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- Björkman, Sven E., et al.
(författare)
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In vivo recovery of factor VIII and factor IX : intra- and interindividual variance in a clinical setting
- 2007
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Ingår i: Haemophilia. - : Wiley. - 1351-8216 .- 1365-2516. ; 13:1, s. 2-8
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Tidskriftsartikel (refereegranskat)abstract
- In vivo recovery (IVR) is traditionally used as a parameter to characterize the pharmacokinetic properties of coagulation factors. It has also been suggested that dosing of factor VIII (FVIII) and factor IX (FIX) can be adjusted according to the need of the individual patient, based on an individually determined IVR value. This approach, however, requires that the individual IVR value is more reliably representative for the patient than the mean value in the population, i.e. that there is less variance within than between the individuals. The aim of this investigation was to compare intra- and interindividual variance in IVR (as U dL−1 per U kg−1) for FVIII and plasma-derived FIX in a cohort of non-bleeding patients with haemophilia. The data were collected retrospectively from six clinical studies, yielding 297 IVR determinations in 50 patients with haemophilia A and 93 determinations in 13 patients with haemophilia B. For FVIII, the mean variance within patients exceeded the between-patient variance. Thus, an individually determined IVR value is apparently no more informative than an average, or population, value for the dosing of FVIII. There was no apparent relationship between IVR and age of the patient (1.5–67 years). For FIX, the mean variance within patients was lower than the between-patient variance, and there was a significant positive relationship between IVR and age (13–69 years). From these data, it seems probable that using an individual IVR confers little advantage in comparison to using an age-specific population mean value. Dose tailoring of coagulation factor treatment has been applied successfully after determination of the entire single-dose curve of FVIII:C or FIX:C in the patient and calculation of the relevant pharmacokinetic parameters. However, the findings presented here do not support the assumption that dosing of FVIII or FIX can be individualized on the basis of a clinically determined IVR value.
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- Eriksson, Leif, 1970, et al.
(författare)
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ALOS PALSAR Calibration and Validation Results from Sweden
- 2007
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Ingår i: IEEE Geoscience and Remote Sensing Symposium (IGARSS 2007), Barcelona, Spain, July 23-27, 2007. ; DOI: 10.1109/IGARSS.2007.4423115, s. 1589-1592
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In 2006 calibration activities for ALOS PALSAR wereconducted in Sweden. Four five-metre trihedral corner reflectorsand three smaller dihedral reflectors were deployed and operatedduring eight months. 23 PALSAR scenes were acquired over thecalibration site allowing an evaluation of the quality and temporalstability of the data. Results show that the co-polarized datahave been stable during the whole calibration period with variationsin the trihedral responses lower than 0.7 dB. The measuredresolution in azimuth was 4.4 m and in slant range 4.7 m forsingle polarization images and 9.5 m for polarimetric data. Forthe cross-polarized data large variations in the dihedral responseswere found. It is assumed that this is caused by a larger sensitivityto pointing errors. For the polarimetric data, estimation ofFaraday rotation gave values ranging from 0.1º to 3º.
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- Fransson, J.E.S., et al.
(författare)
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Detection of clear-cuts using ALOS PALSAR satellite images
- 2008
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Ingår i: Proceedings of the European Conference on Synthetic Aperture Radar, EUSAR. - 2197-4403. ; 1-4
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Konferensbidrag (refereegranskat)abstract
- The objective of this study is to make a first evaluation of the possibilities to detect forest clear-cuts using high-resolution ALOS PALSAR FBD (Fine Beam Dual polarization) satellite images. New operational applications for mapping of changes in forest cover are of interest for government authorities in Sweden and in other countries with similar needs. The study was conducted in southern Sweden and included seven old coniferous stands located on flat terrain. Three of the stands were clear-felled and the remaining stands were left untreated for reference. Altogether, six PALSAR FBD images (look angle 34.3°, HH- and HV-polarization) acquired during the summer and fall seasons were analyzed. The difference in backscattering coefficient between the reference and the clear-felled stands was on average 2.4 dB and 2.9 dB for the HH- and HV-polarization, respectively. When comparing the backscattering coefficient before and after clear-felling the drop was found to be 1.7 dB and 2.3 dB for the HH- and HV-polarization, respectively.
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- Fransson, J.E.S., et al.
(författare)
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Mapping of Wind-Thrown Forests Using VHF/UHF SAR Images
- 2007
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Ingår i: IEEE 2007 International Geoscience and Remote Sensing Symposium (IGARSS 2007), Barcelona, Spain, July 23-27 2007. ; DOI: 10.1109/IGARSS.2007.4423313, s. 2350-2353
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- SAR images from the Swedish airborne CARABAS-II and LORA systems have been visually analyzed over simulated wind-thrown forest at both single tree and stand level. In ideal conditions, the results show that LORA is more accurate than CARABAS-II at detecting wind-thrown trees, regardless of tree size and direction of the fallen trees relative to flight heading. Furthermore, the visible single trees in the LORA images appeared more distinct than in the CARABAS-II images, which could be explained by the high resolution in the LORA images. Based on visual interpretation, it is likely that the detection of wind-thrown forests could be improved using VHF/UHF SAR images acquired both prior to and after a storm event.
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| 7. |
- Ketels, Christian, et al.
(författare)
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Clusters in the EU-10 new member countries
- 2007
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Ingår i: INNOVATION CLUSTERS IN THE 10 NEW MEMBER STATES OF THE EUROPEAN UNION. - Brussels : European Communities. - 9279031961 ; , s. 49-62
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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