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- Knowles, Charles H., et al.
(author)
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Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group
- 2009
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In: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 1432-0533 .- 0001-6322. ; 118:2, s. 271-301
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Journal article (peer-reviewed)abstract
- The term gastrointestinal neuromuscular disease describes a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular, including interstitial cell of Cajal, dysfunction. Such disorders commonly have impaired motor activity, i.e. slowed or obstructed transit with radiological evidence of transient or persistent visceral dilatation. Whilst sensorimotor abnormalities have been demonstrated by a variety of methods in these conditions, standards for histopathological reporting remain relatively neglected. Significant differences in methodologies and expertise continue to confound the reliable delineation of normality and specificity of particular pathological changes for disease. Such issues require urgent clarification to standardize acquisition and handling of tissue specimens, interpretation of findings and make informed decisions on risk-benefit of full-thickness tissue biopsy of bowel or other diagnostic procedures. Such information will also allow increased certainty of diagnosis, facilitating factual discussion between patients and caregivers, as well as giving prognostic and therapeutic information. The following report, produced by an international working group, using established consensus methodology, presents proposed guidelines on histological techniques and reporting for adult and paediatric gastrointestinal neuromuscular pathology. The report addresses the main areas of histopathological practice as confronted by the pathologist, including suction rectal biopsy and full-thickness tissue obtained with diagnostic or therapeutic intent. For each, indications, safe acquisition of tissue, histological techniques, reporting and referral recommendations are presented.
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| 2. |
- Moestl, C., et al.
(author)
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The structure of an earthward propagating magnetic flux rope early in its evolution : comparison of methods
- 2009
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In: Annales Geophysicae. - 0992-7689 .- 1432-0576. ; 27:5, s. 2215-2224
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Journal article (peer-reviewed)abstract
- We analyze a magnetic signature associated with the leading edge of a bursty bulk flow observed by Cluster at -19 R-E downtail on 22 August 2001. A distinct rotation of the magnetic field was seen by all four spacecraft. This event was previously examined by Slavin et al. (2003b) using both linear force-free modeling as well as a curlometer technique. Extending this work, we apply here single- and multi-spacecraft Grad-Shafranov (GS) reconstruction techniques to the Cluster observations and find good evidence that the structure encountered is indeed a magnetic flux rope and contains helical magnetic field lines. We find that the flux rope has a diameter of approximately 1 R-E, an axial field of 26.4 nT, a velocity of approximate to 650 km/s, a total axial current of 0.16 MA and magnetic fluxes of order 10(5) Wb. The field line twist is estimated as half a turn per RE. The invariant axis is inclined at 40 degrees to the ecliptic plane and 10 degrees to the GSM equatorial plane. The flux rope has a force-free core and non-force-free boundaries. When we compare and contrast our results with those obtained from minimum variance, single-spacecraft force-free fitting and curlometer techniques, we find in general fair agreement, but also clear differences such as a higher inclination of the axis to the ecliptic. We further conclude that single- spacecraft methods have limitations which should be kept in mind when applied to THEMIS observations, and that non-force-free GS and curlometer techniques are to be preferred in their analysis. Some properties we derived for this earthward - moving structure are similar to those inferred by Lui et al. (2007), using a different approach, for a tailward-moving flux rope observed during the expansion phase of the same substorm.
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