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- Brownlie, Rebecca J, et al.
(författare)
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Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb.
- 2008
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Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 205:4, s. 883-95
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Tidskriftsartikel (refereegranskat)abstract
- FcgammaRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or function predisposes to autoimmunity. To determine if increased expression of FcgammaRIIb can modulate these processes, we created transgenic mice overexpressing FcgammaRIIb on B cells or macrophages. Overexpression of FcgammaRIIb on B cells reduced the immunoglobulin G component of T-dependent immune responses, led to early resolution of collagen-induced arthritis (CIA), and reduced spontaneous systemic lupus erythematosus (SLE). In contrast, overexpression on macrophages had no effect on immune responses, CIA, or SLE but increased mortality after Streptococcus pneumoniae infection. These results help define the role of FcgammaRIIb in immune responses, demonstrate the contrasting roles played by FcgammaRIIb on B cells and macrophages in the control of infection and autoimmunity, and emphasize the therapeutic potential for modulation of FcgammaRIIb expression on B cells in inflammatory and autoimmune disease.
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| 3. |
- Fecht, H. -J, et al.
(författare)
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Thermophysical properties of liquids : Modelling and non-metallic materials
- 2005
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Ingår i: ESA SP. - 0379-6566 .- 1609-0438. ; :1281, s. 24-35
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Tidskriftsartikel (refereegranskat)abstract
- The accurate knowledge and high-precision measurements of the thermophysical properties of liquids is necessary for the numerical modeling of industrial processes where the solid-liquid phase transformation plays a crucial role. The reduction of magnetic levitation forces in microgravity leads either to a significant improvement in accuracy or makes the measurement possible in the first place. High-precision measurements on chemically highly reactive melts require containerless processing using non-contact diagnostic tools. Scientific precursor experiments were conducted in the TEMPUS containerless processing facility during the Spacelab IML-2 and MSL-1 missions, also.
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| 4. |
- Staender, Sonja, et al.
(författare)
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Clinical classification of itch: a position paper of the international forum for the study of itch
- 2007
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 1651-2057 .- 0001-5555. ; 87:4, s. 291-294
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Tidskriftsartikel (refereegranskat)abstract
- Chronic itch is a common and distressing symptom that arises from a variety of skin conditions and systemic diseases. Despite this, there is no clinically based classification of pruritic diseases to assist in the diagnosis and cost-effective medical care of patients with pruritus. The proposed classification focuses on clinical signs and distinguishes between diseases with and without primary or secondary skin lesions. Three groups of conditions are proposed: pruritus on diseased (inflamed) skin (group I), pruritus on non-diseased (non-inflamed) skin (group II), and pruritus presenting with severe chronic secondary scratch lesions, such as prurigo nodularis (group III). The next part classifies the underlying diseases according to different categories: dermatological diseases, systemic diseases including diseases of pregnancy and drug-induced pruritus, neurological and psychiatric diseases. In some patients more than one cause may account for pruritus (category "mixed") while in others no underlying disease can be identified (category "others"). This is the first version of a clinical classification worked out by the members of the International Forum for the Study of Itch. It is intended to serve as a diagnostic route for better evaluation of patients with chronic pruritus and aims to improve patients' care.
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