| 1. |
- Mustafa, Mudassir Imran, 1978-
(författare)
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Sustaining the Usefulness of eHealth Research Software : Lessons Learned in Action Design Research
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Research software is vital to advancement in the sciences, engineering, humanities, and all other fields. Scientific research is dependent on the quality of and accessibility to research software. Research software is often developed hastily to solve one-off problems, leading to flimsy code that is not sustainable or usable beyond the lifetime of a given research project and is difficult for researchers, outside of the original context, to use, reuse or extend. It is critical to address the many challenges related to the development, deployment, and maintenance of research software. Therefore, there is a growing concern in the scientific community regarding designing sustainable research software. The academic research context refers to the environment or community concerned with scientific research, sponsored by research grants and public funding. Despite the increasing dependence on research software, software development practices in academia lag far behind those in the commercial sector.Health care relies on a very complex information technology architecture with many different IT components and also has a highly complex governance structure alongside the very rapid technology development. Additionally, there are ever-increasing demands and needs from health care users for more flexibility, more functionality and making the care transparent and patient-centred. Taken together, this poses significant challenges for eHealth and Information Systems researchers, as each artefact, depending on the context, has different quality characteristics to operationalise the requirements under consideration.The research objective is to explore what Information Systems researchers and practitioners need to be aware of for sustaining the usefulness of eHealth research software, in the academic research context. This longitudinal action design research (ADR) project, with its three cases, was conducted in an eHealth research project over a period of six years. Contributions from this research include the identification of quality characteristics and their enactment in the actual organisational settings, as well as empirically grounded design principles and a typology for sustaining the usefulness of eHealth research software, based on a formalisation of learning in the three ADR cases. This dissertation also contributes to the method space with the introduction of the augmented action design research (AADR) method, an extension of ADR, on how to conduct multiple ADR projects that build towards an overarching knowledge aim.Practice contributions are the design and development of internet-based eHealth research software to offer patients psychological treatment and support for issues resulting from physical illnesses, while also providing a chance for researchers to study the effectiveness of the aid provided. The dissertation also contributed in a broader sense to the research software development practice, as the findings extend to research areas in which research software is needed to read and interpret research data, and where software must continue to function so that it allows continued access and use of research data.
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| 2. |
- Eriksson, Helena, 1978-, et al.
(författare)
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Education and Career Choices : How the School Can Support Young People to Develop Knowledge and Decision-making Skills
- 2018
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Ingår i: Universal Journal of Educational Research. - Alhambra, CA : Horizon Research Publishing. - 2332-3205 .- 2332-3213. ; 6:9, s. 1900-1908
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Tidskriftsartikel (refereegranskat)abstract
- Contemporary society is characterized by rapid changes in the labor market, increased flow of information, and more opportunities to make choices in relation to education and career. Previous research has demonstrated how many young people in school don't think they get the support they need to make such choices. The overall aim of this article is to contribute to more in-depth knowledge of what kind of support and knowledge young adults describe as important in order to be able to make informed choices. This knowledge might help school to better support young people in acquiring the knowledge, skills, and attitudes in relation to their education and career choices. The article is based on interviews with 25-year-old men and women. 23 interviews were conducted. In sum, the analysis indicates that guidance activities that aims to contribute to knowledge about the labor market, programs and courses and requirements for different education programs would probably be perceived as more fruitful by the young adults if they are organized in a combination of different levels, i.e. both as group activities (exhibitions, general information/discussion) and individual activities (personal information/discussion). Further, the authors demonstrate that roles and expectations between pupils, teachers and guidance counselors should be discussed and clarified.
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| 3. |
- Högdin, Sara, 1972-, et al.
(författare)
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Strategies to strengthen outlook of life among young people : A case study in a Swedish municipality
- 2016
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Ingår i: SWSD 2016.
