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Sökning: WFRF:(Gustafsson Ida) > (2020-2024)

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1.
  • Kanoni, Stavroula, et al. (författare)
  • Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
  • 2022
  • Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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2.
  • Andersson-Sköld, Yvonne, 1957, et al. (författare)
  • Microplastics from tyre and road wear: a literature review
  • 2020
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • This literature review concerns microplastics from tyre and road wear caused by road traffic. As there is limited knowledge about microplastics in general, and microplastics from road traffic in particular, the Swedish Government commissioned the Swedish National Road and Transport Research Institute (VTI) to, during 2018-2020, develop and disseminate knowledge about microplastics from road traffic. The chapters in this report summarises existing knowledge about microplastics from road traffic with respect to the following aspects: sources, spread and presence; effects on and risk to the environment and human health; characteristics and chemical composition; tyre and road wear; sampling methods; analysis and sample preparation; and measures. The report also includes a chapter with overall conclusions, and a chapter about further research, development and investigation needs. The purpose of this report is to provide a basis for reducing the generation and spread of microplastics from road traffic. One aim of the report is to collate and disseminate knowledge about microplastics generated by tyre and road wear, and to review the current level of knowledge. A second aim is to identify knowledge gaps and research requirements in relation to microplastics from road traffic. This literature review is based on a review of scientific articles and reports, as well as technical literature and some information from experts and industry.
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3.
  • Andersson-Sköld, Yvonne, 1957-, et al. (författare)
  • Mikroplast från däck- och vägslitage : en kunskapssammanställning
  • 2020
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Denna kunskapssammanställning handlar om mikroplast från vägtrafikens däck- och vägslitage. Eftersom kunskapen om mikroplaster från vägtrafiken är begränsad samtidigt som däckslitage bedöms vara den största källan till utsläpp av mikroplast i Sverige, gav regeringen inom ramen för sitt arbete med plast och mikroplast Statens väg- och transportforskningsinstitut (VTI) i uppdrag att under 2018– 2020 ta fram och sprida kunskap om mikroplast från vägtrafiken. Varje kapitel i denna rapport sammanfattar befintlig kunskap om mikroplast från vägtrafiken avseende en eller flera aspekter. Dessa aspekter är: källor, spridning och förekomst; miljö- och hälsoeffekter samt risker; egenskaper och kemisk sammansättning; däck- och vägslitage; provtagningsmetoder; analys- och provberedningsmetoder samt åtgärder. Dessutom finns ett kapitel med sammanfattande slutsatser och allra sist ett kapitel om forsknings-, utvecklings- och utredningsbehov.Syftet med rapporten är att den ska utgöra ett underlag för att minska emissioner och spridning av mikroplast från vägtrafiken. Ett mål med rapporten är att sammanställa och sprida kunskap om mikroplast från däck- och vägslitage och att redogöra för nuvarande kunskapsläge. Ytterligare ett mål är att identifiera kunskaps- och forskningsbehov avseende mikroplast från vägtrafiken.Underlaget till denna kunskapssammanställning utgörs av vetenskapliga artiklar och rapporter samt facklitteratur och information från branschen och från experter.
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4.
  • Axelsson, Ida, et al. (författare)
  • Impact of storage time prior to cryopreservation on mechanical properties of aortic homografts
  • 2024
  • Ingår i: Cell and Tissue Banking. - : Springer Science and Business Media LLC. - 1389-9333 .- 1573-6814. ; 25:1, s. 27-37
  • Tidskriftsartikel (refereegranskat)abstract
    • Optimal time spans in homograft procurement are still debatable among tissue banks and needs to be further investigated. Cell viability decreases at longer preparation intervals, but the effect on collagen and elastic fibers has not been investigated to the same extent. These fibers are of importance to the homograft elasticity and strength. The objective of this study was to analyze the mechanical properties of homograft tissue at different time spans in the procurement process. Ten aortic homografts were collected at the Tissue Bank in Lund. Twelve samples were obtained from each homograft, cryopreserved in groups of three after 2–4 days, 7–9 days, 28–30 days, and 60–62 days in antibiotic decontamination. Mechanical testing was performed with uniaxial tensile tests, calculating elastic modulus, yield stress and energy at yield stress. Two randomly selected samples were assessed with light microscopy. Procurement generated a total of 120 samples, with 30 samples in each time group. Elastic modulus and yield stress was significantly higher in samples cryopreserved after 2–4 days (2.7 MPa (2.5-5.0) and 0.78 MPa (0.68-1.0)) compared to 7–9 days (2.2 MPa (2.0-2.6) and 0.53 MPa (0.46–0.69)), p = 0.008 and 0.011 respectively. Light microscopy did not show any difference in collagen and elastin at different time spans. There was a significant decrease in elastic modulus and yield stress after 7 days of decontamination at 4 °C compared to 2–4 days. This could indicate some deterioration of elastin and collagen at longer decontamination intervals. Clinical significance of these findings remains to be clarified.
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5.
  • Björkman, Ida, et al. (författare)
  • Person-centred care on the move : An interview study with programme directors in Swedish higher education
  • 2022
  • Ingår i: BMC Medical Education. - : Springer Science and Business Media LLC. - 1472-6920. ; 22:1
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: There is an increasing trend towards person-centred care (PCC) worldwide, suggesting that PCC should be mastered by future health care professionals. This study aims to explore programme directors' views on facilitators and barriers to implementing PCC in four of the largest national study programmes in Sweden training future health care professionals.METHODS: A qualitative design was applied and interviews were conducted with 19 programme directors of Swedish national study programmes in medicine, nursing, occupational therapy and physiotherapy. The interviews were analysed using qualitative content analysis. Themes were sorted according to the Consolidated Framework for Implementation Research (CFIR) in an abductive approach. COREQ guidelines were applied.RESULTS: The overarching theme, as interpreted from the programme directors' experiences, was 'Person-centred care is on the move at different paces.' The theme relates to the domains identified by the CFIR as outer setting, innovation, inner setting and process. PCC was understood as something familiar but yet new, and the higher education institutions were in a state of understanding and adapting PCC to their own contexts. The movement in the outer setting consists of numerous stakeholders advocating for increased patient influence, which has stirred a movement in the inner setting where the higher educational institutions are trying to accommodate these new demands. Different meanings and values are ascribed to PCC, and the concept is thus also 'on the move', being adapted to traditions at each educational setting.CONCLUSION: Implementation of PCC in Swedish higher education is ongoing but fragmented and driven by individuals with a specific interest. There is uncertainty and ambiguity around the meaning and value of PCC and how to implement it. More knowledge is needed about the core of PCC as a subject for teaching and learning and also didactic strategies suitable to support students in becoming person-centred practitioners.
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6.
  • Blomqvist, Göran, 1963-, et al. (författare)
  • Microplastics in snow in urban traffic environments
  • 2023
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Microplastics from road traffic, mainly from tyre wear, are globally considered to be one of the largest sources of microplastic contamination in the environment. Plastics can either be deposited in the road vicinity, at the roadside and in ditches or spread via stormwater and air to the environment and receiving water bodies. In cold climates, microplastics, as well as other traffic-related pollutants, can be temporarily stored in snow and ice on and around roads and streets. The location and concentration of these pollutants is influenced by winter operations, where ploughing and skid control contribute to redistribution, and by melting and compaction of ice and snow. This creates reservoirs of microplastics and other pollutants, which are released into stormwater or surrounding soil during thaws, but also provides an opportunity to reduce the spread of microplastics by managing snow and ice appropriately. In the present report, a case study of microplastics in snow has been carried out in the municipality of Karlstad in Sweden, to get an idea of the potential variation, both in terms of concentration and total amounts in relation to traffic and the location of the sampling in the street environment. Microplastics have been analysed by pyrolysis GC/MS to identify tyre-specific polymers in combination with eight commonly occurring plastic types. In addition, six municipalities in different parts of the country responded to a questionnaire on microplastics in snow and urban snowmelt management. The results show that microplastics related to tyre wear (rubber polymers) tend to be present in higher concentrations on and near the carriageway. Other plastics show a less clear link to traffic. Along a salted bicycle lane, an elevated level of polypropylene, from which the brush of the sweep-salting machine is made, could be detected in the surface layer of the snow. In general, knowledge about microplastics in urban snow is low in the municipalities that responded to the survey.
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7.
