| 1. |
|
|
| 2. |
- Höjer, Ingrid, 1953, et al.
(författare)
-
Recognition of education and schooling in case files for children and young people placed in out-of-home care
- 2018
-
Ingår i: Children and youth services review. - : Elsevier BV. - 0190-7409. ; 93, s. 135-142
-
Tidskriftsartikel (refereegranskat)abstract
- © 2018 Elsevier Ltd The aim of the article is to describe and discuss how issues related to schooling and educational achievement are recognized and addressed in social services case files for children and young people placed in out-of-home care (OHC) in the city of Gothenburg, Sweden. Four cohorts were included in the study: children born 1967, 1977, 1987 and 1992. 40 case files were selected from each cohort (38 from the 1977 cohort), in total 158 cases. The analyses were made through a counting of rows related to schooling and education in the documents. Results were then processed in the statistical program SPSS. The results show that the level of recognition of schooling/education was low, and that it was more frequent when the child/young person had behaviour problems and/or was placed in residential care. Little attention was paid to changes of schools. On a positive note, there was an increased attention to education and schooling for the two latter cohorts (1987, 1992), and the involvement of children, young people and parents was also more visible. To conclude, the acknowledgement of schooling and education that should be present in all placements in OHC was not generally visible in the documents in the case files, although the level of attention had increased. The message for practice is that this issue need more attention on several levels: better planning for the transition between old and new school, a developed cooperation between social services, foster/residential care and schools and a pro-active approach from social services concerning education and schooling.
|
|
| 3. |
|
|
| 4. |
- Collen, Anna-Clara, 1970, et al.
(författare)
-
Cardiac structure and function is related to current blood pressure rather than to previous hypertensive pregnancy
- 2015
-
Ingår i: Journal of Human Hypertension. - : Springer Science and Business Media LLC. - 0950-9240 .- 1476-5527. ; 29:11, s. 702-704
-
Tidskriftsartikel (refereegranskat)abstract
- One-hundred five women were examined with echocardiography and ambulatory blood pressure measurements 40 years post partum to evaluate the effect of former hypertensive pregnancies versus current blood pressure on cardiac structure and function. Hypertensive pregnancies did not have an adverse effect on the heart, but current minor elevation in blood pressure had a negative impact on the myocardium. The increased prevalence of hypertension following hypertensive pregnancies may be a crucial factor regarding the increased risk for cardiovascular disease shown in affected women.
|
|
| 5. |
- Collen, Anna-Clara, 1970, et al.
(författare)
-
Cardiovascular response to stress and perceived stress is not altered 40 years after hypertensive pregnancies
- 2015
-
Ingår i: Hypertension in Pregnancy. - : Informa UK Limited. - 1064-1955 .- 1525-6065. ; 34:1, s. 116-124
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: Women experiencing hypertensive pregnancies have an increased risk for cardiovascular disease. Whether stress increase the risk is unknown. The objective was to test if cardiovascular response to stress and/or perceived stress differed in relation to blood pressure status during pregnancy 40 years earlier. Methods: Cardiovascular response was examined with mental stress test, and perceived stress was evaluated with a questionnaire in 105 women. Results: Resting heart rate was higher, and pulse reactivity was lower in women with previous hypertensive pregnancies. Neither blood pressure nor perceived stress differed. Conclusion: Response to physical or psychological stress is not affected many years after pregnancy.
|
|
| 6. |
- Dahlgren, Madelene, et al.
(författare)
-
T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells
- 2015
-
Ingår i: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 194:11, s. 5187-5199
-
Tidskriftsartikel (refereegranskat)abstract
- Development of long-lived humoral immunity is dependent on CXCR5-expressing T follicular helper (Tfh) cells, which develop concomitantly to effector Th cells that support cellular immunity. Conventional dendritic cells (cDCs) are critical APCs for initial priming of naive CD4(+) T cells but, importantly, also provide accessory signals that govern effector Th cell commitment. To define the accessory role of cDCs during the concurrent development of Tfh and effector Th1 cells, we performed high-dose Ag immunization in conjunction with the Th1-biased adjuvant polyinosinic: polycytidylic acid (pI:C). In the absence of cDCs, pI: C failed to induce Th1 cell commitment and IgG2c production. However, cDC depletion did not impair Tfh cell differentiation or germinal center formation, and long-lived IgG1 responses of unaltered affinity developed in mice lacking cDCs at the time point for immunization. Thus, cDCs are required for the pI: C-driven Th1 cell fate commitment but have no crucial accessory function in relation to Tfh cell differentiation.
|
|
| 7. |
- Danielsson, Helena, et al.
(författare)
-
Förstudie F-gaser : Identifiering av delar i den svenska beräkningsmodellen där förbättringspotential finns
- 2016
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Projektets syfte är att hitta möjliga vägar att förbättra den svenska beräkningsmodellen för emissioner av F-gaser. Genom att jämföra den svenska rapporteringen med andra jämförbara länders har delar identifierats i Sveriges rapportering som särskilt viktiga att se över, verifiera eller korrigera. Detta gäller framför allt uppdelning av emissioner av F-gaser från kommersiell, industriell och stationär kyla som idag rapporteras sammanslaget. Det är också viktigt att läckagefaktorerna ses över för dessa koder. Även för kyltransporter och mobil luftkonditionering bör läckagefaktorer ses över och verifieras eller eventuellt korrigeras, för mobil luftkonditionering framför allt för senare år. Mängder F-gaser i importerade produkter bör utredas vidare för att i ett första steg få en uppfattning om storleksordningen. Detta gäller bland annat F-gaser i importerade vägfordon, arbetsmaskiner, tåg och båtar. Slutligen finns anledning att undersöka hur stora mängder SF6 som används som spårgas, som elektrisk isolergas vid sterilisering med elektronstrålning av medicinsk utrustning samt förekomst i läkemedel.
|
|
| 8. |
|
|
| 9. |
- Fritz, Helena, et al.
(författare)
-
The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.
- 2015
-
Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:8
-
Tidskriftsartikel (refereegranskat)abstract
- High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.
|
|
| 10. |
- Golubinskaya, Veronika, 1974, et al.
