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Mucosal Plasma Cell...
Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome : Jejunal Barrier Alterations Underlying Clinical Manifestations
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- Pardo-Camacho, Cristina (författare)
- Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain
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- Ganda Mall, John-Peter, 1988- (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Vall Hebron Inst Recerca, Spain
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- Martínez, Cristina (författare)
- Vascular and Renal Translational Research Group, Lleida Institute for Biomedical Research Dr. Pifarré. Foundation (IRBLleida), Lleida, Spain,Vasc & Renal Translat Res Grp, Spain
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- Pigrau, Marc (författare)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Spain
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- Expósito, Elba (författare)
- Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain
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- Albert-Bayo, Mercé (författare)
- Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain
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- Melón-Ardanaz, Elisa (författare)
- Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain
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- Nieto, Adoración (författare)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall Hebron Inst Recerca, Spain; Vall Hebron Hosp Univ, Spain
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- Rodiño-Janeiro, Bruno (författare)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain
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- Fortea, Marina (författare)
- Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain
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- Guagnozzi, Danila (författare)
- Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall Hebron Inst Recerca, Spain; Vall Hebron Inst Recerca, Spain; Vall Hebron Hosp Univ, Spain
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- Rodriguez-Urrutia, Amanda (författare)
- Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Mental Health, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain,Univ Autonoma Barcelona, Spain; Vall Hebron Hosp Univ, Spain; Inst Salud Carlos III, Spain
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- de Torres, Inés (författare)
- Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Pathology, Hospital Universitari Vall d'Hebrón, Barcelona, Spain,Univ Autonoma Barcelona, Spain; Hosp Univ Vall Hebron, Spain
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- Santos-Briones, Ignacio (författare)
- Facultat Ciències de la Salut, Universitat Ramon LLull-Blanquerna, Barcelona, Spain,Univ Ramon LLull Blanquerna, Spain
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- Azpiroz, Fernando (författare)
- Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain,Vall Hebron Hosp Univ, Spain; Inst Salud Carlos III, Spain
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- Lobo, Beatriz (författare)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall Hebron Inst Recerca, Spain; Univ Autonoma Barcelona, Spain; Vall Hebron Hosp Univ, Spain
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- Alonso-Cotoner, Carmen (författare)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain,Vall Hebron Inst Recerca, Spain; Univ Autonoma Barcelona, Spain; Vall Hebron Hosp Univ, Spain; Inst Salud Carlos III, Spain
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- Santos, Javier (författare)
- Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain,Vall Hebron Inst Recerca, Spain; Univ Autonoma Barcelona, Spain; Vall Hebron Hosp Univ, Spain; Inst Salud Carlos III, Spain
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- González-Castro, Ana M. (författare)
- Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain
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- Vicario, Maria (författare)
- Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Department of Gastrointestinal Health, Nestlé Institute of Health Sciences, Société des Produits Nestlé S.A., Nestlé Research, Vers-chez-les-Blanc, Lausanne, Switzerland
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(creator_code:org_t)
- 2022-06-28
- 2022
- Engelska.
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Ingår i: Cells. - Basel : MDPI. - 2073-4409. ; 11:13
- Relaterad länk:
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https://doi.org/10.3...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Irritable bowel syndrome (IBS) is a disorder of brain-gut interaction characterised by abdominal pain and changes in bowel habits. In the diarrhoea subtype (IBS-D), altered epithelial barrier and mucosal immune activation are associated with clinical manifestations. We aimed to further evaluate plasma cells and epithelial integrity to gain understanding of IBS-D pathophysiology. One mucosal jejunal biopsy and one stool sample were obtained from healthy controls and IBS-D patients. Gastrointestinal symptoms, stress, and depression scores were recorded. In the jejunal mucosa, RNAseq and gene set enrichment analyses were performed. A morphometric analysis by electron microscopy quantified plasma cell activation and proximity to enteric nerves and glycocalyx thickness. Immunoglobulins concentration was assessed in the stool. IBS-D patients showed differential expression of humoral pathways compared to controls. Activation and proximity of plasma cells to nerves and IgG concentration were also higher in IBS-D. Glycocalyx thickness was lower in IBS-D compared to controls, and this reduction correlated with plasma cell activation, proximity to nerves, and clinical symptoms. These results support humoral activity and loss of epithelial integrity as important contributors to gut dysfunction and clinical manifestations in IBS-D. Additional studies are needed to identify the triggers of these alterations to better define IBS-D pathophysiology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Nyckelord
- IBS-D
- intestinal barrier dysfunction
- intestinal glycocalyx
- intestinal plasma cells
- mucosal nerve fibres
- mucosal ultrastructure
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Pardo-Camacho, C ...
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Ganda Mall, John ...
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Martínez, Cristi ...
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Pigrau, Marc
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Expósito, Elba
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Albert-Bayo, Mer ...
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Melón-Ardanaz, E ...
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Nieto, Adoración
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Rodiño-Janeiro, ...
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Fortea, Marina
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Guagnozzi, Danil ...
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Rodriguez-Urruti ...
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de Torres, Inés
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Santos-Briones, ...
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Azpiroz, Fernand ...
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Lobo, Beatriz
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Alonso-Cotoner, ...
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Santos, Javier
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González-Castro, ...
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Vicario, Maria
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Annan klinisk me ...
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