| 1. |
- Bousquet, Jean, et al.
(författare)
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Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018) : Change management in allergic rhinitis and asthma multimorbidity using mobile technology
- 2019
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 143:3, s. 864-879
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Tidskriftsartikel (refereegranskat)abstract
- Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.
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| 2. |
- Gálvez, Antonio, et al.
(författare)
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Hybrid Models and Digital Twins for Condition Monitoring : HVAC System for Railway
- 2019
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Ingår i: EUROSIM 2019. - : ARGESIM Publisher. ; , s. 52-52
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The passenger transportation,safety is more important than efficiency or reliability. Therefore, it is vital to maintain the proper condition of the equipment related to the passengers’ comfort and safety.This manuscriptexplainsthe methodology ofcomplete development and implementation of both hybrid model and digital twin3.0for a HVAC inrailways. The objective of this is to monitor the condition of the HVAC where it matters to the comfort and safety of the passengers in the trains. The level3.0of digital twinwill be develop for the diagnosis and prognosis of HVAC by using the hybrid modeling.The descriptionillustratedin this paper is focused on the methodology used to implement the hybrid model approach and both the need and advantages to use a hybrid model approach instead of thedata-based approach.One of the particularitiesconsidered doing the developmentwas the importanceof the safety and environmental risk whichwere included in the risk quantification of the failure modes. In train companies the maintainers replace critical components in early stages of degradation, thus, using a data-based model might loses important information and does not givegood support to manage the maintenance instructions.Developing a physicsbased-model will be able to generate synthetic data for the behavior of the components in advanced stages of degradation and combiningitwith the data-based modellead to formhybrid model with a large number of failure modes that were unpredictable. Finally,the outcome is beneficialfor the proper functioning of the systems, hence, the safety of the passengers.
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| 3. |
- Gonzalez-Gaya, Belen, et al.
(författare)
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Biodegradation as an important sink of aromatic hydrocarbons in the oceans
- 2019
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Ingår i: Nature Geoscience. - : Nature Publishing Group. - 1752-0894 .- 1752-0908. ; 12:2, s. 119-125+2
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Tidskriftsartikel (refereegranskat)abstract
- Atmospheric deposition of semivolatile aromatic hydrocarbons accounts for an important input of organic matter to the surface ocean. Nevertheless, the biogeochemical cycling and sinks of semivolatile aromatic hydrocarbons in the ocean remain largely uncharacterized. Here we present measurements of 64 polycyclic aromatic hydrocarbons in plankton and seawater from the Atlantic, Pacific, Indian and Southern Oceans, as well an assessment of their microbial degradation genes. Concentrations of the more hydrophobic compounds decreased when the plankton biomass was higher, consistent with the relevance of the biological pump. The mass balance for the global oceans showed that the settling fluxes of aromatic hydrocarbons in the water column were two orders of magnitude lower than the atmospheric deposition fluxes. This imbalance was high for low molecular weight hydrocarbons, such as phenanthrene and methylphenanthrenes, highly abundant in the dissolved phase. Parent polycyclic aromatic hydrocarbons were depleted to a higher degree than alkylated polycyclic aromatic hydrocarbons, and the degradation genes for polycyclic aromatic hydrocarbons were found to be ubiquitous in oceanic metagenomes. These observations point to a key role of biodegradation in depleting the bioavailable dissolved hydrocarbons and to the microbial degradation of atmospheric inputs of organic matter as a relevant process for the marine carbon cycle.
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