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| 2. |
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| 3. |
- Bjelke, Ulf, et al.
(författare)
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Rödlistade arter och naturvård i sand- och grustäkter
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Naturligt störningspräglade sandmarker hyser en artrik och konkurrenskänslig flora och fauna. Sådana livsmiljöer har minskat drastiskt under 1900-talet. Under samma period ökade antalet sand- och grustäkter. Trots att täkterna ofta innebär stora ingrepp i naturen kan de utgöra viktiga ersättningshabitat för arter knutna till sandiga miljöer. Sedan några decennier så minskar även sand- och grustäkter starkt, beroende på att samhället vill bevara naturliga sand- och grusresurser. Produktionen har medvetet flyttats till bergkrossanläggningar och det ges idag mycket få tillstånd för utökad verksamhet eller nya sandtäkter. Från fler än 5 000 aktiva täkter på 1990-talet har antalet sjunkit till färre än 1 000. Täkter som avslutas har ofta föreskrifter om att planas ut och övertäckas vilket gör att deras naturvärden spolieras. Drygt 300 rödlistade arter har gynnats av sandtäkter när ursprungshabitaten minskat. Steklar och skalbaggar utgör de största grupperna med närmare två tredjedelar av arterna. Södra Sverige hyser störst rikedom av dessa arter men såväl täkter som arternas mer naturliga miljöer är bristfälligt undersökta, särskilt i glest befolkade delar av landet. För att bevara dessa täktlevande arter krävs att naturvården arbetar för att förhindra att avslutade täkter planas ut eller täcks över. Det är av stor betydelse att naturvårdande myndigheter ges tillräckliga styrmedel och ekonomiska resurser att arbeta med täkter. Genom enkla åtgärder kan de skapade livsmiljöerna i täkter bevaras till en låg kostnad jämfört med andra alternativa biotopvårdande åtgärder. Rapporten belyser artsamhällena som kan finnas i täkter samt viktiga strategier och åtgärder för naturvård i dessa miljöer. Rapporten har finansierats av Naturvårdsverket och av SLU:s medel för fortlöpande miljöanalys.
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| 5. |
- Fritz, Martin, 1937
(författare)
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Framtida utmaningar och möjligheter
- 2011
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Ingår i: Bergsbruk : gruvor och metallframställning. - Stockholm : Norstedts. - 9789187760587 ; , s. 202-205
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Fritz, Martin, 1937
(författare)
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Kris och förnyelse, 1900-talets första hälft
- 2011
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Ingår i: Bergsbruk : gruvor och metallframställning. - Stockholm : Norstedts. - 9789187760587 ; , s. 126-145
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Fritz, Martin, et al.
(författare)
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Potentials for prosperity without growth: Ecological sustainability, social inclusion and the quality of life in 38 countries
- 2014
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Ingår i: Ecological Economics. - : Elsevier BV. - 0921-8009. ; 108, s. 191-199
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Tidskriftsartikel (refereegranskat)abstract
- Recent contributions to ecological economics and related social sciences indicate that issues such as climate change, resource depletion and environmental degradation cannot be effectively addressed under conditions of continued economic growth. This paper aims at empirically identifying structural potentials and policy challenges for prosperity at scaleswhere economic development remainswithin ecological carrying capacities. Building on the growing literature that interprets prosperity ‘beyond’ economic growth, the paper presents a threedimensional concept to operationalise prosperity in terms of ecological sustainability, social inclusion, and the quality of life. These dimensions are measured using data from sources such as TheWorld Bank, the Global Footprint Network and the OECD. The results of cluster and correspondence analyses indicate the existence of five ‘prosperity regimes’ and demonstrate that all aspects of prosperity – including (unsatisfactory) ecological performance – are linked to economic development. However, our findings also indicate that in order to achieve a decent minimum of prosperity moderate levels of the material living standard are sufficient. Further increases in the material living standard do not lead to significant additional prosperity; instead they cause greater environmental harms. The paper concludes by highlighting potentials for prosperity for each of the ‘prosperity regimes’ and corresponding policy challenges.
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| 10. |
- Hardwick, Martin, et al.
(författare)
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A roadmap for STEP-NC-enabled interoperable manufacturing
- 2013
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Ingår i: The International Journal of Advanced Manufacturing Technology. - : Springer Science and Business Media LLC. - 0268-3768 .- 1433-3015. ; 68:5-8, s. 1023-1037
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Tidskriftsartikel (refereegranskat)abstract
- The STEP-NC-AP 238 and ISO 14649 standard is the result of a 10-year international effort to replace the RS274D (ISO 6983) G and M code standard with a modern associative language that connects the CAD design data used to determine the machining requirements for an operation with the CAM process data that is used in creating a machining solution to satisfy these requirements. STEP-NC builds on the previous 10 years effort to develop the STEP neutral data standard for CAD data, and uses the modern geometric constructs in that standard to specify device independent tool paths, and CAM independent volume removal features. STEP-Manufacturing, Team 24 in Working Group 3 (WG3) of ISO TC184/SC4, is developing and validating the STEP-NC standard in liaison with Working Group (WG7) of ISO TC184/SC1 who provides the domain-specific input (ISO 14649) used within the standard. This paper reviews the demonstrations carried out by STEP-Manufacturing over the past 10 years. These demonstrations have been international collaborations between industry, academia, and research agencies. Each demonstration focused on extending the STEP-NC data model for a different application.