  • Eklund, Ida, et al. (författare)
  • Patients' Experiences of Pain and Postoperative Nausea and Vomiting in the Early Postoperative Period After an Elective Knee Arthroplasty
  • 2020
  • Ingår i: Journal of Perianesthesia Nursing. - : Elsevier. - 1089-9472 .- 1532-8473. ; 35:4, s. 382-388
  • Tidskriftsartikel (refereegranskat)abstract
    • PurposeThe aim of this study is to explore patients' experience of pain and postoperative nausea and vomiting (PONV) in the early postoperative period after knee arthroplasties.DesignThis is a retrospective cohort study with a quantitative approach. Data from patients registered in the Swedish Perioperative Registry were used. We used the Strenghtening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines for cross-sectional studies.MethodsData were collected from patients (N = 439) undergoing knee arthroplasties. The analysis was performed with descriptive and analytic statistics.FindingsThe findings indicate that women experienced significantly higher levels of pain than men and suffered significantly more often from PONV. However, the relationship of postoperative pain and PONV was not significant. There was also no significance for the relationship among postoperative pain, PONV, and age.ConclusionsCare needs to be sensitive to differences in experiencing pain and PONV depending on sex or gender bias, with a goal of increasing the equality in care.
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8.
  • Envall, Ida, et al. (författare)
  • Existing evidence related to soil retention of phosphorus from on-site wastewater treatment systems in boreal and temperate climate zones : a systematic map
  • 2023
  • Ingår i: Environmental Evidence. - : Springer Nature. - 2047-2382. ; 12:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: In Sweden there are nearly one million soil-based on-site wastewater treatment systems (OWTSs). OWTSs may contribute to eutrophication of surface waters, due to the discharge of phosphorus (P). Hence, in certain cases, a high P removal rate (up to 90%) of OWTSs is required by Swedish authorities. Since these requirements may have costly consequences to property owners, it is debated whether they are too strict. In this debate, it is often claimed that the soil retention of P occurring in the natural environments may be underestimated by authorities. Soil retention is the inhibition of the transport of P through the ground, due to different chemical, physical and biological processes occurring there. These processes make the P transport slower, which may reduce the unwanted impact on receiving water bodies. However, the efficiency of soil retention of P remains unclear. The objective of this systematic map was to collect, code, organise and elucidate the relevant evidence related to the topic, to be able to guide stakeholders through the evidence base, and to support future research synthesising, commissioning, and funding. The systematic map was carried out in response to needs declared by the Swedish Agency for Marine and Water Management but the conclusions should be valid for a wider range of countries across boreo-temperate regions.Methods: Searches were made for peer-reviewed and grey literature using bibliographic databases, search engines, specialist websites, and stakeholder contacts. The references were screened for relevance according to a predefined set of eligibility criteria. A detailed database of the relevant studies was compiled. Data and metadata that enable evaluation and discussion of the character and quality of the evidence base were extracted and coded. Special focus was placed on assessing if existing evidence could contribute to policy and practice decision making. Descriptive information about the evidence base was presented in tables and figures. An interactive evidence atlas and a choropleth were created, displaying the locations of all studies.Review findings: 234 articles out of 10,797 screened records fulfilled the eligibility criteria. These articles contain 256 studies, performed in the field or in the laboratory. Six different study types were identified, based on where the measurements were conducted. Most studies, including laboratory studies, lack replicates. Most field studies are observational case studies.Conclusions: It is not possible to derive valid generic measures of the efficiency of soil retention of P occurring in the natural soil environment from available research. Neither does the evidence base allow for answering the question of the magnitude of the potential impact of OWTSs on the P concentration in recipients on a general basis, or under what conditions OWTSs generally have such an impact. A compilation of groundwater studies may provide examples of how far the P may reach in x years, but the number of groundwater studies is insufficient to draw any general conclusions, given the complexity and variability of the systems. Future research should strive for replicated study designs, more elaborate reporting, and the establishment of a reporting standard.
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9.
  • Envall, Ida, et al. (författare)
  • What evidence exists related to soil retention of phosphorus from on-site wastewater treatment systems in boreal and temperate climate zones? : A systematic map protocol
  • 2020
  • Ingår i: Environmental Evidence. - : BMC. - 2047-2382. ; 9:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Soil-based on-site wastewater treatment systems (OWSs) are suspected to contribute to eutrophication of surface waters, due to the discharge of phosphorus (P). However, along the flow path between the facilities and surface waters, different processes contribute to delay the transport of phosphorus through the ground. This may reduce the unwanted impact on receiving water bodies. However, the strength and significance of this so-called soil retention remains unclear. In Sweden, there are nearly one million OWSs. To protect surface waters, a high P removal rate (up to 90%) is often required by the local municipalities. However, since these requirements may have costly consequences to property owners, it is debated as to whether they are too strict. In this debate, it is often claimed that the retention of P occurring in natural environments may be underestimated by authorities. Accordingly, there is a need for a scrutiny of the available evidence related to soil retention of phosphorus from OWSs. This is the objective of the planned systematic map. Focus will be on boreal and temperate climate zones. Methods Searches will be made for peer-reviewed articles and grey literature using bibliographic databases, search engines, specialist websites and stakeholder contacts. The references will be screened for relevance according to a predefined set of eligibility criteria. At stage one, after testing and clarifying the eligibility criteria, the references will be single-screened based on title and abstract. At stage two, potentially relevant references will be screened in full-text independently by two reviewers. We will compile a detailed database of the relevant studies. Moreover, a narrative report will be produced, describing the research landscape in general terms. This will be carried out with a conceptual model, describing the processes involved in P retention in natural environments, as a foundation. It will be discussed where the respective studies/study types fit into the conceptual model, and also evaluated how each study/study type can be related to the overarching question of eutrophication. Moreover, we will describe identified knowledge gaps that warrant further primary research effort, as well as identified knowledge clusters that could be suitable for systematic reviews.
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10.
  • Gorgisyan, Jenny, et al. (författare)
  • Evalutation of two commercial deep learning OAR segmentation models for prostate cancer treatment
  • 2022
  • Konferensbidrag (refereegranskat)abstract
    • Purpose or ObjectiveTo evaluate two commercial, CE labeled deep learning-based models for automatic organs at risk segmentation on planning CT images for prostate cancer radiotherapy. Model evaluation was focused on assessing both geometrical metrics and evaluating a potential time saving.Material and MethodsThe evaluated models consisted of RayStation 10B Deep Learning Segmentation (RaySearch Laboratories AB, Stockholm, Sweden) and MVision AI Segmentation Service (MVision, Helsinki, Finland) and were applied to CT images for a dataset of 54 male pelvis patients. The RaySearch model was re-trained with 44 clinic specific patients (Skåne University Hospital, Lund, Sweden) for the femoral head structures to adjust the model to our specific delineation guidelines. The model was evaluated on 10 patients from the same clinic. Dice similarity coefficient (DSC) and Hausdorff distance (95th percentile) was computed for model evaluation, using an in-house developed Python script. The average time for manual and AI model delineations was recorded.ResultsAverage DSC scores and Hausdorff distances for all patients and both models are presented in Figure 1 and Table 1, respectively. The femoral head segmentations in the re-trained RaySearch model had increased overlap with our clinical data, with a DSC (mean±1 STD) for the right femoral head of 0.55±0.06 (n=53) increasing to 0.91±0.02 (n=10) and mean Hausdorff (mm) decreasing from 55±7 (n=53) to 4±1 (n=10) (similar results for the left femoral head). The deviation in femoral head compared to the RaySearch and MVision original models occurred due to a difference in the femoral head segmentation guideline in the clinic specific data, see Figure 2. Time recording of manual delineation was 13 minutes compared to 0.5 minutes (RaySearch) and 1.4 minutes (MVision) for the AI models, manual correction not included.ConclusionBoth AI models demonstrate good segmentation performance for bladder and rectum. Clinic specific training data (or data that complies to the clinic specific delineation guideline) might be necessary to achieve segmentation results in accordance to the clinical specific standard for some anatomical structures, such as the femoral heads in our case. The time saving was around 90%, not including manual correction.
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12.
  • Gustafsson, Christian Jamtheim, et al. (författare)
  • Federated training of segmentation models for radiation therapy treatment planning
  • 2024
  • Ingår i: Radiotherapy and Oncology. - 0167-8140 .- 1879-0887. ; 194, s. S4819-S4822
  • Tidskriftsartikel (refereegranskat)abstract
    • Radiotherapy treatment planning takes substantial time, several hours per patient, as it involves manual segmentation of tumor and risk organs. Segmentation networks can be trained to automatically perform the segmentations, but typically require large annotated datasets for training. Sharing of sensitive data between hospitals, to create a larger dataset, is often difficult due to ethics and GDPR. Here we therefore demonstrate that federated learning is a solution to this problem, as then only the segmentation model is sent between each hospital and a global server. We export and preprocess brain tumor images from the oncology departments in Linköping and Lund, and use federated learning to train a global segmentation model using two different frameworks.
