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- Bjerkenstedt, L, et al.
(författare)
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On the pathophysiology of schizophrenia
- 2003
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Ingår i: NORDIC JOURNAL OF PSYCHIATRY. - 0803-9488. ; 57:2, s. 92-92
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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- Backman, L, et al.
(författare)
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Age-related cognitive deficits mediated by changes in the striatal dopamine system
- 2000
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Ingår i: AMERICAN JOURNAL OF PSYCHIATRY. - : AMER PSYCHIATRIC PRESS, INC. - 0002-953X. ; 157:4, s. 635-637
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The study examined the influence of losses in dopaminergic function on age-related cognitive deficits. Method: Eleven healthy subjects (21-68 years of age) completed a set of cognitive tasks used to assess perceptual speed and episodic memory.
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- Backman, L, et al.
(författare)
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Dopamine and cognitive functioning: Brain imaging findings in Huntington's disease and normal aging
- 2001
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Ingår i: SCANDINAVIAN JOURNAL OF PSYCHOLOGY. - : BLACKWELL PUBL LTD. - 0036-5564. ; 42:3, s. 287-296
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Tidskriftsartikel (refereegranskat)abstract
- Recent brain imaging studies in Huntington's disease CHD) and normal aging suggest a relationship between central dopaminergic neurotransmission and cognitive performance. Results demonstrate substantial losses in dopamine (DA) function in both. HD and ag
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- Talvik, M, et al.
(författare)
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A cross-validation study on the relationship between central D-2 receptor occupancy and serum perphenazine concentration
- 2004
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Ingår i: Psychopharmacology. - Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden. Glostrup Univ Hosp, Dept Clin Biochem, Glostrup, Denmark. : SPRINGER. - 0033-3158 .- 1432-2072. ; 175:2, s. 148-153
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: There is a need for laboratory measures to guide clinical treatment with antipsychotic drugs. For serum concentration of the classical antipsychotic drug perphenzine an optimal therapeutic interval has been identified between 2 and 6 nmol/l. Positron emission tomography (PET) studies have suggested an optimal interval in central dopamine D-2 receptor occupancy of between 65 and 80%. Objectives: The aim of the present cross-validation study in clinically stable schizophrenic patients was to examine the relationship between the optimal interval in central D-2 receptor occupancy and the therapeutic window for serum perphenazine concentration. Methods: Six patients who had responded to maintenance treatment with perphenazine decanoate were examined with PET and [C-11]raclopride during steady-state conditions. Blood sampling was carried out for minimum serum perphenazine concentration and during the PET examination. Results: The serum perphenazine concentration was between 1.8 and 9 nmol/l and the D-2 receptor occupancy varied between 66 and 82%. The relationship between central receptor occupancy and serum drug concentration was curvilinear. Mild extrapyramidal symptoms were present in the patient with the highest D-2 receptor occupancy. Conclusions: The previously suggested therapeutic window in serum perphenazine concentration is in good agreement with the optimal interval suggested for central D-2 receptor occupancy. Serum concentrations at low dose levels may therefore serve as a useful tool in clinical monitoring of antipsychotic drug treatment.
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- Farde, L, et al.
(författare)
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A PET study of
- 2000
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Ingår i: The international journal of neuropsychopharmacology. - 1469-5111. ; 3:3, s. 203-214
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Tidskriftsartikel (refereegranskat)
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- Farde, L
(författare)
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Brain imaging and personality traits
- 2000
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Ingår i: INTERNATIONAL JOURNAL OF PSYCHOLOGY. - 0020-7594. ; 35:3-4, s. 23-23
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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