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- Haglund, B J, et al.
(författare)
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Mapping of the "intervention channels" as a part of the community diagnosis process of the Stockholm Cancer Prevention Program (SCPP)
- 1988
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Ingår i: Scandinavian journal of primary health care. Supplement. - 0284-6020. ; 1, s. 65-72
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Tidskriftsartikel (refereegranskat)abstract
- The Stockholm Cancer Prevention Program is to our knowledge the first community intervention program in the world aiming of a reduction in the incidence of cancer. A community diagnosis model has been used in the planning. A thorough description of different organizations in the local communities of Stockholm has been made. A model for describing the organizations or collaborators has been worked out, including description of the organizations and its environment, objectives of activities, possible activities to reach the objectives, resources needed, incentives for collaborative partners, formative evaluation criteria and anticipated problems and solutions. The main method of description has been by use of keyperson interviews. This was found to be a good method to reach commitment to the program.
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- Höglund, P, et al.
(författare)
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Antiarrhythmic effect of amperozide, a novel psychotropic compound with class III antiarrhythmic properties, on digoxin-induced arrhythmias in the guinea-pig
- 1986
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Ingår i: Journal of Pharmacy and Pharmacology. - : Oxford University Press (OUP). - 0022-3573 .- 2042-7158. ; 38:11, s. 3-861
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Tidskriftsartikel (refereegranskat)abstract
- Amperozide is a novel psychotropic compound with specific effect in limbic brain areas. Preliminary findings have also indicated an antiarrhythmic effect in-vitro. Injections of saline, amperozide, melperone, thioridazine, bretylium or lignocaine, were given i.p. to anaesthetized guinea-pigs, which 10 min later were given digoxin s.c. to induce arrhythmia. In a series of control experiments none of these compounds caused arrhythmia in combination with the vehicle of digoxin. The time to arrhythmia was significantly prolonged after treatment with amperozide, melperone and bretylium compared with saline, but there were no differences between the treatments. The digoxin concentrations in plasma at death varied considerably within the groups and no statistical significance was found.
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- Nyholm, R., et al.
(författare)
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Submicrometer-resolution photoelectron-spectroscopy at MAX Lab
- 1989
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 60:7, s. 2168-2171
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Tidskriftsartikel (refereegranskat)abstract
- The design of a photoemission microprobe beamline at the MAX laboratory is presented. The beamline will utilize the radiation from a 26 period undulator on the 550-MeV MAX storage ring. The beamline will be capable of providing about 1010 photons/s of monochromatized radiation (bandwidth better than 0.25 eV) in the energy range of 20 to 150 eV focused into a submicrometer focal spot. It will be used for scanning photoemission experiments with a lateral resolution better than 1 μm. The optical system is comprised of a plane-grating monochromator with a Kirkpatrick-Baez objective and a specially designed ellipsoidal focusing mirror.
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- Thornell, L E, et al.
(författare)
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Intermediate filament and associated proteins in the human heart : an immunofluorescence study of normal and pathological hearts.
- 1984
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Ingår i: European Heart Journal. - 0195-668X .- 1522-9645. ; 5 Suppl F, s. 231-41
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Tidskriftsartikel (refereegranskat)abstract
- The cytoskeleton of human ventricular myocardium in normal and pathological hearts has been analysed with immunocytochemical techniques. Specific antibodies against the intermediate filament proteins desmin (Mr 55 000) and vimentin (Mr 58 000) and antibodies against two cytoskeleton-associated proteins, a spectrin-like protein (Mr 230 000) and vinculin (Mr 130 000), have been used. We show that desmin is localized in the myocytes as an intermyofibrillar lattice at the Z disk level of the myofibrils, and at the intercalated disks. The spectrin-like protein is localized as a transverse striated pattern interlinked with fine longitudinal strands in the subplasmalemmal region of the myocytes. Vinculin is abundant in the intercalated disks and in myotendinous junctions but occurs also at the peripheral sarcolemma in the form of a regular repeat of dots and of fine bar-like extensions into the cytoplasm from the dots. These patterns were observed both in normal and in abnormal hearts, but a number of altered patterns in pathological myocytes were also seen. It is concluded that the intermediate filament system has important implications in the structural function of normal and abnormal hearts but that further studies are needed to elucidate how the different components are related to each other and how they are influenced by different disease processes.