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| 11. |
- Hardwick, Martin, et al.
(författare)
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Enabling the Crowd Sourcing of Very Large Product Models
- 2013
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Ingår i: Digital Product and Process Development Systems. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783642413285 - 9783642413292 ; , s. 254-272
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Bokkapitel (refereegranskat)abstract
- Part 21 is a public domain file format for the geometry of assemblies and is widely used by industry to describe design and manufacturing specifications for airplanes, automobiles, ships, buildings and other products. We describe a proposed new edition of Part 21 that includes URI’s and JavaScript to enable the crowd sourcing of very large product models.
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| 12. |
- Jensen, Torben Haugaard, et al.
(författare)
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Imaging of Metastatic Lymph Nodes by X-ray Phase-Contrast Micro-Tomography
- 2013
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Invasive cancer causes a change in density in the affected tissue, which can be visualized by x-ray phase-contrast tomography. However, the diagnostic value of this method has so far not been investigated in detail. Therefore, the purpose of this study was, in a blinded manner, to investigate whether malignancy could be revealed by non-invasive x-ray phase-contrast tomography in lymph nodes from breast cancer patients. Seventeen formalin-fixed paraffin-embedded lymph nodes from 10 female patients (age range 37-83 years) diagnosed with invasive ductal carcinomas were analyzed by X-ray phase-contrast tomography. Ten lymph nodes had metastatic deposits and 7 were benign. The phase-contrast images were analyzed according to standards for conventional CT images looking for characteristics usually only visible by pathological examinations. Histopathology was used as reference. The result of this study was that the diagnostic sensitivity of the image analysis for detecting malignancy was 100% and the specificity was 87%. The positive predictive value was 91% for detecting malignancy and the negative predictive value was 100%. We conclude that x-ray phase-contrast imaging can accurately detect density variations to obtain information regarding lymph node involvement previously inaccessible with standard absorption x-ray imaging.
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| 13. |
- Jønsson, Knud A, et al.
(författare)
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Ecological and evolutionary determinants for the adaptive radiation of the Madagascan vangas.
- 2012
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 109:17, s. 6620-5
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Tidskriftsartikel (refereegranskat)abstract
- Adaptive radiation is the rapid diversification of a single lineage into many species that inhabit a variety of environments or use a variety of resources and differ in traits required to exploit these. Why some lineages undergo adaptive radiation is not well-understood, but filling unoccupied ecological space appears to be a common feature. We construct a complete, dated, species-level phylogeny of the endemic Vangidae of Madagascar. This passerine bird radiation represents a classic, but poorly known, avian adaptive radiation. Our results reveal an initial rapid increase in evolutionary lineages and diversification in morphospace after colonizing Madagascar in the late Oligocene some 25 Mya. A subsequent key innovation involving unique bill morphology was associated with a second increase in diversification rates about 10 Mya. The volume of morphospace occupied by contemporary Madagascan vangas is in many aspects as large (shape variation)--or even larger (size variation)--as that of other better-known avian adaptive radiations, including the much younger Galapagos Darwin's finches and Hawaiian honeycreepers. Morphological space bears a close relationship to diet, substrate use, and foraging movements, and thus our results demonstrate the great extent of the evolutionary diversification of the Madagascan vangas.
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| 14. |
- Klein, Jan Philipp, et al.
(författare)
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The EVIDENT-trial: protocol and rationale of a multicenter randomized controlled trial testing the effectiveness of an online-based psychological intervention
- 2013
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Ingår i: BMC Psychiatry. - : BioMed Central. - 1471-244X. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundDepressive disorders are among the leading causes of worldwide disability with mild to moderate forms of depression being particularly common. Low-intensity treatments such as online psychological treatments may be an effective way to treat mild to moderate depressive symptoms and prevent the emergence or relapse of major depression.Methods/DesignThis study is a currently recruiting multicentre parallel-groups pragmatic randomized-controlled single-blind trial. A total of 1000 participants with mild to moderate symptoms of depression from various settings including in- and outpatient services will be randomized to an online psychological treatment or care as usual (CAU). We hypothesize that the intervention will be superior to CAU in reducing depressive symptoms assessed with the Personal Health Questionnaire (PHQ-9, primary outcome measure) following the intervention (12 wks) and at follow-up (24 and 48 wks). Further outcome parameters include quality of life, use of health care resources and attitude towards online psychological treatments.DiscussionThe study will yield meaningful answers to the question of whether online psychological treatment can contribute to the effective and efficient prevention and treatment of mild to moderate depression on a population level with a low barrier to entry.
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| 16. |
- Koch, Max, et al.
(författare)
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Building the Eco-Social State: Do Welfare Regimes Matter?
