| 1. |
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| 2. |
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| 3. |
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| 4. |
- Abrikosov, IA, et al.
(författare)
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Magnetically induced crystal structure and phase stability in Fe1-cCoc
- 1996
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Ingår i: PHYSICAL REVIEW B-CONDENSED MATTER. - : AMER INST PHYSICS. - 0163-1829. ; 54:5, s. 3380-3384
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We present an ab initio determination of the crystallographic phase stability of Fe-Co alloys as a function of concentration, using the coherent potential approximation. A bcc --> hcp phase transition is found at a concentration of 85 at.% of Co, in good
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| 5. |
- Anisimov, AN, et al.
(författare)
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Orbital magnetism and magnetic anisotropy probed with ferromagnetic resonance
- 1999
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Ingår i: PHYSICAL REVIEW LETTERS. - : AMERICAN PHYSICAL SOC. - 0031-9007. ; 82:11, s. 2390-2393
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Via ferromagnetic resonance both the magnetic anisotropy energy (MAE) and the spectroscopic splitting tensor (g tensor) for a bcc Fe-2/V-5(001) superlattice are measured independently. The theoretically proposed proportionality between the anisotropy of t
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| 6. |
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| 7. |
- Baden, Susanne P., 1952, et al.
(författare)
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Accumulation and elimination kinetics of manganese from different tissues of the Norway lobster Nephrops norvegicus (L.)
- 1999
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Ingår i: Aquatic Toxicology. - 0166-445X. ; 46:2, s. 127-137
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Tidskriftsartikel (refereegranskat)abstract
- The exposure of marine benthic animals to dissolved manganese (Mn) occurs from metalliferous outlets or the enhanced flux of dissolved manganese from sediments during hypoxia. A prerequisite to valid interpretation of manganese concentrations measured in animals in situ is a thorough understanding of accumulation and elimination rates of this metal by relevant target tissues in organisms exposed to environmentally realistic manganese concentrations. Norway lobster, Nephrops norvegicus, accumulated manganese when exposed to solutions of < 0.06 (background), 5 and 10 mg Mn l(-1) for 20 days and was allowed to eliminate any accumulated manganese in undosed sea water for a further 20 days. During this period individual N. norvegicus were dissected into a number of components (brain, ventral ganglion, haemolymph, midgut gland, gills and exoskeleton) and the manganese concentration of each was analysed. Manganese accumulation reached a plateau after 1.25 days in all tissues except for midgut gland, which continued to accumulate manganese during the entire exposure period. In general, the manganese elimination was significantly slower than accumulation and reached a plateau after 1.25-2.5 days (except the gills) following exposure to clean sea water. The accumulation factor (AF), when compared to maximum concentrations in control and exposed animals, was highest in the haemolymph (x 88) followed by nerve tissue (x 22) at the 10 mg Mn l(-1) exposure. The concentration factor (CF), when comparing manganese accumulation in tissues (wet weight) with exposure concentration, was 1.2-3.5 and for most tissues was similar for both exposure concentrations or slightly higher in the 5 mg Mn l(-1) exposure-indicating net accumulation of manganese in all tissues with a saturation effect with increasing exposure concentrations. Thus, from these experiments it may be concluded that measured manganese concentrations in N. norvegicus give an indication of recent exposure to manganese concentrations in the bottom waters of their habitats. (C) 1999 Elsevier Science B.V. All rights reserved.
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| 8. |
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| 9. |
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| 10. |
- Daya, DDNB, et al.
(författare)
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Interaction of mev atomic ions with molecular solids: Ion track structure and sputtering phenomena
- 1997
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Ingår i: RADIATION MEASUREMENTS. - : PERGAMON-ELSEVIER SCIENCE LTD. - 1350-4487. ; 28:1-6, s. 101-110
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Recent results obtained in our research groups from studies of the interactions of swift, heavy atomic ions with molecular solids are concisely outlined. The focus is on material ejection (sputtering) and surface track formation. The experimental techniqu
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| 11. |
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| 12. |
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| 13. |
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| 14. |
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| 15. |
- Eriksson, J, et al.
(författare)
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Damage cross sections and surface track dimensions of biomolecular surfaces bombarded by swift-heavy-ions
- 1996
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS. - : ELSEVIER SCIENCE BV. ; 107:1-4, s. 281-286
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We measured damage cross sections of the peptide LHRH for various MeV ions with the same velocity and compared the data with simple hit theory calculations. We employed scanning force microscopy to measure dimensions of surface tracks in amino acid L-vali
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| 16. |
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| 17. |
- ERIKSSON, J, et al.