(författare)
-
Bestrophin-3 Expression in a Subpopulation of Astrocytes in the Neonatal Brain After Hypoxic-Ischemic Injury
- 2019
-
Ingår i: Frontiers in Physiology. - : Frontiers Media SA. - 1664-042X. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Bestrophin-3, a potential candidate for a calcium-activated chloride channel, recently was suggested to have cell-protective functions. We studied the expression and alternative splicing of bestrophin-3 in neonatal mouse brain and after hypoxic-ischemic (HI) injury and in human neonatal brain samples. HI brain injury was induced in 9-day old mice by unilateral permanent common carotid artery occlusion in combination with exposure to 10% oxygen for 50 min. Endoplasmic reticulum stress was induced by thapsigargin treatment in primary culture of mouse brain astrocytes. We also investigated expression of bestrophin-3 protein in a sample of human neonatal brain tissue. Bestrophin-3 protein expression was detected with immunohistochemical methods and western blot; mRNA expression and splicing were analyzed by RT-PCR. HI induced a brain tissue infarct and a pronounced increase in the endoplasmic reticulum-associated marker CHOP. Three days after HI a population of astrocytes co-expressed bestrophin-3 and nestin in a penumbra-like area of the injured hemisphere. However, total levels of Bestrophin-3 protein in mouse cortex were reduced after injury. Mouse astrocytes in primary culture also expressed bestrophin-3 protein, the amount of which was reduced by endoplasmic reticulum stress. Bestrophin-3 protein was detected in astrocytes in the hippocampal region of the human neonatal brain which had patchy white matter gliosis and neuronal loss in the Sommer's sector of the Ammon's horn (CA1). Analysis of bestrophin-3 mRNA in mouse brain with and without injury showed the presence of two truncated spliced variants, but no full-length mRNA. Total amount of bestrophin-3 mRNA increased after HI, but showed only minor injury-related change. However, the splice variants of bestrophin-3 mRNA were differentially regulated after HI depending on the presence of tissue injury. Our results show that bestrophin-3 is expressed in neonatal mouse brain after injury and in the human neonatal brain with pathology. In mouse brain bestrophin-3 protein is upregulated in a specific astrocyte population after injury and is co-expressed with nestin. Splice variants of bestrophin-3 mRNA respond differently to HI, which might indicate their different roles in tissue injury.
|
|
| 11. |
- Golubinskaya, Veronika, 1974, et al.
(författare)
-
Bestrophin-3 is differently expressed in normal and injured mouse glomerular podocytes.
- 2015
-
Ingår i: Acta physiologica (Oxford, England). - : Wiley. - 1748-1716 .- 1748-1708. ; 214:4, s. 481-496
-
Tidskriftsartikel (refereegranskat)abstract
- Bestrophins are putative calcium-activated chloride channels. Recently cell-protective functions for Bestrophin-3 (Best3) were proposed. Best3 exists in different splice variants. We have here examined expression, alternative splicing and localization of Best3 in mouse podocytes under normal conditions and during endoplasmic reticulum (ER) stress.
|
|
| 12. |
- Gustafsson, Anna, et al.
(författare)
-
Gas6-Axl signaling in presence of Sunitinib is enhanced, diversified and sustained in renal tumor cells, resulting in tumor-progressive advantages
- 2017
-
Ingår i: Experimental Cell Research. - : Elsevier BV. - 0014-4827. ; 355:1, s. 47-56
-
Tidskriftsartikel (refereegranskat)abstract
- Clear Cell Renal Cell Carcinoma (CCRCC) is a lethal cancer with bad prognosis due to development of chemoresistance and recurrence of more aggressive tumors. Investigation of Gas6-mediated Axl signaling in CCRCC and endothelial cells reveals a Sunitinib resistant Gas6-Axl signaling that is sustained and enhanced and specifically triggers downstream AKT and PRAS40 activation in an intensified manner. Gas6-induced Axl signaling in presence of Sunitinib is also diversified displaying onset of Axl-dependent EGFR and METR activation and activation of classical MAPK pathways. Gas6+Sunitinib-adapted CCRCC cells present increased viability and decreased apoptosis and enhanced production of the multi-tumorigenic Osteopontin (OPN) and of one of its activator matrix metalloproteinase-7. Axl activity is necessary for CCRCC cell sphere formation and the ability of the cells to attach after non-adhesive growth. In addition, Gas6+Sunitinib-adapted CCRCC cells displayed enhanced migration and sphere formation, both mechanisms being Axl and OPN dependent. Altogether, this suggests that Sunitinib while targeting endothelial cells and tumor angiogenesis, simultaneously provides protumorigenic effects due to a constitutively, intensified and divergent Gas6-Axl system. Implications: Gas6-mediated Axl signaling, which is enhanced and diversified in the presence of Sunitinib possibly contributes to acquired chemoresistance, recurrence of aggressive disease and metastasis of CCRCC tumors. Therefore, combinatorial Axl-targeted therapy might be beneficial for CCRCC patients intended for Sunitinib treatment.
|
|
| 13. |
|
|
| 14. |
- Gustafsson (Emilsson), Sara, Biträdande professor, 1974-, et al.
(författare)
-
Lokal implementering av Agenda 2030 och Globala målen : en kort översikt av regioners och kommuners erfarenheter, möjligheter och utmaningar
- 2018
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Med Agenda 2030 och FN:s 17 Globala mål för hållbar utveckling initierades en ny era för det globala hållbarhetsarbetet med tydligt fokus på målstyrning, där samverkan och integration är nyckelbegrepp. Globala målen skulle kunna bidra till ett mer proaktivt och allomfattande hållbarhetsarbete genom att arbetet bättre operationaliseras och integreras i såväl internationella, nationella, regionala som lokala policyer och strategier. Men det kan också finnas en risk att denna nya globala Agenda kan leda till det bara är retoriken och inramningen som ändras och inte praktiken. Hur man ska gå tillväga på regional och lokal nivå för att implementera Globala målen finns inte särskilt tydligt beskrivet i Agenda 2030. Det pågår dock mycket aktivitet kopplat till de globala målen på såväl regional som lokal nivå, vilket betyder att erfarenhetsbanken för implementering av de globala målen växer för varje dag.Regioner och kommuner är institutioner som står för kontinuitet och långsiktighet i det lokala och regionala hållbarhetsarbetet. Då flera av målen är av mellankommunal och kommunal art skulle de regionala och lokala nivåerna kunna utgöra eller bidra till plattformar och ha samordnande roller för strategisk samverkan kring hållbarhetsfrågor i allmänhet och de globala målen i synnerhet.Det finns redan ett utvecklat hållbarhetsarbete inom kommuner och regioner. Därför är det viktigt att reflektera över hur det kan förhållas till de Globala målen för undersöka hur de kan integreras i processerna istället för att bli separata projekt. Det är även viktigt att reflektera över redan existerande samverkansformer och arenor. De globala målen skulle kunna ses som ett instrument för att samordna den flora av hållbarhetsinitiativ som redan finns i de regionala och kommunala kontexterna, vilket skulle kunna bidra till att man ökar verkningsfullheten i det existerande hållbarhetsarbetet och ”levlar” (höjer) hållbarhetsprestandan till nästa nivå.Den här rapporten, som är en förstudie, är den första inom forskningsprojektet ”Förbättrad regional och lokalhållbarhetsprestanda genom integrering av FN:s globala hållbarhetsmål (LETS[1]). Projektet fyller en viktig funktion i att samla, sammanställa, analysera och kommunicera erfarenheter och därmed bidra med ny kunskap och inspiration till tillvägagångssätt för regioner och kommuner som står i begrepp att integrera de globala målen. Syftet med den här studien, som är en förstudie till LETS, och den här rapporten är inte att var heltäckande och allomfattande, utan den fyller främst funktionen att utgöra underlag för de kommande etapperna i forskningsprojektet LETS vad gäller tex. urval av djupstudieobjekt, litteratursökning etc. Den ger en översiktlig bild av kunskapsläget våren 2018 med utgångspunkt från forskningsfrågorna i forskningsprojektet LETS. Syftet med att sammanställa det här underlaget i en rapport fyller förhoppningsvis en funktion som inspiration till de kommuner och regioner som idag är i eller ska påbörja processen att implementera Globala målen.Studien baseras på dels en genomgång av vetenskaplig litteratur och andra rapporter och dels en övergripande intervjustudie med miljö/hållbarhetsstrateger (eller motsvarande) i 15 kommuner och 4 regioner i Sverige. Medan litteraturstudien har ett internationellt perspektiv är intervjustudien mer fokuserad till svenska förhållanden (vilket också är fokus för forskningsprojektet LETS).I litteraturundersökningen har vi även gått tillbaka till tidigare globala initiativ, som Agenda 21 och Milleniemålen, för att reflektera över vilka lärdomar som kan dras från dessa processer och hur det kan utnyttjas i arbetet med de Globala målen.De globala målen har beskrivits i en rad olika publikationer under de senaste åren, men är först nyligen dessa har börjat ge exempel på hur målen omsatts i praktik, vilket ju inte är särskilt överraskande. Utifrån de artiklar och rapporter vi studerat för den här rapporten har vi valt ut ett antal teman, utifrån forskningsprojektets övergripande syfte och frågeställningar. Rapporten ger bland annat exempel på de utmaningar och möjligheter med regional och lokal implementering som vi identifierat i litteraturen. Många av både möjligheterna och utmaningarna som litteraturen beskriver handlar om samverkan och det tvärsektoriella arbetssättet. Den inneboende komplexiteten hos de Globala målen seglar upp som en av utmaningarna, och detta kopplat till hur En av utmaningarna, som nämns på flera ställen i litteraturen är Globala målens inneboende komplexitet och svårigheten att anpassa målen och indikatorerna till lokal nivå. Andra utmaningar som identifierats är svårigheten att samla intressenter med rätt kunskap och engagemang. Vidare diskuteras data som en utmaning och då handlar det om tillgång till data och tillgång till tillförlitliga data. Samordning kunskap är andra aspekter som pekas ut som utmaningar. Bland de möjligheter som vi identifierat i litteraturgenomgången. När det gäller utmaningar handlar det mycket om att hållbarhetsarbetet kan få ett uppsving, att det kan underlätta beslutsfattande, öka resurseffektivitet samt underlätta för kunskapsbyggande. Vidare nämns att detta gemensamma ramverk skulle kunna underlätta för att visualisera och jämföra hållbarhetsarbetet mellan olika organisationer samt att det kn underlätta för samarbete kring dessa frågor eftersom man pratar samma hållbarhetsspråk.Det finns även ett stort antal vetenskapliga artiklar och olika rapporter som beskriver olika slags verktyg som ska stötta och underlätta för implementeringen av Globala målen. Det finns verktyg som ger stöd till såväl inventering som mätning och uppföljning. Men det finns också verktyg för att underlätta samverkan mellan olika aktörer.Utifrån de intervjuer vi gjort för den här studien kan vi konstatera att många kommuner och regioner är i uppstartsfasen av att implementera Global målen. Det handlar i stor utsträckning om att integrera målen i strategier och att förankra och kommunicera. Utifrån intervjuerna kan vi utläsa att den främsta potentialen som kommunerna och regionerna i den här studien ser med Globala målen handlar om att få struktur och stöd i sina processer för hållbar utveckling. En annan potential är att få ett gemensamt hållbarhetsspråk som fungerar över organisationsgränser och nationsgränser. De hinder som kommunerna och regionerna upplever är framförallt koppade till svårigheten att konkretisera Globala målen och att omsätta dem i lokal praktik i kärnverksamheten. En annan utmaning som flera nämnde var svårigheten att mäta och följa upp arbetet med målen.Trots att vi har identifierat en mängd utmaningar, både genom litteraturgenomgången och i de intervjuer vi gjort för den här studien, ser vi också att det finns en tilltro till och en potential i att implementera Globala målen i regioner och kommuner. Genom att utgå från redan existerande hållbarhetsarbete, identifiera vad som redan görs och hur det kan stärkas upp genom tydligare koppling till Globala målen skulle de kunna underlätta för ett mer sammanhållet och systematiskt hållbarhetsarbete internt i organisationerna men även för samverkan kring dessa frågor med andra aktörer. Tid är en viktig resurs i detta sammanhang och därför behöver det avsättas tid för att jobba med dessa frågor i organisationerna och man måste låta arbetet ta tid. 2030 är inte långt borta, men hållbarhetsarbetet i kommunerna och regionerna behöver ett längre perspektiv än så.
|
|
| 15. |
- Gustafsson, Helena, et al.
(författare)
-
Depression and subsequent risk of Parkinson disease : A nationwide cohort study
- 2015
-
Ingår i: Neurology. - 0028-3878 .- 1526-632X. ; 84:24, s. 2422-2429
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To investigate the long-term risk of Parkinson disease (PD) after depression and evaluate potential confounding by shared susceptibility to the 2 diagnoses.METHODS: The nationwide study cohort included 140,688 cases of depression, matched 1:3 using a nested case-control design to evaluate temporal aspects of study parameters (total, n = 562,631). Potential familial coaggregation of the 2 diagnoses was investigated in a subcohort of 540,811 sibling pairs. Associations were investigated using multivariable adjusted statistical models.RESULTS: During a median follow-up period of 6.8 (range, 0-26.0) years, 3,260 individuals in the cohort were diagnosed with PD. The multivariable adjusted odds ratio (OR) for PD was 3.2 (95% confidence interval [CI], 2.5-4.1) within the first year of depression, decreasing to 1.5 (95% CI, 1.1-2.0) after 15 to 25 years. Among participants with depression, recurrent hospitalization was an independent risk factor for PD (OR, 1.4; 95% CI, 1.1-1.9 for ≥5 vs 1 hospitalization). In family analyses, siblings' depression was not significantly associated with PD risk in index persons (OR, 1.1; 95% CI, 0.9-1.4).CONCLUSIONS: The time-dependent effect, dose-response pattern for recurrent depression, and lack of evidence for coaggregation among siblings all indicate a direct association between depression and subsequent PD. Given that the association was significant for a follow-up period of more than 2 decades, depression may be a very early prodromal symptom of PD, or a causal risk factor.
|
|
| 16. |
- Gustafsson, Helena, et al.