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Konferensbidrag (refereegranskat)abstract
- There is a continuous increase in mental health problems, such as stress symptoms, among young people in the Nordic countries. One source of stress concerns young people’s outlook of life in general, and more specific the choice of education and future carrier. Previous studies show that high education has positive impact on a person’s health, but also on regional development. The research project is based on a case study in a Swedish municipality with low educational level. The aim of the study is to explore and understand the low education among the citizens. The study starts in young person’s perspective on their future. Further, how adults in home, school and the neighborhood, influence the young person’s educational and carrier choices. The analyses of the results are based on theories on gender and cultural/social capital. The empirical material consists of surveys and interview studies with young people, teachers and guidance counsellors. The results show that young people often feel unsure of their future chooses and often ask for more support from adults regarding their future education. Several students find it stressful to manage their career choices, particularly if their parents do not have sufficient knowledge to support them in such matters. Teachers and guidance counselors describe a lack of strategies to support and addressing issues of education and future work, but also how they should be passive in relation to influencing the students. In conclusion, the results show the importance, when it comes to social work and social development practices on preventing mental health problems among young people, to develop strategies for working with young person’s educational and carrier choices. In this project some strategies have been identified, on local political and school level, to strengthen outlook of life among young people.
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| 4. |
- Högdin, Sara, 1972-, et al.
(författare)
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Young people's educational and career choices : A case study among young people, guidance counsellors and teachers in a Swedish municipality
- 2016
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Ingår i: NERA2016. ; , s. 89-89
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Konferensbidrag (refereegranskat)abstract
- In a changing and complex world, young people are expected to make decisions and choices regarding their education and future careers. At the same time, there is a continuous increase in mental health problems, such as stress symptoms, among young people in the Nordic countries. One source of stress concerns young people’s outlook on life in general, and more specifically their choice of education and career. This paper is based on a research project in a Swedish municipality with a low level of education. The overall aim of the project was to explore and understand the low education among the citizens in the municipality. The aim of this paper is to illustrate how career counsellors and teachers view their role in supporting students when it comes to these choices, and how young people view the support they receive and have received during their years at compulsory and upper secondary school. The empirical material consists of surveys and interview studies with young people, teachers and career counsellors. The analyses of the results are based on Pierre Bourdieu’s theory of field, capital and habitus with a gender perspective from Beverley Skeggs’ theory on gender and capital. The study takes young people’s perspectives of their education and careers as its starting point. It also examines the support they have received from career counsellors and teachers at compulsory and upper secondary school and also from their parents and other significant persons in their home environment. The analyses show that there are differences in how professionals and young people view study and career guidance. Young people often express a feeling of uncertainty when it comes to their future choices and request more guidance from adults regarding possible opportunities. Several students find it stressful to manage their career choices, particularly if their parents do not have sufficient knowledge to support them in such matters. Girls express a feeling of stress in relation to educational choices more often than boys. Teachers and career counsellors describe a lack of strategies when it comes to vocational guidance and how to address issues of education and future work within the current curriculum. They also express a fear of influencing young people and therefore take a more passive approach in these matters. In conclusion, the results show that there is a gap between young people’s requests for guidance from adults at school and teachers’ and career counsellors’ view of their role in these matters. The results highlights the importance of developing strategies for working with educational and career choices at compulsory school as one way of preventing mental health problems among young people.
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| 5. |
- Isaksson, Anna, 1980-, et al.
(författare)
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The consequences of individualization for boys in the Swedish school system
- 2016
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Konferensbidrag (refereegranskat)abstract
- The aim of this presentation/working paper is to contribute to the knowledge about why young men generally are less likely to study at the university than young women. Previous studies and reports have pointed out a number of explanations for that. Young men’s reluctance to go on to higher education, as well as boys’ relatively low grades in primary and secondary schools, has been explained with reference to gender theoretical arguments about constraining constructions of masculinity. Several gender-oriented studies show that it is not considered compatible with certain types of masculinity constructions to make an e ort in school and show an interest in further studies. A term used to explain the boys’ poor performance in school and lack of interest in higher studies is antiplugg kultur (cf. eg Nordberg 2008 SOU 2009: 64). is presentation/working paper aims to challenge these explanations and expand the understanding of why young men tend to not to see higher education as an option. e empirical data consists of extensive quanti- tative and qualitative studies in a western Swedish municipality during 2011-2014. e point of departure is primarily in the young men’s own stories about teaching in primary and secondary school and their perceptions of their interactions with teachers, study and career counsellors and others. e interplay between and consequences of contemporary constructions of masculinity (Connell, 1995-2003), and the individualisation of society (Giddens 1991; Beck 1992), which is reflected in the teachers and study and career counsellors practitioners, are the main theoretical elements to interpret the empirical material.
