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Sökning: WFRF:(Ge M) > (2000-2004)

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  • Scherer, SW, et al. (författare)
  • Human chromosome 7: DNA sequence and biology
  • 2003
  • Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 300:5620, s. 767-772
  • Tidskriftsartikel (refereegranskat)abstract
    • DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical genetic data, including 440 chromosome rearrangement breakpoints associated with disease. This approach enabled the discovery of candidate genes for developmental diseases including autism.
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  • Power, DM, et al. (författare)
  • Thyroid hormones in growth and development of fish
  • 2001
  • Ingår i: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. - 1532-0456. ; 130:4, s. 447-459
  • Tidskriftsartikel (refereegranskat)abstract
    • The thyroid hormones (THs), thyroxine (T-4) and triiodothyronine (T-3) are products of the thyroid gland in all vertebrates. Their role in early development and metamorphosis is well established in mammals and amphibians, respectively, and recently several studies in fish have highlighted the importance of THs during flatfish metamorphosis. THs are present in high quantities in fish eggs and are presumably of maternal origin. During embryogenesis the concentration of T-4 and T-3 in the eggs decrease until endogenous production starts. Thyroid hormone receptors (TR) have been isolated from several teleosts and in common with tetrapods two receptor isoforms have been identified, TR alpha and TR beta. Both the receptors are expressed in early embryos and larvae of the Japanese flounder (Paralichthys olivaceus), zebrafish (Danio rerio) and seabream (Sparus aurata) although a different temporal pattern is apparent. The role of THs and TRs in fish embryogenesis, larval development and during metamorphosis will be discussed. (C) 2001 Elsevier Science Inc. All rights reserved.
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  • Svahn, MG, et al. (författare)
  • Adding functional entities to plasmids
  • 2004
  • Ingår i: The journal of gene medicine. - : Wiley. - 1099-498X .- 1521-2254. ; 66 Suppl 1, s. S36-S44
  • Tidskriftsartikel (refereegranskat)
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  • Resultat 1-22 av 22

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