| 1. |
- Abazov, V. M., et al.
(författare)
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The upgraded DO detector
- 2006
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 565:2, s. 463-537
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Tidskriftsartikel (refereegranskat)abstract
- The DO experiment enjoyed a very successful data-collection run at the Fermilab Tevatron collider between 1992 and 1996. Since then, the detector has been upgraded to take advantage of improvements to the Tevatron and to enhance its physics capabilities. We describe the new elements of the detector, including the silicon microstrip tracker, central fiber tracker, solenoidal magnet, preshower detectors, forward muon detector, and forward proton detector. The uranium/liquid -argon calorimeters and central muon detector, remaining from Run 1, are discussed briefly. We also present the associated electronics, triggering, and data acquisition systems, along with the design and implementation of software specific to DO.
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| 2. |
- Abazov, V. M., et al.
(författare)
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Measurement of the B-s(0) lifetime using semileptonic decays
- 2006
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:24, s. 241801-
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Tidskriftsartikel (refereegranskat)abstract
- We report a measurement of the B-s(0) lifetime in the semileptonic decay channel B-s(0)-> D-s(-)mu(+)nu X (and its charge conjugate), using approximately 0.4 fb(-1) of data collected with the D0 detector during 2002-2004. Using 5176 reconstructed D-s(-)mu(+) signal events, we have measured the B-s(0) lifetime to be tau(B-s(0))=1.398 +/- 0.044(stat)(-0.025)(+0.028)(syst) ps. This is the most precise measurement of the B-s(0) lifetime to date.
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| 3. |
- Abazov, V. M., et al.
(författare)
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Measurement of the top quark mass in the dilepton channel
- 2007
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 655:1-2, s. 7-14
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the top quark mass in the dilepton channel based on approximately 370 pb(-1) of data collected by the DO experiment during Run R of the Fermilab Tevatron collider. We employ two different methods to extract the top quark mass. We show that both methods yield consistent results using ensemble tests of events generated with the DO Monte Carlo simulation. We combine the results from the two methods to obtain a top quark mass m(t) = 178.1 +/- 8.2 GeV. The statistical uncertainty is 6.7 GeV and the systematic uncertainty is 4.8 GeV.
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| 4. |
- Abazov, V. M., et al.
(författare)
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Search for a heavy resonance decaying into a Z plus jet final state in p(p)over-bar collisions at root s=1.96 TeV using the D0 detector
- 2006
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Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 74:1, s. 011104-
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Tidskriftsartikel (refereegranskat)abstract
- We have searched for a heavy resonance decaying into a Z+jet final state in p (p) over bar collisions at a center of mass energy of 1.96 TeV at the Fermilab Tevatron collider using the D0 detector. No indication for such a resonance was found in a data sample corresponding to an integrated luminosity of 370 pb(-1). We set upper limits on the cross section times branching fraction for heavy resonance production at the 95% C.L. as a function of the resonance mass and width. The limits are interpreted within the framework of a specific model of excited quark production.
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| 5. |
- Abazov, V. M., et al.
(författare)
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Search for neutral Higgs bosons decaying to tau pairs in p(p)over-bar collisions at root s=1.96 TeV
- 2006
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:12, s. 121802-
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Tidskriftsartikel (refereegranskat)abstract
- A search for the production of neutral Higgs bosons Phi decaying into tau(+)tau(-) final states in p (p) over bar collisions at a center-of-mass energy of 1.96 TeV is presented. The data, corresponding to an integrated luminosity of approximately 325 pb(-1), were collected by the D0 experiment at the Fermilab Tevatron Collider. Since no excess compared to the expectation from standard model processes is found, limits on the production cross section times branching ratio are set. The results are combined with those obtained from the D0 search for Phi b((b) over bar)-> b (b) over barb((b) over bar) and are interpreted in the minimal supersymmetric standard model.
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| 6. |
- Abazov, V. M., et al.
