| 1. |
- Arora, Satish, et al.
(författare)
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Effect of Everolimus Initiation and Calcineurin Inhibitor Elimination on Cardiac Allograft Vasculopathy in De Novo Heart Transplant Recipients
- 2018
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Ingår i: Circulation. Heart failure. - 1941-3297. ; 11:9, s. 004050-004050
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Tidskriftsartikel (refereegranskat)abstract
- Background Cardiac allograft vasculopathy (CAV) limits survival after heart transplantation, and the effect of different immunosuppressive regimens on CAV is not fully understood. The randomized SCHEDULE trial (Scandinavian Heart Transplant Everolimus De Novo Study With Early Calcineurin Inhibitors Avoidance) evaluated whether initiation of the proliferation signal inhibitor everolimus and early cyclosporine elimination can reduce CAV development. Methods and Results The SCHEDULE trial was a multicenter Scandinavian trial, where 115 de novo heart transplantation recipients were randomized to everolimus with complete cyclosporine withdrawal 7 to 11 weeks after heart transplantation or standard cyclosporine-based immunosuppression. Seventy-six (66%) patients had matched intravascular ultrasound examinations at baseline and 12 and 36 months. Intravascular ultrasound analysis evaluated maximal intimal thickness, percent atheroma volume, and total atheroma volume. Qualitative plaque analysis using virtual histology assessed fibrous, fibrofatty, and calcified tissue as well as necrotic core. Serum inflammatory markers were measured in parallel. The everolimus group (n=37) demonstrated significantly reduced CAV progression as compared with the cyclosporine group (n=39) at 36 months (Δ maximal intimal thickness, 0.09±0.05 versus 0.15±0.16 mm [ P=0.03]; Δ percent atheroma volume, 5.3±2.8% versus 7.6±5.9% [ P=0.03]; and Δ total atheroma volume, 33.9±71.2 versus 54.2±96.0 mm3 [ P=0.34], respectively]. At 36 months the number of everolimus patients with rejection graded ≥2R was 15 (41%) as compared with 5 (13%) in the cyclosporine group ( P=0.01). Everolimus did not affect CAV morphology or immune marker activity during the follow-up period. Conclusions The SCHEDULE trial demonstrates that everolimus initiation and early cyclosporine elimination significantly reduces CAV progression at 12 months, and this beneficial effect is clearly sustained at 36 months. Clinical trial registration URL: https://www.clinicaltrials.gov . Unique identifier: NCT01266148.
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| 2. |
- Gullestad, Lars, et al.
(författare)
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Long-term outcomes of thoracic transplant recipients following conversion to everolimus with reduced calcineurin inhibitor in a multicenter, open-label, randomized trial
- 2016
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Ingår i: Transplant International. - : Wiley-Blackwell Publishing Inc.. - 0934-0874 .- 1432-2277. ; 29:7, s. 819-829
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Tidskriftsartikel (refereegranskat)abstract
- The NOCTET study randomized 282 patients ≥1 year after heart or lung transplantation to continue conventional calcineurin inhibitor (CNI) therapy or to start everolimus with reduced-exposure CNI. Last follow-up, at ≥5 years postrandomization (mean: 5.6 years) was attended by 72/140 everolimus patients (51.4%) and 91/142 controls (64.1%). Mean measured GFR remained stable in the everolimus group from randomization (51.3 ml/min) to last visit (51.4 ml/min) but decreased in controls (from 50.5 ml/min to 45.3 ml/min) and was significantly higher with everolimus at last follow-up (P = 0.004). The least squares mean (SE) change from randomization was -1.5 (1.7)ml/min with everolimus versus -7.2 (1.7)ml/min for controls (difference: 5.7 [95% CI 1.7; 9.6]ml/min; P = 0.006). The difference was accounted for by heart transplant patients (difference: 6.9 [95% 2.3; 11.5]ml/min; P = 0.004). Lung transplant patients showed no between-group difference at last follow-up. Rates of rejection, death, and major cardiac events were similar between groups, as was graft function. Pneumonia was more frequent with everolimus (18.3% vs. 6.4%). In conclusion, introducing everolimus in maintenance heart transplant patients, with reduced CNI, achieves a significant improvement in renal function which is maintained for at least 5 years, but an early renal benefit in lung transplant patients was lost. Long-term immunosuppressive efficacy was maintained.
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| 3. |
- Gustafsson, Erik, et al.
(författare)
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Carbon cycling on the East Siberian Arctic Shelf – a change in air-sea CO2 flux induced by mineralization of terrestrial organic carbon
- 2017
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Ingår i: Biogeosciences. - : Copernicus GmbH. - 1726-4170 .- 1726-4189.
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Tidskriftsartikel (refereegranskat)abstract
- Measurements from the SWERUS-C3 and ISSS-08 Arctic expeditions were used to calibrate and validate a new physical-biogeochemical model developed to quantify key carbon cycling processes on the East Siberian Arctic Shelf (ESAS). The model was used in a series of experimental simulations with the specific aim to investigate the pathways of terrestrial dissolved and particulate organic carbon (DOCter and POCter) supplied to the shelf. Rivers supply on average 8.5 Tg C yr−1 dissolved inorganic carbon (DIC), and further 8.5 and 1.1 Tg C yr−1 DOCter and POCter respectively. Based on observed and simulated DOC concentrations and stable isotope values (δ13CDOC) in shelf waters, we estimate that only some 20 % of the riverine DOCter is labile. According to our model results, an additional supply of approximately 14 Tg C yr−1 eroded labile POCter is however required to describe the observed stable isotope values of DIC (δ13CDIC). Degradation of riverine DOCter and POCter results in a 1.8 Tg C yr−1 reduction in the uptake of atmospheric CO2, while degradation of eroded POCter results in an additional 10 Tg C yr−1 reduction. Our calculations indicate nevertheless that the ESAS is an overall small net sink for atmospheric CO2 (1.7 Tg C yr−1). The external carbon sources are largely compensated by a net export from the shelf to the Arctic Ocean (31 Tg C yr−1), and to a smaller degree by a permanent burial in the sediments (2.7 Tg C yr−1).
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| 4. |
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| 5. |
- Humborg, Christoph, et al.
(författare)
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Sea-air exchange patterns along the central and outer East Siberian Arctic Shelf as inferred from continuous CO2, stable isotope, and bulk chemistry measurements
- 2017
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Ingår i: Global Biogeochemical Cycles. - 0886-6236 .- 1944-9224. ; 31:7, s. 1173-1191
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Tidskriftsartikel (refereegranskat)abstract
- This large-scale quasi-synoptic study gives a comprehensive picture of sea-air CO 2 fluxes during the melt season in the central and outer Laptev Sea (LS) and East Siberian Sea (ESS). During a 7 week cruise we compiled a continuous record of both surface water and air CO 2 concentrations, in total 76,892 measurements. Overall, the central and outer parts of the ESAS constituted a sink for CO 2 , and we estimate a median uptake of 9.4 g C m -2 yr -1 or 6.6 Tg C yr -1 . Our results suggest that while the ESS and shelf break waters adjacent to the LS and ESS are net autotrophic systems, the LS is a net heterotrophic system. CO 2 sea-air fluxes for the LS were 4.7 g C m -2 yr -1 , and for the ESS we estimate an uptake of 7.2 g C m -2 yr -1 . Isotopic composition of dissolved inorganic carbon (δ 13 C DIC and δ 13 C CO2 ) in the water column indicates that the LS is depleted in δ 13 C DIC compared to the Arctic Ocean (ArcO) and ESS with an offset of 0.5‰ which can be explained by mixing of δ 13 C DIC -depleted riverine waters and 4.0 Tg yr -1 respiration of OC ter ; only a minor part (0.72 Tg yr -1 ) of this respired OC ter is exchanged with the atmosphere. Property-mixing diagrams of total organic carbon and isotope ratio (δ 13 C SPE-DOC ) versus dissolved organic carbon (DOC) concentration diagram indicate conservative and nonconservative mixing in the LS and ESS, respectively. We suggest land-derived particulate organic carbon from coastal erosion as an additional significant source for the depleted δ 13 C DIC .
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| 6. |
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| 7. |
- Nelson, Lærke M., et al.
