Sökning: WFRF:(Fu Junfen)
> (2022) >
High Prevalence of ...
High Prevalence of Cardiometabolic Comorbidities Among Children and Adolescents With Severe Obesity From a Large Metropolitan Centre (Hangzhou, China)
-
- Wang, Jinling (författare)
- Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Endocrinol,Sch Med, Hangzhou, Peoples R China.
-
- Lin, Hu (författare)
- Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Endocrinol,Sch Med, Hangzhou, Peoples R China.
-
- Chiavaroli, Valentina (författare)
- Pescara Publ Hosp, Neonatal Intens Care Unit, Pescara, Italy.;Univ Auckland, Liggins Inst, Auckland, New Zealand.
-
visa fler...
-
- Jin, Binghan (författare)
- Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Endocrinol,Sch Med, Hangzhou, Peoples R China.
-
- Yuan, Jinna (författare)
- Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Endocrinol,Sch Med, Hangzhou, Peoples R China.
-
- Huang, Ke (författare)
- Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Endocrinol,Sch Med, Hangzhou, Peoples R China.
-
- Wu, Wei (författare)
- Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Endocrinol,Sch Med, Hangzhou, Peoples R China.
-
- Dong, Guanping (författare)
- Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Endocrinol,Sch Med, Hangzhou, Peoples R China.
-
- Derraik, José G. B. (författare)
- Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning,Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Endocrinol, Sch Med, Hangzhou, Peoples R China; Univ Auckland, Liggins Inst, Auckland, New Zealand; Chiang Mai Univ, Res Inst Hlth Sci, Environm & Occupat Hlth Sci & Noncommunicable Dis, Chiang Mai, Thailand
-
- Fu, Junfen (författare)
- Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Endocrinol,Sch Med, Hangzhou, Peoples R China.
-
visa färre...
-
Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Endocrinol,Sch Med, Hangzhou, Peoples R China Pescara Publ Hosp, Neonatal Intens Care Unit, Pescara, Italy.;Univ Auckland, Liggins Inst, Auckland, New Zealand. (creator_code:org_t)
- 2022-05-19
- 2022
- Engelska.
-
Ingår i: Frontiers in Endocrinology. - : Frontiers Media S.A.. - 1664-2392. ; 13
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: This study aimed to describe the clinical characteristics of children and adolescents with obesity, and the prevalence of cardiometabolic comorbidities over 10 years in this population from a large metropolitan centre in China.Methods: This was a cross-sectional study (2008–2017) of patients aged <18 years with obesity [body mass index (BMI) ≥ 95th percentile for age and sex] enrolled at the Department of Endocrinology, Children’s Hospital of Zhejiang University School of Medicine (Hangzhou, Zhejiang Province). Clinical assessments included anthropometry, blood pressure, liver ultrasound, lipid profile, oral glucose tolerance test, and uric acid. For examination of outcomes, our study cohort was stratified by sex and age bands (<10 vs. ≥10 years), with the study period also split into two strata (2008–2012 and 2013–2017).Results: A total of 2,916 patients (1,954 boys and 962 girls) were assessed at a mean age of 10.5 years. Patients almost invariably presented severe obesity (median BMI SDS = 2.98; Q1 = 2.60, Q3 = 3.39). Obesity-related comorbidities were common among boys and girls, including type 2 diabetes mellitus (2.6% and 3.6%, respectively), abnormal glycaemia (33.6% and 35.5%, respectively), hypertension (33.9% and 32.0%, respectively), dyslipidaemia (35.2% and 39.6%, respectively), hyperuricaemia (16.2% and 8.3%, respectively), acanthosis nigricans (71.9% and 64.0%, respectively), abnormal liver function (66.9% and 47.0%, respectively), and non-alcoholic fatty liver disease (NAFLD) (63.8% and 45.1%, respectively); 38.7% of boys and 44.4% of girls aged ≥10 years had metabolic syndrome. Notably, the incidence of many cardiometabolic comorbidities was in 2013–2017 compared to 2008–2012. For example, rates of hypertension among boys aged <10 years and aged ≥10 years rose from 28.4% and 26.5% to 48.0% and 35.8%, respectively, and in girls from 20.3% and 20.8% to 41.7% and 39.6%, respectively. In 2013–2017, 9.5% of girls in the older group had metabolic syndrome compared to 2.2% in 2008–2013.Conclusions: We observed a high incidence of obesity-related cardiometabolic comorbidities among Chinese children and adolescents with severe obesity over 10 years. It was particularly concerning that rates of several comorbidities rose markedly over the study period, highlighting the need to address the obesity epidemic early in life (in China and elsewhere) to prevent the development of obesity-related comorbidities and, subsequently, of overt disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- abnormal liver function
- acanthosis nigricans
- blood pressure
- China
- glucose metabolism
- hypertension
- insulin sensitivity
- NAFLD
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Wang, Jinling
-
Lin, Hu
-
Chiavaroli, Vale ...
-
Jin, Binghan
-
Yuan, Jinna
-
Huang, Ke
-
visa fler...
-
Wu, Wei
-
Dong, Guanping
-
Derraik, José G. ...
-
Fu, Junfen
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Folkhälsovetensk ...
- Artiklar i publikationen
-
Frontiers in End ...
- Av lärosätet
-
Uppsala universitet