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Swarm Intelligence-...
Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets
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Best, Myron G. (author)
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Sol, Nik (author)
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't Veld, Sjors G. J. G. In (author)
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Vancura, Adrienne (author)
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Muller, Mirte (author)
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Niemeijer, Anna-Larissa N. (author)
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Fejes, Aniko V. (author)
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- Tjon Kon Fat, Lee-Ann (author)
- Umeå universitet,Onkologi
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't Veld, Anna E. Huis In (author)
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Leurs, Cyra (author)
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Le Large, Tessa Y. (author)
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Meijer, Laura L. (author)
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Kooi, Irsan E. (author)
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Rustenburg, Francois (author)
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Schellen, Pepijn (author)
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Verschueren, Heleen (author)
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Post, Edward (author)
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Wedekind, Laurine E. (author)
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Bracht, Jillian (author)
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Esenkbrink, Michelle (author)
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Wils, Leon (author)
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Favaro, Francesca (author)
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Schoonhoven, Jilian D. (author)
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Tannous, Jihane (author)
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Meijers-Heijboer, Hanne (author)
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Kazemier, Geert (author)
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Giovannetti, Elisa (author)
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Reijneveld, Jaap C. (author)
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Idema, Sander (author)
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Killestein, Joep (author)
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Heger, Michal (author)
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de Jager, Saskia C. (author)
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Urbanus, Rolf T. (author)
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Hoefer, Imo E. (author)
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Pasterkamp, Gerard (author)
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Mannhalter, Christine (author)
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Gomez-Arroyo, Jose (author)
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Bogaard, Harm-Jan (author)
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Noske, David P. (author)
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Vandertop, W. Peter (author)
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van den Broek, Daan (author)
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Ylstra, Bauke (author)
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- Nilsson, Jonas A. (author)
- Umeå universitet,Onkologi,Vrije Univ Amsterdam Med Ctr, Canc Ctr Amsterdam, Dept Neurosurg, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands
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Wesseling, Pieter (author)
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Karachaliou, Niki (author)
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Rosell, Rafael (author)
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Lee-Lewandrowski, Elizabeth (author)
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Lewandrowski, Kent B. (author)
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Tannous, Bakhos A. (author)
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de Langen, Adrianus J. (author)
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Smit, Egbert F. (author)
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van den Heuvel, Michel M. (author)
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Wurdinger, Thomas (author)
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(creator_code:org_t)
- Elsevier, 2017
- 2017
- English.
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In: Cancer Cell. - : Elsevier. - 1535-6108 .- 1878-3686. ; 32:2, s. 238-252
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA sequencing libraries (n = 779). This resulted in accurate TEP-based detection of early- and late-stage non-small-cell lung cancer (n = 518 late-stage validation cohort, accuracy, 88%; AUC, 0.94; 95% CI, 0.92-0.96; p < 0.001; n = 106 early-stage validation cohort, accuracy, 81%; AUC, 0.89; 95% CI, 0.83-0.95; p < 0.001), independent of age of the individuals, smoking habits, whole-blood storage time, and various inflammatory conditions. PSO enabled selection of gene panels to diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Best, Myron G.
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Sol, Nik
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't Veld, Sjors G ...
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Vancura, Adrienn ...
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Muller, Mirte
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Niemeijer, Anna- ...
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show more...
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Fejes, Aniko V.
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Tjon Kon Fat, Le ...
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't Veld, Anna E. ...
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Leurs, Cyra
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Le Large, Tessa ...
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Meijer, Laura L.
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Kooi, Irsan E.
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Rustenburg, Fran ...
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Schellen, Pepijn
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Verschueren, Hel ...
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Post, Edward
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Wedekind, Laurin ...
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Bracht, Jillian
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Esenkbrink, Mich ...
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Wils, Leon
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Favaro, Francesc ...
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Schoonhoven, Jil ...
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Tannous, Jihane
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Meijers-Heijboer ...
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Kazemier, Geert
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Giovannetti, Eli ...
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Reijneveld, Jaap ...
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Idema, Sander
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Killestein, Joep
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Heger, Michal
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de Jager, Saskia ...
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Urbanus, Rolf T.
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Hoefer, Imo E.
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Pasterkamp, Gera ...
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Mannhalter, Chri ...
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Gomez-Arroyo, Jo ...
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Bogaard, Harm-Ja ...
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Noske, David P.
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Vandertop, W. Pe ...
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van den Broek, D ...
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Ylstra, Bauke
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Nilsson, Jonas A ...
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Wesseling, Piete ...
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Karachaliou, Nik ...
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Rosell, Rafael
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Lee-Lewandrowski ...
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Lewandrowski, Ke ...
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Tannous, Bakhos ...
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de Langen, Adria ...
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Smit, Egbert F.
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van den Heuvel, ...
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Wurdinger, Thoma ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Cell
- By the university
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Umeå University