(författare)
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Effect of Calcineurin Inhibitor-Free Everolimus-Based Immunosuppressive Regimen on Albuminuria and Glomerular Filtration Rate after Heart Transplantation
- 2017
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Ingår i: Transplantation. - 0041-1337. ; 101:11, s. 2793-2800
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Albuminuria in maintenance heart transplantation (HTx) is associated with poor renal response when switching to a calcineurin inhibitor (CNI)-lowered or free immunosuppressive regimen using everolimus (EVR), but the significance of albuminuria associated with EVR treatment after early CNI withdrawal in de novo HTx is unknown. METHODS: We tested if glomerular filtration rate (mGFR, measured by CrEDTA clearance) was associated with urine albumin/creatinine ratio (UACR) post-HTx in a subgroup of patients included in the SCHEDULE trial, where de novo HTx patients (n=115) were randomized to EVR with complete CNI elimination 7–11 weeks post-HTx or standard CNI immunosuppression. RESULTS: In 66 patients UACR measures were available at 1 year. In 7 patients in the EVR group a CNI was reintroduced within 12 months. Median mGFR was significantly higher in the EVR group both 1 and 3 years post-HTx (p=0.0004, p=0.03). Median UACR at 1 year was significantly higher in the EVR group (p=0.002). There was no correlation between log(UACR) at 1 year and mGFR at 1 or 3 years (r=−0.01, p=0.9; r=0.15, p=0.26), and in the EVR group nor between log(UACR) at 1 year and change in mGFR (Δ1-3 years) (r=0.27, p=0.14). Excluding patients in the EVR group in whom a CNI was reintroduced did not significantly change the results. CONCLUSIONS: The effects of EVR with early CNI withdrawal after HTx on albuminuria and renal function appear dissociated; hence the clinical significance of albuminuria in this setting is uncertain and should not necessarily rule out EVR-based immunosuppression.
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| 8. |
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| 9. |
- Relbo Authen, Anne, et al.
(författare)
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Effect of everolimus vs calcineurin inhibitors on quality of life in heart transplant recipients during a 3-year follow-up : Results of a randomized controlled trial (SCHEDULE)
- 2017
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Ingår i: Clinical Transplantation. - : Wiley. - 0902-0063 .- 1399-0012. ; 31:9
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Tidskriftsartikel (refereegranskat)abstract
- The Scandinavian heart transplant everolimus de novo study with early calcineurin inhibitors avoidance (SCHEDULE) trial was a 12 month, randomized, open-label, parallel-group trial that compared everolimus (EVR; n=56) to conventional CsA (n=59) immunosuppression. Previously, we reported that EVR outperformed CsA in improving renal function and coronary artery vasculopathy, despite a higher rejection rate with EVR. This study aimed to compare the effects of these treatments on quality of life (QoL). Within five post-operative days, patients (mean age 50±13 years, 27% women) were randomized to EVR or a standard CsA dosage (CsA group). This study assessed quality of life (QoL), based on the Short Form-36, EuroQol-5D, and Beck Depression Inventory (BDI). Assessments were performed pre-HTx and 12 and 36 months post-HTx. At 12 and 36 months, the groups showed similar improvements in Short Form-36 measures (at pre-HTx, 12 and 36 months the values were as follows: Physical component summary: EVR: 31.5±110.9, 49.1±9.7, and 47.9±10.6; P<.01; CsA: 32.5±8.2, 48.4±8.5, and 46.5±11.5; P<.01; mental component summary: EVR: 46.0±12.0, 51.7±11.9, and 52.1±13.0; P<.01; CsA: 38.2±12.5, 53.4±7.1, and 54.3±13.0; P<.01); similar decrease in mean BDI (EVR: 10.9±10.2, 5.4±4.7, and 8.1±9.0; P<.01; CsA: 11.8±7.1, 6.3±5.4, and 6.2±6.5; P<.01); and similar Euro Qol-improvements. Thus, in this small-sized study, EVR-based and conventional CsA immunosuppressive strategies produced similar QoL improvements.
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| 10. |
- Abdollahi Sani, Negar, et al.
(författare)
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Flexible lamination-fabricated ultra-high frequency diodes based on self-supporting semiconducting composite film of silicon micro-particles and nano-fibrillated cellulose
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Low cost and flexible devices such as wearable electronics, e-labels and distributed sensors will make the future "internet of things" viable. To power and communicate with such systems, high frequency rectifiers are crucial components. We present a simple method to manufacture flexible diodes, operating at GHz frequencies, based on self-adhesive composite films of silicon micro-particles (Si-ΌPs) and glycerol dispersed in nanofibrillated cellulose (NFC). NFC, Si-ΌPs and glycerol are mixed in a water suspension, forming a self-supporting nanocellulose-silicon composite film after drying. This film is cut and laminated between a flexible pre-patterned Al bottom electrode and a conductive Ni-coated carbon tape top contact. A Schottky junction is established between the Al electrode and the Si-ΌPs. The resulting flexible diodes show current levels on the order of mA for an area of 2 mm2, a current rectification ratio up to 4 × 103 between 1 and 2 V bias and a cut-off frequency of 1.8 GHz. Energy harvesting experiments have been demonstrated using resistors as the load at 900 MHz and 1.8 GHz. The diode stack can be delaminated away from the Al electrode and then later on be transferred and reconfigured to another substrate. This provides us with reconfigurable GHz-operating diode circuits.
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| 11. |
- Andersson Ersman, Peter, et al.
(författare)
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All-printed large-scale integrated circuits based on organic electrochemical transistors
- 2019
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- The communication outposts of the emerging Internet of Things are embodied by ordinary items, which desirably include all-printed flexible sensors, actuators, displays and akin organic electronic interface devices in combination with silicon-based digital signal processing and communication technologies. However, hybrid integration of smart electronic labels is partly hampered due to a lack of technology that (de)multiplex signals between silicon chips and printed electronic devices. Here, we report all-printed 4-to-7 decoders and seven-bit shift registers, including over 100 organic electrochemical transistors each, thus minimizing the number of terminals required to drive monolithically integrated all-printed electrochromic displays. These relatively advanced circuits are enabled by a reduction of the transistor footprint, an effort which includes several further developments of materials and screen printing processes. Our findings demonstrate that digital circuits based on organic electrochemical transistors (OECTs) provide a unique bridge between all-printed organic electronics (OEs) and low-cost silicon chip technology for Internet of Things applications. © 2019, The Author(s).
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| 12. |
- Andersson Ersman, Peter, et al.
(författare)
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Screen printed digital circuits based on vertical organicelectrochemical transistors
- 2017
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Ingår i: Flexible and Printed Electronics. - : IOP Publishing. - 2058-8585. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- Vertical organic electrochemical transistors (OECTs) have been manufactured solely using screenprinting. The OECTs are based on PEDOT:PSS (poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonic acid)), which defines the active material for both the transistor channel and the gateelectrode. The resulting vertical OECT devices and circuits exhibit low-voltage operation, relativelyfast switching, small footprint and high manufacturing yield; the last three parameters are explainedby the reliance of the transistor configuration on a robust structure in which the electrolyte verticallybridges the bottom channel and the top gate electrode. Two different architectures of the verticalOECT have been manufactured, characterized and evaluated in parallel throughout this report. Inaddition to the experimental work, SPICE models enabling simulations of standalone OECTs andOECT-based circuits have been developed. Our findings may pave the way for fully integrated, lowvoltageoperating and printed signal processing systems integrated with e.g. printed batteries, solarcells, sensors and communication interfaces. Such technology can then serve a low-cost basetechnology for the internet of things, smart packaging and home diagnostics applications.
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| 13. |
- Andreassen, A. K., et al.
