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- Stevens, Kristen N, et al.
(författare)
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19p13.1 is a triple negative-specific breast cancer susceptibility locus
- 2012
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Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 72, s. 1795-
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Tidskriftsartikel (refereegranskat)abstract
- The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with risk of ovarian cancer. Here we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status, using 48,869 breast cancer cases and 49,787 controls from the Breast Cancer Association Consortium (BCAC). Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly associated with ER-negative breast cancer risk [rs8170 Odds Ratio (OR)=1.10, 95% Confidence Interval (CI) 1.05 - 1.15, p=3.49 x 10-5] and triple negative (TN) (ER, PR and HER2 negative) breast cancer [rs8170 OR=1.22, 95% CI 1.13 - 1.31, p=2.22 x 10-7]. However, rs8170 was no longer associated with ER-negative breast cancer risk when TN cases were excluded [OR=0.98, 95% CI 0.89 - 1.07, p=0.62]. In addition, a combined analysis of TN cases from BCAC and the Triple Negative Breast Cancer Consortium (TNBCC) (n=3,566) identified a genome-wide significant association between rs8170 and TN breast cancer risk [OR=1.25, 95% CI 1.18 - 1.33, p=3.31 x 10-13]. Thus, 19p13.1 is the first triple negative-specific breast cancer risk locus and the first locus specific to a histological subtype defined by ER, PR, and HER2 to be identified. These findings provide convincing evidence that genetic susceptibility to breast cancer varies by tumor subtype and that triple negative tumors and other subtypes likely arise through distinct etiologic pathways.
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| 15. |
- Chan, SSM, et al.
(författare)
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Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease
- 2014
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Ingår i: Alimentary Pharmacology and Therapeutics. - : Wiley-Blackwell. - 0269-2813 .- 1365-2036. ; 39:8, s. 834-842
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Tidskriftsartikel (refereegranskat)abstract
- Background There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, could prevent Crohn's disease (CD).Aim To conduct a prospective study to investigate the association between increased intake of DHA and risk of CD.Methods Overall, 229702 participants were recruited from nine European centres between 1991 and 1998. At recruitment, dietary intakes of DHA and fatty acids were measured using validated food frequency questionnaires. The cohort was monitored through to June 2004 to identify participants who developed incident CD. In a nested case-control analysis, each case was matched with four controls; odds ratios (ORs) were calculated for quintiles of DHA intake, adjusted for total energy intake, smoking, other dietary fatty acids, dietary vitamin D and body mass index.Results Seventy-three participants developed incident CD. All higher quintiles of DHA intake were inversely associated with development of CD; the highest quintile had the greatest effect size (OR=0.07; 95% CI=0.02-0.81). The OR trend across quintiles of DHA was 0.54 (95% CI=0.30-0.99, P-trend=0.04). Including BMI in the multivariate analysis, due to its correlation with dietary fat showed similar associations. There were no associations with the other dietary fatty acids studied.Conclusion There were inverse associations, with a biological gradient between increasing dietary docosahexaenoic acid intakes and incident Crohn's disease. Further studies in other populations should measure docosahexaenoic acid to determine if the association is consistent and the hypothesis tested in randomised controlled trials of purely docosahexaenoic acid supplementation.
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| 16. |
- Grip, H. F., et al.
(författare)
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Output synchronization for heterogeneous networks of non-introspective, non-right-invertible agents
- 2013
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Ingår i: Proceedings of the American Control Conference 2013. - : American Automatic Control Council. - 9781479901777 ; , s. 5791-5796
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Konferensbidrag (refereegranskat)abstract
- We consider the output synchronization problem for a heterogeneous network of linear agents. The agents are non-introspective, meaning that they do not have access to their own state or output; the only information available to each agent comes from the network, in the form of a linear combination of its output relative to that of neighboring agents. The basis for our study is a design previously presented by the authors, which was based on an additional assumption requiring the agents to be right-invertible. Here we dispense with the assumption of right-invertibility and instead introduce a new assumption based on solvability of a particular set of regulator equations.
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| 17. |
- Wang, X., et al.
(författare)
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Consensus in the network with uniform constant communication delay
- 2012
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Ingår i: Decision and Control (CDC), 2012 IEEE 51st Annual Conference on. - : IEEE. ; , s. 5318-5323
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Konferensbidrag (refereegranskat)abstract
- This paper studies the consensus among identical agents that are at most critically unstable and coupled through networks with uniform constant communication delay. An achievable upper bound of delay tolerance is obtained which explicitly depends on agent dynamics and network topology. The dependence on network topology disappears in the case of undirected networks. For any delay satisfying this upper bound, a controller design methodology without exact knowledge of the network topology is proposed so that the multi-agent consensus in a set of unknown networks can be achieved. Moreover, when the network topology is known, a larger delay tolerance is possible via a topology-dependent consensus controller. The results are illustrated by simulations.
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| 18. |
- Wang, X., et al.
(författare)
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Synchronization for heterogeneous networks of introspective right-invertible agents with uniform constant communication delay
- 2013
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Ingår i: 2013 IEEE 52nd Annual Conference on Decision and Control (CDC). - : IEEE conference proceedings. - 9781467357142 ; , s. 5198-5203
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Konferensbidrag (refereegranskat)abstract
- This paper studies output synchronization and regulation problem for heterogeneous networks of introspective right-invertible agents with uniform constant communication delay. A decentralized design based on shaping the agent dynamics using their self-knowledge and structural properties is developed. In the output synchronization problem, the proposed controller design tolerates arbitrary bounded communication delay and large network uncertainties. In the output regulation problem, it requires relative output measurement of the exosystem only in one agent. Moreover, the design method can also be applied to formation control problems.
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| 19. |
- Wang, X., et al.
(författare)
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Synchronization for homogeneous networks of non-introspective, non-right-invertible, discrete-time agents with uniform constant communication delay
- 2013
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Ingår i: 2013 IEEE 52nd Annual Conference on Decision and Control (CDC). - : IEEE conference proceedings. - 9781467357142 ; , s. 7351-7357
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Konferensbidrag (refereegranskat)abstract
- This paper studies the synchronization problem for homogeneous networks of non-introspective, non-rightinvertible, discrete-time agents with unknown uniform constant communication delay. We solve the problem for a set of communication topologies via a decentralized low-gain based synchronization controller if the delay satisfies the proposed upper bound, which in general depends on the identical agent model and some characteristics of the communication topology.
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| 20. |
- Yang, Tao, et al.
(författare)
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Semi-global regulation of output synchronization for heterogeneous networks of non-introspective, invertible agents subject to actuator saturation
- 2012
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Ingår i: 2012 IEEE 51st Annual Conference on Decision and Control (CDC). - : IEEE. - 9781467320665 ; , s. 5298-5303
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Konferensbidrag (refereegranskat)abstract
- In this paper, we consider the semi-global regulation of output synchronization problem for heterogeneous networks of invertible linear agents subject to actuator saturation. That is, we regulate the output of each agent according to an a priori specified reference model. The network communication infrastructure provides each agent with a linear combination of its own output relative to that of neighboring agents, and it allows the agents to exchange information about their own internal observer estimates, while some agents have access to their own outputs relative to the reference trajectory.
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