(författare)
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Search for particles decaying into a Z boson and a photon in p(p)over-bar collisions at root s=1.96 TeV
- 2006
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 641:6, s. 415-422
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Tidskriftsartikel (refereegranskat)abstract
- We present the results of a search for a new particle X produced in p (p) over bar collisions at root s- = 1.96 TeV and subsequently decaying to Z gamma. The search uses 0.3 fb(-1) of data collected with the DO detector at the Fermilab Tevatron Collider. We set limits on the production cross section times the branching fraction sigma(p (p) over bar -> X) x B(X -> Z gamma) that range from 0.4 to 3.5 pb at the 95% C.L. for X with invariant masses between 100 and 1000 GeV/c(2), over a wide range of X decay widths.
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| 7. |
- Abazov, V. M., et al.
(författare)
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Search for R-parity violating supersymmetry via the LL(E)over-bar couplings lambda(121), lambda(122) or lambda(133) in p(p)over-bar collisions at root s=1.96 TeV
- 2006
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 638:5-6, s. 441-449
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Tidskriftsartikel (refereegranskat)abstract
- A search for gaugino pair production with a trilepton signature in the framework of R-parity violating supersymmetry via the couplings; lambda(121), lambda(122), or lambda(133) is presented. The data, corresponding to an integrated luminosity of L approximate to 360 pb(-1), were collected from April 2002 to August 2004 with the D0 detector at the Fermilab Tevatron Collider, at a center-of-mass energy of root s = 1.96 TeV. This analysis considers final states with three charged leptons with the flavor combinations eel, mu mu l, and ee tau (l = e or mu). No evidence for supersymmetry is found and limits at the 95% confidence level are set on the gaugino pair production cross section and lower bounds on the masses of the lightest neutralino and chargino are derived in two supersymmetric models.
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| 8. |
- Abazov, V. M., et al.
(författare)
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Search for resonant second generation slepton production at the Fermilab Tevatron
- 2006
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:11, s. 111801-
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Tidskriftsartikel (refereegranskat)abstract
- We present a search for supersymmetry in the R-parity violating resonant production and decay of smuons and muon sneutrinos in the channels mu ->chi(0)(1)mu, mu ->chi(0)(2,3,4)mu, and nu(mu)->chi(+/-)(1,2)mu. We analyzed 0.38 fb(-1) of integrated luminosity collected between April 2002 and August 2004 with the D0 detector at the Fermilab Tevatron Collider. The observed number of events is in agreement with the standard model expectation, and we calculate 95% C.L. limits on the slepton production cross section times branching fraction to gaugino plus muon, as a function of slepton and gaugino masses. In the framework of minimal supergravity, we set limits on the coupling parameter lambda(')(211), extending significantly previous results obtained in Run I of the Tevatron and at the CERN LEP collider.
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| 9. |
- Abazov, V. M., et al.
(författare)
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Search for the rare decay B-s(0)->phi mu(+)mu(-) with the D0 detector
- 2006
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Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 74:3, s. 031107-
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Tidskriftsartikel (refereegranskat)abstract
- We present a search for the flavor-changing neutral current decay B-s(0)->phi mu(+)mu(-) using about 0.45 fb(-1) of data collected in p (p) over bar collisions at root s=1.96 TeV with the D0 detector at the Fermilab Tevatron Collider. We find an upper limit on the branching ratio of this decay normalized to B-s(0)-> J/psi phi of B(B-s(0)->phi mu(+)mu(-))/B(B-s(0)-> J/psi phi)< 4.4x10(-3) at the 95% C.L. Using the central value of the world average branching fraction of B-s(0)-> J/psi phi, the limit corresponds to B(B-s(0)->phi mu(+)mu(-))< 4.1x10(-6) at the 95% C.L., the most stringent upper bound to date.
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| 10. |
- Abazov, V. M., et al.
(författare)
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Limits on anomalous trilinear gauge couplings from WW -> e(+)e(-), WW -> e(+/-)mu(-/+), and WW ->mu(+)mu(-) events from pp collisions at root s=1.96 TeV
- 2006
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Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 74:5, s. 057101-
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Tidskriftsartikel (refereegranskat)abstract
- Limits are set on anomalous WW gamma and WWZ trilinear gauge couplings using W+W--> e(+)nu(e)e(-)(nu) over bar (e), W+W--> e(+/-)nu(e)mu(-/+)nu(mu), and W+W-->mu(+)nu(mu)mu(-)(nu) over bar (mu) events. The data set was collected by the Run II D0 detector at the Fermilab Tevatron Collider and corresponds to approximately 250 pb(-1) of integrated luminosity at root s=1.96 TeV. Under the assumption that the WW gamma couplings are equal to the WWZ couplings and using a form factor scale of Lambda=2.0 TeV, the combined 95% C.L. one-dimensional coupling limits from all three channels are -0.32
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| 11. |
- Abazov, V. M., et al.
