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- Boström, Hans, et al.
(författare)
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PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.
- 1996
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Ingår i: Cell. - : Elsevier BV. - 0092-8674. ; 85:6, s. 863-73
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Tidskriftsartikel (refereegranskat)abstract
- A mouse platelet-derived growth factor A chain (PDGF-A) null allele is shown to be homozygous lethal, with two distinct restriction points, one prenatally before E10 and one postnatally. Postnatally surviving PDGF-A-deficient mice develop lung emphysema secondary to the failure of alveolar septation. This is apparently caused by the loss of alveolar myofibroblasts and associated elastin fiber deposits. PDGF alpha receptor-positive cells in the lung having the location of putative alveolar myofibroblast progenitors were specifically absent in PDGF-A null mutants. We conclude that PDGF-A is crucial for alveolar myofibroblast ontogeny. We have previously shown that PDGF-B is required in the ontogeny of kidney mesangial cells. The PDGFs therefore appear to regulate the generation of specific populations of myofibroblasts during mammalian development. The two PDGF null phenotypes also reveal analogous morphogenetic functions for myofibroblast-type cells in lung and kidney organogenesis.
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- Axelsson, I, et al.
(författare)
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[Recommendations for prevention of iron deficiency. Delay cow's milk intake as a beverage to infants until 10-12 months of age!]. : Rekommendationer för att förebygga järnbrist. Vänta med komjölk som dryck tills barnet är 10-12 månader!
- 1999
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 96:18, s. 2206-8
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Tidskriftsartikel (refereegranskat)abstract
- Breast-feeding is to be encouraged during the first six months of life. Iron deficiency is extremely rare in exclusively breast-fed infants during this period. Any cow-milk based formula used should be iron-fortified. During the second half of infancy, the iron content of weaning foods is important in preventing iron deficiency. Indeed, owing to the low iron content of dairy products, it is hard to compose a weaning diet sufficiently rich in iron to meet the demands of rapidly growing infants, if it is to include substantial amounts of cow milk, sour milk or yoghurt. Accordingly, the Paediatric Committee on Nutrition and Health, of the Swedish Paediatric Association and the National Food Administration, recommend delaying the introduction of cow's milk and cow-milk products until the infant is 10-12 months of age. Until then, breast-feeding, and the use of iron-fortified formula or gruel with modified protein and sodium content are encouraged; iron-fortified porridges of softer consistency can be prepared to circumvent the need of extra fluids, or porridge can be served with breast milk or iron-fortified formula; small amounts of milk may be used for cooking purposes.
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- Axelsson, I, et al.
(författare)
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[The AD-drops can be replaced by D-drops]. : AD-dropparna kan ersättas med D-droppar
- 1999
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 96:18, s. 2200-4
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Tidskriftsartikel (refereegranskat)abstract
- Since 1932, when vitamin A and D supplementation, in the form of cod liver oil, was introduced in Sweden, rickets has been a rare diagnosis among Swedish infants. In 1978, the National Board of Health and Welfare issued recommendations of daily supplementation with 300 micrograms (1000 IU) of vitamin A and 10 micrograms (400 IU) of vitamin D. This has recently been under review by the Paediatric Committee on Nutrition and Health, of the Swedish Paediatric Association and the National Food Administration, who concluded that there is no reason to retain vitamin A supplementation, but that vitamin D supplementation should continue to be recommended at the same daily dose (400 IU).
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- Edlund, B, et al.
(författare)
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Anthropometry, body composition and body image in dieting and non-dieting 8-16-year-old Swedish girls.
- 1999
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Ingår i: Acta Paediatrica. - 0803-5253 .- 1651-2227. ; 88:5, s. 537-44
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Tidskriftsartikel (refereegranskat)abstract
- Anthropometry, body composition and body image were studied in 122 Swedish 8-16-y-old girls and their parents. The subjects participated in a 3-y prospective longitudinal study and were selected randomly after stratification for grades from those scoring in the upper vs. the lower thirds of the Children's Eating Attitudes Test (ChEAT) score distribution. The ChEAT was completed 6 mo before the present study together with a demographic and dieting questionnaire and a questionnaire for the estimation of body size. In total 43% (n = 52) admitted ever dieting ("Dieters") and 25% (n = 30) admitted that they were currently trying to lose weight. The anthropometric and body composition data indicated that ChEAT High-scorers and Dieters were somewhat fatter than Low-scorers and Non-dieters, although this pattern was not shown among the 8-y-olds or the 14-y-olds (High-scorers). The mothers of the ChEAT High-scorers were found to be somewhat fatter than the other mothers. A current vs. ideal body shape discrepancy was shown for both High-scorers and Dieters, with a larger discrepancy for the Dieters. All groups believed that their parents were aspiring for a leaner body.
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- Gebre-Medhin, M
(författare)
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Jodbrist i ett internationellt perspektiv
- 1995
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Ingår i: Scandinavian Journal of Nutrition - Näringsforskning. ; 39, s. 36-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Wennbo, H, et al.
(författare)
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Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice.
- 1997
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Ingår i: The Journal of clinical investigation. - 0021-9738 .- 1558-8238. ; 100:11, s. 2744-51
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Tidskriftsartikel (refereegranskat)abstract
- Transgenic mice overexpressing the human growth hormone gene develop mammary carcinomas. Since human growth hormone gene can activate both the growth hormone receptor (GHR) and the prolactin (PRL) receptor (PRLR), it is not clear which receptor system is responsible for the malignant transformation. To clarify the receptor specificity, we created transgenic mice with two different genes: (a) transgenic mice overexpressing the bovine growth hormone (bGH) gene having high levels of bGH only activating the GHR and also high serum levels of IGF-I; and (b) transgenic mice overexpressing the rat PRL (rPRL) gene that have elevated levels of PRL (one line 150 ng/ml and one line 13 ng/ml) only binding to the PRLR and with normal IGF-I levels. When analyzed histologically, all of the PRL transgenic female mice developed mammary carcinomas at 11-15 mo of age. Only normal mammary tissue was observed among the bGH transgenic animals and the controls. Cell lines established from a tumor produced rPRL and expressed PRLR. In organ culture experiments, an auto/paracrine effect of rPRL was demonstrated. In conclusion, activation of the PRLR is sufficient for induction of mammary carcinomas in mice, while activation of the GHR is not sufficient for mammary tumor formation.
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