(författare)
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Everolimus Initiation With Early Calcineurin Inhibitor Withdrawal in De Novo Heart Transplant Recipients: Three-Year Results From the Randomized SCHEDULE Study
- 2016
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Ingår i: American Journal of Transplantation. - : WILEY-BLACKWELL. - 1600-6135 .- 1600-6143. ; 16:4, s. 1238-1247
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Tidskriftsartikel (refereegranskat)abstract
- In a randomized, open-label trial, de novo heart transplant recipients were randomized to everolimus (3-6ng/mL) with reduced-exposure calcineurin inhibitor (CNI; cyclosporine) to weeks 7-11 after transplant, followed by increased everolimus exposure (target 6-10ng/mL) with cyclosporine withdrawal or standard-exposure cyclosporine. All patients received mycophenolate mofetil and corticosteroids. A total of 110 of 115 patients completed the 12-month study, and 102 attended a follow-up visit at month 36. Mean measured GFR (mGFR) at month 36 was 77.4mL/min (standard deviation [SD] 20.2mL/min) versus 59.2mL/min (SD 17.4mL/min) in the everolimus and CNI groups, respectively, a difference of 18.3mL/min (95% CI 11.1-25.6mL/min; p < 0.001) in the intention to treat population. Multivariate analysis showed treatment to be an independent determinant of mGFR at month 36. Coronary intravascular ultrasound at 36 months revealed significantly reduced progression of allograft vasculopathy in the everolimus group compared with the CNI group. Biopsy-proven acute rejection grade 2R occurred in 10.2% and 5.9% of everolimus- and CNI-treated patients, respectively, during months 12-36. Serious adverse events occurred in 37.3% and 19.6% of everolimus- and CNI-treated patients, respectively (p=0.078). These results suggest that early CNI withdrawal after heart transplantation supported by everolimus, mycophenolic acid and steroids with lymphocyte-depleting induction is safe at intermediate follow-up. This regimen, used selectively, may offer adequate immunosuppressive potency with a sustained renal advantage. A follow-up study of the SCHEDULE trial, which randomized de novo heart transplant recipients to everolimus with cyclosporine discontinuation or to standard-exposure cyclosporine, shows that measured glomerular filtration rate remains significantly higher in the everolimus group at three years posttransplant, with significantly reduced progression of allograft vasculopathy compared to cyclosporine therapy.
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| 14. |
- Aref, Thomas, 1980, et al.
(författare)
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Quantum Acoustics with Surface Acoustic Waves
- 2016
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Ingår i: Superconducting Devices in Quantum Optics. - Cham : Springer International Publishing. - 9783319240916 ; , s. 217-244
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- It has recently been demonstrated that surface acoustic waves (SAWs) can interact with superconducting qubits at the quantum level. SAW resonators in the GHz frequency range have also been found to have low loss at temperatures compatible with superconducting quantum circuits. These advances open up new possibilities to use the phonon degree of freedom to carry quantum information. In this chapter, we give a description of the basic SAW components needed to develop quantum circuits, where propagating or localized SAW-phonons are used both to study basic physics and to manipulate quantum information. Using phonons instead of photons offers new possibilities which make these quantum acoustic circuits very interesting. We discuss general considerations for SAW experiments at the quantum level and describe experiments both with SAW resonators and with interaction between SAWs and a qubit. We also discuss several potential future developments.
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| 15. |
- Arora, S., et al.
(författare)
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The Effect of Everolimus Initiation and Calcineurin Inhibitor Elimination on Cardiac Allograft Vasculopathy in De Novo Recipients: One-Year Results of a Scandinavian Randomized Trial
- 2015
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Ingår i: American Journal of Transplantation. - : Elsevier BV. - 1600-6135. ; 15:7, s. 1967-1975
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Tidskriftsartikel (refereegranskat)abstract
- Early initiation of everolimus with calcineurin inhibitor therapy has been shown to reduce the progression of cardiac allograft vasculopathy (CAV) in de novo heart transplant recipients. The effect of de novo everolimus therapy and early total elimination of calcineurin inhibitor therapy has, however, not been investigated and is relevant given the morbidity and lack of efficacy of current protocols in preventing CAV. This 12-month multicenter Scandinavian trial randomized 115 de novo heart transplant recipients to everolimus with complete calcineurin inhibitor elimination 7-11 weeks after HTx or standard cyclosporine immunosuppression. Ninety-five (83%) patients had matched intravascular ultrasound examinations at baseline and 12 months. Mean (SD) recipient age was 49.9 +/- 13.1 years. The everolimus group (n=47) demonstrated significantly reduced CAV progression as compared to the calcineurin inhibitor group (n=48) (Maximal Intimal Thickness 0.03 +/- 0.06 and 0.08 +/- 0.12mm, Percent Atheroma Volume 1.3 +/- 2.3 and 4.2 +/- 5.0%, Total Atheroma Volume 1.1 +/- 19.2mm(3) and 13.8 +/- 28.0mm(3) [all p-values0.01]). Everolimus patients also had a significantly greater decline in levels of soluble tumor necrosis factor receptor-1 as compared to the calcineurin inhibitor group (p=0.02). These preliminary results suggest that an everolimus-based CNI-free can potentially be considered in suitable de novo HTx recipients.
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| 16. |
- Baygan, Arjang, et al.
(författare)
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Safety and Side Effects of Using Placenta-Derived Decidual Stromal Cells for Graft-versus-Host Disease and Hemorrhagic Cystitis
- 2017
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Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Mesenchymal stromal cells (MSCs) are increasingly used in regenerate medicine. Placenta-derived decidual stromal cells (DSCs) are a novel therapy for acute graft-versus-host-disease (GVHD) and hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT). DSCs are more immunosuppressive than MSCs. We assessed adverse events and safety using DSCs among 44 treated patients and 40 controls. The median dose of infused cells was 1.5 (range 0.9–2.9) × 106 DSCs/kg. The patients were given 2 (1–5) doses, with a total of 82 infusions. Monitoring ended 3 months after the last DSC infusion. Three patients had transient reactions during DSC infusion. Laboratory values, hemorrhages, and transfusions were similar in the two groups. The frequency of leukemic relapse (2/2, DSC/controls) and invasive fungal infections (6/6) were the same in the two groups. Causes of death were those seen in HSCT patients: infections (5/3), respiratory failure (1/1), circulatory failure (3/1), thromboembolism (1/0), multiorgan failure (0/1), and GVHD and others (2/7). One-year survival for the DSC patients with GVHD was 67%, which was significantly better than achieved previously at our center. One-year survival was 90% in the DSC-treated HC group. DSC infusions appear safe. Randomized studies are required to prove efficacy.
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| 17. |
- Beni, Valerio, 1972-, et al.
(författare)
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Printed electrochemical instruments for biosensors
- 2015
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Ingår i: ECS Transactions. - : The Electrochemical Society. - 9781607685395 ; , s. 1-13
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Konferensbidrag (refereegranskat)abstract
- Mobile diagnostics for healthcare, food safety and environmental monitoring, demand a new generation of inexpensive sensing systems suitable for production in high volume. Herein we report on the development of a new disposable electrochemical instrument exploiting the latest advances in printed electronics and printed biosensors. The current system is manufactured under ambient conditions with all interconnections printed; electrochemical measurements and data elaboration are realized by the integration onto the platform of two chips: a MICROCHIP-PIC24F16KA101 and a Texas Instrument's LMP91000. A PEDOT.PSS vertical electrochromic display (VECD) is also incorporated into the system to visualize the data. A printed Enfucell 3V manganese dioxide battery was used to deliver the required power. Finally, in order to demonstrate the utility of the system, screen-printed sensors for the detection of glucose were added and the performance of the overall system was evaluated.
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| 18. |
- Beni, Valerio, et al.
(författare)
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Printed electrochemical instruments for biosensors
- 2015
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Ingår i: ECS Journal of Solid State Science and Technology. - : Electrochemical Society Inc.. - 2162-8769 .- 2162-8777. ; 4:10, s. S3001-S3005
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Tidskriftsartikel (refereegranskat)abstract
- Mobile diagnostics for healthcare, food safety and environmental monitoring, demand a new generation of inexpensive sensing systems suitable for production in high volume. Herein we report on the development of a new disposable electrochemical instrument exploiting the latest advances in printed electronics and printed biosensors. The current system is manufactured under ambient conditions with all interconnections printed; electrochemical measurements and data elaboration are realized by the integration onto the platform of two chips: a MICROCHIP-PIC24F16KA101 and a Texas Instrument's LMP91000. A PEDOT.PSS vertical electrochromic display (VECD) is also incorporated into the system to visualize the data. A printed Enfucell 3V manganese dioxide battery was used to deliver the required power. Finally, in order to demonstrate the utility of the system, screen-printed sensors for the detection of glucose were added and the performance of the overall system was evaluated.