(författare)
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Measurement of beta (t -> Wb)/beta(t -> Wq) at root s=1.96 TeV
- 2006
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 639:6, s. 616-622
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Tidskriftsartikel (refereegranskat)abstract
- We present the measurement of R = B(t -> Wb)/B(t -> Wq) in pp collisions at root s = 1.96 TeV, using 230 pb(-1) of data collected by the DO experiment at the Fermilab Tevatron Collider. We fit simultaneously R and the number (N-tt) of selected top quark pairs (tt), to the number of identified b-quark jets in events with one electron or one muon, three or more jets, and high transverse energy imbalance. To improve sensitivity, kinematical properties of events with no identified b-quark jets are included in the fit. We measure R = 1.03(-0.17)(0.19) (stat + syst), in good agreement with the standard model. We set lower limits of R > 0.61 and vertical bar V-tb vertical bar > 0.78 at 95% confidence level.
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| 12. |
- Abazov, V. M., et al.
(författare)
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Measurement of the CP-violation parameter of B-0 mixing and decay with p(p)over-bar ->mu mu X data
- 2006
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Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 74:9, s. 092001-
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Tidskriftsartikel (refereegranskat)abstract
- We measure the dimuon charge asymmetry A in p (p) over bar collisions at a center of mass energy root s=1960 GeV. The data was recorded with the D0 detector and corresponds to an integrated luminosity of approximately 1.0 fb(-1). Assuming that the asymmetry A is due to asymmetric B-0 <->(B) over bar (0) mixing and decay, we extract the CP-violation parameter of B-0 mixing and decay: ((epsilon B0))/(1+vertical bar epsilon B0 vertical bar 2)=(AB0)/(4)= -0.0023 +/- 0.0011(stat)+/- 0.0008(syst).A(B)(0) is the dimuon charge asymmetry from decays of B-0(B) over bar (0) pairs. The general case, with CP violation in both B-0 and B-s(0) systems, is also considered. Finally we obtain the forward-backward asymmetry that quantifies the tendency of mu(+) to go in the proton direction and mu(-) to go in the antiproton direction. The results are consistent with the standard model and constrain new physics.
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| 13. |
- Abazov, V. M., et al.
(författare)
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Measurement of the isolated photon cross section in p(p)over-bar collisions at root s=1.96 TeV
- 2006
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 639:3-4, s. 151-158
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Tidskriftsartikel (refereegranskat)abstract
- The cross section for the inclusive production of isolated photons has been measured in p (p) over bar collisions at root s = 1.96 TeV with the DO detector at the Fermilab Tevatron Collider. The photons span transverse momenta 23 to 300 GeV and have pseudorapidity vertical bar n vertical bar < 0.9. The cross section is compared with the results from two next-to-leading order perturbative QCD calculations. The theoretical predictions agree with the measurement within uncertainties.
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| 14. |
- Abazov, V. M., et al.
(författare)
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Measurement of the ratios of the Z/gamma*+ >= n jet production cross sections to the total inclusive Z/gamma* cross section in p(p)over-bar collisions at root s=1.96 TeV
- 2008
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 658, s. 112-
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Tidskriftsartikel (refereegranskat)abstract
- We present a study of events with Z bosons and associated jets produced at the Fermilab Tevatron collider in p p collisions at a center of mass energy of 1.96 TeV The data sample consists of nearly 14000 Z/gamma* -> e(+)e(-) candidates corresponding to an integrated luminosity of 0.4 fb(-1) collected with the D circle divide detector. Ratios of the Z/gamma*+ >= n jet cross sections to the total inclusive Z/gamma* cross section have been measured for n = 1-4 jets, and found to be in good agreement with a next-to-leading order QCD calculation and with a tree-level QCD prediction with parton shower simulation and hadronization.