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13.
  • Gustafsson, Ida, et al. (författare)
  • Breastfeeding and experienced exposedness in partner relationshiop
  • 2023
  • Ingår i: Abstract Book The Nordic Breastfeeding Conference 2023.
  • Konferensbidrag (refereegranskat)abstract
    • BREASTFEEDING AND EXPERIENCED EXPOSEDNESS IN PARTNER RELATIONSHIPIda Gustafsson RN, RM, Lecturer, PhD-studentFaculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, SwedenGunilla Carlsson RN, PhD, ProfessorFaculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, SwedenKatarina Karlsson RN, PhDFaculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, SwedenAleksandra Jarling RN, PhD, LecturerFaculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, SwedenLina Palmér RN, RM, PhD, Associate Professor, DocentFaculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, Sweden Background: About 110 000 children are born in Sweden annually. The vast majority of their mothers wish to breastfeed, and also initiate breastfeeding. An important factor for continued breastfeeding is support, especially from the partner. It is likely that lack of support can lead to perceived vulnerability in the partner relationship. Intimate partner violence (IPV) during pregnancy is in Sweden nearly as common as gestational diabetes and the frequency seems to rise postpartum. IPV is multifaceted and encompasses many types and degrees of violence. In a caring science perspective the experience of vulnerability and/or exposedness in partner relationship during breastfeeding (or breastfeeding desire) risks negatively affecting womens health and well-being, regardless of the reason or degree of exposedness. For care to be caring - that is, support health and well-being - knowledge is needed from the perspective of the exposed women. Previous lifeworld theoretical research has shown that breastfeeding may be experienced as an existential challenge and that exposedness to violence during the childbearing period means a long-lasting embodied experience. In this project, these two phenomena are intertwined into a common phenomenon - Breastfeeding in case of experienced exposedness in a partner relationship. Aim: The purpose of the PhD-project is to develop in-depth knowledge of existential meanings of breastfeeding in case of experienced exposedness in a partner relationship (Study 1-2), and what it means to be cared for (Study 3), as well as to give care and support in this context (Study 4). Methods: The project has a reflective lifeworld approach. Data has been collected through lifeworld interviews and written lifeworld stories and will be analyzed using a phenomenological or hermeneutical approach. Results & Conclusion: The results and conclusions of the first study are expected to be completed in the summer of 2023 and will be presented at the conference.
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14.
  • Gustafsson, Ida, 1986-, et al. (författare)
  • Clinical introduction and evaluation of the Existential Breastfeeding Difficulty Scale (ExBreastS) in the context of child health care
  • 2023
  • Ingår i: Abstract Book.
  • Konferensbidrag (refereegranskat)abstract
    • CLINICAL INTRODUCTION AND EVALUATION OF THE EXISTENTIAL BREASTFEEDING DIFFICULTY SCALE (EXBREASTS) IN THE CONTEXT OF CHILD HEALTH CAREIda Gustafsson RN, RM, Lecturer, PhD-studentFaculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, SwedenMalin Spångby RN, MNScChild Health Services, Region Jönköping County, Jönköping, SwedenAnn Arvidsdal RN, MNScChild Health Services, Region Jönköping County, Jönköping, SwedenMarie Golsäter RN, PhD, DocentChild Health Services, Region Jönköping County, Jönköping, SwedenCHILD Research Group, School of Health and Welfare, Jönköping University, Jönköping, SwedenDepartment of Health, Medicine and Caring, Linköping University, Linköping, SwedenLina Palmér RN, RM, Associate Professor, DocentFaculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, Sweden Background: Breastfeeding, both with and without perceived difficulties, can be experienced as an existential journey. Therefore, care needs to be based on the woman's breastfeeding story and carers need to be prepared to handle the existential questions that may arise. Previous research shows that healthcare professionals struggle with providing individually tailored care. The Existential Breastfeeding Difficulty Scale (ExBreastS) was developed based on lifeworld theoretical research on women's experiences of initiating breastfeeding with or without breastfeeding difficulties and was in this study introduced in child healthcare in a Swedish region. This was done to evaluate its ability to support child healthcare nurses to conduct existentially oriented caring dialogues with the breastfeeding story in focus.  Aim: Describe child healthcare nurses’ lived experience of how ExBreastS influences the caring dialogue. Methods: Lifeworld interviews were conducted with 17 child healthcare nurses about their experience of using ExBreastS to support caring dialogues with breastfeeding women. The interviews were conducted either individually, in pairs or in groups. The material was analyzed through thematic analysis based on descriptive phenomenology. Results: The results show that ExBreastS contributes to the re-evaluation of the importance of the caring dialogue because the existential significance of breastfeeding is given more space. ExBreastS also makes new perspectives of the breastfeeding story visible for both woman and carer. However, if the instrument itself receives too much of the nurse’s focus, there is a risk that the caring dialogue will be overshadowed. Conclusions: ExBreastS supports caring dialogues based on the breastfeeding story through its focus on the existential aspects of breastfeeding. However, this requires time, support from the organization and an awareness that caring dialogues can have no manual.
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15.
  • Gustafsson, Ida, et al. (författare)
  • The Existential Breastfeeding Difficulty Scale's influences on the caring dialogue-Child healthcare nurses' lived experiences
  • 2022
  • Ingår i: Scandinavian Journal of Caring Sciences. - : Wiley. - 0283-9318 .- 1471-6712.
  • Tidskriftsartikel (refereegranskat)abstract
    • Breastfeeding is experienced as an existential journey, and breastfeeding difficulties put mothers in existentially vulnerable situations. For care to be caring, it must be based on the mother's breastfeeding story. Previous research show that healthcare professionals struggle to perform individualised breastfeeding care. The Existential Breastfeeding Difficulty Scale (ExBreastS) was developed to support an existential focus in caring dialogues and was introduced in child healthcare in Sweden. The aim of this study is to describe child healthcare nurses' lived experience of how the Existential Breastfeeding Difficulty Scale (ExBreastS) influences the caring dialogue. Seventeen child healthcare nurses with experience in using ExBreastS as a basis for caring dialogues with breastfeeding mothers were interviewed, in groups, pairs or individually. The interviews were analysed using a thematic analysis based on descriptive phenomenology. The results show that the caring dialogue becomes re-evaluated when using ExBreastS because existential aspects of breastfeeding is acknowledged. ExBreastS also visualises new perspectives of the mother's breastfeeding experiences. However, the use of ExBreastS also risks overshadowing the caring dialogue when the nurses focus too much on the instrument. The use of ExBreastS supports caring dialogues-and caring care-by highlighting the existential aspects of breastfeeding/breastfeeding difficulties and the uniqueness of every mothers' breastfeeding experience. However, the instrument sometimes evokes a vulnerability in the nurses that calls for support from the care organisation.
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16.
  • Gustafsson, Mats, 1966-, et al. (författare)
  • Effekt på dammförråd och PM10-halter av tunnelstädning
  • 2022
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Driftmetoder mot höga partikelhalter orsakade av vägdamm i gatu- och vägmiljöer har under lång tid utvärderats i vanlig gatumiljö. Resultaten är dock ofta förhållandevis svårtolkade på grund av inverkan av meteorologi och omfattande inblandning från andra partikelkällor än just den gata som studeras. För att komma vidare med mer detaljerade studier av metodik och strategi och för att få mer lättolkade resultat, kan studierna förflyttas in i vägtunnlar. Dessa har en mer kontrollerad miljö med små meteorologiska variationer och en tydlig och helt dominerande partikelkälla – trafiken. Projektet ”Utvärdering av tekniker och strategier för damningsminimerad väg- och gatudrift i tunnelmiljö” avsåg att utvärdera olika varianter av damningsminimerande åtgärder i Södra länken, med fokus på dammbindningsstrategier och städning. På grund av säkerhetsmotiv fick vi inte möjlighet att testa olika dammbindningsstrategier varför projektet har fokuserat enbart på städning och i föreliggande rapport presenteras resultatet från två utvärderingar; en genomförd i januari, då partikelkällorna är starka och dammförrådet stort och en i juni, då källorna är svaga och dammförrådet litet. I januari städade först den så kallade supersugen och sedan Disa-Clean och i juni städade maskinerna i omvänd ordning. För utvärdering av effekterna användes VTI:s vägdammsprovtagare WDS II och luftkvalitetsdata från den mätstation i tunneln som testerna genomfördes vid. Resultaten visar att dammförrådet minskas mer i kombinationen i januari, det vill säga av högtryckstvätt följt av vakuumsug, än tvärtom, som i juni. Även om PM10-data är mer svårtolkade finns indikationer på att halterna i januari minskar något, medan halterna i juni snarare ökar efter städinsatsen. Resultatet att högtryckstvätt följt av vakuumsug fungerar väl för att städa bort vägdamm styrks av snarlika studier genomförda i Norge med samma utvärderingsteknik (WDS).