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- Wester, P, et al.
(författare)
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Monoamine metabolite concentrations and cholinesterase activities in cerebrospinal fluid of progressive dementia patients : relation to clinical parameters.
- 1988
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Ingår i: Acta Neurologica Scandinavica. - 0001-6314 .- 1600-0404. ; 77:1, s. 12-21
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Tidskriftsartikel (refereegranskat)abstract
- Forty-five well clinically characterized patients with progressive dementia were investigated for lumbar cerebrospinal fluid (CSF) monoamine metabolites and cholinesterase activities. Monoamine concentrations were determined by reverse phase liquid chromatography with electrochemical detection and the cholinergic enzymes were measured photometrically. Firstly, all clinical and CSF parameters were studied in statistical cluster analyses to detect groups of variables which demonstrated a high correlation with respect to each other. The CSF transmitter markers were then used in multiple regression models to explain the variance of clinical variables as chosen from the cluster analyses. The degree of dementia, as assessed by global deterioration score (GDS) and activity in daily life (ADL) status, as well as the Alzheimer-related symptoms dyspraxia and dysphasia, were associated with low AChE activities in CSF. A presumed subgroup of dementia patients clinically characterized by asymmetry of neurological signs, increased unilateral tonus, stepwise progression, and high Hachinski score, showed low HVA concentrations in CSF. These data suggest a coupling of clinical/neurological parameters to different CSF transmitter profils and, thus, that CSF biochemical parameters are of use as antemortem markers in dementia conditions.
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| 18. |
- Wollmer, P, et al.
(författare)
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Measurement of pulmonary density by means of X-ray computerized tomography. Relation to pulmonary mechanics in normal subjects
- 1986
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Ingår i: Chest. - : Elsevier BV. - 0012-3692. ; 90:3, s. 91-387
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Tidskriftsartikel (refereegranskat)abstract
- We examined the relationship between pulmonary density, measured with computerized tomography, and pulmonary mechanics (static pulmonary volume; pulmonary resistance) in 39 normal subjects (20 nonsmokers and 19 smokers). Pulmonary density decreased with increasing static elastic recoil pressure, and smokers consistently showed higher pulmonary density than nonsmokers. Pulmonary density, measured at full inspiration, correlated inversely with total lung capacity. Pulmonary density showed a ventrodorsal gradient, which was greater at low elastic recoil pressure than at high recoil pressure. The study shows that pulmonary density is related to the mechanical properties of the lung in normal subjects. Increased pulmonary density appears to be a sensitive indicator of pulmonary damage induced by smoking. Further studies of the relationship between pulmonary density and pulmonary mechanics in disease seem warranted.
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- Zegar, I., et al.
(författare)
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The B - Z Transition in Poly [d(G-C) d(G-C)] After Covalent Binding of Anti- Benzo(a)Pyrenediolepoxide
- 1987
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Ingår i: Structure, dynamics, and function of biomolecules : the first EBSA workshop, a Marcus Wallenberg symposium (Structure, dynamics, and function of biomolecules : the first EBSA workshop, a Marcus Wallenberg symposium /Structure, dynamics, and function of biomolecules : the first EBSA workshop, a Marcus Wallenberg symposium Structure, dynamics, and function of biomolecules : the first EBSA workshop, a Marcus Wallenberg symposium (A. Ehrenberg, R. Rigler, A. Gräslund and L. Nilsson, eds.). - 3540172793 ; , s. 238-241
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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