(författare)
-
Kongenital trombotisk trombocytopen purpura - Ett fall med atypisk bild upptäckt i vuxen ålder
- 2019
-
Ingår i: Läkartidningen. - 0023-7205. ; 116:7
-
Tidskriftsartikel (refereegranskat)abstract
- Congenital thrombocytopenic purpura (TTP) is a rare but serious condition. We present a case of a 29-year-old woman, diagnosed with this disease in adulthood. The episode that led to diagnosis was triggered by quetiapine. She presented with neurological symptoms and laboratory findings including low platelets and elevated creatinine. Interestingly, the signs of hemolysis were very subtle. Her symptoms were relieved by withdrawal of the medicine. The diagnosis was confirmed by very low ADAMTS13 activity, lack of antibodies against ADAMTS13 and the presence of a compound heterozygous ADAMTS13 mutation. Despite prophylactic plasma infusions, the patient developed a second episode of microangiopathy, leading to an extensive cerebral infarction. It is possible that even the latter episode was triggered by drugs. We suggest that the diagnosis of TTP should be considered in patients with neurological symptoms and unexplained thrombocytopenia.
|
|
| 17. |
- Gustafsson, Helena, et al.
(författare)
-
Low muscle strength in late adolescence and Parkinson disease later in life
- 2015
-
Ingår i: Neurology. - 0028-3878 .- 1526-632X. ; 84:18, s. 1862-1869
-
Tidskriftsartikel (refereegranskat)abstract
- Objective:To evaluate maximal isometric muscle force at 18 years of age in relation to Parkinson disease (PD) later in life.Methods:The cohort consisted of 1,317,713 men who had their muscle strength measured during conscription (1969-1996). Associations between participants' muscle strength at conscription and PD diagnoses, also in their parents, were examined using multivariate statistical models.Results:After adjustment for confounders, the lowest compared to the highest fifth of handgrip strength (hazard ratio [HR] 1.38, 95% confidence interval [CI] 1.06-1.79), elbow flexion strength (HR 1.34, 95% CI 1.02-1.76), but not knee extension strength (HR 1.24, 95% CI 0.94-1.62) was associated with an increased risk of PD during follow-up. Furthermore, men whose parents were diagnosed with PD had reduced handgrip (fathers: mean difference [MD] -5.7 N [95% CI -7.3 to -4.0]; mothers: MD -5.0 N [95% CI -7.0 to -2.9]) and elbow flexion (fathers: MD -4.3 N [95% CI -5.7 to -2.9]; mothers: MD -3.9 N [95% CI -5.7 to -2.2]) strength, but not knee extension strength (fathers: MD -1.1 N [95% CI -2.9 to 0.8]; mothers: MD -0.7 N [95% CI -3.1 to 1.6]), than those with no such familial history.Conclusions:Maximal upper extremity voluntary muscle force was reduced in late adolescence in men diagnosed with PD 30 years later. The findings suggest the presence of subclinical motor deficits 3 decades before the clinical onset of PD.
|
|
| 18. |
- Gustafsson, Helena, et al.
(författare)
-
Parkinsons Disease : A population-based investigation of life satisfaction and employment
- 2015
-
Ingår i: Journal of Rehabilitation Medicine. - : Medical Journals Sweden AB. - 1650-1977 .- 1651-2081. ; 47:1, s. 45-51
-
Tidskriftsartikel (refereegranskat)abstract
- Objective:To investigate relationships between individuals' socioeconomic situations and quality of life in working-aged subjects with Parkinson's disease.Methods:A population-based cohort comprising 1,432 people with Parkinson's disease and 1,135 matched controls, who responded to a questionnaire. Logistic regression analysis was performed to identify factors associated with life satisfaction and likelihood of employment.Results:In multivariate analyses, Parkinson's disease was associated with an increased risk of dissatisfaction with life (odds ratio (OR) = 5.4, 95% confidence interval (95% CI) = 4.2-7.1) and reduced likelihood of employment (OR = 0.30, 95% CI = 0.25-0.37). Employers' support was associated with greater likelihood of employment (p < 0.001). Twenty-four percent of people with Parkinson's disease for ≥ 10 years remained employed and 6% worked full-time. People with Parkinson's disease also more frequently experienced work demands that exceeded their capacity; this factor and unemployment independently correlated with greater risk of dissatisfaction with life (both p < 0.05).Conclusion:People with Parkinson's disease have an increased risk of dissatisfaction with life. Employment situation is important for general life satisfaction among working-aged individuals. People with Parkinson's disease appear to find it difficult to meet the challenge of achieving a balanced employment situation.
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
- Gustafsson, Markus, et al.
(författare)
-
Risk of Permanent Medical Impairment (RPMI) in Car Crashes Correlated to Age and Gender
- 2015
-
Ingår i: Traffic Injury Prevention. - : Informa UK Limited. - 1538-9588 .- 1538-957X. ; 16:4, s. 353-361
-
Tidskriftsartikel (refereegranskat)abstract
- Objective:As fatalities from car crashes decrease, focus on medical impairment following car crashes becomes more essential. This study assessed the risk of permanent medical impairment based on car occupant injuries. The aim was to study whether the risk of permanent medical impairment differs depending on age and gender.Methods:In total, 36,744 injured occupants in car crashes that occurred between 1995 and 2010 were included. All initial injuries (n = 61,440) were classified according to the Abbreviated Injury Scale (AIS) 2005. If a car occupant still had residual symptoms 3years after a crash, the case was classed as a permanent medical impairment. In total, 5,144 injuries led to permanent medical impairment. The data were divided into different groups according to age and gender as well as levels of permanent impairment. The risk of permanent medical impairment was established for different body regions and injury severity levels, according to the AIS.Results:The cervical spine was the body region that had the highest number of diagnoses, and occupants who sustained injuries to the upper and lower extremities had the highest risk of medical impairment for both genders. Females aged 60 and above had a higher risk of permanent medical impairment from fractures in the extremities compared to males in the same age group and younger females. Females aged 44 or younger had a higher risk of permanent medical impairment from whiplash-associated disorders (WAD) than males in the same age group. Minor and moderate injuries (AIS 1-2) had a higher risk of permanent medical impairment among older car occupants compared to younger ones.Conclusions:Differences in long-term outcome were dependent on both gender and age. Differences between age groups were generally greater than between genders. The vast majority of permanent medical impairments resulted from diagnoses with a low risk of fatality. The results emphasize the impact of age and gender in long-term consequences from car crashes. They could be used when designing safety technology in cars as well as to improve health care by contributing to better allocation of rehabilitation resources following trauma.
|
|
| 22. |
|
|
| 23. |
- Gustafsson, Susanne, 1963, et al.