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17.
  • Gustafsson, Mats, 1966-, et al. (författare)
  • NORDUST II : Nordic Road Dust Project Phase II
  • 2024
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Road dust is an important source to airborne particles in the Nordic countries. It consists of wear products from road pavement, tyres, brakes, traction sand, salt and dust dragged in from adjacent unbound roads or deposited from nearby or long distance dust sources, like building sites and farmland. The cold climate in the Nordic countries enhances the formation of road dust compared to most European countries, since it promotes the use of studded tyres, which abrades the road surfaces, and winter maintenance where dust forming material is added to the road surfaces.The NORDUST II project has aimed to enhance knowledge about road dust emissions through extensive investigations, including laboratory and field studies, measurements, modeling, and future scenarios. An initial work package summarized current knowledge on mitigating road dust emissions. It found that dust binding solutions are most effective during acute dust episodes, while sweeping is beneficial on a seasonal basis. Preventive measures during autumn and winter can reduce airborne dust in spring. A core component of the project was experimental parameterization of processes in the NORTRIP emissions model. Studies revealed that vehicle weight and speed significantly influence particulate matter (PM) emissions, with heavier vehicles and higher speeds increasing emissions. The type of tire and road surface properties also play crucial roles.Experiments showed that winter sand is quickly crushed into finer fractions when driven over, but only a small portion of the sand mass is crushed. Coarse particles are removed more efficiently than finer particles at low speeds, but all particles are removed at speeds above 20 km/h. A field test in Linköping, Sweden, examined the removal of the dust binder CMA by traffic. Results indicated that the NORTRIP model could largely replicate the impact of traffic migration on CMA concentrations. 
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18.
  • Gustafsson, Mats, 1966-, et al. (författare)
  • Street sweeping : a source to, or measure against, microplastic emissions?
  • 2023
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Microplastics from road traffic are mainly caused by tyre wear, which is globally considered to be one of the largest sources of microplastics. Tyre wear particles have been shown to occur in all media (road surface, air, soil, stormwater, lakes and rivers and coastal sediments) and are dispersed both by runoff and by atmospheric transport. To reduce the dispersion and possible effects of road traffic microplastics emissions, measures can be taken to prevent the formation of particles and to prevent their dispersion through treatment measures. This study focuses on street cleaning as a method to reduce emissions, but as many street cleaning methods are based on the use of plastic brushes, cleaning as a source of microplastics has also been considered. The study was carried out in collaboration with the municipality of Karlstad and included a review of how street cleaning is carried out in Karlstad in relation to uptake and dispersion of microplastics. Furthermore, a comparison between two cleaning machines (elevator and vacuum) has been made and a monitoring of microplastic amounts on the road surface during different phases of spring sweeping has been carried out. In order to estimate the amount of plastic torn from the brushes, weighing of the brushes has been carried out. In order to gain knowledge about the work of more municipalities on street sweeping from a microplastic perspective, a questionnaire study was sent out to six municipalities in different parts of the country. The results show that both cleaning machines have the capacity to reduce the amount of microplastics on the road surface. However, during spring sweeping, the amount of polypropylene (the most common plastic in the brushes) on the road surface increases. The distribution of analysed plastics differs significantly between the road surface and the material collected by the machines. This is thought to be due to the fact that the machines mainly collect coarser fractions, while finer fractions remain on the road surface. Knowledge of, and thus consideration of, microplastics in relation to operational measures such as street cleaning is currently low among the municipalities surveyed, but awareness exists, as does the need for support in implementing possible measures. The present study shows a complex problem picture and represents a first step in understanding how street cleaning can be used as a measure, but also indicates that the wear of plastic brushes leads to a net emission of microplastics.
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19.
  • Hjelmér, Ida, et al. (författare)
  • Quality of life among female childhood cancer survivors with and without premature ovarian insufficiency
  • 2023
  • Ingår i: Journal of Cancer Survivorship. - : Springer Science and Business Media LLC. - 1932-2259 .- 1932-2267. ; 17:1, s. 101-109
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: Due to an increase in survival, a growing population of childhood cancer survivors (CCS) is present. However, female CCS are at risk of developing premature ovarian insufficiency (POI) after cancer treatment. POI involves a decreased chance of conceiving and the increased infertility state has a large impact on affected individuals’ health and mental life. The objective of this study was to investigate health state and well-being among female CCS with and without POI and healthy controls (HC). Methods: Female CCS treated in southern Sweden between 1964 and 2008 were included. Each patient was matched with a HC. The final study population included 167 female CCS and 164 HC that were examined between October 2010 and January 2015 at the Reproductive Medicine Centre at Skåne University Hospital in Malmö, Sweden. All participants, except for two HCs, answered an EQ-5D-3L questionnaire for measuring health state including a visual analogue scale (VAS) for estimating well-being. Results: There were 22 CCS with POI, none of the HC had POI. The mean health state differed among groups (unadjusted: P = 0.002; adjusted: P = 0.007). A difference in mean experienced well-being among groups was noted (unadjusted: P = 0.003; adjusted: P = 0.012). Lowest well-being was found in the CCS group with POI (P = 0.024). Conclusions: Female CCS have a significantly decreased health state and well-being. Female CCS with POI additionally have the lowest self-estimated well-being. Implications for Cancer Survivors: Female CCS with POI should be identified early in order to give them adequate information and support.
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20.
  • Jhun, Mina-A, et al. (författare)
  • A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
  • 2021
  • Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups. Abnormal blood lipid levels are important risk factors for cardiovascular and other various diseases. Here the authors conduct a large-scale multi-ethnic epigenome-wide association study combined with epigenetic (cis-QTL and eQTM) data, and identify CpG-lipid traits associations that are specific to or common across racial/ethnic groups.
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21.
  • Johannesson, Mikael, 1959-, et al. (författare)
  • Redovisning av regeringsuppdrag om mikroplast från vägtrafiken
  • 2021
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Denna rapport är en redovisning av det regeringsuppdrag VTI fick i december 2017 om att ta fram och sprida kunskap om mikroplast från vägtrafiken och som löpte fram till den 1 juni 2021. Uppdraget omfattade en budget på totalt 20 Mkr. Anledningen till uppdraget var bl.a. att kunskapen om mikroplast från vägtrafiken är mycket begränsad samtidigt som däck- och vägslitagepartiklar från vägtrafiken är en stor källa. Uppdraget var ett led i regeringens arbete att nationellt och internationellt genomföra insatser för att minska problemen med plast i miljön. Rapporten är strukturerad utifrån den kunskap som specifikt efterfrågas i uppdraget, som t.ex. kunskap om hur partiklarna sprids och vad man kan göra åt det, samt vad regeringen önskar att VTI ska göra, som t.ex. skriva vetenskapliga artiklar, samverka med myndigheter och sprida kunskap.Denna rapport är en sammanfattning av de aktiviteter som genomförts och de resultat som kommit fram inom ramen för uppdraget. Kunskapen om mikroplast från däck- och vägslitagepartiklar har från en låg nivå ökat snabbt under senare år genom forskning som bedrivits inom och utanför regerings-uppdraget. Det gäller t.ex. kunskap om beredning och analys av prover, däckpartiklars fysiska och kemiska egenskaper, däck- och vägslitagepartiklars förekomst i väg- och gatumiljö, deras potentiella spridningsvägar, vilka potentiella styrmedel och åtgärder som finns.
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22.
  • Järlskog, Ida, 1991, et al. (författare)
  • Concentrations of tire wear microplastics and other traffic-derived non-exhaust particles in the road environment
  • 2022
  • Ingår i: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 170
  • Tidskriftsartikel (refereegranskat)abstract
    • Tire wear particles (TWP) are assumed to be one of the major sources of microplastic pollution to the environment. However, many of the previously published studies are based on theoretical estimations rather than field measurements. To increase the knowledge regarding actual environmental concentrations, samples were collected and analyzed from different matrices in a rural highway environment to characterize and quantify TWP and other traffic-derived non-exhaust particles. The sampled matrices included road dust (from kerb and in-between wheeltracks), runoff (water and sediment), and air. In addition, airborne deposition was determined in a transect with increasing distance from the road. Two sieved size fractions (2–20 µm and 20–125 µm) were analyzed by automated Scanning Electron Microscopy/Energy Dispersive X-ray spectroscopy (SEM/EDX) single particle analysis and classified with a machine learning algorithm into the following subclasses: TWP, bitumen wear particles (BiWP), road markings, reflecting glass beads, metals, minerals, and biogenic/organic particles. The relative particle number concentrations (%) showed that the runoff contained the highest proportion of TWP (up to 38 %). The share of TWP in kerb samples tended to be higher than BiWP. However, a seasonal increase of BiWP was observed in coarse (20–125 µm) kerb samples during winter, most likely reflecting studded tire use. The concentration of the particle subclasses within airborne PM80-1 decreases with increasing distance from the road, evidencing road traffic as the main emission source. The results confirm that road dust and the surrounding environment contain traffic-derived microplastics in both size fractions. The finer fraction (2–20 µm) dominated (by mass, volume, and number) in all sample matrices. These particles have a high potential to be transported in water and air far away from the source and can contribute to the inhalable particle fraction (PM10) in air. This highlights the importance of including also finer particle fractions in future investigations.
