| 1. |
- Clark, Andrew G., et al.
(författare)
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Evolution of genes and genomes on the Drosophila phylogeny
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
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Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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| 2. |
- Lindblad-Toh, Kerstin, et al.
(författare)
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Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- 2005
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
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Tidskriftsartikel (refereegranskat)abstract
- Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
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| 3. |
- Farina, D, et al.
(författare)
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Discharge variability of motor units in an intrinsic muscle of transplanted hand
- 2008
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Ingår i: Journal of neurophysiology. - : American Physiological Society. - 0022-3077 .- 1522-1598. ; 99:5, s. 2232-2240
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Tidskriftsartikel (refereegranskat)abstract
- The study analyzed the discharge characteristics of the motor units in an intrinsic muscle of a transplanted hand. Multichannel electromyographic (EMG) recordings were obtained in 11 experimental sessions over 16 mo starting from day 205 after a hand was transplanted in a 35-yr-old man who had lost his right hand 22 yr earlier. The action potentials discharged by single motor units were identified from the surface EMG signals of the abductor digiti minimi muscle in the transplanted hand as the individual performed 60-s maximal and linearly increasing (ramp) contractions. Discharge rate decreased from 27.1 ± 8.4 pulses per second (pps) at the start of the maximal contractions to 17.2 ± 2.9 pps at the end ( P < 0.001) and increased from 17.4 ± 4.3 to 22.1 ± 5.0 pps during the ramp contractions ( P < 0.05). The SD of the interspike interval (ISI) nearly related to the mean ISI with a similar regression slope for the maximal (0.49 ± 0.09) and ramp contractions (0.43 ± 0.10). The coefficient of variation for ISI was higher than values in able-bodied persons and did not change during either the maximal (36.8 ± 10.8%) or the ramp contractions (35.9 ± 7.4%). High-frequency bursts of activity with <20 ms between two and six action potentials occurred during both maximal and ramp contractions. In conclusion, motor neurons that reinnervated a muscle in a transplanted hand discharged action potentials with a high degree of variability that suggested greater synaptic noise during the voluntary contractions.
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| 4. |
- de la Luna, E., et al.
(författare)
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RECENT RESULTS ON THE DISCREPANCY BETWEEN ELECTRON TEMPERATURE MEASUREMENTS IN HIGH TEMPERATURE PLASMAS IN JET
- 2009
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Ingår i: ELECTRON CYCLOTRON EMISSION AND ELECTRON CYCLOTRON RESONANCE HEATING. - : WORLD SCIENTIFIC PUBL CO PTE LTD. ; , s. 200-
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Konferensbidrag (refereegranskat)abstract
- The long standing disagreement between the central electron temperature measured by Thomson scattering and electron cyclotron emission (2nd harmonic, X-mode) in high performance plasmas observed in JET and TFTR is reexamined. In this paper we report on recent analysis carried out in JET with the aim of investigating the role of different plasma parameters, such as plasma heating scheme and fuelling, on the appearance of this discrepancy. Our analysis shows that the appearance of the discrepancy between the temperature diagnostics is correlated with the appearance of a high energy tail in the ion distribution function.
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| 5. |
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| 6. |
- Martínez-Ortega, José-Fernán, et al.
(författare)
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An approach for applying multi-agent technology into wireless sensor networks
- 2007
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Ingår i: Euro American Conference on Telematics and Information Systems - Proceedings of the 2007 Euro American Conference on Telematics and Information Systems, EATIS 2007. - New York, NY, USA : ACM Press. - 9781595935984 ; , s. Article number a22-
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Konferensbidrag (refereegranskat)abstract
- The present work describes how the concepts and foundations defined for multi-agent system technology can be applied in to a Wireless SensorNetwork (WSN), specifically it is focused on how multi-agent system technology's mechanisms and implementations could facilitate the development of systems based on WSN. In this respect, an architectural model where the above mentioned concepts, foundations and mechanisms come together is proposed, in order to define applications and services on WSN. Validation of the proposed architecture is made by means of its use in a perimeter security scenario ("tracking"). It is important to mention, that partial results of this work have been developed in the project PROPSI (Perimeter Protection by means of Wireless Sensor Networks).
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