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| 15. |
- Abazov, V. M., et al.
(författare)
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Measurement of the top quark mass in the lepton plus jets final state with the matrix element method
- 2006
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Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 74:9, s. 092005-
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the top quark mass with the matrix element method in the lepton+jets final state. As the energy scale for calorimeter jets represents the dominant source of systematic uncertainty, the matrix element likelihood is extended by an additional parameter, which is defined as a global multiplicative factor applied to the standard energy scale. The top quark mass is obtained from a fit that yields the combined statistical and systematic jet energy scale uncertainty. Using a data set of 0.4 fb(-1) taken with the D0 experiment at Run II of the Fermilab Tevatron Collider, the mass of the top quark is measured using topological information to be: m(top)(center dot+jets)(topo)=169.2(-7.4)(+5.0)(stat+JES)(-1.4)(+1.5)(syst) GeV, and when information about identified b jets is included: m(top)(center dot+jets)(b-tag)=170.3(-4.5)(+4.1)(stat+ JES)(-1.8)(+1.2)(syst) GeV. The measurements yield a jet energy scale consistent with the reference scale.
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| 16. |
- Abazov, V. M., et al.
(författare)
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Search for associated Higgs boson production WH -> WWW*-> l(+/-)nu l('+/-)nu(')+X in p(p)over-bar collisions at root S=1.96 TeV
- 2006
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:15, s. 151804-
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Tidskriftsartikel (refereegranskat)abstract
- We present a search for associated Higgs boson production in the process p (p) over bar -> WH -> WWW*-> l(+/-)nu l('+/-)nu(')+X in final states containing two like-sign isolated electrons or muons (e(+/-)e(+/-), e(+/-)mu(+/-), or mu(+/-)mu(+/-)). The search is based on D0 run II data samples corresponding to integrated luminosities of 360-380 pb(-1). No excess is observed over the predicted standard model background. We set 95% C.L. upper limits on sigma ->(p (p) over bar WH) x Br(H -> WW*) between 3.2 and 2.8 pb for Higgs boson masses from 115 to 175 GeV.
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| 17. |
- Abazov, V. M., et al.
(författare)
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Search for neutral, long-lived particles decaying into two muons in p(p)over-bar collisions at root s=1.96 TeV
- 2006
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:16, s. 161802-
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Tidskriftsartikel (refereegranskat)abstract
- We present a search for a neutral particle, pair produced in pp collisions at root s=1.96 TeV, which decays into two muons and lives long enough to travel at least 5 cm before decaying. The analysis uses approximate to 380 pb(-1) of data recorded with the D0 detector. The background is estimated to be about one event. No candidates are observed, and limits are set on the pair-production cross section times branching fraction into dimuons + X for such particles. For a mass of 10 GeV and lifetime of 4x10(-11) s, we exclude values greater than 0.14 pb (95% C.L.). These results are used to limit the interpretation of NuTeV's excess of dimuon events.
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| 18. |
- Abazov, V. M., et al.
(författare)
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Search for pair production of scalar bottom quarks in p(p)over-bar collisions at root s = 1.96 TeV
- 2006
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:17, s. 171806-
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Tidskriftsartikel (refereegranskat)abstract
- A search for direct production of scalar bottom quarks ((b) over bar) is performed with 310 pb(-1) of data collected by the D0 experiment in p (p) over bar collisions at root s = 1.96 TeV at the Fermilab Tevatron Collider. The topology analyzed consists of two b jets and an imbalance in transverse momentum due to undetected neutralinos (chi(0)(1)), with chi(0)(1) assumed to be the lightest supersymmetric particle. We find the data consistent with standard model expectations, and set a 95% C.L. exclusion domain in the (m(b), m(chi 1)(0)) mass plane, improving significantly upon the results from run I of the Tevatron.
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| 19. |
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| 20. |
- Abazov, V. M., et al.