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23.
  • Järlskog, Ida, 1991-, et al. (författare)
  • Differentiating and Quantifying Carbonaceous (Tire, Bitumen, and Road Marking Wear) and Non-carbonaceous (Metals, Minerals, and Glass Beads) Non-exhaust Particles in Road Dust Samples from a Traffic Environment
  • 2022
  • Ingår i: Water, Air and Soil Pollution. - : Springer. - 0049-6979 .- 1573-2932. ; 233:9
  • Tidskriftsartikel (refereegranskat)abstract
    • Tires, bitumen, and road markings are important sources of traffic-derived carbonaceous wear particles and microplastic (MP) pollution. In this study, we further developed a machine-learning algorithm coupled to an automated scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDX) analytical approach to classify and quantify the relative number of the following subclasses contained in environmental road dust: tire wear particles (TWP), bitumen wear particles (BiWP), road markings, reflecting glass beads, metallics, minerals, and biogenic/organics. The method is non-destructive, rapid, repeatable, and enables information about the size, shape, and elemental composition of particles 2-125 mu m. The results showed that the method enabled differentiation between TWP and BiWP for particles > 20 mu m with satisfying results. Furthermore, the relative number concentration of the subclasses was similar in both analyzed size fractions (2-20 mu m and 20-125 mu m), with minerals as the most dominant subclass (2-20 mu m x = 78%, 20-125 mu m x = 74%) followed by tire and bitumen wear particles, TBiWP, (2-20 mu m x = 19%, 20-125 mu m x = 22%). Road marking wear, glass beads, and metal wear contributed to x = 1%, x = 0.1%, and x = 1% in the 2-20-mu m fraction and to x = 0.5%, x = 0.2%, and x = 0.4% in the 20-125-mu m fraction. The present results show that road dust appreciably consists of TWP and BiWP within both the coarse and the fine size fraction. The study delivers quantitative evidence of the importance of tires, bitumen, road marking, and glass beads besides minerals and metals to wear particles and MP pollution in traffic environments based on environmental (real-world) samples
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24.
  • Järlskog, Ida, 1991-, et al. (författare)
  • Microplastic emissions from wear of road markings : overview and assessment for Swedish conditions
  • 2024
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Traffic-derived microplastics, i.e., tyre wear particles, wear from polymer-modified bitumen, and road marking wear are assumed to be one of the largest sources of microplastic contamination. Road markings as a source of microplastic emissions are still a rather unexplored research area, and there arestill large knowledge gaps regarding annual wear, concentrations in different environments, and eventual risks for flora and fauna.  This report has aimed to estimate the annual wear of road markings in Sweden and to investigate the knowledge on a municipal level related to road markings and wear. In addition, road markings from different traffic environments have been documented throughout the project, and the wear on these has been investigated. The project has also aimed to clarify which processes that contribute to the wear of road markings, as well as to map out which types of road markings that are subjected to specific types of wear. A survey was sent out to all municipalities in Sweden with questions about the type of road marking material, annual purchases, budget, wear rate, wear-prone traffic environments, and main causes of wear on road markings. In total, we received answers from 223 out of 290 municipalities. The result from the survey indicates that transverse road markings (e.g., yield lines, and pedestrian crossings), driving lines, and lines within roundabouts wear fast and that winter maintenance, use of studded tyres, and traffic loads are the main causes to wear. In general, the knowledge was low regarding annual purchases/applied amounts and many of the municipals mentioned that they do not have the budget to maintain road markings to a desirable extent. For upcoming procurements, we recommend the municipalities to make higher demands on the quality of the material, as well as adhesion and maintenance which might result in lower costs, a need for less material, and thereby also a reduced wear. 
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25.
  • Järlskog, Ida, 1991, et al. (författare)
  • Occurrence of tire and bitumen wear microplastics on urban streets and in sweepsand and washwater
  • 2020
  • Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 729
  • Tidskriftsartikel (refereegranskat)abstract
    • Tire and road wear particles have been identified as a potential major source of microplastics in the environment. However, more knowledge of the emissions and their further fate in the environment is needed, and the effectiveness and benefits of potential measures must be investigated to support future risk management efforts. Here the concentrations of tire and bitumen microplastic particles (TBMP) on roads and in nearby in stormwater, sweepsand and washwater were measured for the first time within the same area and time period. The analysis also included plastic, paint and fiber particles. Road dust was sampled on the road surface using a wet dust sampler, before and after street sweeping on two occasions. On each of these occasions, and several occasions during a four-month period with frequent street sweeping, sweepsand and washwater, as well as flow-weighted sampling of stormwater, were collected. TBMP concentrations were operationally defined, using density separation for some samples, followed by analysis by stereo microscopy. Sodium iodide (NaI) was found to be effective for density separation of TBMP. The largest proportion of anthropogenic microplastics detected consisted of tire tread wear and bitumen. The number of TBMP ≥100 μm in the WDS samples was up to 2561 particles/L. Sweepsand and washwater contained high amounts of TBMP ≥100 μm, up to 2170 particles/kg dw and 4500 particles/L, respectively. The results show that the sweeper collects considerable amounts of TBMP, and thus weekly sweeping might prevent further transport of TBMP to the receiving stormwater. In stormwater the number of particles ≥100 μm was up to 3 particles/L and ≥ 20 μm was up to 5900 particles/L showing the importance of analysing smaller microparticle sizes than 100 μm in all samples in future studies. This study also confirms that there is a substantial volume of TBMP generated from traffic that enters the environment.
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26.
  • Järlskog, Ida, 1991-, et al. (författare)
  • Reply to road markings and microplastics - a critical literature review
  • 2024
  • Ingår i: Transportation Research Part D. - : Elsevier. - 1361-9209 .- 1879-2340. ; 132
  • Tidskriftsartikel (refereegranskat)abstract
    • This is a reply to the recently published paper Road markings and microplastics - A critical literature review. In our opinion, that paper presented a deceptive picture, of why we found it necessary to write a short reply where we comment on two major flaws: the stated lack of road markings in environmental samples, and the definition of microplastics. We discuss possible reasons for the absence of positive findings in environmental samples and relate that to two of the major issues within the research area of microplastics- the complexity of environmental samples and the analytical difficulties. We also argue that it can be relevant for upcoming studies to report both total microplastic concentration and polymer content to facilitate the comparison between studies since the definition of microplastics might change over time. 
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27.
  • Järlskog, Ida, 1991, et al. (författare)
  • Traffic-related microplastic particles, metals, and organic pollutants in an urban area under reconstruction
  • 2021
  • Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 774
  • Tidskriftsartikel (refereegranskat)abstract
    • In urban environments, particularly areas under reconstruction, metals, organic pollutants (OP), and microplastics (MP), are released in large amounts due to heavy traffic. Road runoff, a major transport route for urban pollutants, contributes significantly to a deteriorated water quality in receiving waters. This study was conducted in Gothenburg, Sweden, and is unique because it simultaneously investigates the occurrence of OP, metals, and MP on roads and in stormwater from an urban area under reconstruction. Correlations between the various pollutants were also explored. The study was carried out by collecting washwater and sweepsand generated from street sweeping, road surface sampling, and flow-proportional stormwater sampling on several occasions. The liquid and solid samples were analyzed for metals, polycyclic aromatic hydrocarbons (PAH), oxy-PAH, aliphatics, aromatics, phthalates, and MP. The occurrence of OP was also analyzed with a non-target screening method of selected samples. Microplastics, i.e. plastic fragments/fibers, paint fragments, tire wear particles (TWP) and bitumen, were analyzed with a method based on density separation with sodium iodide and identification with a stereo microscope, melt-tests, and tactile identification. MP concentrations amounted to 1500 particles/L in stormwater, 51,000 particles/L in washwater, and 2.6 × 106 particles/kg dw in sweepsand. In stormwater, washwater and sweepsand, MP ≥20 μm were found to be dominated by TWP (38%, 83% and 78%, respectively). The results confirm traffic as an important source to MP, OP, and metal emissions. Concentrations exceeding water and sediment quality guidelines for metals (e.g. Cu and Zn), PAH, phthalates, and aliphatic hydrocarbons in the C16–C35 fraction were found in most samples. The results show that the street sweeper collects large amounts of polluted materials and thereby prevents further spread of the pollutants to the receiving stormwater.
