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- Hollo, G, et al.
(author)
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Referral for first glaucoma surgery in Europe, the ReF-GS study
- 2019
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In: European journal of ophthalmology. - : SAGE Publications. - 1724-6016 .- 1120-6721. ; 29:4, s. 406-416
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Journal article (peer-reviewed)abstract
- To analyze the appropriateness of referrals for incisional glaucoma-surgery in Europe. Methods: Referrals for the first open-angle glaucoma surgery between January and October 2017 were analyzed in 18 countries: 8 “old” European Union, 7 “new” European Union and 3 non-European Union European countries. Results: Most eyes had primary open-angle or exfoliative glaucoma. The average mean deviation was −13.8 dB with split fixation in 44.3%. No structural progression analysis was made before the referrals. The most common medications were the combination of a prostaglandin analog, timolol and a carbonic anhydrase inhibitor (30.0%), and all other combinations comprising ⩾ 3 molecules (33.8%). Laser trabeculoplasty was reported in only 18.4%. Of the 294 referrals, 41.5% were appropriate and timely, 35.0% appropriate but later than optimal, and 17.6% appropriate but too late (minimal vision maintained). The treatment period was significantly longer (median: 7 years) in the “old” European Union countries than in the other groups (3 and 2 years, respectively). No between-group differences were seen in intraocular pressure and mean deviation, but the non-European Union group referred the patients at significantly lower cup/disk ratio and eye drop usage than the other groups. Split fixation was significantly more common in the “old” (60.6%) than the “new” European Union countries (38.7%), and in both EU country-groups than in the non-European Union countries (13.6%). Conclusions: Of 294 European open-angle glaucoma referrals for first glaucoma-surgery, 41.5% were completely satisfactory. The damage was typically advanced, and the care varied considerably among the countries. This suggests that further efforts are necessary to improve glaucoma care in Europe.
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- Jung, Christian, et al.
(author)
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A comparison of very old patients admitted to intensive care unit after acute versus elective surgery or intervention
- 2019
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In: Journal of critical care. - : W B SAUNDERS CO-ELSEVIER INC. - 0883-9441 .- 1557-8615. ; 52, s. 141-148
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Journal article (peer-reviewed)abstract
- Background: We aimed to evaluate differences in outcome between patients admitted to intensive care unit (ICU) after elective versus acute surgery in a multinational cohort of very old patients (80 years; VIP). Predictors of mortality, with special emphasis on frailty, were assessed.Methods: In total, 5063 VIPs were induded in this analysis, 922 were admitted after elective surgery or intervention, 4141 acutely, with 402 after acute surgery. Differences were calculated using Mann-Whitney-U test and Wilcoxon test. Univariate and multivariable logistic regression were used to assess associations with mortality.Results: Compared patients admitted after acute surgery, patients admitted after elective surgery suffered less often from frailty as defined as CFS (28% vs 46%; p < 0.001), evidenced lower SOFA scores (4 +/- 5 vs 7 +/- 7; p < 0.001). Presence of frailty (CFS >4) was associated with significantly increased mortality both in elective surgery patients (7% vs 12%; p = 0.01), in acute surgery (7% vs 12%; p = 0.02).Conclusions: VIPs admitted to ICU after elective surgery evidenced favorable outcome over patients after acute surgery even after correction for relevant confounders. Frailty might be used to guide clinicians in risk stratification in both patients admitted after elective and acute surgery.
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- Bonmann, Marlene, 1988, et al.
(author)
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Drain current saturation in graphene field-effect transistors at high fields
- 2018
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Conference paper (other academic/artistic)abstract
- Development of competitive high frequency graphene field-effect transistors (GFETs) is hindered, first of all, by a zero-bandgap phenomenon in monolayer graphene, which prevents the drain current saturation and limits significantly the GFET power gain. An approach has been proposed to realise the drain current saturation in GFETs without a bandgap formation, but via velocity saturation of the charge carriers at high fields [1]. In this work, we report on the performance of GFETs fabricated using high quality CVD monolayer graphene and modified technology, which reduce the concentration of traps generating the charge carriers at high fields [2]. Fig. 1 shows typical output characteristics of GFETs with gate length of 0.5 μm. The drain current clearly reveals the saturation trends at high fields, which we associate with the saturation of the carrier velocity, see inset to Fig. 2 [2]. Fig. 2 shows typical measured (extrinsic) transit frequency (fT) and the maximum frequency of oscillation (fmax), which are characteristics of the current and power gain, respectively. Since fT and fmax are proportional to the carrier velocity, they reveal similar saturation behaviour. We analyse the saturation effects by applying the Fermi-Dirac carrier statistics. The fT and fmax are up to 34 GHz and 37 GHz, respectively, which are highest among those reported so far for the GFETs with similar gate length and comparable with those reported for Si MOSFETs [3].
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