(författare)
-
A Cross-Cultural Adaptation of the ICECAP-O: Reliability and Validity in Swedish 70-Year-Old Persons
- 2017
-
Ingår i: 21st International Association of Gerontology and Geriatrics (IAGG) World Congress, July 23-27, 2017 San Francisco, California. Innovation in Aging, 1 (S1), s. 752. - : Oxford University Press (OUP). - 2399-5300.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Few Quality of Life (QoL) measures tap into the concept of capability, i.e. genuine opportunities to 'do' and 'be' the things that a person deems important in life. The ICECAP-O is one such instrument. This presentation includes test-retest reliability, item relevance, face- and content validity, and accessibility of the ICECAP-O in a Swedish context. Thirty-nine 70-year-olds who took part in a population-based study completed the Swedish version of the ICECAP-O on two occasions, and another 18 partook in cognitive interviews. Test-retest reliability was analyzed for the index and separate items, and participants rated item relevance on a Visual Analogue Scale. A standardized classification scheme was used to quantify any identified response problems, and a thematic analysis was applied to capture participants’ experiences of completing the measure and perceptions of included attributes. Test-retest showed that the index score had good stability, ICC of 0.80 (95 % CI 0.62-0.90). However, Kappa was low for each separate item, and ranged from 0.18 (Control) to 0.41 (Role). Participants gave their highest relevance rating to Attachment and the lowest to Enjoyment. In the cognitive interviews, three participants (18%) had problems completing ICECAP-O, and out of 80 question segments, judged problems occurred for five (6%). Most participants perceived the attributes as understandable even though the meaning of Control brought some uncertainty. ICECAP-O has potential for becoming a valuable addition to the supply of QoL measures in research and health and social care in Sweden. However, we recommend further research on more diverse groups of older person.
|
|
| 24. |
- Gustafsson, Susanne, 1963, et al.
(författare)
-
Face and content validity and acceptability of the Swedish ICECAP-O capability measure: Cognitive interviews with 70-year-old persons
- 2018
-
Ingår i: Health Psychology Research. - : Open Medical Publishing. - 2420-8124 .- 2281-2075. ; 6:1, s. 1-8
-
Tidskriftsartikel (refereegranskat)abstract
- This study is part of a project that aims to culturally adapt the Investigating Choice Experiments for the Preferences of Older People-CAPability Index (ICECAP-O) for use in research and health and social care in Sweden. The objective was to evaluate face and content validity and acceptability. Eighteen 70-year-old community-dwelling persons participated in cognitive interviews. A standardized classification scheme was used to quantify any identified response problems, and a thematic analysis was applied to capture participants' perceptions of included attributes and experiences of completing the measure. The results show that three participants (18%) had problems completing ICECAP-O, and that judged problems occurred for five (6%) of participants responses in the standardized classification scheme. Most participants perceived the attributes as understandable even though the meaning of Control brought some uncertainty. ICECAP-O seems to measure what it is supposed to measure, quality of life (QoL) with a capability approach, and acceptability is satisfactory. ICECAP-O has potential for becoming a valuable addition to the supply of QoL measures in research and health and social care in Sweden. However, we recommend further research on more diverse groups of older persons.
|
|
| 25. |
- Hellsten, Sofie, et al.
(författare)
-
Påverkan på atmosfäriskt nedfall och luftkvaliten i Sverige av SO2-emissioner från vulkanutbrottet på Island, 2014-2015 : Utvärdering med Krondroppsnätets mätningar och EMEP modellen
- 2017
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Den 31 augusti 2014 till 27 februari 2015 pågick ett vulkanutbrott på Island med utsläpp av svaveldioxid (SO2) i samma storleksordning som de dubbla antropogena utsläppen från Europa under ett år. Merparten av svavelutsläppen från vulkanen skedde under september till november 2014. Vulkanutbrottet påverkade periodvis luftkvaliteten i Sverige, framför allt under september och oktober 2014. och i synnerhet i norra Sverige som normalt har en relativt ren miljö utan större föroreningskällor.Samtliga mätplatser inom Krondroppsnätet visade förhöjda lufthalter av SO2 i september 2014 jämfört med tidigare år. Den uppmätta genomsnittliga SO2-halten i september 2014 över Sverige, var sex gånger så hög som motsvarande treårsmedelvärde för september under 2011-2013. Ökningen var störst i norra Sverige, där lufthalterna var 25 gånger högre än normalt. I södra och mellersta Sverige var ökningen betydligt mindre, ungefär 3 gånger så hög i mellersta Sverige och dubbelt så hög i södra Sverige. Spridningsmodellering med EMEP-modellen visade att över 90 % av SO2-halterna under september 2014 i norra Sverige hade sitt ursprung i SO2-emissioner från vulkanutbrottet.I likhet med lufthalterna ökade svavelnedfallet mest i norra Sverige, men för nedfallet var ökningen störst under oktober månad. Detta kan förklaras av att nederbördsmängden under oktober månad var hög. September månad karaktäriserades av en låg nederbördsmängd, varför en stor mängd av torrdepositionen av svavel från september, det vill säga den deposition som fastnar i trädkronorna, sköljdes ner med regnet och samlades in i krondroppsmätningarna under träd-kronorna först under oktober månad. Detta bidrog till att den totala svaveldepositionen (alltså mätningarna via krondropp) blev hög under oktober.Nedfallet av svavel med nederbörden (våtdepositionen) var ca tre gånger så hög under oktober 2014 över Sverige jämfört med motsvarande treårsmedelvärde för oktober under 2011-2013. Totaldepositionen som krondropp ökade ännu mer och var ca fem gånger högre. Nedfallet ökade mest i norra Sverige, där nedfallet över öppet fält ökade med 350 % och totaldepositionen som krondropp ökade drygt 1200 %. Motsvarande ökning i mellersta Sverige var 270 % för nedfallet över öppet fält och 760 % för totaldepositionen som krondropp. I södra Sverige var ökningen bara 130 % respektive 220 %. Spridningsberäkningen med EMEP-modellen visade att våtdepositions-andelen från vulkanen var mer än 80 % i vissa delar av norra Sverige, under tiden för vulkanutbrottet (september 2014 – februari 2015).Även om mätresultaten visar på kraftiga förhöjningar av SO2-halter och svavelnedfall på månads-basis, så syns effekten inte lika tydligt om man analyserar data för årsmedelvärden (hydrologiska år), framförallt inte i södra och mellersta Sverige. Detta beror framförallt på att inledningen av vulkanutbrottet (september 2014) tillfaller det hydrologiska året 2013/2014, medan återstoden av vulkanutbrottet tillfaller det hydrologiska året 2014/2015. Om man däremot analyserar data på kalenderåret 2014 så syns effekten tydligt i hela landet.Även om det antropogena svavelnedfallet och lufthalterna av SO2 minskat dramatiskt i Sverige under de senaste 30 åren, belyser den här studien vikten av att upprätthålla luftkvalitetsmätningar. Krondroppsnätets mätningar bekräftar inte bara återhämtning, utan är också ett användbart verktyg för att spåra effekterna av specifika föroreningshändelser såsom vulkaniska utsläpp av SO2.
|
|
| 26. |
- Hellsten, Sofie, et al.