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28.
  • Järlskog, Ida, 1991-, et al. (författare)
  • Trafiken – ett miljöproblem som rullar på
  • 2023. - 1
  • Ingår i: Luft & miljö. Om luftmiljö och svensk luftövervakning 2023. - Stockholm : Naturvårdsverket. - 9789162013080 ; , s. 48-53
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • I dag står slitaget av vägar, däck och bromsar för 44 procent av Sveriges totala årliga utsläpp av inandningsbara partiklar (PM10). Slitage av däck bedöms dessutom vara den största källan till mikroplast. Är den pågående elektrifieringen lösningen, eller skapar den bara andra problem?
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29.
  • Järlskog, Ida, 1991-, et al. (författare)
  • Trafikrelaterade mikroplaster i luftburna partiklar : Sammanställning av källfördelning i prover från Hornsgatan och Sveavägen 2020–2021
  • 2024
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • I denna rapport har partikelinnehållet i luftprover insamlade med passiva Sigma-II mätare i anslutning till befintliga mätstationer på Hornsgatan och Sveavägen analyserats och sammanställts. Prover samlades in under tre perioder mellan oktober och december 2020 samt under fyra perioder mellan mars och april 2021. Syftet har varit att kvantifiera andelen trafikrelaterad mikroplast i proverna, det vill säga däckpartiklar och vägmarkeringspartiklar. Alla prover har analyserats med en automatiserad SEM/EDX-metod i storleksfraktionen 1‒80 μm och partiklarna har kategoriserats in i följande partikelklasser: mineralpartiklar, metallpartiklar, organiska partiklar (t.ex. växtdelar och pollen), däckpartiklar större än 5 μm, bitumenpartiklar större än 5 μm, däck- och bitumenpartiklar mindre än 5 μm (TBiWP <5 μm), vägmarkeringspartiklar samt glaspärlor. Resultaten presenteras både som relativ sammansättning, det vill säga antal partiklar/partikelklass (%), masskoncentration i μg/m3, och som massprocent (%). Resultaten redovisar både hela den provtagna fraktionen, 1‒80 μm, och uppdelat i storleksfraktionen 2.5‒10 μm, där den sistnämnda är tänkt att kunna jämföras med befintliga luftmätningar.
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30.
  • Kommunerna och hållbar utveckling : Demokrati, välfärd och lokal utveckling
  • 2022
  • Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
    • I 25 år har Centrum för kommunstrategisk forskning, CKS, varit ett nav för forskning och samverkan kring kommunal och regional utveckling. Den här boken är en del i uppmärksammandet av 25-årsjubiléet.Boken är en antologi som belyser frågor om hållbar utveckling utifrån kommunernas olika roller och ansvar för samhällsstrukturer och samhällsprocesser. Författarna till de olika kapitlen är forskare vid CKS och forskare som ingår i CKS samarbetsnätverk. I de olika kapitlen sammanfattas i flera fall forskning som har sträckt sig över många år. På så sätt visar vi genom den här boken hur kontinuiteten genom vår centrumbildning har bidragit till en livskraftig struktur för fördjupad kommunstrategisk och regionstrategisk forskning som tagit stöd i dialoger med miljöer utanför och innanför forskarsamhället.Redaktör för boken är Brita Hermelin, professor i kulturgeografi vid CKS. Övriga författare är Magnus Dahlstedt, David Ekholm, Gissur Ó Erlingsson, Ida Grundel, Sara Gustafsson, Robert Jonsson, Martin Klinthäll, Dick Magnusson, Kristina Trygg, Susanne Wallman Lundåsen, Emanuel Wittberg, Johan Wänström och Richard Öhrvall.
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31.
  • Marcks, Nick, et al. (författare)
  • Re-appraisal of the obesity paradox in heart failure : a meta-analysis of individual data
  • 2021
  • Ingår i: Clinical Research in Cardiology. - : Springer Nature. - 1861-0684 .- 1861-0692. ; 110:8, s. 1280-1291
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Higher body mass index (BMI) is associated with better outcome compared with normal weight in patients with HF and other chronic diseases. It remains uncertain whether the apparent protective role of obesity relates to the absence of comorbidities. Therefore, we investigated the effect of BMI on outcome in younger patients without co-morbidities as compared to older patients with co-morbidities in a large heart failure (HF) population. Methods In an individual patient data analysis from pooled cohorts, 5,819 patients with chronic HF and data available on BMI, co-morbidities and outcome were analysed. Patients were divided into four groups based on BMI (i.e. <= 18.5 kg/m(2), 18.5-25.0 kg/m(2); 25.0-30.0 kg/m(2); 30.0 kg/m(2)). Primary endpoints included all-cause mortality and HF hospitalization-free survival. Results Mean age was 65 +/- 12 years, with a majority of males (78%), ischaemic HF and HF with reduced ejection fraction. Frequency of all-cause mortality or HF hospitalization was significantly worse in the lowest two BMI groups as compared to the other two groups; however, this effect was only seen in patients older than 75 years or having at least one relevant co-morbidity, and not in younger patients with HF only. After including medications and N-terminal pro-B-type natriuretic peptide and high-sensitivity cardiac troponin concentrations into the model, the prognostic impact of BMI was largely absent even in the elderly group with co-morbidity. Conclusions The present study suggests that obesity is a marker of less advanced disease, but does not have an independent protective effect in patients with chronic HF. [GRAPHICS] .
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32.
  • Margaryan, Ashot, et al. (författare)
  • Population genomics of the Viking world
  • 2020
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 585:7825, s. 390-396
  • Tidskriftsartikel (refereegranskat)abstract
    • The maritime expansion of Scandinavian populations during the Viking Age (about ad750–1050) was a far-flung transformation in world history1,2. Here we sequenced the genomes of 442humans from archaeological sites across Europe and Greenland (to a median depth of about 1×) to understand the global influence of this expansion. We find the Viking period involved gene flow into Scandinavia from the south and east. We observe genetic structure within Scandinavia, with diversity hotspots in the south and restricted gene flow within Scandinavia. We find evidence for a major influx of Danish ancestry into England; a Swedish influx into the Baltic; and Norwegian influx into Ireland, Iceland and Greenland. Additionally, we see substantial ancestry from elsewhere in Europe entering Scandinavia during the Viking Age. Our ancient DNA analysis also revealed that a Viking expedition included close family members. By comparing with modern populations, we find that pigmentation-associated loci have undergone strong population differentiation during the past millennium, and trace positively selected loci—including the lactase-persistence allele of LCT and alleles of ANKA that are associated with the immune response—in detail. We conclude that the Viking diaspora was characterized by substantial transregional engagement: distinct populations influenced the genomic makeup of different regions of Europe, and Scandinavia experienced increased contact with the rest of the continent.
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33.
  • Mattsson, Karin, et al. (författare)
  • Tyre and road wear particles from source to sea
  • 2023
  • Ingår i: Microplastics and Nanoplastics. - : Springer. - 2662-4966. ; 3:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Tyre and road wear particles (TRWP) are an important microplastics contributor to the environment, although direct observations along suggested pathways are virtually absent. There are concerns for both human health and ecosystems from TRWP exposure and leached chemicals. Due to great analytical challenges in detection and characterization, almost nothing is known about the physicochemical characteristics, occurrence, fate and transport of TRWP in the environment. Diverse tyre types exist for different seasons and vehicle profiles, and their formulations are undisclosed proprietary information.Here we show TRWP dispersion in marine sediments, and a direct link between tyre formulation, tread hardness and TRWP emissions. Softer tyres with higher natural rubber and carbon black content generate higher particle wear. Sediment TRWP dominates the microplastics assemblage close to the city, while showing a much more steeply reducing concentration gradient with distance from the source, suggesting different transport behaviour compared to lower density microplastics. This implies that urbanized coastal ecosystems are impacted by the accumulating TRWP, with consequences for sediment ecosystems.
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34.