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| 19. |
- Berggren, Magnus, et al.
(författare)
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Browsing the Real World using Organic Electronics, Si-Chips, and a Human Touch
- 2016
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Ingår i: Advanced Materials. - : Wiley. - 0935-9648 .- 1521-4095. ; 28:10, s. 1911-1916
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Tidskriftsartikel (refereegranskat)abstract
- Two different e-labels were developed to explore the feasibility and to identify scientifi c and engineering challenges of the Real-World-Web platform. First was a printed biosensor e-label, comprising Si-chips with an array of different printegrated devices, and second, an e-label to explore the feasibility of transferring data, through the human body, between a mobile device and different distributed e-labels, adhered onto the body or onto dedicated devices and surfaces of one's ambience. The silicon chips utilized in e-labels, include analogue and digital circuitry to receive and handle sensory input, to perform signal processing, and to transmit information to antennas and displays. When used, the e-label is turned on, and a sample is then added onto the sensor area. The display provides simple instructions and updated information to the user. All data handling, electrical probing, and analysis of the sensor is performed by the Si-chips, and the sensing data is finally shown in the printed display. The second e-label exemplifies an ID-tag for body area networks (BAN) communication applications, which, in part, is manufactured and integrated in the same way as the first e-label, but with another choice of Si-chips and capacitive antennas.
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| 20. |
- Brolin, Gustav, et al.
(författare)
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The accuracy of quantitative parameters in Tc-99m-MAG3 dynamic renography : a national audit based on virtual image data
- 2016
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Ingår i: Clinical Physiology and Functional Imaging. - : Wiley. - 1475-0961 .- 1475-097X. ; 36:2, s. 146-154
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Tidskriftsartikel (refereegranskat)abstract
- Assessment of image analysis methods and computer software used in Tc-99m-MAG3 dynamic renography is important to ensure reliable study results and ultimately the best possible care for patients. In this work, we present a national multicentre study of the quantification accuracy in Tc-99m-MAG3 renography, utilizing virtual dynamic scintigraphic data obtained by Monte Carlo-simulated scintillation camera imaging of digital phantoms with time-varying activity distributions. Three digital phantom studies were distributed to the participating departments, and quantitative evaluation was performed with standard clinical software according to local routines. The differential renal function (DRF) and time to maximum renal activity (T-max) were reported by 21 of the 28 Swedish departments performing Tc-99m-MAG3 studies as of 2012. The reported DRF estimates showed a significantly lower precision for the phantom with impaired renal uptake than for the phantom with normal uptake. The T-max estimates showed a similar trend, but the difference was only significant for the right kidney. There was a significant bias in the measured DRF for all phantoms caused by different positions of the left and right kidney in the anterior-posterior direction. In conclusion, this study shows that virtual scintigraphic studies are applicable for quality assurance and that there is a considerable uncertainty associated with standard quantitative parameters in dynamic Tc-99m-MAG3 renography, especially for patients with impaired renal function.
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| 21. |
- Brooke, Robert, 1989-, et al.
(författare)
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Supercapacitors on demand : All-printed energy storage devices with adaptable design
- 2019
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Ingår i: Flexible and Printed Electronics. - : Institute of Physics Publishing. - 2058-8585. ; 4:1
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Tidskriftsartikel (refereegranskat)abstract
- Demands on the storage of energy have increased for many reasons, in part driven by household photovoltaics, electric grid balancing, along with portable and wearable electronics. These are fast-growing and differentiated applications that need large volume and/or highly distributed electrical energy storage, which then requires environmentally friendly, scalable and flexible materials and manufacturing techniques. However, the limitations on current inorganic technologies have driven research efforts to explore organic and carbon-based alternatives. Here, we report a conducting polymer:cellulose composite that serves as the active material in supercapacitors which has been incorporated into all-printed energy storage devices. These devices exhibit a specific capacitance of ≈90 F g -1 and an excellent cyclability (>10 000 cycles). Further, a design concept coined 'supercapacitors on demand' is presented, which is based on a printing-cutting-folding procedure, that provides us with a flexible production protocol to manufacture supercapacitors with adaptable configuration and electrical characteristics.
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| 22. |
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| 23. |
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| 24. |
- Comasco, Erika, et al.
(författare)
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Psychiatric symptoms in adolescents: FKBP5 genotype-early life adversity interaction effects
- 2015
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Ingår i: European Child and Adolescent Psychiatry. - : Springer. - 1018-8827 .- 1435-165X. ; 24:12, s. 1473-1483
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Tidskriftsartikel (refereegranskat)abstract
- Psychiatric disorders are multi-factorial and their symptoms overlap. Constitutional and environmental factors influence each other, and this contributes to risk and resilience in mental ill-health. We investigated functional genetic variation of stress responsiveness, assessed as FKBP5 genotype, in relation to early life adversity and mental health in two samples of adolescents. One population-based sample of 909 12-year-old adolescents was assessed using the Life Incidence of Traumatic Events scale and the Strengths and Difficulties Questionnaire. One sample of 398 17-year-old adolescents, enriched for poly-victimized individuals (USSS), was assessed using the Juvenile Victimization Questionnaire and the Trauma Symptom Checklist for Children (TSCC). The FKBP5 rs1360780 and rs3800373 polymorphisms were genotyped using a fluorescence-based competitive allele-specific PCR. Most prominently among poly-victimized older male adolescents, the least common alleles of the polymorphisms, in interaction with adverse life events, were associated with psychiatric symptoms, after controlling for ethno-socio-economic factors. The interaction effect between rs3800373 and adverse life events on the TSCC sub-scales-anxiety, depression, anger, and dissociation-and with the rs1360780 on dissociation in the USSS cohort remained significant after Bonferroni correction. This pattern of association is in line with the findings of clinical and neuroimaging studies, and implies interactive effects of FKBP5 polymorphisms and early life environment on several psychiatric symptoms. These correlates add up to provide constructs that are relevant to several psychiatric symptoms, and to identify early predictors of mental ill-health.
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| 25. |
- Dalmar, Abdirisak Ahmed, et al.
(författare)
-
Rebuilding research capacity in fragile states : the case of a Somali-Swedish global health initiative
- 2017
-
Ingår i: Global Health Action. - Abingdon : Informa UK Limited. - 1654-9716 .- 1654-9880. ; 10:1
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents an initiative to revive the previous Somali-Swedish Research Cooperation, which started in 1981 and was cut short by the civil war in Somalia. A programme focusing on research capacity building in the health sector is currently underway through the work of an alliance of three partner groups: six new Somali universities, five Swedish universities, and Somali diaspora professionals. Somali ownership is key to the sustainability of the programme, as is close collaboration with Somali health ministries. The programme aims to develop a model for working collaboratively across regions and cultural barriers within fragile states, with the goal of creating hope and energy. It is based on the conviction that health research has a key role in rebuilding national health services and trusted institutions.
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| 26. |
- Denby, B. R., et al.
(författare)
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Road salt emissions : A comparison of measurements and modelling using the NORTRIP road dust emission model
- 2016
-
Ingår i: Atmospheric Environment. - : Elsevier Ltd. - 1352-2310 .- 1873-2844. ; 141, s. 508-522
-
Tidskriftsartikel (refereegranskat)abstract
- De-icing of road surfaces is necessary in many countries during winter to improve vehicle traction. Large amounts of salt, most often sodium chloride, are applied every year. Most of this salt is removed through drainage or traffic spray processes but a certain amount may be suspended, after drying of the road surface, into the air and will contribute to the concentration of particulate matter. Though some measurements of salt concentrations are available near roads, the link between road maintenance salting activities and observed concentrations of salt in ambient air is yet to be quantified. In this study the NORTRIP road dust emission model, which estimates the emissions of both dust and salt from the road surface, is applied at five sites in four Nordic countries for ten separate winter periods where daily mean ambient air measurements of salt concentrations are available. The model is capable of reproducing many of the salt emission episodes, both in time and intensity, but also fails on other occasions. The observed mean concentration of salt in PM10, over all ten datasets, is 4.2 μg/m3 and the modelled mean is 2.8 μg/m3, giving a fractional bias of −0.38. The RMSE of the mean concentrations, over all 10 datasets, is 2.9 μg/m3 with an average R2 of 0.28. The mean concentration of salt is similar to the mean exhaust contribution during the winter periods of 2.6 μg/m3. The contribution of salt to the kerbside winter mean PM10 concentration is estimated to increase by 4.1 ± 3.4 μg/m3 for every kg/m2 of salt applied on the road surface during the winter season. Additional sensitivity studies showed that the accurate logging of salt applications is a prerequisite for predicting salt emissions, as well as good quality data on precipitation. It also highlights the need for more simultaneous measurements of salt loading together with ambient air concentrations to help improve model parameterisations of salt and moisture removal processes. © 2016 The Authors
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| 27. |
- Ekenberg, Love, et al.