(författare)
-
Påverkan på atmosfäriskt nedfall och luftkvaliten i Sverige av SO2-emissioner från vulkanutbrottet på Island, 2014-2015
- 2017
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Den 31 augusti 2014 till 27 februari 2015 pågick ett vulkanutbrott på Island med utsläpp av svaveldioxid (SO2) i samma storleksordning som de dubbla antropogena utsläppen från Europa under ett år. Merparten av svavelutsläppen från vulkanen skedde under september till november 2014. Vulkanutbrottet påverkade periodvis luftkvaliteten i Sverige, framför allt under september och oktober 2014. och i synnerhet i norra Sverige som normalt har en relativt ren miljö utan större föroreningskällor. Samtliga mätplatser inom Krondroppsnätet visade förhöjda lufthalter av SO2 i september 2014 jämfört med tidigare år. Den uppmätta genomsnittliga SO2-halten i september 2014 över Sverige, var sex gånger så hög som motsvarande treårsmedelvärde för september under 2011-2013. Ökningen var störst i norra Sverige, där lufthalterna var 25 gånger högre än normalt. I södra och mellersta Sverige var ökningen betydligt mindre, ungefär 3 gånger så hög i mellersta Sverige och dubbelt så hög i södra Sverige. Spridningsmodellering med EMEP-modellen visade att över 90 % av SO2-halterna under september 2014 i norra Sverige hade sitt ursprung i SO2-emissioner från vulkanutbrottet. I likhet med lufthalterna ökade svavelnedfallet mest i norra Sverige, men för nedfallet var ökningen störst under oktober månad. Detta kan förklaras av att nederbördsmängden under oktober månad var hög. September månad karaktäriserades av en låg nederbördsmängd, varför en stor mängd av torrdepositionen av svavel från september, det vill säga den deposition som fastnar i trädkronorna, sköljdes ner med regnet och samlades in i krondroppsmätningarna under träd¬kronorna först under oktober månad. Detta bidrog till att den totala svaveldepositionen (alltså mätningarna via krondropp) blev hög under oktober. Nedfallet av svavel med nederbörden (våtdepositionen) var ca tre gånger så hög under oktober 2014 över Sverige jämfört med motsvarande treårsmedelvärde för oktober under 2011-2013. Totaldepositionen som krondropp ökade ännu mer och var ca fem gånger högre. Nedfallet ökade mest i norra Sverige, där nedfallet över öppet fält ökade med 350 % och totaldepositionen som krondropp ökade drygt 1200 %. Motsvarande ökning i mellersta Sverige var 270 % för nedfallet över öppet fält och 760 % för totaldepositionen som krondropp. I södra Sverige var ökningen bara 130 % respektive 220 %. Spridningsberäkningen med EMEP-modellen visade att våtdepositions¬andelen från vulkanen var mer än 80 % i vissa delar av norra Sverige, under tiden för vulkanutbrottet (september 2014 – februari 2015). Även om mätresultaten visar på kraftiga förhöjningar av SO2-halter och svavelnedfall på månads-basis, så syns effekten inte lika tydligt om man analyserar data för årsmedelvärden (hydrologiska år), framförallt inte i södra och mellersta Sverige. Detta beror framförallt på att inledningen av vulkanutbrottet (september 2014) tillfaller det hydrologiska året 2013/2014, medan återstoden av vulkanutbrottet tillfaller det hydrologiska året 2014/2015. Om man däremot analyserar data på kalenderåret 2014 så syns effekten tydligt i hela landet. Även om det antropogena svavelnedfallet och lufthalterna av SO2 minskat dramatiskt i Sverige under de senaste 30 åren, belyser den här studien vikten av att upprätthålla luftkvalitetsmätningar. Krondroppsnätets mätningar bekräftar inte bara återhämtning, utan är också ett användbart verktyg för att spåra effekterna av specifika föroreningshändelser såsom vulkaniska utsläpp av SO2. This report is only available in Swedish. English summary is available in the report.
|
|
| 27. |
- Hörder, Helena M, et al.
(författare)
-
A Cross-Cultural Adaptation of the ICECAP-O : Test–Retest Reliability and Item Relevance in Swedish 70-Year-Olds
- 2016
-
Ingår i: Societies. - : MDPI. - 2075-4698. ; 6:4
-
Tidskriftsartikel (refereegranskat)abstract
- Background: While there is a plethora of Quality of Life (QoL) measures, the Investigating Choice Experiments for the Preferences of Older People—CAPability index (ICECAP-O) is one of the few that taps into the concept of capability, i.e., opportunities to 'do' and 'be' the things that one deems important in life. We aimed to examine test–retest reliability of the ICECAP-O in a Swedish context and to study item relevance.Methods: Thirty-nine 70-year-olds who took part in a population-based health study completed the Swedish version of the ICECAP-O on two occasions. We analyzed the test–retest reliability for the index and for the individual items. Participants also rated the relevance of each item on a visual analogue scale (0–100).Results: Test–retest reliability for the index score was in good agreement with an ICC of 0.80 (95% CI 0.62–0.90). However, Kappa was low for each item and ranged from 0.18 (control) to 0.41 (role). For attachment, we found a systematic disagreement with lower ratings at the second test occasion. Participants gave their highest relevance rating to attachment and lowest to enjoyment.Conclusion: The Swedish version of the ICECAP-O had good test–retest agreement, similar to that observed for the English version. Item level agreement was problematic, however, highlighting a need for future research.
|
|
| 28. |
- Isaksson, Helena S., 1978-, et al.
(författare)
-
Whole genome microarray expression analysis in blood leucocytes identifies pathways linked to signs and symptoms of a patient with hypercalprotectinaemia and hyperzincaemia
- 2018
-
Ingår i: Clinical and Experimental Immunology. - : Wiley-Blackwell Publishing Inc.. - 0009-9104 .- 1365-2249. ; 191:2, s. 240-251
-
Tidskriftsartikel (refereegranskat)abstract
- A child, 2 years with the "hypercalprotectinemia with hyperzincemia" clinical syndrome presented with atypical symptoms and signs, notably persistent fever of around 38°C, thrombocythaemia of >700 x 10(9) /L, and a predominance of persistent intestinal symptoms. In an effort to find a cure by identifying the dysregulated pathways we analyzed whole-genome mRNA expression by the Affymetrix HG U133 PLUS 2.0 array on three occasions 3 to 5 months apart. Major upregulation was demonstrated for the JAK/STAT pathway including in particular CD177, S100A8, S100A9, and S100A12, accounting for the thrombocytosis; a large number of interleukins, their receptors, and activators, accounting for the febrile apathic state; and the HMBG1 gene, possibly accounting for part of the intestinal symptoms. These results show that gene expression array technology may assist the clinician in the diagnostic workup of individual patients with suspected syndromal states of unknown origin, and the expression data can guide the selection of optimal treatment directed at the identified target pathways.
|
|
| 29. |
- Marouli, Eirini, et al.
(författare)
-
Rare and low-frequency coding variants alter human adult height
- 2017
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 542:7640, s. 186-190
-
Tidskriftsartikel (refereegranskat)abstract
- Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
|
|
| 30. |
- Mattsson, Sofia, et al.