  • Melander, Ida, 1991- (författare)
  • Att göra sin röst hörd : Sjukdomsförhandlande diskurser, genrer och berättelser om endometrios
  • 2022
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The main purpose of this thesis is to describe how situated health-related meaning-making about endometriosis is accomplished in three different health-related contexts. Health communication is ever relevant; throughout history, people have become ill, thought about their health and, in many cases, sought care. It is also a shifting practice, in the sense that it changes over time. This thesis explores health communication and negotiations of health and illness in three patient-oriented, alternative and new settings: knowledge negotiations in online discussion forums, seeking care through so-called ‘self-referrals’, and multimodal illness narratives.Specifically, meaning-making about endometriosis is explored. Endometriosis is a chronic condition which, despite its high prevalence, is still relatively unknown, both in society at large and in actual healthcare encounters. This makes the disease a good example to highlight texts and interaction as health communication.The thesis combines a discourse analytical and social semiotic framework, which entails a focus on knowledge, power and available resources for communicating about a disease. In the first study, discussion forum threads dealing with endometriosis are analyzed, showing how illness is negotiated by means of personal and particular experiences. In the second study, self-referrals written for specialist care are explored as an emergent genre, specifically highlighting the resources used to argue for care, as well as patients’ experiences of seeking care in this way. Finally, the third study analyzes illness narratives on Instagram, showing how illness is narrated on a specific platform, within a specific community.Collectively, the three studies shine a light on different ways of participating in health-related settings, and how this is tied to expertise, personal experience, and patient agency. The thesis also contributes to our understanding of how illness communities are formed: the typical patient emerging is active and knowledgeable, fights for care and endures being questioned by a poor quality healthcare service.
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35.
  • Ortiz Rios, Rodomiro Octavio, et al. (författare)
  • Oil crops for the future
  • 2020
  • Ingår i: Current Opinion in Plant Biology. - : Elsevier BV. - 1369-5266 .- 1879-0356. ; 56, s. 181-189
  • Forskningsöversikt (refereegranskat)abstract
    • Agriculture faces enormous challenges including the need to substantially increase productivity, reduce environmental footprint, and deliver renewable alternatives that are being addressed by developing new oil crops for the future. The efforts include domestication of Lepidium spp. using genomics-aided breeding as a cold hardy perennial high-yielding oil crop that provides substantial environmental benefits, expands the geography for oil crops, and improves farmers’ economy. In addition, genetic engineering in Crambe abyssinica may lead to a dedicated industrial oil crop to replace fossil oil. Redirection of photosynthates from starch to oil in plant tubers and cereal endosperm also provides a path for enhancing oil production to meet the growing demands for food, fuel, and biomaterials. Insect pheromone components are produced in seed oil plants in a cost-effective and environmentally friendly pest management replacing synthetically produced pheromones. Autophagy is explored for increasing crop fitness and oil accumulation using genetic engineering in Arabidopsis.
  •  
36.
  • Palmér, Lina, 1979-, et al. (författare)
  • A Theoretical Model on Caring for Mothers With Initial Breastfeeding Difficulties : The Breastfeeding Story as a Hub for Caring Practice
  • 2021
  • Ingår i: International journal for human caring. - : International Association for Human Caring. - 1091-5710. ; 25:1, s. 45-59
  • Tidskriftsartikel (refereegranskat)abstract
    • In the context of breastfeeding care, models are lacking that can guide caring practice. This article examines the prerequisites for care to be caring, based on research about breastfeeding difficulties. These prerequisites are presented as a theoretical model of caring that demonstrates that a genuine caring relationship, embodied wisdom, and an ability to create a space for dwelling, together with cultural awareness, form the prerequisites for the breastfeeding story to be a hub in caring practice. The model contributes to the development of caring practices that embrace the existentiality of each woman's breastfeeding experiences. 
  •  
37.
  • Polukarova, Maria, 1992-, et al. (författare)
  • Organic pollutants, nano- and microparticles in street sweeping road dust and washwater
  • 2020
  • Ingår i: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 135
  • Tidskriftsartikel (refereegranskat)abstract
    • Road areas are pollution hotspots where many metals, organic pollutants (OPs) and nano/microparticles accumulate before being transported to receiving waters. Particles on roads originate from e.g. road, tyre and vehicle wear, winter road maintenance, soil erosion, and deposition. Street sweeping has the potential to be an effective and affordable practice to reduce the occurrence of road dust, and thereby the subsequent spreading of pollutants, but there is currently little knowledge regarding its effectiveness. In this paper we investigate the potential of street sweeping to reduce the amounts of OPs and nano/microparticles reaching stormwater, in a case study sampling road dust and washwater from a street sweeping machine, road dust before and after sweeping, and stormwater. The compound groups generally found in the highest concentrations in all matrices were aliphatics C5–C35 > phthalates > aromatics C8–C35 > PAH-16. The concentrations of aliphatics C16–C35 and PAHs in washwater were extremely high at ≤ 53,000 µg/L and ≤ 120 µg/L, respectively, and the highest concentrations were found after a 3-month winter break in sweeping. In general, fewer aliphatic and aromatic petroleum hydrocarbons and PAHs were detected in road dust samples than in washwater. The relative composition of the specific PAH-16 suggests tyre wear, vehicle exhausts, brake linings, motor oils and road surface wear as possible sources. The study indicates that many of the hydrophobic compounds quantified in washwater are attached to small particles or truly dissolved. The washwater contains a wide range of small particles, including nanoparticles in sizes from just below 1 nm up to 300 nm, with nanoparticles in the size range 25–300 nm present in the highest concentrations. The results also indicated agglomeration of nanoparticles in the washwater. The street sweeping collected a large amount of fine particles and associated pollutants, leading to the conclusion that washwater from street sweeping needs to be treated before disposal.
  •  
38.
  • Rødland, Elisabeth S., et al. (författare)
  • Analytical challenges and possibilities for the quantification of tire-road wear particles
  • 2023
  • Ingår i: TrAC. Trends in analytical chemistry. - : Elsevier. - 0165-9936 .- 1879-3142. ; 165:August
  • Tidskriftsartikel (refereegranskat)abstract
    • As one of the largest sources of microplastic particle emissions, tire-road wear particle mixtures (TRWPs) pose a potentially high threat to various environmental compartments. Their heterogenous properties, from varying particle size, density, shape, texture, elemental and chemical composition, cause chal-lenging analytical workflows. Current analytical methods for TRWP can be summarized in two main groups: single-particle-based and bulk-based methods. Both groups include a large variation of methods, with different demands for sampling and sample pre-treatment, and different possible outputs. This review provides an overview of the current analytical methods used for TRWP studies and in particularly quantifications, with focus on methods that have been peer-reviewed and tested for environmental samples. The review presents current possibilities and limitations with the different analytical ap-proaches, as well as highlighting gaps in the current TRWP knowledge and information needed to move this research field forward.
  •  
39.
  • Sonderby, Ida E., et al. (författare)
  • Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
  • 2020
  • Ingår i: Molecular Psychiatry. - : Nature Publishing Group. - 1359-4184 .- 1476-5578. ; 25:3, s. 584-602
  • Tidskriftsartikel (refereegranskat)abstract
    • Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = −0.71 to −1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = −0.95, P = 0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P = 0.0032, 8.9 × 10−6, 1.7 × 10−9, 3.5 × 10−12 and 1.0 × 10−4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non-carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.
  •  
40.
  • Sønderby, Ida E., et al. (författare)
  • 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
  • 2021
  • Ingår i: Translational Psychiatry. - : Nature Publishing Group. - 2158-3188. ; 11:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Human carriers display a high prevalence of micro- and macrocephaly in deletion and duplication carriers, respectively. The underlying brain structural diversity remains largely unknown. We systematically called CNVs in 38 cohorts from the large-scale ENIGMA-CNV collaboration and the UK Biobank and identified 28 1q21.1 distal deletion and 22 duplication carriers and 37,088 non-carriers (48% male) derived from 15 distinct magnetic resonance imaging scanner sites. With standardized methods, we compared subcortical and cortical brain measures (all) and cognitive performance (UK Biobank only) between carrier groups also testing for mediation of brain structure on cognition. We identified positive dosage effects of copy number on intracranial volume (ICV) and total cortical surface area, with the largest effects in frontal and cingulate cortices, and negative dosage effects on caudate and hippocampal volumes. The carriers displayed distinct cognitive deficit profiles in cognitive tasks from the UK Biobank with intermediate decreases in duplication carriers and somewhat larger in deletion carriers-the latter potentially mediated by ICV or cortical surface area. These results shed light on pathobiological mechanisms of neurodevelopmental disorders, by demonstrating gene dose effect on specific brain structures and effect on cognitive function.
  •  
41.