(författare)
-
Deliberation, representation, equity : research approaches, tools and algorithms for participatory processes
- 2017
-
Bok (övrigt vetenskapligt/konstnärligt)abstract
- What can we learn about the development of public interaction in e-democracy from a drama delivered by mobile headphones to an audience standing around a shopping center in a Stockholm suburb? In democratic societies there is widespread acknowledgment of the need to incorporate citizens' input in decision-making processes in more or less structured ways. But participatory decision making is balancing on the borders of inclusion, structure, precision and accuracy. To simply enable more participation will not yield enhanced democracy, and there is a clear need for more elaborated elicitation and decision analytical tools. This rigorous and thought-provoking volume draws on a stimulating variety of international case studies, from flood risk management in the Red River Delta of Vietnam, to the consideration of alternatives to gold mining in Ro?ia Montana in Transylvania, to the application of multi-criteria decision analysis in evaluating the impact of e-learning opportunities at Uganda's Makerere University. Editors Love Ekenberg (senior research scholar, International Institute for Applied Systems Analysis [IIASA], Laxenburg, professor of Computer and Systems Sciences, Stockholm University), Karin Hansson (artist and research fellow, Department of Computer and Systems Sciences, Stockholm University), Mats Danielson (vice president and professor of Computer and Systems Sciences, Stockholm University, affiliate researcher, IIASA) and Göran Cars (professor of Societal Planning and Environment, Royal Institute of Technology, Stockholm) draw innovative collaborations between mathematics, social science, and the arts. They develop new problem formulations and solutions, with the aim of carrying decisions from agenda setting and problem awareness through to feasible courses of action by setting objectives, alternative generation, consequence assessments, and trade-off clarifications. As a result, this book is important new reading for decision makers in government, public administration and urban planning, as well as students and researchers in the fields of participatory democracy, urban planning, social policy, communication design, participatory art, decision theory, risk analysis and computer and systems sciences.
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| 28. |
- Englund, Annika, et al.
(författare)
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Hodgkin lymphoma - a survey of children and adolescents treated in Sweden 1985-2009.
- 2015
-
Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 54:1, s. 41-8
-
Tidskriftsartikel (refereegranskat)abstract
- Abstract Background. Hodgkin lymphoma (HL) in children constitutes approximately 30% of all pediatric lymphomas in Sweden. The chance of cure is high, but the frequency of late effects has been considerable. Over recent years, efforts have been made to reduce treatment with maintained survival. Material and methods. All patients 0-17 years, identified in the Swedish Childhood Cancer Register as diagnosed between 1985 and 2009, were included. The material was analyzed using descriptive statistics and for survival estimates the Kaplan-Meier method was used. Results. Three hundred and thirty-four patients were identified during this time period. The median age was 14 years. Male sex was over-represented, especially in lower age groups and in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). In nodular sclerosis and in age group 15-17 years, female sex dominated. Most of the cases presented in stages I or II. B-symptoms were present in 38% of cHL, but only in 7% of NLPHL. The number of patients receiving radiotherapy has been significantly reduced during the period studied. The relapse rate in cHL was 10 ± 2% and in NLPHL 16 ± 7%. The relapse rate was significantly higher in cHL stage IIB compared to other stages in the same therapy group. In cHL 6% died, and in NLPHL 0%. The 5-, 10- and 20-year overall survival estimates in cHL were 96 ± 1%, 95 ± 1% and 90 ± 3%, respectively, with no significant difference when comparing different treatment regimens and time periods. The 5- and 10-year overall survival after relapse in cHL was 81 ± 8% and 75 ± 10%, respectively. Conclusion. During the period studied there is no indication of a decline in survival despite changes in treatment. Survival rates in Sweden are high, and even after relapse chances of cure are high. We were not able to identify any characteristics specific for the group of patients that did not survive.
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| 29. |
- Fazl Mashhadi, Azadeh, 1980, et al.
(författare)
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The Volvo Robust Engineering System: how to make robust design work in an industrial context
- 2016
-
Ingår i: Total Quality Management and Business Excellence. - : Informa UK Limited. - 1478-3371 .- 1478-3363. ; 27:5-6, s. 1-19
-
Tidskriftsartikel (refereegranskat)abstract
- The Volvo Robust Engineering System (VRES) is an adaptation of the robust design concept in an industrial context. It consists of five different principles as a basic value system, and eight practices that contribute to the implementation of system, parameter and tolerance design. VRES was developed through a learning alliancebetween Volvo and Chalmers University of Technology. This paper presents VRES and discusses it in relation to the literature-based robust design methodology, which has been a major inspiration for VRES development. VRES has expanded and validated the concepts previously developed in the literature by adding the elements needed for practical application.
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| 30. |
- Frisch, Andreas, et al.
(författare)
-
Tree Species Composition Predicts Epiphytic Lichen Communities in an African Montane Rain Forest
- 2015
-
Ingår i: Biotropica. - : Wiley. - 0006-3606. ; 47, s. 542-549
-
Tidskriftsartikel (refereegranskat)abstract
- The ecology of many tropical rain forest organisms, not the least in Africa, remains poorly understood. Here, we present a detailed ecological study of epiphytic lichens in the equatorial montane rain forest of Bwindi National Park (331km(2)), Uganda. We evaluated all major lichen growth forms, including selected groups of crustose lichens. In 14 transects at elevations of 1290m to 2500m, we sampled 276 trees belonging to 60 species. We recorded all lichen species on each tree trunk between ground level and 2m above the ground, yielding 191 lichen species in 67 genera, with a mean of 4.7 species per tree. We used non-metric multi-dimensional scaling to separate epiphytic lichen assemblages according to tree species composition and elevation. Structural equation modeling indicated that elevation influenced tree species composition and that tree species composition largely determined lichen species composition. Thus, elevation acted indirectly on the lichen assemblages. Further studies examining factors such as bark properties and lichen colonization ecology may clarify what determines the association between tree species and lichen assemblages. The link between lichen assemblages and large-scale elevation patterns, as well as disturbance and regrowth histories, warrants further study. An analysis of lichen species composition on individual tree species that occur over large elevation ranges would distinguish the effect of tree species on lichen assemblages from the effect of elevation and thus climate. Our study highlights the limited extent of our knowledge of tropical epiphytic lichens.
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| 31. |
- Gilljam, Thomas, et al.
(författare)
-
Heart transplantation in arrhythmogenic right ventricular cardiomyopathy - Experience from the Nordic ARVC Registry
- 2018
-
Ingår i: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 250, s. 201-206
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: There is a paucity of data on heart transplantation (HTx) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), and specific recommendations on indications for listing ARVC patients for HTx are lacking. In order to delineate features pertinent to HTx assessment, we explored the pre-HTx characteristics and clinical history in a cohort of ARVC patients who received heart transplants. Methods: Data from 31 ARVC/HTx patients enrolled in the Nordic ARVC Registry, transplanted between 1988 and 2014 at a median age of 46. years (14-65), were compared with data from 152 non-transplanted probands with Definite ARVC according to 2010 Task Force Criteria from the same registry. Results: The HTx patients were younger at presentation, median 31 vs. 38. years (p = 0.001). There was no difference in arrhythmia-related events. The indication for HTx was heart failure in 28 patients (90%) and ventricular arrhythmias in 3 patients (10%). During median follow-up of 4.9. years (0.04-28), there was one early death and two late deaths. Survival was 91% at 5. years after HTx. Age at first symptoms under 35. years independently predicted HTx in our cohort (OR = 7.59, 95% CI 2.69-21.39, p <. 0.001). Conclusion: HTx in patients with ARVC is performed predominantly due to heart failure. This suggests that current 2016 International Society for Heart and Lung Transplantation heart transplant listing recommendations for other cardiomyopathies could be applicable in many cases when taking into account the haemodynamic consequences of right ventricular failure in conjunction with ventricular arrhythmia.