(författare)
-
Who enrols and graduates from web-based pharmacy education : experiences from Northern Sweden
- 2018
-
Ingår i: Currents in pharmacy teaching and learning. - : Elsevier. - 1877-1297. ; 10:8, s. 1004-1012
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: As a response to the shortage of prescriptionists in Northern Sweden, a web-based Bachelor of Science in Pharmacy program was introduced at Umea. University in 2003. This study explored who is likely to enrol and graduate from the web-based bachelor program and whether the program has addressed the shortage of prescriptionists in rural Northern Sweden.Methods: Data from three different sources were included in this study; the initial cohort including students admitted to the program in 2003 (survey), the entire cohort including all people admitted to the program between 2003 and 2014 (university's admissions data) and the alumni cohort including graduates who participated in an alumni survey in 2015.Results: A typical student of the web-based pharmacy program is female, over 30 years of age, married or in a de-facto relationship and has children. Furthermore, the students graduating before 2009 were more likely to live in Northern Sweden compared to those graduating later.Discussion and conclusion: The results indicate that the introduction of a web-based bachelor of pharmacy program at Umea. University was to some extent able to address the shortage of prescriptionists in Northern Sweden. Web-based education may potentially help address the maldistribution of health professionals by providing flexible education opportunities.
|
|
| 31. |
- Mourtzinis, Georgios, 1974, et al.
(författare)
-
Aldosterone to Renin Ratio as a Screening Instrument for Primary Aldosteronism in a Middle-Aged Population with Atrial Fibrillation.
- 2017
-
Ingår i: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. - : Georg Thieme Verlag KG. - 1439-4286. ; 49:11, s. 831-837
-
Tidskriftsartikel (refereegranskat)abstract
- Atrial fibrillation seems to be overrepresented among patients with primary aldosteronism. The aim of this study was to determine the usefulness of aldosterone to renin ratio as a screening instrument for primary aldosteronism in an atrial fibrillation population with relatively low cardiovascular risk profile. A total of 149 patients <65 years and with history of AF were screened for primary aldosteronism using aldosterone to renin ratio. Pathologically increased aldosterone to renin ratio (>65pmol/mIU) was found in 15 participants (10.1%). Further investigation of the positive screened participants and confirmatory saline infusion test resulted in a diagnosis of primary aldosteronism in four individuals out of 149 (2.6%). Three out of the four individuals with primary aldosteronism had previously been diagnosed with hypertension, but only one out of the four had uncontrolled blood pressure, that is, >140/90mmHg. All participants had normal potassium levels. Individuals with increased aldosterone to renin ratio had significantly higher mean systolic and diastolic blood pressure in comparison to participants with normal aldosterone to renin ratio (136 vs. 126mmHg, p=0.02 and 84 vs. 78mmHg, p=0.02). These findings suggest that assessment of aldosterone to renin ratio can be useful for identification of underlying primary aldosteronism in patients with diagnosed atrial fibrillation and hypertension in spite of well controlled blood pressure and normokalemia.
|
|
| 32. |
- Oliv, Stefan, et al.
(författare)
-
Important work demands for reducing sickness absence among workers with neck or upper back pain: a prospective cohort study
- 2019
-
Ingår i: BMC Musculoskeletal Disorders. - : Springer Science and Business Media LLC. - 1471-2474. ; 20:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background The aim of this study was to investigate what exposure to work demands, physical and psychosocial, is associated with lower levels of sickness absence among workers with neck or upper back pain in different groups, by age, gender, duration of sickness absence and work ability score. Methods This study was a prospective study of 4567 workers with neck or upper back pain. Data on neck or upper back pain, work demand and work ability were obtained from the Swedish Work Environment survey over a 3-year period (2009-2013). Register data on sickness absence, 1 year after each survey was conducted, were obtained from the Swedish health insurance database. Analyses were performed to estimate the association between self-reported work demands and registered sick days > 14 days. The analyses were stratified for gender, age group and work ability score. Results Lower numbers of sick days were found for workers reporting low exposure to lifting >= 15 kg and twisted or forward-leaning work postures. Lower numbers of sick days were found for workers reporting high work control and seated work. The associations were generally stronger in the older age groups for the physical work demands. Conclusions The findings in this study suggest that certain physical work demands and having high control over one's work can result in lower sickness absence, especially among middle-aged and older workers with neck or upper back pain.
|
|
| 33. |
- Oliv, Stefan, et al.
(författare)
-
The Quick Exposure Check (QEC) - Inter-rater reliability in total score and individual items
- 2019
-
Ingår i: Applied Ergonomics. - : Elsevier BV. - 0003-6870. ; 76, s. 32-37
-
Tidskriftsartikel (refereegranskat)abstract
- The development of musculoskeletal disorders has been linked to various risk factors in the work environment including lifting heavy loads, machine and materials handling, work postures, repetitive work, work with handheld vibrating tools, and work stress. The Quick Exposure Check (QEC) was designed to assess exposure to work-related musculoskeletal risk factors affecting the back, shoulder/arm, wrist/hand, and neck. We investigated the inter-rater reliability of the summary scores and individual items of the QEC by comparing two simultaneous assessments of 51 work tasks, performed by 14 different workers. The work tasks were mainly "light" to "moderately heavy". For total scores, the level of disagreement for shoulder/arm had a Relative Position of 0.13 (95% CI: 0.02; 0.23) and no statistically significant random disagreement. Percentage agreement was 63-100% for individual items and 71-88% for total score. Weighted Kappa of agreement for the individual items rated by the assessors were 0.94-0.77; highest for back motion, and lowest for wrist/hand position. The Swedish translation of the Quick Exposure Check has moderate to very good inter-rater reliability with fair to slight levels of systematic disagreement. There was no statistically significant random disagreement.
|
|
| 34. |
- Oliv, Stefan, et al.
(författare)
-
Workplace Interventions can Reduce Sickness Absence for Persons With Work-Related Neck and Upper Extremity Disorders: A One-Year Prospective Cohort Study
- 2019
-
Ingår i: Journal of occupational and environmental medicine. - 1536-5948. ; 61:7, s. 559-564
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The objective of this study was to investigate whether workplace interventions are effective in reducing sickness absence in persons with work-related neck and upper extremity disorders and whether disorder improvement after intervention reduces sickness absence. METHODS: This study was a prospective cohort study of workers with work-related neck pain or upper extremity disorders. Data were obtained from the Swedish "Work-related disorders" and "Work environment" surveys. Register data on sickness-absence 1 year after the surveys were made and obtained from the Swedish health insurance database. RESULTS: A significant lower number of sickness-absence days were found for workers reporting improvement after intervention. CONCLUSION: The findings in this study suggest that workplace intervention can reduce sickness absence for workers with neck or upper extremity disorders only if the intervention improves the disorder. The interventions were most effective in reducing medium long sickness absence periods.
|
|
| 35. |
- Pennbrant, Sandra, 1967-, et al.
