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- Kriz, Vitezslav, et al.
(författare)
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Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero
- 2007
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Ingår i: Developmental Dynamics. - : Wiley. - 1058-8388 .- 1097-0177. ; 236:9, s. 2485-2492
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Tidskriftsartikel (refereegranskat)abstract
- SHB is an Src homology 2 domain-containing adapter protein that has been found to be involved in numerous cellular responses. We have generated an Shb knockout mouse. No Shb-/- pups or embryos were obtained on the C57Bl6 background, indicating an early defect as a consequence of Shb- gene inactivation on this genetic background. Breeding heterozygotes for Shb gene inactivation (Shb+/-) on a mixed genetic background (FVB/C57Bl6/129Sv) reveals a distorted transmission ratio of the null allele with reduced numbers of Shb+/+ and Shb-/- animals, but increased number of Shb+/- animals. The Shb- allele is associated with various forms of malformations, explaining the relative reduction in the number of Shb-/- offspring. Shb-/- animals that were born were viable, fertile, and showed no obvious defects. However, Shb+/- female mice ovulated preferentially Shb- oocytes explaining the reduced frequency of Shb+/+ mice. Our study suggests a role of SHB during reproduction and development.
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- Hedfeldt, Mona, 1979-
(författare)
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Företagande kvinnor i bruksort : arbetsliv och vardagsliv i samspel
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Bergslagen region in Sweden has a history of iron and steel production, and in the small industrial towns in the region, one large employer has often held a strong position. Although the region has gone through structural change since the 1970’s, in previous research, becoming self-employed is perceived of as difficult, since it implies going against a strong working culture. The image of Bergslagen is that of a non-entrepreneurial region. Furthermore, in previous research, the gender contract in the region is characterized as traditional. In this thesis light is shed on women in the region who are self-employed. Topics that are focused on are work experience, role models, family situation and networks. The study builds on qualitative interviews and longitudinal registry based statistics (1993-2003). The interviews were carried out in the municipalities of Norberg and Fagersta with self-employed women in the fields of health and business services. Conclusions drawn concern both the region Bergslagen as an entrepreneurial region and the lives of self-employed women. The situations and conditions under which women become and remain self-employed displays a complex interaction between different areas of life, both in relation to the start-up phase and the subsequent running of their businesses. The idea of the region as non-entrepreneurial is scrutinized. For one, the share of self-employed in the Bergslagen municipalities only differs among men, compared to the national average. The share of self-employed women in the region, however, is similar to the national average. Furthermore, the share of self-employed men and women varies among the municipalities within the region. Thus, it is problematic to speak of the region as non-entrepreneurial and as homogenous when it comes to self-employment and entrepreneurship. These findings indicate that the idea of the region as non-entrepreneurial is an expression of both the region being male coded and women entrepreneurs being subordinated.
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