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| 6. |
- Karakatsanis, Andreas, et al.
(författare)
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Effect of preoperative injection of superparamagnetic iron oxide particles on rates of sentinel lymph node dissection in women undergoing surgery for ductal carcinoma in situ (SentiNot study)
- 2019
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Ingår i: British Journal of Surgery. - : Oxford University Press (OUP). - 0007-1323 .- 1365-2168. ; 106:6
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Tidskriftsartikel (refereegranskat)abstract
- Background: One-fifth of patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) have invasive breast cancer (IBC) on definitive histology. Sentinel lymph node dissection (SLND) is performed in almost half of women having surgery for DCIS in Sweden. The aim of the present study was to try to minimize unnecessary SLND by injecting superparamagnetic iron oxide (SPIO) nanoparticles at the time of primary breast surgery, enabling SLND to be performed later, if IBC is found in the primary specimen. Methods: Women with DCIS at high risk for the presence of invasion undergoing breast conservation, and patients with DCIS undergoing mastectomy were included. The primary outcome was whether this technique could reduce SLND. Secondary outcomes were number of SLNDs avoided, detection rate and procedure-related costs. Results: This was a preplanned interim analysis of 189 procedures. IBC was found in 47 and a secondary SLND was performed in 41 women. Thus, 78.3 per cent of patients avoided SLND (P<0.001). At reoperation, SPIO plus blue dye outperformed isotope and blue dye in detection of the sentinel node (40 of 40 versus 26 of 40 women; P<0.001). Costs were reduced by a mean of 24.5 per cent in women without IBC (3990 versus 5286; P<0.001). Conclusion: Marking the sentinel node with SPIO in women having surgery for DCIS was effective at avoiding unnecessary SLND in this study. Registration number: ISRCTN18430240 (http://www.isrctn.com).
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| 7. |
- Lundström, Sofie, 1971-, et al.
(författare)
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The Meaning of the Lived Experience of Lifestyle Changes for People with Severe Mental Illness.
- 2017
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Ingår i: Issues in Mental Health Nursing. - Philadelphia, PA : Informa UK Limited. - 0161-2840 .- 1096-4673. ; 38:9, s. 717-725
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to elucidate the meaning of the lived experience of lifestyle changes as perceived by people with severe mental illness (SMI). People with SMI who have experience in managing lifestyle changes were interviewed (n = 10). The interviews were analyzed with a phenomenological hermeneutic approach. The findings reveal three themes: (1) struggling with inner and outer limitations, (2) on one's own but together with others and (3) longing for living a life in harmony. The meaning of lifestyle changes can be understood as a person's internal and external endeavors to make well-considered decisions about lifestyle changes. Support should focus on strengthening the person's self-efficacy and should be based on the person's experiences.
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| 8. |
- Söndergaard Hansen, Jesper, et al.
(författare)
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Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation
- 2016
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Ingår i: Metabolism-Clinical and Experimental. - : Elsevier BV. - 0026-0495. ; 65:12, s. 1731-1742
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Tidskriftsartikel (refereegranskat)abstract
- Accumulating evidence suggests that dysregulated glycerol metabolism contributes to the pathophysiology of obesity and type 2 diabetes. Glycerol efflux from adipocytes is regulated by the aquaglyceroporin AQP7, which is translocated upon hormone stimulation. Here, we propose a molecular mechanism where the AQP7 mobility in adipocytes is dependent on perilipin 1 and protein kinase A. Biochemical analyses combined with ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7, and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7, thereby reducing complex formation. Together, these findings are indicative of how glycerol release is controlled in adipocytes, and may pave the way for the future design of drugs against human metabolic pathologies.
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