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- Belitsky, B R, et al.
(författare)
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An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transport
- 1997
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Ingår i: Journal of Bacteriology. - 0021-9193. ; 179:17, s. 5448-5457
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Tidskriftsartikel (refereegranskat)abstract
- The azlB locus of Bacillus subtilis was defined previously by a mutation conferring resistance to a leucine analog, 4-azaleucine (J. B. Ward, Jr., and S. A. Zahler, J. Bacteriol. 116:727-735, 1973). In this report, azlB is shown to be the first gene of an operon apparently involved in branched-chain amino acid transport. The product of the azlB gene is an Lrp-like protein that negatively regulates expression of the azlBCDEF operon. Resistance to 4-azaleucine in azlB mutants is due to overproduction of AzlC and AzlD, two novel hydrophobic proteins.
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- Edell-Gustafsson, Ulla, 1947-, et al.
(författare)
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Measurement of sleep and quality of life before and after coronary artery bypass grafting : A pilot study
- 1997
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Ingår i: International Journal of Nursing Practice. - : Wiley. - 1322-7114 .- 1440-172X. ; 3:4, s. 239-246
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to: (i) test different instruments that focused on sleep, quality of life and personal adjustment in order to evaluate the usefulness of these instruments in a larger study; and (ii) to describe self perceptions of sleep and life situation by patients who had undergone coronary artery bypass grafting (CABG). A one-group pre-test repeated post-test design was used. Six men aged between 51 and 70 years were interviewed, and 24 h polysomnographic recordings were performed before and after the operation. The interviews indicated disturbed sleep and changes in behaviour and mental state immediately postoperatively. Postoperatively the polysomnographic recordings revealed a significant decrease in mean duration of sleep, mean percentage of stage 3-4 sleep and mean rapid eye movement (REM) sleep. One month after surgery the quality of life was improved, while moderate anxiety and sensation of incisional pain persisted. The measurements used in this pilot study provide valuable information into the understanding of altered sleep, quality of life and personal adjustment following CABG.
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- Edéll-Gustafsson, Ulla, et al.
(författare)
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Sleep and quality of life assessment in patients undergoing coronary artery bypass grafting
- 1999
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Ingår i: Journal of Advanced Nursing. - : Wiley. - 0309-2402 .- 1365-2648. ; 29:5, s. 1213-1220
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To examine sleep before and after coronary artery bypass grafting (CABG) as well as measuring of quality of life (QoL), and to see if changes in subjectively rated sleep can be shown objectively by polysomnographic recordings. Sample: A consecutive sample of 38 male patients, aged 45-68, underwent CABG, Twenty-two patients were graded in New York Heart Association (NYHA) classes III or IV, and 16 in class I-II before surgery. METHODS: 24-hour polysomnographic recordings, using the Oxford Medilog 9000 recorder, were performed 2 days prior to surgery, on the first 2 post-operative days and 1 month after surgery. The Nottingham Health Profile instrument (NHP) was used to measure QoL before and after surgery. RESULTS: Following surgery there was a profound decrease in sleep at night, and an increase in daytime sleep. During the second post-operative recording period nocturnal sleep duration was reduced to 253.6 +/- 94.1 minutes, with suppressed stages 3 and 4 sleep and lack, or slight recovery, of REM sleep. Even though there were evident changes in both the distribution and nature of sleep at night, daytime sleep increased and the total duration of sleep during the 24-hour period was not significantly changed. The total sleep time was 421.1 +/- 76.8 minutes before surgery, 483.2 +/- 201.2 in the first period, 433.2 +/-201.4 minutes in the second 24-hour period post-operatively and 443.2 +/- 44.0 minutes at the 1-month follow-up. The NHP instrument demonstrated that 6 months after surgery the quality of life was significantly improved. Polysomnographically measured slow wave sleep was compared with the sleep section in the NHP instrument both before surgery and at 1 month post-operatively. CONCLUSIONS: In the immediate period following CABG, there is a change in distribution of sleep, with reduction in nocturnal sleep duration and an increase in daytime sleep, which had almost returned to pre-operative values 1 month after surgery. QoL scores were improved 6 months after surgery. This study demonstrates the importance of careful assessment of sleep and sleep disturbances for more individualized nursing care in order to promote sleep in the immediate post-operative period.
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- Gustafsson, Claes G. R., 1965
(författare)
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Rosenbergiodendron (Rubiaceae, Gardenieae) resurrected.
- 1995
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Ingår i: E. Robbrecht & E. Smets (eds.), Second International Rubiaceae Conference. Programme and abstracts. Scripta Bot. Belg. 11: 57.. ; 11
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Gustafsson, Claes G. R., 1965
(författare)
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The Neotropical Rosenbergiodendron (Rubiaceae, Gardenieae).