(författare)
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Search for the pair production of scalar top quarks in the acoplanar charm jet final state in p(p)over-bar collisions at root s=1.96 TeV
- 2007
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 645:2-3, s. 119-127
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Tidskriftsartikel (refereegranskat)abstract
- A search for the pair production of scalar top quarks, (t) over tilde, has been performed in 360 pb(-1) of data from pp collisions at a center-of-mass energy of 1.96 TeV, collected by the D phi detector at the Fermilab Tevatron collider. The (t) over tilde decay mode considered is (t) over tilde -> c (chi) over tilde (0)(1), where (chi) over tilde (0)(1) is the lightest supersymmetric particle. The topology analyzed therefore consists of a pair of acoplanar heavy-flavor jets with missing transverse energy. The data and standard model expectation are in agreement, anda 95% C.L. exclusion domain in the (m((t) over tilde), m((chi) over tilde1)(0)) plane has been determined, extending the domain excluded by previous experiments.
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| 21. |
- Abazov, V. M., et al.
(författare)
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Search for the standard model Higgs boson in the p(p)over-bar -> ZH -> v(v)over-barb(b)over-bar channel
- 2006
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:16, s. 161803-
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Tidskriftsartikel (refereegranskat)abstract
- We report a search for the standard model (SM) Higgs boson based on data collected by the D0 experiment at the Fermilab Tevatron Collider, corresponding to an integrated luminosity of 260 pb(-1). We study events with missing transverse energy and two acoplanar b jets, which provide sensitivity to the ZH production cross section in the nu nu bb channel, and to WH production when the lepton from the W ->center dot nu decay is undetected. The data are consistent with the SM background expectation, and we set 95% C.L. upper limits on sigma(pp -> ZH/WH) x B(H -> bb) from 3.4/8.3 to 2.5/6.3 pb, for Higgs-boson masses between 105 and 135 GeV.
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| 22. |
- Abazov, V. M., et al.
(författare)
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Search for W ' boson production in the W ' -> t(b)over-bar decay channel
- 2006
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 641:6, s. 423-431
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Tidskriftsartikel (refereegranskat)abstract
- We present a search for the production of a new heavy gauge boson W' that decays to a top quark and a bottom quark. We have analyzed 230 pb(-1) of data collected with the DO detector at the Fermilab Tevatron collider at a center-of-mass energy of 1.96 TeV. No significant excess of events above the standard model expectation is found in any region of the final state invariant mass distribution. We set upper limits on the production cross section of W' bosons times branching ratio to top quarks at the 95% confidence level for several different W, boson masses. We exclude masses between 200 and 610 GeV for a W' boson with standard-model-like couplings, between 200 and 630 GeV for a W, boson with right-handed couplings that is allowed to decay to both leptons and quarks, and between 200 and 670 GeV for a W' boson with right-handed couplings that is only allowed to decay to quarks.
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| 23. |
- Abazov, V. M., et al.
(författare)
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Experimental discrimination between charge 2e/3 top quark and charge 4e/3 exotic quark production scenarios
- 2007
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 98:4, s. 041801-
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Tidskriftsartikel (refereegranskat)abstract
- We present the first experimental discrimination between the 2e/3 and 4e/3 top quark electric charge scenarios, using top quark pairs (t (t) over bar) produced in p (p) over bar collisions at root s =1.96 TeV by the Fermilab Tevatron Collider. We use 370 pb(-1) of data collected by the D0 experiment and select events with at least one high transverse momentum electron or muon, high transverse energy imbalance, and four or more jets. We discriminate between b- and (b) over bar -quark jets by using the charge and momenta of tracks within the jet cones. The data are consistent with the expected electric charge, |q|=2e/3. We exclude, at the 92% C.L., that the sample is solely due to the production of exotic quark pairs Q (Q) over bar with |q|=4e/3. We place an upper limit on the fraction of Q (Q) over bar pairs rho < 0.80 at the 90% C.L.
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| 24. |
- Abazov, V. M., et al.