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| 32. |
- Gjerstad, Karl-Idar, et al.
(författare)
-
NORDUST : Nordic Road Dust Project
- 2019
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Road dust is an important contributor to airborne particle pollution, especially in the Nordic countries where high road surface wear, due to studded tyre useas well as winter maintenance and operations including sanding and salting are important contributors. Even though the road dust problems are similar, the countries have tackled different parts of the problem with different research approaches, resulting in a complex knowledgebase in need of compilation. A former project, NORTRIP, started this work and implemented the knowledge into an emission model with a specially elaborated road dust focus. The model work has been used to identify knowledge gaps, intended to be filled within the NorDust project. Laboratory tests and controlled and uncontrolled field measurements as well as parametrisation and modelling has been used as tools to find, describe and implement issues concerning road dust formation, suspension and dynamics and road operation effects on emissions in facilities and sites in Finland and Sweden. The NORTRIP model has been implemented and evaluated in Iceland, not previously involved in the model development, to identify input data needs. The project has resulted in an array of findings, of which some have been possible to implement in new parametrisations in the NORTRIP model. In the complex research area of road dust dynamics, the project has also resulted in a lot of practical experiences concerning experimental and measurement designs and evaluation possibilities that future research will be able to benefit from.
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| 33. |
- Gluch, Pernilla, 1968, et al.
(författare)
-
FROM TOOL-MAKING TO TOOL-USING - AND BACK: RATIONALES FOR ADOPTION AND USE OF LCC
- 2018
-
Ingår i: International Journal of Strategic Property Management. - : Vilnius Gediminas Technical University. - 1648-715X .- 1648-9179. ; 22:3, s. 179-190
-
Tidskriftsartikel (refereegranskat)abstract
- Real estate- and property owners' rationales behind the adoption of Life Cycle Costing (LCC) respectively how LCC is actually used in renovation projects, is investigated through empirical data from a questionnaire survey sent to managers in Swedish real estate organisations. The study shows a positive attitude towards LCC. It is perceived to as a flexible and multi-functional tool with a familiar monetary format. Nevertheless, the study also reveals simplistic and undeveloped views of how to use LCC. While much research has focused on developing sophisticated LCC tools, the findings indicate that practitioners' interest in these refinements seems limited. The importance of understanding that LCC is used in a context of multiple and partly competing institutional logics of renovation is emphasised. The paper contributes to a more informed research in development of LCC tools as well as better informed LCC use among real estate and property owners.
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| 34. |
- Gustafsson, Göran, 1955, et al.
(författare)
-
Unveiling Fundamental Relationships in Industrial Product Development
- 2016
-
Ingår i: Procedia CIRP. - : Elsevier. - 2212-8271 .- 2212-8271. ; 50, s. 204-209
-
Tidskriftsartikel (refereegranskat)abstract
- Identification and clarification of relationships between product properties is fundamentally important in industrial product development. The process is however frequently perceived difficult. The presented research aims at clarifying if a visual tool can provide help in this work. The tool is a combination of previously known techniques and has so far been implemented at two product developing companies. Results and reactions from the tests are hitherto positive and the conclusion is therefore that this extended casual diagram can be a useful addition to the product developer’s toolbox.
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| 35. |
- Gustafsson, Henrik, et al.
(författare)
-
Mindfulness and Its Relationship With Perceived Stress, Affect, and Burnout in Elite Junior Athletes
- 2015
-
Ingår i: Journal of Clinical Sport Psychology. - : Human Kinetics. - 1932-9261 .- 1932-927X. ; 9:3, s. 263-281
-
Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to examine the relationship between dispositional mindfulness and burnout and whether this relationship is mediated by perceived stress, negative affect, and positive affect in elite junior athletes. Participants were 233 (123 males and 107 females) adolescent athletes, ranging in age from 15-19 years (M = 17.50; SD = 1.08).Bivariate correlations revealed that mindfulness had a significant negative relationship with both perceived stress and burnout. To investigate mediation, we employed nonparametric bootstrapping analyses. These analyses indicated that positive affect fully mediated links between mindfulness and sport devaluation. Further, positive affect and negative affect partially mediated the relationships between mindfulness and physical/emotional exhaustion, as well as between mindfulness and reduced sense of accomplishment. The results point toward mindfulness being negatively related to burnout in athletes and highlight the role of positive affect. Future research should investigate the longitudinal effect of dispositional mindfulness on stress and burnout.
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| 36. |
- Gustafsson, Lena, et al.
(författare)
-
Rapid ecological response and intensified knowledge accumulation following a north European mega-fire
- 2019
-
Ingår i: Scandinavian Journal of Forest Research. - : Informa UK Limited. - 0282-7581 .- 1651-1891. ; 34:4, s. 234-253
-
Forskningsöversikt (refereegranskat)abstract
- Deepened knowledge on response of biota and ecological processes following fire is essential for a future with warmer climate and more disturbances. In 2014 the first mega-fire (13,100 ha) for at least a century in Scandinavia hit south-central Sweden, in a production forest landscape shaped by clearcutting forestry. Ecological dynamics is followed in >20 projects from universities, authorities and citizen science initiatives, rapidly accumulating substantial amounts of data. We outline projects and summarize their results during the first four years, demonstrating a rapid succession of fungi, lichens, vascular plants, birds, mammals, ticks, butterflies, beetles, and drastically altered carbon dynamics. We characterize forest operations including regeneration measures and point to patterns in pest and pathogen infestations. 8,000 ha is set aside for natural succession, with the rest harvested and managed for forest production, offering excellent opportunities for studies on salvage logging effects, already evident for birds. We demonstrate a strong regrowth of deciduous trees, and the protected part will in some decades likely develop into the largest deciduous-dominated area in boreal north Europe outside Russia. Continued studies of biodiversity and ecological processes are urgent for this unique area.
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| 37. |
- Gustafsson, Mats, et al.
(författare)
-
Att överväga geologin. En idéskrift om geovetenskapliga värden i vägplaneringen
- 2016
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Landskapets geologi, former och andra naturgivna egenskaper har en förhållandevis undanskymd roll i dagens infrastrukturplanering jämfört med den vikt som läggs vid biologiska och ekologiska företeelser och egenskaper. Många gånger är det dessutom endast extremföreteelser som lyfts fram i samband med infrastrukturplaneringen medan det så kallade vardagslandskapet får träda tillbaka, trots att det har en viktig roll för förståelsen av landskapet. Föreliggande rapport visar ett angreppssätt där geovetenskapliga värden inom ett givet geografiskt område definieras i olika teman utifrån en kombination av fältstudier samt historiska och moderna kartor. De tema som används i rapporten baseras delvis på begreppet geodiversitet och omfattar geovetenskapliga egenvärden/pedagogiska värden, ekologiska geovärden, kulturhistoriska geovärden samt geovärden med betydelse för fritid och rekreation. Arbetet har utförts inom det geologiska kartbladet Linköping NV.
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| 38. |
- Gustafsson, Mats, 1966-, et al.
(författare)
-
Driftåtgärder mot PM10 i Stockholm : utvärdering av vintersäsongen 2013–2014
- 2015
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Sedan 2011 pågår ett intensifierat arbete för att sänka halterna av PM10 i Stockholm, där problemen är omfattande. Denna rapport presenterar resultat och utvärdering av insatserna gjorda under vintersäsongen 2013–2014. De lägsta PM10-halterna sedan mätningarna startade i Stockholm, uppmättes under säsongen och miljökvalitetsnormen klaras med bred marginal, vilket åtminstone delvis kan bedömas vara en effekt av de intensifierade åtgärderna. Vintern var dock ovanligt mild och snöfattig och har sannolikt bidragit till att de vanligtvis stora dammängder som ansamlas på vägytan i snö och fukt under vintern kunnat lämna systemet genom suspension, städning och avrinning utan att resultera i höga partikelhalter. Under de torra perioderna har dessutom frekvent dammbindning dämpat halterna. Den vanligtvis kraftiga PM10-toppen på våren har därför i stort sett uteblivit. Den kvartersvisa behandlingen visade sig ge ytterligare effekt på PM10-halterna, medan CMA (kalciummagnesiumacetat) + KF (kaliumformiat) inte kunde visas ha någon extra effekt. Mätningarna av vägdammsförrådet uppvisar samma säsongsvariationer som tidigare år, med stora mängder under vintern och mindre mängder under höst och sen vår. Alla gator, utom Hornsgatan, uppvisar en successiv sänkning av vägdammsmängderna under de tre säsonger som mätningar utförts. Andelen partiklar mindre än 10 μm i vägdammet stiger från höst till vinter och avtar igen under våren. Den organiska andelen varierar i genomsnitt mellan 10 och 20 viktprocent av DL180 (dust load mindre än 180 μm).och uppvisar också en säsongsvariation, där andelen är högre på hösten och som lägst tidig vår. I en specifik utvärdering av städmaskinens effekt på vägdammsförrådet kunde en minskning observeras.
