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Träfflista för sökning "WFRF:(Graf W) srt2:(1995-1999)"

Sökning: WFRF:(Graf W) > (1995-1999)

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1.
  • Kremer, B, et al. (författare)
  • Influence of lamotrigine on progression of early Huntington disease : a randomized clinical trial.
  • 1999
  • Ingår i: Neurology. - 0028-3878 .- 1526-632X. ; 53:5, s. 1000-11
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To assess the efficacy of lamotrigine, a novel antiepileptic drug that inhibits glutamate release, to retard disease progression in Huntington disease (HD).BACKGROUND: Excitatory amino acids may cause selective neuronal death in HD, and lamotrigine may inhibit glutamate release in vivo.METHODS: A double-blinded, placebo-controlled study was conducted of 64 patients with motor signs of less than 5 years' duration who were randomly assigned to either placebo or lamotrigine and assessed at 0 (baseline), 12, 24, and 30 months. The primary response variable was total functional capacity (TFC) score. Secondary response variables included the quantified neurological examination and a set of cognitive and motor tests. Repeated fluorodeoxyglucose measurements of regional cerebral metabolism using PET also were included.RESULTS: Fifty-five patients (28 on lamotrigine, 27 on placebo) completed the study. Neither the primary response variable nor any of the secondary response variables differed significantly between the treatment groups. Both the lamotrigine and the placebo group deteriorated significantly on the TFC, in the lamotrigine group by 1.89 and the placebo group by 2.11 points. No effect of CAG size on the rate of deterioration could be detected.CONCLUSIONS: There was no clear evidence that lamotrigine retarded the progression of early Huntington disease over a period of 30 months. However, more patients on lamotrigine reported symptomatic improvement (53.6 versus 14.8%; p = 0.006), and a trend toward decreased chorea was evident in the treated group (p = 0.08). The study also identified various indices of disease progression, including motor tests and PET studies, that were sensitive to deterioration over time.
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  • Gustafson, Stefan, et al. (författare)
  • Targeting of hyaluronan to tumours via binding to ICAM-1
  • 1995
  • Ingår i: 3rd International Workshop on Hyaluronan in Drug Delivery, Royal Society of Medicine Press, Round Table Series. ; 40
  • Annan publikation (övrigt vetenskapligt/konstnärligt)
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  • Jahnson, S, et al. (författare)
  • Anastomotic breaking strength and healing of anastomoses in rat intestine with and without chronic radiation damage.
  • 1995
  • Ingår i: European Journal of Surgery. - 1102-4151 .- 1741-9271. ; 161:6, s. 425-30
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To assess the influence of chronic radiation damage on anastomotic healing in the small bowel in rats.DESIGN: Controlled laboratory study.SETTING: University hospital, Sweden.MATERIAL: 90 male Sprague-Dawley rats.INTERVENTIONS: A short segment of the distal ileum was exteriorised and irradiated with a single dose (experimental group, n = 45) or exposed only (control group, n = 45). Twenty weeks later resection and anastomosis were done within this segment using 7/0 polypropylene.MAIN OUTCOME MEASURES: The anastomotic breaking strength, the amount of perianastomotic hydroxyproline, and the number of anastomotic complications.RESULTS: The breaking strength and the amount of perianastomotic hydroxyproline were higher in the irradiated than in the non-irradiated group. In contrast, anastomotic complications were significantly more common in irradiated animals.CONCLUSION: Anastomotic complications in irradiated intestine are not related to the amount of perianastomotic collagen or to breaking strength.
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  • Joerger, R, et al. (författare)
  • Influence of incoherent superposition of light on ellipsometric coefficients
  • 1997
  • Ingår i: Applied Optics. ; 36:1, s. 319-327
  • Tidskriftsartikel (refereegranskat)abstract
    • Reflections from the back surface of a transparent substrate influence the evaluation of optical constants of thin films from ellipsometric measurements. If the thickness of the substrate is large compared with the coherence length of the light, the relat
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  • Joerger, R, et al. (författare)
  • Optical properties of inhomogeneous media
  • 1998
  • Ingår i: SOLAR ENERGY MATERIALS AND SOLAR CELLS. - : ELSEVIER SCIENCE BV. - 0927-0248. ; 54:1-4, s. 351-361
  • Tidskriftsartikel (refereegranskat)abstract
    • Inhomogeneous media such as ceramic-metal composites are used in a wide range of applications as functional optical coatings e.g, in selective solar absorber coatings. Their optical properties can be calculated by the use of effective medium theories. The
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