been reported. Objective To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. Animals DNA from 33,747 dogs was genotyped at SOD1:c.118, SOD1:c.52, or both. Spinal cord sections from 249 of these dogs were examined. Methods Retrospective analysis of 35,359 previously determined genotypes at SOD1:c.118G>A or SOD1:c.52A>T and prospective survey to update the clinical status of a subset of dogs from which samples were obtained with a relatively low ascertainment bias. Results The SOD1:c.118A allele was found in cross-bred dogs and in 124 different canine breeds whereas the SOD1:c.52T allele was only found in Bernese Mountain Dogs. Most of the dogs with histopathologically confirmed degenerative myelopathy were SOD1:c.118A homozygotes, but 8 dogs with histopathologically confirmed degenerative myelopathy were SOD1:c.118A/G heterozygotes and had no other sequence variants in their SOD1 amino acid coding regions. The updated clinical conditions of dogs from which samples were obtained with a relatively low ascertainment bias suggest that SOD1:c.118A homozygotes are at a much higher risk of developing degenerative myelopathy than are SOD1:c.118A/G heterozygotes. Conclusions and Clinical Importance We conclude that the SOD1:c.118A allele is widespread and common among privately owned dogs whereas the SOD1:c.52T allele is rare and appears to be limited to Bernese Mountain Dogs. We also conclude that breeding to avoid the production of SOD1:c.118A homozygotes is a rational strategy.
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