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| 39. |
- Gustafsson, Mats, 1966-, et al.
(författare)
-
Driftåtgärder mot PM10 i Stockholm : utvärdering av vintersäsongen 2014–2015
- 2016
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Sedan 2011 pågår ett intensifierat arbete för att sänka halterna av PM10 i Stockholm. Denna rapport presenterar resultat och utvärdering av insatserna gjorda under vintersäsongen 2014–2015. Säsongen uppvisar de lägsta PM10-halterna samt lägst antal dygn över miljökvalitetsnormen för PM10 sedan mätningarna startades i Stockholm år 2000. Beräkningar med NORTRIP-modellen visar att såväl ökad dammbindning, minskad dubbdäcksanvändning, lägre bakgrundshalt som skillnader i meteorologi alla är faktorer som bidragit till att halterna har sjunkit från 2013 till 2015. Behandling med CMA+KF (kaliumformiat) kunde inte visas ge någon extra effekt på PM10-halterna, medan den kvartersvisa dammbindningen gav en ytterligare, men ej statistiskt säkerställd, positiv effekt.Dammförrådet på vägytan har på alla studerade gator utom Hornsgatan en sjunkande trend de senaste tre åren och uppvisar, liksom tidigare säsonger, en säsongsbunden variation med stora mängder på vinter och tidig vår och låga i oktober och maj. Detaljerade mätningar uppvisar en kraftig variation i dammförrådet tvärs gatorna, med stora ansamlingar utanför körfältet. Vägytans textur bedöms spela en viktig roll för dammets ansamling då den påverkar såväl uppvirvlingen från trafiken, som möjligheten att städa bort dammet. Rapporten ger, utifrån säsongens resultat i kombination med data om åtgärder och meteorologi, några förslag till hur åtgärderna kan förbättras och ger även exempel på hur extra behov eller onödiga insatser kan sökas fram ur befintlig data.
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| 40. |
- Gustafsson, Mats, 1966-, et al.
(författare)
-
Driftåtgärder mot PM10 i Stockholm : utvärdering av vintersäsongen 2015–2016
- 2017
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Sedan 2011 pågår ett särskilt arbete i Stockholm för att minska PM10-halterna i staden. Insatserna omfattar främst dammbindning med CMA (kalciummagnesiumacetat) och vakuumsugning med en kraftig, torr vakuumsugningsmaskin. Denna rapport sammanfattar effekter på partikelhalter och vägdammsförråd, av de åtgärder som Stockholms stad utfört under säsongen 2015–2016 och diskuterar hur åtgärderna kan ytterligare förbättras. Miljökvalitetsnormen klarades säsongen 2015–2016 för tredje året i rad, men antalet dagar med PM10-halter över miljökvalitetsnormens gränsvärde var högre än föregående säsong, som hade rekordlågt antal överskridanden. Utvärderingen av dagtids dammbindning försvårades av att CMA även lades ut på referensgatan, vilket medförde alltför stora osäkerheter för att kunna göra någon kvantitativ analys av dess effekt denna säsong. Kvartersvis dammbindning och vakuumsugning kunde inte utvärderas på grund av att en byggarbetsplats kontaminerade mätningarna. Dammförrådet på gatorna varierar från några enstaka g/m2 till cirka 250 g/m2 beroende på gata och årstid och är som högst under vintern (dec–jan). En trend mot lägre dammängder bryts denna säsong på flera gator, vilket möjligen kan bero på jämförelsevis fuktigare gator på våren denna säsong. Analyserna tyder på att dammbindning på våren är viktigt för att hålla PM10-halterna nere, medan dammbindning på hösten och vintern oftare görs ”i onödan” (då halterna sannolikt inte skulle ha överskridit gränsvärdet även utan dammbindning).
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| 41. |
- Gustafsson, Mats, 1966-, et al.
(författare)
-
Driftåtgärder mot PM10 i Stockholm : utvärdering av vintersäsongen 2016/2017
- 2018
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Stockholms stad bedriver sedan 2011 ett arbete med att, genom förbättrade och specifika gatudriftsåtgärder minska uppvirvlingen av vägdamm för att minska partikelhalter i luften. Sedan starten har effekterna på såväl dammförråd som luftkvalitet följts upp av VTI och SLB-analys vid Miljöförvaltningen i Stockholm.Specifika åtgärder har omfattat främst dammbindning med kalciummagnesiumacetat (CMA) och städning med vakuumsug (Disa-Clean). Luftkvalitetsmätningarna visar att miljökvalitetsnormen för PM10 klaras för fjärde året i Stockholm vilket delvis bedöms beror på driftåtgärderna. Den extra dagtida dammbindningen kunde visas sänka dygnsmedelvärdet av PM10 med 6 %, medan den kvartersvisa behandlingen inte kunde visas ha någon tydlig effekt. Vägdammsmängderna mätt som DL180 (vägdamm mindre än 180 μm) tenderar att i genomsnitt ha ökat något jämfört med föregående säsong, särskilt i ytorna mellan hjulspåren. Omläggningen av Folkungagatan har resulterat i kraftigt ökade vägdammsmängder, men också lägre PM10-halter än föregående säsonger. Utvärderingen av möjligheterna att optimera dammbindningen visar att flera dagar med överskridanden på hösten missas, medan flera dagar i januari behandlas med CMA utan att behov egentligen föreligger. Högre precision med prognosbaserade åtgärder behövs för optimering av insatserna.
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| 42. |
- Gustafsson, Mats, 1966-, et al.
(författare)
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Driftåtgärder mot PM10 i Stockholm : utvärdering av vintersäsongen 2017–2018
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Stockholms stad bedriver sedan 2011 ett arbete med att, genom förbättrade och specifika gatudriftsåtgärder, minska uppvirvlingen av vägdamm för att minska partikelhalter i luften. Sedan starten har effekterna på såväl dammförråd som luftkvalitet följts upp av VTI och SLB-analys vid Miljöförvaltningen i Stockholm. Specifika åtgärder har omfattat främst dammbindning med kalciummagnesiumacetat (CMA) och städning med vakuumsug (Disa-Clean). Innevarande säsong har vakuumsugen dock inte använts. Luftkvalitetsmätningarna visar att miljökvalitetsnormen för PM10 klaras för femte året i Stockholm, men halterna är högre än föregående år. Vägdammsmängderna mätt som DL180 (vägdamm mindre än 180 μm) har generellt ökat vilket varit utvecklingen sedan säsongen 2014–2015. Folkungagatan, som fick en ny beläggning 2016, har fortsatt höga vägdammsmängder, men också lägre PM10-halter än före beläggningsbytet. Utvärderingen av möjligheterna att optimera dammbindningen visar att CMA ofta läggs ut trots att PM10-halterna inte skulle överskridits. Maj var särskilt torr och flera överskridanden kunde då ha förhindrats med CMA, men åtgärden avslutas sista april på grund av risk för halka. Högre precision med till exempel prognosbaserade åtgärder skulle sannolikt vara gynnsamt för optimering av insatserna.
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| 43. |
- Gustafsson, Mats, 1966-, et al.
