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- Geborek, Pierre, et al.
(författare)
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Synovial fluid acidosis correlates with radiological joint destruction in rheumatoid arthritis knee joints
- 1989
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Ingår i: Journal of Rheumatology. - 0315-162X. ; 16:4, s. 468-472
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Tidskriftsartikel (refereegranskat)abstract
- Metabolic variables in samples of synovial fluid (SF) from 33 rheumatoid arthritis (RA) knees were analyzed. These variables were correlated with radiological destruction and SF proteoglycan concentrations. SF acidosis correlated with radiological involvement (rs = 0.62, p less than 0.002), but not with proteoglycan concentrations. A weak correlation was found between SF acidosis and granulocyte concentrations (rs = 0.37, 0.02 less than p less than 0.05). Metabolic variables covaried as expected. Samples from right and left knees from the same patients correlated regarding cellular and metabolic variables. Our results indicate insufficient nutritional supply in RA joints with increasing radiological involvement.
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| 2. |
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| 3. |
- Saxne, Tore, et al.
(författare)
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Difference in cartilage proteoglycan level in synovial fluid in early rheumatoid arthritis and reactive arthritis.
- 1985
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Ingår i: The Lancet. - 1474-547X. ; 2/8447:8447, s. 127-128
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Tidskriftsartikel (refereegranskat)abstract
- Cartilage proteoglycans were measured, by the use of an enzyme-linked immunosorbent assay, in synovial fluids obtained from 109 unselected patients attending an outpatient rheumatology clinic because of inflammation of the knee. The content of proteoglycans in synovial fluid was inversely related to the degree of joint destruction shown on X-ray. The proteoglycan concentrations in knee-joint exudates were higher in patients with reactive arthritis than in patients with rheumatoid arthritis having synovitis of corresponding duration and lacking radiological evidence of cartilage destruction. The measurement of proteoglycan levels may therefore be useful in differentiating between the two conditions.
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