Biophotonic methods in microcirculation imaging

• Visible and near-infrared light, particularly in the wavelength region of 600-1100 nm, offer a window into human and animal tissues due to reduced scattering and absorption. We review the main biophotonic methods applied to visualisation and assessment of the microcirculation and document the progress made over the past 10 years in particular. Applications, particularly in human skin, are of special topical importance due to an improved knowledge of its role and its value as a surrogate for other organs in drug testing at a time when drug development is under severe pressure. © 2007.

Nyckelord

Biophotonics

Capillaroscopy

Laser Doppler

Laser speckle

Microcirculation imaging

Perfusion monitoring

Photo-acoustic tomography (PAT)

Tissue viability imaging (TiVi)

TECHNOLOGY

TEKNIKVETENSKAP

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