- 1998
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Ingår i: Brittonia. ; 50, s. 452-466
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Tidskriftsartikel (refereegranskat)abstract
- Rosenbergiodendron has usually been relegated to the synonymy of Randia, but differs from Randia by being unarmed and having hermaphrodite flowers and pollen in monads. Three species are recognized. One new combination, R. formosum var. nitidum, is made. Rosenbergiodendron formosum is neotypified. Rosenbergiodendron formosum var. nitidum, R. longiflorum, R. densiflorum and Randia speciosa are lectotypified. A key to the species, descriptions, illustrations, and distribution maps are provided.
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| 9. |
- Gustafsson, Claes M, 1966, et al.
(författare)
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The DNA ligands influence the interactions between the herpes simplex virus 1 origin binding protein and the single strand DNA-binding protein, ICP-8.
- 1995
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Ingår i: The Journal of biological chemistry. - 0021-9258. ; 270:32, s. 19028-34
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Tidskriftsartikel (refereegranskat)abstract
- The herpes simplex virus type 1 (HSV-1) origin binding protein, OBP, is a DNA helicase specifically stimulated by the viral single strand DNA-binding protein, ICP-8. The stimulation is dependent on direct protein-protein interactions between the C-terminal domain of OBP, delta OBP, and ICP 8 (Boehmer, P.E., Craigie, M.C., Stow, N.D., and Lehman, I.R. (1994) J. Biol. Chem. 269, 29329-29334). We have now observed that this interaction is dramatically influenced by the nature of the DNA ligand. Stable complexes between delta OBP, ICP 8, and double-stranded DNA, presented either as a specific duplex oligonucleotide or a restriction fragment containing the HSV-1 origin of replication, oriS, can be detected by gel chromatography and gel electrophoresis. In contrast, a single-stranded oligonucleotide, oligo(dT)65, will completely disrupt the complex between delta OBP and ICP 8. We therefore suggest that the interaction between delta OBP and ICP 8 serves to position the single strand DNA-binding protein with high precision onto single-stranded DNA at a replication fork or at an origin of DNA replication.
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- Kanter, Theo, 1954-, et al.
(författare)
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Agent Enabled Road-Warriors
- 1998
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Ingår i: Voice Over the Net (VON) Europe ´98 in Oslo. June 1998.
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Konferensbidrag (refereegranskat)
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- Vidal, Olle, et al.
(författare)
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Disproportional body growth in female estrogen receptor-alpha-inactivated mice.
- 1999
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Ingår i: Biochemical and biophysical research communications. - : Elsevier BV. - 0006-291X. ; 265:2, s. 569-71
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Tidskriftsartikel (refereegranskat)abstract
- Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERalpha and ERbeta, have been cloned. The aim of the present study was to investigate the function of ERalpha in the regulation of body growth and skeletal growth. Adult female mice with inactivated ERalpha (ERalpha-/-) demonstrated an increased body weight compared with wild-type mice (114% of control). However, the length of the appendicular skeleton was decreased in adult ERalpha-/- mice (femur 93% of control). In contrast, the axial skeleton was normal (crown-rump length 98% of control). The decreased growth of the appendicular skeleton was associated with decreased serum levels of IGF-I (77% of control), indicating that the GH/IGF-I axis may be involved in the decreased longitudinal bone growth seen in female ERalpha-/- mice.
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| 17. |
- Windahl, Sara H, 1971, et al.
(författare)
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Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice.
- 1999
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Ingår i: The Journal of clinical investigation. - 0021-9738. ; 104:7, s. 895-901
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Tidskriftsartikel (refereegranskat)abstract
- Ovariectomy in young, growing rodents results in decreased trabecular bone mineral density (BMD) and increased radial growth of the cortical bone. Both of these effects are reversed by treatment with estrogen. The aim of the present study was to determine the physiological role of estrogen receptor-beta (ERbeta) on bone structure and bone mineral content (BMC). The BMC was increased in adult (11 weeks old), but not prepubertal (4 weeks old), female ERbeta(-/-) mice compared with wild-type (WT) mice. This increase in BMC in females was not due to increased trabecular BMD, but to an increased cross-sectional cortical bone area associated with a radial bone growth. Male ERbeta(-/-) mice displayed no bone abnormalities compared with WT mice. Ovariectomy decreased the trabecular BMD to the same extent in adult female ERbeta(-/-) mice as in WT mice. The expression levels of osteoblast-associated genes - alpha1(I) collagen, alkaline phosphatase, and osteocalcin mRNAs - were elevated in bone from adult ERbeta(-/-) females compared with WT mice. These observations provide a possible explanation for the increased radial bone growth seen in female mutants, suggesting a repressive function for ERbeta in the regulation of bone growth during female adolescence. In summary, ERbeta is essential for the pubertal feminization of the cortical bone in female mice but is not required for the protective effect of estrogens on trabecular BMD.
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