(författare)
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Measurement of the t(t)over-bar production cross section in p(p)over-bar collisions at root s=1.96 TeV using secondary vertex b tagging
- 2006
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Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 74:11, s. 112004-
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Tidskriftsartikel (refereegranskat)abstract
- We report a new measurement of the t (t) over bar production cross section in p (beta) over bar collisions at a center-of-mass energy of 1.96 TeV using events with one charged lepton (electron or muon), missing transverse energy, and jets. Using 425 pb(-1) of data collected using the D0 detector at the Fermilab Tevatron Collider, and enhancing the t (t) over bar content of the sample by tagging b jets with a secondary vertex tagging algorithm, the t (t) over bar production cross section is measured to be sigma(p (t) over bar -> t (t) over bar +X)=6.6 +/- 0.9(stat+syst) +/- 0.4(lum) pb. This cross section is the most precise D0 measurement to date for t (t) over bar production and is in good agreement with standard model expectations.
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| 25. |
- Abazov, V. M., et al.
(författare)
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Measurement of B-d mixing using opposite-side flavor tagging
- 2006
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Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 74:11, s. 112002-
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Tidskriftsartikel (refereegranskat)abstract
- We report on a measurement of the B-d(0) mixing frequency and the calibration of an opposite-side flavor tagger in the D0 experiment. Various properties associated with the b quark on the opposite side of the reconstructed B meson are combined using a likelihood-ratio method into a single variable with enhanced tagging power. Its performance is tested with data, using a large sample of reconstructed semileptonic B ->mu(DX)-X-0 and B ->mu(DX)-X-* decays, corresponding to an integrated luminosity of approximately 1 fb(-1). The events are divided into groups depending on the value of the combined tagging variable, and an independent analysis is performed in each group. Combining the results of these analyses, the overall effective tagging power is found to be epsilon D-2=(2.48 +/- 0.21(-0.06)(+0.08))%. The measured B-d(0) mixing frequency Delta m(d)=0.506 +/- 0.020(stat)+/- 0.016(syst) ps(-1) is in good agreement with the world average value.
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| 26. |
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| 27. |
- Baker, Naomi L., et al.
(författare)
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Molecular consequences of dominant Bethlem myopathy collagen VI mutations
- 2007
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Ingår i: Annals of Neurology. - : Wiley. - 1531-8249 .- 0364-5134. ; 62:4, s. 390-405
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Dominant mutations in the three collagen VI genes cause Bethlem myopathy, a disorder characterized by proximal muscle weakness and commonly contractures of the fingers, wrists, and ankles. Although more than 20 different dominant mutations have been identified in Bethlem myopathy patients, the biosynthetic consequences of only a subset of these have been studied, and in many cases, the pathogenic mechanisms remain unknown. Methods: We have screened fourteen Bethlem myopathy patients for collagen VI mutations and performed detailed analyses of collagen VI biosynthesis and intracellular and extracellular assembly. Results: Collagen VI abnormalities were identified in eight patients. One patient produced around half the normal amount of alpha 1(VI) messenger RNA and reduced amounts of collagen VI protein. Two patients had a previously reported mutation causing skipping of COL6A1 exon 14, and three patients had novel mutations leading to in-frame deletions toward the N-terminal end of the triple-helical domain. These mutations have different and complex effects on collagen VI intracellular and extracellular assembly. Two patients had single amino acid substitutions in the A-domains of COL6A2 and COL6A3. Collagen VI intracellular and extracellular assembly was normal in one of these patients. Interpretation: The key to dissecting the pathogenic mechanisms of collagen VI mutations lies in detailed analysis of collagen VI biosynthesis and assembly. The majority of mutations result in secretion and deposition of structurally abnormal collagen VI. However, one A-domain mutation had no detectable effect on assembly, suggesting that it acts by compromising collagen VI interactions in the extracellular matrix of muscle.
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| 28. |
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| 29. |
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| 30. |
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| 31. |
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| 32. |
- Rana, A., et al.