(författare)
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Mätning av luftkvalitet vid TestSite E18
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Mätningar av luftkvalitet (PM10 och NOX (NO och NO2)) har genomförts under perioden 2013-03-16 till 2014-03-26 vid Testsite E18, belägen längs E18 mellan Västerås och Enköping. Vid Testsite E18 görs kontinuerliga mätningar av trafik (i östgående riktning) och meteorologi (temperatur, luftfuktighet, nettoinstrålning, vindstyrka, vindriktning). På platsen fanns även under mätperioden optisk utrustning för mätning av vägfukt. Huvudsyftet med mätningarna är att skapa ett dataunderlag för en motorvägsmiljö, som i ett senare skede kan användas för modellering av luftkvalitet och beräkning av exponering och hälsoeffekter. Resultaten visar att halterna inte överskrider gällande miljökvalitetsnormer. PM10 och NO2 är högst under vår och höst och lägre under sommarperioden. Korrelationen mellan PM10 och kvävoxider är höga på våren, låga på sommaren och medelhöga på hösten och vintern, vilket tyder på att källorna till PM10 sommartid på Testsite E18 i huvudsak är andra än trafiken. Vägytans fuktighet reducerar PM10-halterna tydligt under våren då vägdamm är en viktig partikelkälla. På dygnsbasis följer kvävedioxidhalterna och PM10 trafikflödena, men med ett tydligare sekundärt minimum mitt på dagen för kväveoxider. Testsite E18 genererar stora datamängder om trafik och meteorologi, som kan användas för att analysera samband mellan dessa faktorer och luftföroreningar på platsen. Dessa data kan också användas för utveckling och validering av emissionsmodeller, t.ex. NORTRIP.
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| 44. |
- Gustafsson, Mats, 1966-, et al.
(författare)
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Optidrift : optimerad vinter- och barmarksdrift för bättre luftkvalitet
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Drift av gator och vägar påverkar, förutom framkomlighet och säkerhet, även miljöaspekter som luftkvalitet. Åtgärder som sandning och saltning påverkar halten av inandningsbara partiklar (PM10) i luften. Driftåtgärder som görs för att minska uppvirvlingen av partiklar på våren kan å andra sidan ha effekt på vinterdriften, genom att de saltlösningar som används också fungerar som halkbekämpningsmedel. Projektet har undersökt möjligheterna att optimera gatudriften ur dessa aspekter, med ett fokus på luftkvalitet. I olika aktiviteter inhämtades synpunkter och erfarenheter kring problembild och lösningar från bransch, väghållare och praktiker. En provtagare för vägdamm, WDS II, vidareutvecklades. Utvärderingar av olika spol- och städvarianters effekt på dammförrådet visade att en positiv effekt av metoderna kräver att det finns förhållandevis mycket damm på vägytan. Optimeringstester visade att god prognosstyrning av insatserna är viktigt för ett bra resultat. En kriteriebaserad analys visade att ingen optimering av dammbindningen skett under projektperioden. Sammantaget har projektets ursprungliga mål att kunna föreslå en optimerad gatudrift i en stadsdel i Stockholm inte nåtts, främst beroende av gällande driftkontrakt och av miljökvalitetsmålets (PM10) och framkomlighetens höga prioritet i staden. Däremot har Optidrift identifierat framgångsfaktorer och problem med gatudriften, resulterat i ökad kunskap om gatudriftens effekter på dammförråd och luftkvalitet samt tagit fram användbara utvärderingsmetoder och scenarioanalyser användbara i fortsatt arbete med att förbättra och optimera vinter- och barmarksdrift.
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| 45. |
- Gustafsson, Mats, 1966-, et al.
(författare)
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Particles in road and railroad tunnel air : sources, properties and abatement measures
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- High levels of air pollution are a common problem in both road and railroad tunnels. Sources and emission processes however differ significantly, as reflected by aerosols physical and chemical properties. As particle concentrations and properties affect exposure of and health effects for people on platforms and in vehicles, effective ways to reduce emissions and exposure are important. This study aims to improve the knowledge of the differences between PM10 in the rail and road tunnel environments, their sources and the possibilities to address problems with high particulate levels. Measurement campaigns were carried out at Arlanda Central, a railroad tunnel station below Arlanda airport and in Söderleden road tunnel, a road tunnel in central Stockholm.The results show large differences in concentration levels, size distributions and in composition of the particles. The railroad tunnel aerosol consisted of coarse particles with high iron content, while the properties of the coarse particles in the road tunnel were strongly influenced by whether the road surface was wet or dry. In wet conditions, concentrations were relatively low and iron and sulfur dominating elements, while silicon, potassium, calcium and iron from suspension and road wear dominated during dry conditions. The content of elemental carbon, most likely from the pantograph, were unexpectedly high in the railroad tunnel. An older type of train with a large proportion of mechanical brakes were suggested to be responsible to the main particle emissions in the railway tunnel. The report concludes with a discussion and proposals for action against particle sources in the various underground environments.
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| 46. |
- Gustafsson, Mats, 1966-, et al.
(författare)
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Road dust load dynamics and influencing factors for six winter seasons in Stockholm, Sweden
- 2019
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Ingår i: Atmospheric Environment: X. - : Elsevier BV. - 2590-1621.
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Tidskriftsartikel (refereegranskat)abstract
- Traffic related non-exhaust particulate sources and road dust are an increasingly important source for PM10 air pollution as exhaust sources are decreasing due to regulations. In the Nordic countries, the road dust problem is enhanced by use of studded tyres, causing increased road wear and winter road maintenance including gritting. Efforts to reduce road dust emissions requires knowledge on temporal and spatial road dust load dynamics. The city of Stockholm, Sweden, has therefore financed seasonal (October to May) road dust sampling to be able to optimize their winter and spring time street operation measures for reduced road dust emissions. This work describes the outcome of six seasons (2011/2012–2016/2017) of road dust sampling in five central streets using the VTI wet dust sampler (WDS).The results show that road dust load, expressed as DL180 (dust load smaller than 180 μm) has a seasonal variation with the highest loads (up to 200 g/m2) in late winter and early spring and a minimum (down to about 15 g/m2) in early autumn and late spring. The dust load varies between streets and is depending on pavement surface properties. On a smaller scale the dust load has a high variability across streets due to differences in rates of suspension from different parts of the road surface, with low amounts in wheel tracks and higher in-between and outside the tracks. Between 2 and 30% of the DL180 is smaller than 10 μm and could directly contribute to PM10 emissions. In general, higher road surface texture leads to higher dust loads, but the condition of the pavement (e.g. cracks, aggregate loss) might also have an effect. A new, wear resistant pavement accumulated markedly higher road dust amounts than a several years old pavement. This paper closes with a discussion on the complex relation between road dust load and PM10 concentrations and a discussion on the challenges and comparability of road dust sampling techniques and measures.
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| 47. |
- Gustafsson, Oscar, 1989, et al.
(författare)
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An assessment of Bayesian IVIM model fitting
- 2016
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Ingår i: ISMRM 2016 Annual Meeting. 7-13 May, Singapore. - : International Society for Magnetic Resonance in Medicine.
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Konferensbidrag (refereegranskat)abstract
- Bayesian model fitting has been proposed as an alternative to the commonly used least squares fitting of the IVIM model. In this work we used Monte Carlo simulations to study the convergence of a Markov Chain Monte Carlo implementation of Bayesian model fitting and compared the resulting model parameters to two least squares model fitting methods. We saw that the convergence of the Bayesian model fitting procedure was affected by noise and compartment sizes. Bayesian model fitting was beneficial for the diffusion coefficient and the perfusion fraction, especially at low SNR
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| 48. |
- Gustafsson, Oscar, 1989, et al.
(författare)
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Can Cramer-Rao Lower Bound be used to find optimal b-values for IVIM?
- 2016
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Ingår i: ISMRM 2016 Annual Meeting. 7-13 May, Singapore. - : International Society for Magnetic Resonance in Medicine.
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Konferensbidrag (refereegranskat)abstract
- Cramer-Ráo Lower Bound is commonly used in experiment design optimization. Here we use it to find optimal b-value schemes for IVIM imaging. The optimization was generalized with regard to averaging and the characteristics of the results, given the input and the constraints, were studied. The resulting schemes never included more than the minimum number of four unique b-values, even though multiple sets of tissue parameters were included in the optimization. The optimized b-value schemes were compared to a typical one using simulations.
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| 49. |
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| 50. |
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