(författare)
-
Information about sexual activity after hip replacement : A literature review
- 2018
-
Ingår i: Nordic journal of nursing research. - : SAGE Publications. - 2057-1585 .- 2057-1593. ; 38:3, s. 119-127
-
Tidskriftsartikel (refereegranskat)abstract
- Sexual activity is an important aspect of quality of life and contributes to healing and recovery. Adequate information may minimize post-operative risks and improve wellbeing. The aim of this literature review was to identify and review articles regarding the information on sexual activity after hip replacement provided to or obtained by patients and partners prior to their hip replacement surgery. The literature search was performed in the following databases: CINAHL, PubMed/Medline, MEDLINE (via Ebscoost) and Scopus. The results underline the importance of providing hip replacement patients and partners with relevant information, to reduce their concerns and improve their satisfaction and quality of life. Such information could promote person-centered care for patient and partner, and increase long-term cost-effectiveness for the healthcare organization. Information to patients and partners on post-hip-replacement sexual limitations has not been closely studied. Further research is needed to help healthcare providers promote patients’ and partners’ sexual health and quality of life and improve wellbeing.
|
|
| 36. |
- Sagrén, Cecilia, 1959-, et al.
(författare)
-
Framtidsfrågor Restaureringskonst 2016-2017 Kungl Konsthögskolan
- 2017
-
Rapport (populärvet., debatt m.m.)abstract
- Restaureringskonst vid Kungl Konsthögskolan i Stockholm har läsåret 2016-2017 haft temat Framtidsfrågor. Utöver professionskunskap och teori har fronten och framtidsfrågor inom ämnet studerats. Publikationen visar en del av årets arbete i form av artiklar. Praktisk träning i dokumentation och värdering avspeglas liksom gemensamma studieresor, föreläsningar och milstolpar inom restaurering. Framtidsfrågor har inga enkla svar med för att kunskapsuppbyggnaden ska ligga i fronten är Restaureringskonst en aktiv deltagare i diskussionen.
|
|
| 37. |
- Stigson, Helena, 1979, et al.
(författare)
-
Differences in Long-Term Medical Consequences Depending on Impact Direction Involving Passenger Cars
- 2015
-
Ingår i: Traffic Injury Prevention. - : Informa UK Limited. - 1538-9588 .- 1538-957X. ; 16, s. S133-S139
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: There is limited knowledge of the long-term medical consequences for occupants injured in car crashes in various impact directions. Thus, the objective was to evaluate whether injuries leading to permanent medical impairment differ depending on impact direction. Methods: In total, 36,743 injured occupants in car crashes that occurred between 1995 and 2011 were included. All initial injuries (n = 61,440) were classified according to the Abbreviated Injury Scale (AIS) 2005. Injured car occupants were followed for at least 3years to assess permanent medical impairment. The data were divided into different groups according to impact direction and levels of permanent impairment. The risk of permanent medical impairment was established for different body regions and injury severity levels, according to AIS. Results: It was found that almost 12% of all car occupants sustained a permanent medical impairment. Given an injury, car occupants involved in rollover crashes had the highest overall risk to sustain a permanent medical impairment. Half of the head injuries leading to long-term consequences occurred in frontal impacts. Far-side occupants had almost the same risk as near-side occupants. Occupants who sustained a permanent medical impairment from cervical spine injuries had similar risk in all impact directions (13%) except from rollover (17%). However, these injuries occurred more often in rear crashes. Most of the injuries leading to long-term consequences were classified as minor injuries by AIS for all impact directions. Conclusions: Studying crash data from a perspective of medical impairment is important to identify injuries that might not be prioritized only considering the AIS but might lead to lower quality of life for the occupant and also costs for society. These results can be used for road transport system strategies and for making priority decisions in vehicle design.
|
|
| 38. |
- Svanbäck, Annika, et al.
(författare)
-
Reducing agricultural nutrient surpluses in a large catchment - Links to livestock density
- 2019
-
Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 648, s. 1549-1559
-
Tidskriftsartikel (refereegranskat)abstract
- The separation between crop- and livestock production is an important driver of agricultural nutrient surpluses in many parts of the world. Nutrient surpluses can be symptomatic of poor resource use efficiency and contribute to environmental problems. Thus, it is important not only to identify where surpluses can be reduced, but also the potential policy tools that could facilitate reductions. Here, we explored linkages between livestock production and nutrient flows for the Baltic Sea catchment and discuss management practices and policies that influence the magnitude of nutrient surpluses. We found that the majority of nutrients cycled through the livestock sector and that large nitrogen and phosphorus surpluses often occurred in regions with high livestock density. Imports of mineral fertilizers and feed to the catchment increased overall surpluses, which in turn increased the risk of nutrient losses from agriculture to the aquatic environment. Many things can be done to reduce agricultural nutrient surpluses; an important example is using manure nutrients more efficiently in crop production, thereby reducing the need to import mineral fertilizers. Also, existing soil P reserves could be used to a greater extent, which further emphasizes the need to improve nutrient management practices. The countries around the Baltic Sea used different approaches to manage agricultural nutrient surpluses, and because eight of the coastal countries are members in the European Union (EU), common EU policies play an important role in management. We observed reductions in surpluses between 2000 and 2010 in some countries, which suggested the influence of different approaches to management and policy and that there are opportunities for further improvement. However, the separation between crop and livestock production in agriculture appears to be an underlying cause of nutrient surpluses; thus, further research is needed to understand how policy can address these structural issues and increase sustainability in food production.
|
|
| 39. |
- Turcot, Valerie, et al.
(författare)
-
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
- 2018
-
Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 50:1, s. 26-41
-
Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are similar to 10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed similar to 7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
|
|
| 40. |
- Wänman, Johan, et al.
(författare)
-
Metastatic spinal cord compression as the first sign of malignancy : Outcome after surgery in 69 patients
- 2017
-
Ingår i: Acta Orthopaedica. - : Taylor & Francis. - 1745-3674 .- 1745-3682. ; 88:4, s. 457-462
-
Tidskriftsartikel (refereegranskat)abstract
- Background and purpose - Metastatic spinal cord compression (MSCC) as the initial manifestation of malignancy (IMM) limits the time for diagnostic workup; most often, treatment is required before the final primary tumor diagnosis. We evaluated neurological outcome, complications, survival, and the manner of diagnosing the primary tumor in patients who were operated for MSCC as the IMM.Patients and methods - Records of 69 consecutive patients (51 men) who underwent surgery for MSCC as the IMM were reviewed. The patients had no history of cancer when they presented with pain (n = 2) and/or neurological symptoms (n = 67).Results - The primary tumor was identified in 59 patients. In 10 patients, no specific diagnosis could be established, and they were therefore defined as having cancer of unknown primary tumor (CUP). At the end of the study, 16 patients were still alive (median follow-up 2.5 years). The overall survival time was 20 months. Patients with CUP had the shortest survival (3.5 months) whereas patients with prostate cancer (6 years) and myeloma (5 years) had the longest survival. 20 of the 39 patients who were non-ambulatory preoperatively regained walking ability, and 29 of the 30 ambulatory patients preoperatively retained their walking ability 1 month postoperatively. 15 of the 69 patients suffered from a total of 20 complications within 1 month postoperatively.Interpretation - Postoperative survival with MSCC as the IMM depends on the type of primary tumor. Surgery in these patients maintains and improves ambulatory function.
|
|