(författare)
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An edge services framework (esf) for egee, lcg, AND osg
- 2006
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Konferensbidrag (refereegranskat)abstract
- We report on first experiences with building and operating an Edge Services Framework (ESF) based on Xen virtual machines instantiated via the Workspace Service available in Globus Toolkit, and developed as a joint project between EGEE, LCG, and OSG. Many computing facilities are architected with their compute and storage clusters behind firewalls. Edge Services are instantiated on a small set of gateways to provide access to these clusters via standard grid interfaces. Experience on EGEE, LCG, and OSG has shown that at least two issues are of critical importance when designing an infrastructure in support of Edge Services. The first concerns Edge Service configuration. It is impractical to assume that each virtual organization (VO) using a facility will employ the same Edge Service configuration, or that different configurations will coexist easily. Even within a VO, it should be possible to run different versions of the same Edge Service simultaneously. The second issue concerns resource usage: since Edge Services may become a bottleneck to a site, it is essential that an ESF be able to effectively arbitrate resource usage (e.g., memory, CPU, and networking) among different VOs. By providing virtualization on the level of instruction set architecture, virtual machines allow configuration of independent software stacks for each VM executing on a resource. Modern implementations of this abstraction are extremely efficient and have outstanding fine-grained enforcement capabilities. To securely deploy virtual machines, we use the Workspace Service from the Globus Toolkit, which allows a VO administrator to dynamically launch appropriately-configured system images. In addition, we are developing a library of such images, reflecting the needs of presently participating communities ATLAS, CMS, and CDF. We will report on first experiences building and operating this Edge Services Framework.
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| 33. |
- Sundstrom, Jeffrey M., et al.
(författare)
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Phosphorylation site mapping of endogenous proteins : a combined MS and bioinformatics approach
- 2009
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 8:2, s. 798-807
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Tidskriftsartikel (refereegranskat)abstract
- We present a novel approach that combines MALDI-TOF profile analysis and bioinformatics-based inclusion criteria to comprehensively predict phosphorylation sites on a single protein of interest from limiting sample. It is technologically difficult to unambiguously identify phosphorylated residues, as many physiologically important phosphorylation sites are of too low abundance in vivo to be unambiguously assigned by mass spectrometry. Conversely, phosphorylation site prediction algorithms, while increasingly accurate, nevertheless overestimate the number of phosphorylation sites. In this study, we show that MODICAS, an MS data management and analysis tool, can be effectively merged with the bioinformatics attributes of residue conservation and phosphosite prediction to generate a short list of putative phosphorylation sites that can be subsequently verified by additional methodologies such as phosphospecific antibodies or mutational analysis. Therefore, the combination of MODICAS driven MS data analysis with bioinformatics-based filtering represents a substantial increase in the ability to putatively identify physiologically relevant phosphosites from limited starting material.
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| 34. |
- Boles, RG, et al.
(författare)
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Sex ratios and mitochondrial genetics in migraine
- 2008
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Ingår i: Cephalalgia : an international journal of headache. - : SAGE Publications. - 1468-2982. ; 28:9, s. 1001-1002
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 35. |
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| 36. |
- Carter, Jim, et al.
(författare)
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The GOTHI Model of Tactile and Haptic Interaction
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The paper presents the GOTHI model of tactile and haptic interaction. The GOTHI-05 workshop (October 2005) brought researchers together to develop a collection of ergonomic guidance and a framework for organizing this guidance. After a number of individual presentations, the participants worked together to develop a model of tactile and haptic interaction. The inaugural meeting of ISO TC159/SC4/WG9 further refined this model and adopted it as the basis for a new standard ISO 9241- 920 Ergonomics of human-system interaction — Guidance on tactile and haptic interactions.
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| 37. |
- Fischer, Joern, et al.
(författare)
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Integrating resilience thinking and optimisation for conservation.
- 2009
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Ingår i: Trends in Ecology & Evolution. - : Elsevier BV. - 0169-5347 .- 1872-8383. ; 24:10, s. 549-54
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Tidskriftsartikel (refereegranskat)abstract
- Conservation strategies need to be both effective and efficient to be successful. To this end, two bodies of research should be integrated, namely 'resilience thinking' and 'optimisation for conservation,' both of which are highly policy relevant but to date have evolved largely separately. Resilience thinking provides an integrated perspective for analysis, emphasising the potential of nonlinear changes and the interdependency of social and ecological systems. By contrast, optimisation for conservation is an outcome-oriented tool that recognises resource scarcity and the need to make rational and transparent decisions. Here we propose that actively embedding optimisation analyses within a resilience-thinking framework could draw on the complementary strengths of the two bodies of work, thereby promoting cost-effective and enduring conservation outcomes.