- 2014
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Ingår i: Journal of Social Policy. - 0047-2794. ; 43:4, s. 679-703
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Tidskriftsartikel (refereegranskat)abstract
- Authors such as Dryzek, Gough and Meadowcroft have indicated that social-democratic welfare states could be in a better position to deal with development of the ‘green’ or ‘eco’state, and the intersection of social and environmental policies, than conservative or liberal welfare regimes (synergy hypothesis). However, this hypothesis has as yet not been examined in comparative empirical research. Based on comparative empirical data from EUROSTAT, the World Bank, the OECD, the Global Footprint Network and the International Social Survey Programme, we are carrying out two research operations: First, by applying correspondence analysis, we contrast the macro-structural welfare and sustainability indicators of thirty countries and ask whether clusters largely follow the synergy hypothesis. Second, we raise the issue of whether differences in the institutional and organisational capabilities of combining welfarewith environmental policies are reflected in people’s attitudes and opinions. With regard to the first issue, our results suggest that there is no ‘automatic’ development of the ecostate based on already existing advanced welfare institutions. Representatives of all welfare regimes are spread across established, deadlocked, failing, emerging and endangered ecostates. As for the second issue, the results are mixed. While responses to the statements ‘economic growth always harms the environment’ and ‘governments should pass laws to make ordinary people protect the environment, even if it interferes with people’s rights to make their own decisions’did not vary according to welfare regimes, people from social-democratic countries expressed more often than average their willingness to accept cuts in their standard of living in order to protect the environment.
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| 17. |
- Leblond, Claire S, et al.
(författare)
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Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders.
- 2012
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Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 8:2
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Tidskriftsartikel (refereegranskat)abstract
- Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders with a complex inheritance pattern. While many rare variants in synaptic proteins have been identified in patients with ASD, little is known about their effects at the synapse and their interactions with other genetic variations. Here, following the discovery of two de novo SHANK2 deletions by the Autism Genome Project, we identified a novel 421 kb de novo SHANK2 deletion in a patient with autism. We then sequenced SHANK2 in 455 patients with ASD and 431 controls and integrated these results with those reported by Berkel et al. 2010 (n=396 patients and n=659 controls). We observed a significant enrichment of variants affecting conserved amino acids in 29 of 851 (3.4%) patients and in 16 of 1,090 (1.5%) controls (P=0.004, OR=2.37, 95% CI=1.23-4.70). In neuronal cell cultures, the variants identified in patients were associated with a reduced synaptic density at dendrites compared to the variants only detected in controls (P=0.0013). Interestingly, the three patients with de novo SHANK2 deletions also carried inherited CNVs at 15q11-q13 previously associated with neuropsychiatric disorders. In two cases, the nicotinic receptor CHRNA7 was duplicated and in one case the synaptic translation repressor CYFIP1 was deleted. These results strengthen the role of synaptic gene dysfunction in ASD but also highlight the presence of putative modifier genes, which is in keeping with the "multiple hit model" for ASD. A better knowledge of these genetic interactions will be necessary to understand the complex inheritance pattern of ASD.
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| 19. |
- Marques, Paul, et al.
(författare)
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Estimating driver risk using alcohol biomarkers, interlock blood alcohol concentration tests and psychometric assessments: initial descriptives
- 2010
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Ingår i: Addiction. - : Wiley. - 1360-0443 .- 0965-2140. ; 105:2, s. 226-239
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Tidskriftsartikel (refereegranskat)abstract
- Aim To identify alcohol biomarker and psychometric measures that relate to drivers' blood alcohol concentration (BAC) patterns from ignition interlock devices (IIDs). Design, setting, participants, measurements In Alberta, Canada, 534 drivers, convicted of driving under the influence of alcohol (DUI), installed IIDs and agreed to participate in a research study. IID BAC tests are an established proxy for predicting future DUI convictions. Three risk groups were defined by rates of failed BAC tests. Program entry and follow-up blood samples (n = 302, 171) were used to measure phosphatidyl ethanol (PETH), carbohydrate deficient transferrin (%CDT), gamma glutamyltransferase (GGT) and other biomarkers. Program entry urine (n = 130) was analyzed for ethyl glucuronide (ETG) and ethyl sulphate (ETS). Entry hair samples were tested for fatty acid ethyl esters (FAEE) (n = 92) and ETG (n = 146). Psychometric measures included the DSM-4 Diagnostic Interview Schedule Alcohol Module, Alcohol Use Disorders Identification Test (AUDIT), the time-line follow-back (TLFB), the Drinker Inventory of Consequences (DRINC) and the Temptation and Restraint Inventory (TRI). Findings Except for FAEE, all alcohol biomarkers were related significantly to the interlock BAC test profiles; higher marker levels predicted higher rates of interlock BAC test failures. PETH, the strongest with an overall analysis of variance F ratio of 35.5, had significant correlations with all nine of the other alcohol biomarkers and with 16 of 19 psychometric variables. Urine ETG and ETS were correlated strongly with the IID BAC tests. Conclusions The findings suggest that several alcohol biomarkers and assessments could play an important role in the prediction and control of driver alcohol risk when re-licensing.
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