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Increased survival ...
Increased survival with mechanical ventilation in post-tuberculosis patients with the combination of respiratory failure and chest wall deformity
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Jäger, Linda (författare)
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- Franklin, Karl (författare)
- Umeå universitet,Lungmedicin
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- Midgren, Bengt (författare)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Löfdahl, Kerstin, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Ström, Kerstin (författare)
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: Chest. - : Elsevier BV. - 1931-3543 .- 0012-3692. ; 133:1, s. 156-160
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background Patients who have suffered from tuberculosis are at risk of respiratory failure with hypercapnea from chest wall deformity and hypoxia from pulmonary sequelae. The combination of hypercapnea and hypoxia justifies both mechanical ventilation and oxygen therapy as treatment options. We aimed to study which treatment mode is associated with the best survival in patients with the combination of respiratory failure and chest wall deformity from tuberculosis. Methods Swedish patients starting oxygen therapy or mechanical ventilation between 1996 and 2004 due to the combination of respiratory failure and chest wall deformity from tuberculosis were eligible for conclusion. They were followed prospectively until October 2006, with death as the primary outcome. Results A cohort of 188 patients was included. Eighty-five received mechanical ventilation and 103 received oxygen therapy alone. No patients were excluded and none was lost to follow-up. Mechanical ventilation was associated with a significantly better survival than oxygen therapy alone, even after adjustments for age, gender, concomitant respiratory disease, blood gas tensions and vital capacity, with an adjusted hazard risk of death of 0.35 (95% CI 0.17-0.70). Conclusion Patients with the combination of respiratory failure and chest wall deformity from tuberculosis had a significantly better survival when treated with home mechanical ventilation than with long-term oxygen therapy alone. We recommend home mechanical ventilation with or without supplementary oxygen as the first choice of treatment for these patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- survival
- respiratory insufficiency
- recommendations
- mechanical ventilation
- oxygen inhalation therapy
- treatment
- tuberculosis
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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