(författare)
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HEAVY-ION-INDUCED SPUTTERING AND CRATERING OF BIOMOLECULAR SURFACES
- 1995
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS. - : ELSEVIER SCIENCE BV. - 0168-583X. ; 101:1-2, s. 142-147
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We measured the electronic-stopping-power dependences of mega-electronvolt atomic-ion-induced sputtering and cratering of bio-organic targets. We employed a collector method to study relative total yields of sputtered intact peptide molecules and scanning
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| 18. |
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| 19. |
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| 20. |
- Eriksson, J., et al.
(författare)
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Regularization tools for training large feed-forward neural networks using automatic differentiation
- 1998
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Ingår i: Optimization Methods & Software. ; 10:1, s. 49-69
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Tidskriftsartikel (refereegranskat)abstract
- We describe regularization tools for training large-scale artificial feed-forward neural networks. We propose algorithms that explicitly use a sequence of Tikhonov regularized nonlinear least squares problems. For large-scare problems, methods using new special purpose automatic differentiation are used in a conjugate gradient method for computing a truncated Gauss-Newton search direction. The algorithms developed utilize the structure of the problem in different ways and perform much better than a Polak-Ribiere based method. All algorithms are tested using benchmark problems and guidelines by Lutz Prechelt in the Probenl package. All software is written in Matlab and gathered in a toolbox.
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| 21. |
- Eriksson, J, et al.
(författare)
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Total yield and polar-angle distributions of biomolecules sputtered by fast heavy ions
- 1996
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Ingår i: PHYSICAL REVIEW B-CONDENSED MATTER. - : AMER INST PHYSICS. - 0163-1829. ; 54:21, s. 15025-15033
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Direct measurements of the number of peptide molecules ejected per fast heavy ion impact (total yield) and data on polar-angle distributions of the total amount of sputtered bioorganic material are presented. These data allow direct comparisons with sputt
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| 22. |
- Eriksson, Jan W, et al.
(författare)
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A stable peroxovanadium compound with insulin-like action in human fat cells
- 1996
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Ingår i: Diabetologia. - 0012-186X .- 1432-0428. ; 39:2, s. 235-242
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Tidskriftsartikel (refereegranskat)abstract
- Aqueous solutions of peroxovanadium (pV) compounds are potent insulin-mimics in various types of cell. Since chemical instability is a problem with these agents, we studied the insulin-like action in human fat cells of a stable pV complex, bpV(pic). It enhanced 14C-U-glucose uptake in a dose-dependent manner by approximately twofold which was slightly less than the effect of insulin (approximately threefold). The pV complex did not alter cell-surface insulin binding and submaximal concentrations did not influence cellular sensitivity to insulin action on glucose uptake. The bpV(pic) inhibited the lipolytic effect of isoprenaline to the same extent as insulin; however, when the cGMP-inhibitable low-Km phosphodiesterase (cGI-PDE) was blocked with the specific inhibitor OPC 3911, the antilipolytic effect of insulin, but not that of bpV(pic), was completely prevented. Moreover, when lipolysis was stimulated by the non-hydrolysable cAMP analogue N6-monobutyryl cAMP, bpV(pic), in contrast to insulin, maintained an antilipolytic effect. These findings indicate that bpV(pic) exerts its antilipolytic effect not only through cGI-PDE activation, similar to the effect of insulin, but also by means of other mechanisms. The tyrosine kinase activity of insulin receptors from human placenta was not altered by the pV compound itself, whereas bpV(pic) clearly enhanced insulin-stimulated activity. In contrast, in situ tyrosine phosphorylation of the insulin receptor Β-subunit as well as that of several other proteins was clearly increased in cells which were treated with bpV(pic), whereas vanadate only amplified insulin-stimulated tyrosine phosphorylation. In conclusion, bpV(pic) exerts powerful insulin-like effects in human fat cells and may be a new and potentially useful agent in the management of insulin-resistant states.
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| 23. |
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| 24. |
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| 25. |
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| 26. |
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| 27. |
- ERIKSSON, P, et al.
(författare)
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Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction
- 1995
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 92:6, s. 1851-1855
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Tidskriftsartikel (refereegranskat)abstract
- Increased plasminogen-activator inhibitor 1 (PAI-1) activity is a common finding in patients with coronary heart disease. Here we provide evidence for an independent, etiological role of PAI-1 in myocardial infarction. The 4G allele of a recently described common 4/5-guanine-tract (4G/5G) polymorphism in the PAI-1 promoter is associated with higher plasma PAI-1 activity. The prevalence of the 4G allele is significantly higher in patients with myocardial infarction before the age of 45 than in population-based controls (allele frequencies of 0.63 vs. 0.53). Both alleles bind a transcriptional activator, whereas the 5G allele also binds a repressor protein to an overlapping binding site. In the absence of bound repressor, the basal level of PAI-1 transcription is increased.
