| 1. |
- Olsen, Are, 1972, et al.
(författare)
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Overview of the Nordic Seas CARINA data and salinity measurements
- 2009
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Ingår i: Earth System Science Data Discussions. - 1866-3591. ; 2, s. 1-25
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Tidskriftsartikel (refereegranskat)abstract
- Water column data of carbon and carbon relevant hydrographic and hydrochemical parameters from 188 previously non-publicly available cruises in the Arctic, Atlantic, and Southern Ocean have been retrieved and merged into a new database: CARINA (CARbon IN the Atlantic). The data have been subject to rigorous quality control (QC) in order to ensure highest possible quality and consistency. The data for most of the parameters included were examined in order to quantify systematic biases in the reported values, i.e. secondary quality control. Significant biases have been corrected for in the data products, i.e. the three merged files with measured, calculated and interpolated values for each of the three CARINA regions; the Arctic Mediterranean Seas (AMS), the Atlantic (ATL) and the Southern Ocean (SO). With the adjustments the CARINA database is consistent both internally as well as with GLODAP (Key et al., 2004) and is suitable for accurate assessments of, for example, oceanic carbon inventories and uptake rates and for model validation. The Arctic Mediterranean Seas includes the Arctic Ocean and the Nordic Seas, and the quality control was carried out separately in these two areas. This contribution provides an overview of the CARINA data from the Nordic Seas and summarises the findings of the QC of the salinity data. One cruise had salinity data that were of questionable quality, and these have been removed from the data product. An evaluation of the consistency of the quality controlled salinity data suggests that they are consistent to at least 0.05.
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| 2. |
- Falck, Emma, et al.
(författare)
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Interaction of fusidic acid with lipid membranes: Implications to the mechanism of antibiotic activity
- 2006
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Ingår i: Biophysical Journal. - : Elsevier BV. - 1542-0086 .- 0006-3495. ; 91:5, s. 1787-1799
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Tidskriftsartikel (refereegranskat)abstract
- We have studied the effects of cholesterol and steroid-based antibiotic fusidic acid (FA) on the behavior of lipid bilayers using a variety of experimental techniques together with atomic-scale molecular dynamics simulations. Capillary electrophoretic measurements showed that FA was incorporated into fluid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine membranes. Differential scanning calorimetry in turn showed that FA only slightly altered the thermodynamic properties of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayers, whereas cholesterol abolished all endotherms when the mole fraction of cholesterol (X-chol) was > 0.20. Fluorescence spectroscopy was then used to further characterize the influence of these two steroids on DPPC large unilamellar vesicles. In the case of FA, our result strongly suggested that FA was organized into lateral microdomains with increased water penetration into the membrane. For cholesterol/DPPC mixtures, fluorescence spectroscopy results were compatible with the formation of the liquid-ordered phase. A comparison of FA and cholesterol-induced effects on DPPC bilayers through atomistic molecular dynamics simulations showed that both FA and cholesterol tend to order neighboring lipid chains. However, the ordering effect of FA was slightly weaker than that of cholesterol, and especially for deprotonated FA the difference was significant. Summarizing, our results show that FA is readily incorporated into the lipid bilayer where it is likely to be enriched into lateral microdomains. These domains could facilitate the association of elongation actor-G into lipid rafts in living bacteria, enhancing markedly the antibiotic efficacy of FA.
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| 3. |
- Laring, Jonas, 1951, et al.
(författare)
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Simulation for manufacturing engineering (ViPP)
- 2005
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Ingår i: SAE Technical Papers. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191 .- 2688-3627. ; Digital Human Modeling for Design and Engineering Symposium
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this project is to develop methodologies and supportive tools to handle introduction and administration of ergonomics simulation tools for manufacturing engineering. The main result will be a web-based handbook for effective use of digital human modelling tools inside companies and between suppliers and companies. ViPP is divided in three parts: Part A: Studies will be done with the purpose to advise on proper content of input data and on method for assessment of simulations' results. Part B: Studies will be done in order to check reliability of used digital human tools: (1) intra- and inter-individual differences concerning simulation results, (2) vision analysis and (3) the importance of the digital human model appearance/representation on simulation results. Part C: A handbook will be written on virtual production planning for pre production engineers, designers and decision makers. Copyright © 2005 SAE International.
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