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Tetratricopeptide-l...
Tetratricopeptide-like repeats in type-III-secretion chaperones and regulators
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Pallen, Mark J (författare)
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- Francis, Matthew S (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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Fütterer, Klaus (författare)
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(creator_code:org_t)
- 2003
- 2003
- Engelska.
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Ingår i: FEMS Microbiology Letters. - 0378-1097 .- 1574-6968. ; 223:1, s. 53-60
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Efficient type-III secretion depends on cytosolic molecular chaperones, which bind specifically to the translocators and effectors. In the past there has been a tendency to shoe-horn all type-III-secretion chaperones into a single structural and functional class. However, we have shown that the LcrH/SycD-like chaperones consist of three central tetratricopeptide-like repeats that are predicted to fold into an all-alpha-helical array that is quite distinct from the known structure of the SycE class of chaperones. Furthermore, we predict that this array creates a peptide-binding groove that is utterly different from the helix-binding groove in SycE. We present a homology model of LcrH/SycD that is consistent with existing mutagenesis data. We also report the existence of tetratricopeptide-like repeats in regulators of type-III secretion, such as HilA from Salmonella enterica and HrpB from Ralstonia solanacearum. The discovery of tetratricopeptide-like repeats in type-III-secretion regulators and chaperones provides a new conceptual framework for structural and mutagenesis studies and signals a potential unification of prokaryotic and eukaryotic chaperone biology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Tetratricopeptide repeat
- Type-III secretion
- Chaperone
- Homology search
- Homology modelling
- LcrH
- Protein–protein interaction
- Microbiology
- Mikrobiologi
- Infectious Diseases
- infektionssjukdomar
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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