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| 28. |
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| 29. |
- Eriksson, Susanne P., 1964, et al.
(författare)
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Behaviour and tolerance to hypoxia in juvenile Norway lobster (Nephrops norvegicus) of different ages
- 1997
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Ingår i: Marine Biology. - 0025-3162. ; 128:1, s. 49-54
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Tidskriftsartikel (refereegranskat)abstract
- The annual occurrence of hypoxia (<25% oxygen saturation) in the bottom waters along the Swedish west coast coincides with the postlarval settlement of Norway lobster, Nephrops norvegicus (L.). This study investigates behaviour and the experimental effects of low oxygen concentrations in juvenile N. norvegicus of different ages. All experimental individuals were reared to the juvenile (postlarval) stage in the laboratory and then given sediment as a substratum. Behavioural responses to low oxygen concentrations were tested in early and late Postlarvae 1 exposed to normoxia (>80% oxygen saturation, pO(2) > 16.7 kPa), moderate hypoxia (30% oxygen saturation, pO(2) = 6.3 kPa) and hypoxia (25% oxygen saturation, pO(2) = 5.2 kPa). The experiments were run for a maximum period of 24 h or until individuals died. Behaviour was studied using sequential video recordings of four behavioural activities: digging, walking, inactivity or flight (escape swimming up into the water column). Behaviour and mortality changed with lowered oxygen concentrations; energetically costly activities (such as walking) were reduced, and activity in general declined. In normoxia, juveniles initially walked and then burrowed, but when exposed to hypoxia they were mainly inactive with occasional outbursts of escape swimming. To increase oxygen availability the juveniles were observed to raise their bodies on stilted legs (similar to adults in hypoxic conditions), but oxygen saturations of 25% were lethal within 24 h. The results suggest that the main gas exchanges of early postlarval stages occur over the general body surface. Burrowing behaviour was tested in Postlarvae 1 and 2 of different ages held in >80% oxygen saturation for 1 wk. The difference in time taken to complete a V-shaped depression or a U-shaped burrow was measured. The results showed a strong negative relationship between postlarval age and burrowing time, but all individuals made a burrow. Juveniles were more sensitive to hypoxia than adults. Thus, the possible consequences of episodic hypoxia for the recruitment of Nephrops norvegicus and for the recolonization of severely affected areas are discussed.
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| 30. |
- Eriksson, Susanne P., 1964, et al.
(författare)
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Manganese in the haemolymph and tissues of the Norway lobster, Nephrops norvegicus (L.), along the Swedish west coast, 1993-1995
- 1998
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Ingår i: Hydrobiologia. - 0018-8158. ; 376, s. 255-264
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Tidskriftsartikel (refereegranskat)abstract
- Spatial and temporal differences in manganese levels in Norway lobsters, Nephrops norvegicus, were compared with the concentrations of manganese in their environment. Animals were collected twice yearly (spring and autumn) from seven stations along the Swedish west coast and from one site in the Faroe Islands, during 1993-94, and analysed for manganese tissue concentration and content. Animals were also collected from the Swedish stations in the autumn of 1995 and compared with animals from a stressful environment, frequently exposed to hypoxia. There were large spatial differences and the animals collected in the Faroe Islands contained (in most tissues) one order of magnitude less manganese than the animals collected along the Swedish west coast. The manganese level of the haemolymph correlated most closely with the manganese concentration the animal was exposed to in the field. The manganese concentration of the female gonad tissue did however not differ with space nor time and remained stable around 5.1 mu g Mn g(-1) dw tissue throughout the investigation. Animals taken from an area with known repeated hypoxia in the bottom water, had high levels of manganese in especially the gills. Their mean manganese concentration was over 20 times higher (1560 mu g Mn g(-1) dw tissue) than the manganese concentration in animals from the other Swedish stations. They also had more than threefold the amount of manganese in the brain, giving a mean concentration of 193 mu g Mn g(-1) dw tissue.
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| 31. |
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| 32. |
- Hakman, Inger, et al.
(författare)
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Storage protein accumulation during zygotic and somatic embryo development in Picea abies (Norway spruce)
- 1990
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Ingår i: Physiologia Plantarum. - : Wiley. - 0031-9317 .- 1399-3054. ; 80:3, s. 441-445
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Tidskriftsartikel (refereegranskat)abstract
- Total protein was extracted from zygotic embryos and from somatic embryos of Picea abies (L.) Karst. (Norway spruce) cultured in vitro at different times during their development. An analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and 2-dimensional gel electrophoresis of the protein extracts showed that protein composition and the temporal changes in protein abundance were very similar in the two embryo types. Both zygotic and somatic embryos accumulated storage proteins in abundance during their maturation phase of growth; the somatic embryos when cultured on medium containing 90 mM sucrose and 7.6 μM ABA. The major storage proteins are composed of polypeptides with molecular masses of about 22, 28, 33 and 42 kDa and they are identical in both embryo types according to their molecular mass and average isoelectric points. These proteins are also the most abundant proteins in the female gametophytic tissue of the mature seed.