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| 38. |
- Gardner, Ann, et al.
(författare)
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Differences at brain SPECT between depressed females with and without adult ADHD and healthy controls : etiological considerations
- 2009
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Ingår i: Behavioral and Brain Functions. - London, United Kingdom : BioMed Central (BMC). - 1744-9081. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Background: Comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and mood disorders is common. Alterations of the cerebellum and frontal regions have been reported in neuro-imaging studies of ADHD and major depression.Methods: Thirty chronically depressed adult females of whom 16 had scores below, and 14 scores above, cut-offs on the 25-items Wender Utah Retrospective Scale (WURS-25) and the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) were divided into subgroups designated "Depression" and "Depression + ADHD", respectively. Twenty-one of the patients had some audiological symptom, tinnitus and/or hearing impairment. The patients were investigated with other rating scales and 99mTc-HMPAO SPECT. Controls for 99mTc-HMPAO SPECT were 16 healthy females. SPECT was analyzed by both statistical parametric mapping (SPM2) and the computerized brain atlas (CBA). Discriminant analysis was performed on the volumes of interest generated by the CBA, and on the scores from rating scales with the highest group differences.Results: The mean score of a depression rating scale (MADRS-S) was significantly lower in the "Depression" subgroup compared to in the "Depression + ADHD" subgroup. There was significantly decreased tracer uptake within the bilateral cerebellum at both SPM and CBA in the "Depression + ADHD" subgroup compared to in the controls. No decrease of cerebellar tracer uptake was observed in "Depression". Significantly increased tracer uptake was found at SPM within some bilateral frontal regions (Brodmann areas 8, 9, 10, 32) in the "Depression + ADHD" subgroup compared to in "Depression". An accuracy of 100% was obtained for the discrimination between the patient groups when thalamic uptake was used in the analysis along with scores from Socialization and Impulsivity scales.Conclusions: The findings confirm the previous observation of a cerebellar involvement in ADHD. Higher bilateral frontal 99mTc-HMPAO uptake in "Depression + ADHD" compared to in "Depression" indicate a difference between these subgroups. 99mTc-HMPAO uptake mechanisms are discussed.
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| 39. |
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| 40. |
- Johannesson, Henrik, et al.
(författare)
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Phase-specific gene expression underlying morphological adaptations of the dimorphic human pathogenic fungus, Coccidioides posadasii
- 2006
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Ingår i: Fungal Genetics and Biology. - : Elsevier BV. - 1087-1845 .- 1096-0937. ; 43:8, s. 545-559
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Tidskriftsartikel (refereegranskat)abstract
- Coccidioides posadasii is a dimorphic fungal pathogen that grows as a Wlamentous saprobe in the soil and as endosporulating spheruleswithin the host. To identify genes speciWc to the pathogenic phase of Co. posadasii, we carried out a large-scale study of gene expression intwo isolates of the species. From the sequenced Co. posadasii genome, we chose 1000 open reading frames to construct a 70-mer microarray.RNA was recovered from both isolates at three life-cycle phases: hyphae, presegmented spherules, and spherules releasing endospores.Comparative hybridizations were conducted in a circuit design, permitting comparison between both isolates at all three life-cyclephases, and among all life-cycle phases for each isolate. By using this approach, we identiWed 92 genes that were diVerentially expressedbetween pathogenic and saprobic phases in both fungal isolates, and 43 genes with consistent diVerential expression between the two parasiticdevelopmental phases. Genes with elevated expression in the pathogenic phases of both isolates included a number of genes thatwere involved in the response to environmental stress as well as in the metabolism of lipids. The latter observation is in agreement withprevious studies demonstrating that spherules contain a higher proportion of lipids than saprobic phase tissue. Intriguingly, we discoveredstatistically signiWcant and divergent levels of gene expression between the two isolates proWled for 64 genes. The results suggest thatincorporating more than one isolate in the experimental design oVers a means of categorizing the large collection of candidate genes thattranscriptional proWling typically identiWes into those that are strain-speciWc and those that characterize the entire species.
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| 41. |
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