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Sökning: WFRF:(Galvez Antonio) > (2020)

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1.
  • Gálvez, Antonio, et al. (författare)
  • Synthetic Data Generation in Hybrid Modelling of Railway HVAC System
  • 2020
  • Ingår i: 17th IMEKO TC 10 and EUROLAB Virtual Conference. - : International Measurement Confederation (IMEKO). ; , s. 79-84
  • Konferensbidrag (refereegranskat)abstract
    • This paper proposes a hybrid model (HyM)for a heating, ventilation and air conditioning (HVAC) system installed in a passenger train. This HyM fuses data from two sources: data taken from the real system and synthetic data generated using a physics-based model of the HVAC.The physical model of the HVAC was developed to include the sensors located in the real system and new virtual sensors reproducing the behaviour of the system while a failure mode (FM) is simulated.Statistical features are calculated from the selected signals. These features are labelled according to the related FMs and are merged with the features calculated from the data from the real system. This data fusion allows us to classify the condition indicators of the system according to the FMs. The merged features are used to train a neural network (NN), which achieves a remarkable accuracy.Accuracy is a key concern of future research on the detection and diagnosis of a multiple faults and the estimation of the remaining useful life (RUL) through prognosis. The outcome is beneficial for the proper functioning of the system and the safety of the passengers.
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2.
  • Santos-Lozano, Alejandro, et al. (författare)
  • Successful aging : Insights from proteome analyses of healthy centenarians
  • 2020
  • Ingår i: Aging. - : Impact Journals, LLC. - 1945-4589. ; 12:4, s. 3502-3515
  • Tidskriftsartikel (refereegranskat)abstract
    • Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging.
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