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- Alsmark, Cecilia M., et al.
(författare)
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The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae
- 2004
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 101:26, s. 9716-9721
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Tidskriftsartikel (refereegranskat)abstract
- We present the complete genomes of two human pathogens, Bartonella quintana (1,581,384 bp) and Bartonella henselae (1,931,047 bp). The two pathogens maintain several similarities in being transmitted by insect vectors, using mammalian reservoirs, infecting similar cell types (endothelial cells and erythrocytes) and causing vasculoproliferative changes in immunocompromised hosts. A primary difference between the two pathogens is their reservoir ecology. Whereas B. quintana is a specialist, using only the human as a reservoir, B. henselae is more promiscuous and is frequently isolated from both cats and humans. Genome comparison elucidated a high degree of overall similarity with major differences being B. henselae specific genomic islands coding for filamentous hemagglutinin, and evidence of extensive genome reduction in B. quintana, reminiscent of that found in Rickettsia prowazekii. Both genomes are reduced versions of chromosome I from the highly related pathogen Brucella melitensis. Flanked by two rRNA operons is a segment with similarity to genes located on chromosome II of B. melitensis, suggesting that it was acquired by integration of megareplicon DNA in a common ancestor of the two Bartonella species. Comparisons of the vector-host ecology of these organisms suggest that the utilization of host-restricted vectors is associated with accelerated rates of genome degradation and may explain why human pathogens transmitted by specialist vectors are outnumbered by zoonotic agents, which use vectors of broad host ranges.
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- Dupuy, E., et al.
(författare)
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Strato-mesospheric Measurements of Carbon Monoxide with the Odin Sub-millimetre Radiometer: Retrieval and First Results
- 2004
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Ingår i: Geophysical Research Letters. - 1944-8007 .- 0094-8276. ; 31:20
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Tidskriftsartikel (refereegranskat)abstract
- The Sub-Millimetre Radiometer (SMR) aboard the Odin satellite has been measuring vertical profiles of atmospheric trace gases since August 2001. We present the inversion methodology developed for CO measurements and the first retrieval results. CO can be retrieved from a single scan measurement throughout the middle atmosphere, with a typical resolution of similar to3 km and a relative error of similar to10% to similar to25%. Retrieval results are evaluated through comparison with data from the Whole Atmosphere Community Climate Model (WACCM) and observations of the Improved Stratospheric and Mesospheric Sounder (ISAMS) on board the Upper Atmospheric Research Satellite (UARS). Considering the large natural variability of CO, the SMR retrievals give good confirmation of the WACCM results, with an overall agreement within a factor of 2. ISAMS abundances are higher than SMR mixing ratios by a factor of 5-10 above 0.5 hPa from similar to80degreesS to similar to50degreesN.
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- Durbeej, B, et al.
(författare)
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Thermodynamics of the photoenzymic repair mechanism studied by density functional theory
- 2000
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Ingår i: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - : AMER CHEMICAL SOC. - 0002-7863. ; 122:41, s. 10126-10132
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Tidskriftsartikel (refereegranskat)abstract
- The thermodynamics of the different steps in the photoenzymic fragmentation of a thymine dimer is investigated using density functional theory (DFT) methods, including time-dependent (TD) DFT for calculating electronic transition energies, employing a mod
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- Gauld, JW, et al.
(författare)
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Oxidative degradation of pyruvate formate-lyase
- 2000
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Ingår i: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - : AMER CHEMICAL SOC. - 0002-7863. ; 122:9, s. 2035-2040
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Tidskriftsartikel (refereegranskat)abstract
- The reaction mechanisms of oxidative degradation of the anaerobic radical enzyme pyruvate formatelyase (PFL) have been examined at the theoretical hybrid Hartree-Fock/density functional theory level B3-LYP. It is concluded that the most likely scenario in
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8. |
- Himo, F, et al.
(författare)
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Catalytic mechanism of galactose oxidase: A theoretical study
- 2000
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Ingår i: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - : AMER CHEMICAL SOC. - 0002-7863. ; 122:33, s. 8031-8036
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Tidskriftsartikel (refereegranskat)abstract
- Density functional methods, alone and together with molecular mechanics, are used to study the catalytic mechanism of galactose oxidase. This enzyme catalyzes the conversion of primary alcohols to the corresponding aldehydes, coupled with reduction of dio
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- Himo, F, et al.
(författare)
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Substituent effects on OH bond strength and hyperfine properties of phenol, as model for modified tyrosyl radicals in proteins
- 2000
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Ingår i: INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY. - : JOHN WILEY & SONS INC. - 0020-7608. ; 76:6, s. 714-723
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Tidskriftsartikel (refereegranskat)abstract
- Density functional theory is used to investigate the effects of a variety of substituents (CH3, OH, OCH3, SH, SCH3, NH2, NMe2, NO2, F, Cl, CN, and imidazole) on the phenol O-H bond dissociation energy (BDE) and phenoxyl radical hyperfine properties. Subst
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- Nilsson, JA, et al.
(författare)
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Molecular dynamics simulations of plastoquinone in solution
- 2001
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Ingår i: MOLECULAR PHYSICS. - : TAYLOR & FRANCIS LTD. - 0026-8976. ; 99:3, s. 247-253
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Tidskriftsartikel (refereegranskat)abstract
- Molecular dynamics simulations of plastoquinone, an import ant cofactor in the photosynthetic reaction in green plants, are carried out in water solution. Models of both neutral and anionic plastoquinone are built and thoroughly verified. Detailed informa
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- Urban, Joachim, 1964, et al.
(författare)
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Odin/SMR Observations of Stratospheric Water Vapour and its Isotopes: Requirements on Spectroscopy
- 2004
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Ingår i: Proc. Int. Workshop on Critical Evaluation of mm-/submm-wave Spectroscopic Data for Atmos. Observ., 29-30 January 2004, Mito, Japan, edited by Amano, T., Kasai, Y., Manabe, T.. ; , s. 69-74
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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- Wetmore, SD, et al.
(författare)
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Electron affinities and ionization potentials of nucleotide bases
- 2000
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Ingår i: CHEMICAL PHYSICS LETTERS. - : ELSEVIER SCIENCE BV. - 0009-2614. ; 322:1-2, s. 129-135
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Tidskriftsartikel (refereegranskat)abstract
- Density-functional theory (B3LYP functional) is used to investigate the ionization potentials and electron affinities of the DNA and RNA nucleotide bases. For the first time, anions lying lower in energy than the neutral species have been calculated for b
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