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| 33. |
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| 34. |
- Lagriffoule, P., et al.
(författare)
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Peptide nucleic acids with a conformationally constrained chiral cyclohexyl-derived backbone
- 1997
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Ingår i: Chemistry - A European Journal. - 1521-3765 .- 0947-6539. ; 3:6, s. 912-919
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Tidskriftsartikel (refereegranskat)abstract
- Peptide nucleic acid (PNA) is an achiral nucleic acid mimic with a backbone consisting of partly flexible amino-ethyl glycine units. By replacing the aminoethyl portion of the backbone by an amino cyclohexyl moiety, either in the (S,S) or the (R,R) configuration, we have synthesized conformationally constrained PNA residues. PNA oligomers containing (S,S)-cyclohexyl residues were able to form hybrid complexes with DNA or RNA, with little effect on the thermal stability (Delta T-m = +/- 1 degrees C per (S,S) unit, depending on their number and the sequence). In contrast, incorporation of the (R,R) isomer resulted in a drastic decrease in the stability of the PNA-DNA (or RNA) complex (Delta T-m = -8 degrees C per (R,R) unit). In PNA-PNA duplexes, however, the (R,R)- and (S,S)-cyclohexyl residues only exerted a minor effect on the stability, and the complexes formed with the two isomers are of opposite handedness, as evidenced from circular dichroism spectroscopy. In some cases the introduction of a single (S,S) residue in a PNA 15-mer improves its sequence specificity for DNA or RNA. From the thermal stabilities and molecular modeling based on the solution structure of a PNA-DNA duplex determined by NMR techniques, we conclude that the right-handed helix can accommodate the (SIS) isomer more easily than the (R,R) isomer. Thermodynamic measurements of Delta H and Delta S upon PNA-DNA duplex formation show that the introduction of an (S,S)-cyclohexyl unit in the PNA does indeed decrease the entropy loss, indicating a more conformationally constrained structure. However, the more favorable entropic contribution is balanced by a reduced enthalpic gain, indicating that the structure constrained by the cyclohexyl group is not so well suited for DNA hybridization.
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| 35. |
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| 36. |
- Liu, HP, et al.
(författare)
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Structural and magnetic properties of (Fe1-xCox)(3)P compounds: experiment and theory
- 1998
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Ingår i: JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS. - : ELSEVIER SCIENCE BV. - 0304-8853. ; 189:1, s. 69-82
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The structural and magnetic properties of (Fe1 - xCox)(3)P compounds have been investigated by means of X-ray and neutron diffraction experiments, magnetization measurements and first-principles calculations. The saturation magnetization and the transitio
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| 37. |
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| 38. |
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| 39. |
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| 40. |
- Papaleo, RM, et al.
(författare)
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Low-mass secondary-ion ejection from molecular solids by MeV heavy ions: Radial velocity distributions
- 1996
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Ingår i: PHYSICAL REVIEW B-CONDENSED MATTER. - : AMER INST PHYSICS. - 0163-1829. ; 54:5, s. 3173-3183
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Secondary ions sputtered in individual MeV ion impacts are analyzed in a high resolution time-of-flight mass spectrometer. The initial radial velocity distributions of low mass (up to m/z approximate to 300 u) positive and negative secondary ions, sputter
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| 41. |
- Papaleo, RM, et al.
(författare)
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Measurement of MeV ion track structure in an organic solid
- 1996
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Ingår i: PHYSICAL REVIEW LETTERS. - : AMER INST PHYSICS. - 0031-9007. ; 77:4, s. 667-670
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Radial velocities and effective ejection radii of hydrocarbon secondary ions sputtered electronically from polymer films have been experimentally determined. Using these data, the radial profiles of the energy and momentum density in an individual MeV ion
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| 42. |
- Papaleo, RM, et al.
(författare)
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Radial velocity distributions of secondary ions ejected from PTFE by MeV atomic ions
- 1996
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS. - : ELSEVIER SCIENCE BV. ; 107:1-4, s. 308-312
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In this paper, systematic investigations of the initial radial velocity distributions of CnFm+ secondary ions sputtered by 72.3 MeV I-127(+13) ions from polytetrafluoroethylene (PTFE) foils are presented. The initial radial velocity distributions are obta
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