  • van der Meer, Dennis, et al. (författare)
  • Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition
  • 2020
  • Ingår i: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 77:4, s. 420-430
  • Tidskriftsartikel (refereegranskat)abstract
    • Importance: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities.Objective: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance.Design, Setting, and Participants: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019.Main Outcomes and Measures: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2, sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort.Results: Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = -0.41; SE, 0.08; P = 4.9 × 10-8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10-7), and a smaller nucleus accumbens (Cohen d = -0.27; SE, 0.07; P = 7.3 × 10-5). There was also a significant negative dose response on cortical thickness (β = -0.24; SE, 0.05; P = 6.8 × 10-7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks.Conclusions and Relevance: These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders.
  •  
42.
  • Vergaro, Giuseppe, et al. (författare)
  • Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease
  • 2021
  • Ingår i: Journal of Cardiovascular Medicine. - : Wolters Kluwer. - 1558-2027 .- 1558-2035. ; 23:1, s. 28-36
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2).Methods: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values.Results: Patients had a median age of 66 years (interquartile interval 57–74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487–2725), 17 ng/l (9–31) and 30 ng/ml (22–44), respectively. Patients with COPD (n = 1249, 15%) had higher NT-proBNP (P = 0.042) and hs-TnT (P < 0.001), but not sST2 (P = 0.165). Over a median 2.0-year follow-up (1.5–2.5), 1717 patients (21%) died, and 1298 (16%) died from cardiovascular causes; 2255 patients (28%) were hospitalized for HF over 1.8 years (0.9–2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status. The best cut-offs from receiver-operating characteristics analysis were higher in patients with COPD than in those without. Patients with all three biomarkers higher than or equal to end-point- and COPD-status-specific cut-offs were also those with the worst prognosis.Conclusions: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status.
  •  
43.
  • Vergaro, Giuseppe, et al. (författare)
  • Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure
  • 2022
  • Ingår i: ESC Heart Failure. - : John Wiley & Sons. - 2055-5822. ; 9:4, s. 2084-2095
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims To define plasma concentrations, determinants, and optimal prognostic cut-offs of soluble suppression of tumorigenesis-2 (sST2), high-sensitivity cardiac troponin T (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in women and men with chronic heart failure (HF). Methods and results Individual data of patients from the Biomarkers In Heart Failure Outpatient Study (BIOS) Consortium with sST2, hs-cTnT, and NT-proBNP measured were analysed. The primary endpoint was a composite of 1 year cardiovascular death and HF hospitalization. The secondary endpoints were 5 year cardiovascular and all-cause death. The cohort included 4540 patients (age 67 +/- 12 years, left ventricular ejection fraction 33 +/- 13%, 1111 women, 25%). Women showed lower sST2 (24 vs. 27 ng/mL, P < 0.001) and hs-cTnT level (15 vs. 20 ng/L, P < 0.001), and similar concentrations of NT-proBNP (1540 vs. 1505 ng/L, P = 0.408). Although the three biomarkers were confirmed as independent predictors of outcome in both sexes, the optimal prognostic cut-off was lower in women for sST2 (28 vs. 31 ng/mL) and hs-cTnT (22 vs. 25 ng/L), while NT-proBNP cut-off was higher in women (2339 ng/L vs. 2145 ng/L). The use of sex-specific cut-offs improved risk prediction compared with the use of previously standardized prognostic cut-offs and allowed to reclassify the risk of many patients, to a greater extent in women than men, and for hs-cTnT than sST2 or NT-proBNP. Specifically, up to 18% men and up to 57% women were reclassified, by using the sex-specific cut-off of hs-cTnT for the endpoint of 5 year cardiovascular death. Conclusions In patients with chronic HF, concentrations of sST2 and hs-cTnT, but not of NT-proBNP, are lower in women. Lower sST2 and hs-cTnT and higher NT-proBNP cut-offs for risk stratification could be used in women.
  •  
44.
  • Vergaro, Giuseppe, et al. (författare)
  • NT-proBNP for Risk Prediction in Heart Failure : Identification of Optimal Cutoffs Across Body Mass Index Categories
  • 2021
  • Ingår i: JACC. Heart failure. - : American College of Cardiology. - 2213-1779 .- 2213-1787. ; 9:9, s. 653-663
  • Tidskriftsartikel (refereegranskat)abstract
    • ObjectivesThe goal of this study was to assess the predictive power of N-terminal pro–B-type natriuretic peptide (NT-proBNP) and the decision cutoffs in heart failure (HF) across body mass index (BMI) categories.BackgroundConcentrations of NT-proBNP predict outcome in HF. Although the influence of BMI to reduce levels of NT-proBNP is known, the impact of obesity on prognostic value remains uncertain.MethodsIndividual data from the BIOS (Biomarkers In Heart Failure Outpatient Study) consortium were analyzed. Patients with stable HF were classified as underweight (BMI <18.5 kg/m2), normal weight (BMI 18.5-24.9 kg/m2), overweight (BMI 25-29.9 kg/m2), and mildly (BMI 30-34.9 kg/m2), moderately (BMI 35-39.9 kg/m2), or severely (BMI ≥40 kg/m2) obese. The prognostic role of NT-proBNP was tested for the endpoints of all-cause and cardiac death.ResultsThe study population included 12,763 patients (mean age 66 ± 12 years; 25% women; mean left ventricular ejection fraction 33% ± 13%). Most patients were overweight (n = 5,176), followed by normal weight (n = 4,299), mildly obese (n = 2,157), moderately obese (n = 612), severely obese (n = 314), and underweight (n = 205). NT-proBNP inversely correlated with BMI (β = –0.174 for 1 kg/m2; P < 0.001). Adding NT-proBNP to clinical models improved risk prediction across BMI categories, with the exception of severely obese patients. The best cutoffs of NT-proBNP for 5-year all-cause death prediction were lower as BMI increased (3,785 ng/L, 2,193 ng/L, 1,554 ng/L, 1,045 ng/L, 755 ng/L, and 879 ng/L, for underweight, normal weight, overweight, and mildly, moderately, and severely obese patients, respectively) and were higher in women than in men.ConclusionsNT-proBNP maintains its independent prognostic value up to 40 kg/m2 BMI, and lower optimal risk-prediction cutoffs are observed in overweight and obese patients.
  •  
45.
  • Wallengren Gustafsson, Catarina, et al. (författare)
  • Person-centered care content in medicine, occupational therapy, nursing, and physiotherapy education programs
  • 2022
  • Ingår i: BMC medical education. - : Springer Science and Business Media LLC. - 1472-6920. ; 22:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Although person-centered care (PCC) ensures high-quality care for patients, studies have shown that it is unevenly applied in clinical practice. The extent to which future health care providers are currently offered education in PCC at their universities is unclear. We aimed to clarify the PCC content offered to students as a basis for their understanding by exploring the PCC content of Swedish national study programs in medicine, nursing, occupational therapy, and physiotherapy.Using a qualitative document analysis design, we sampled the steering documents from all higher education institutions (n=48) with accreditation in medicine (n=7), nursing (n=25), occupational therapy (n=8), or physiotherapy (n=8) at a single time point. All national study programs (n=4), local program syllabuses (n=48), and local course syllabuses (n=799) were reviewed using a 10-item protocol.We found no content related to PCC in the steering documents at the national level. At the local level, however, signs of PCC were identified in local program syllabuses and local course syllabuses. Seven of the 48 local program syllabuses (15%) included PCC in their intended learning outcomes. Eight of the 799 local course syllabuses (1%) contained course titles that included the phrase 'person-centered care,' and another 101 listed 142 intended learning outcomes referring to PCC. A total of 21 terms connected to PCC were found, and the term 'person-centered care' was most commonly used in the nursing programs and least commonly in the medical programs.There is a broad range in how the national study programs in Sweden have incorporated PCC. The implementation has been driven by a bottom-up strategy. A deliberate and standardized strategy is needed to ensure full implementation of PCC into clinical curricula in higher education.
  •  
46.
  • Wilkinson, Tim, 1978, et al. (författare)
  • Shades of grey-tire characteristics and road surface influence tire and road wear particle (TRWP) abundance and physicochemical properties
  • 2023
  • Ingår i: Frontiers in Environmental Science. - : Frontiers Media S.A.. - 2296-665X. ; 11
  • Tidskriftsartikel (refereegranskat)abstract
    • There is mounting evidence that tire wear particles can harm natural systems, but worldwide trends in car weight and car usage, mean emissions are set to increase. To control tire wear emissions and help understand fate and transport, detailed characterisation of the particles, and the relationship between road surface properties and emission profiles is needed. This study deployed a suite of experiments utilising the advanced road simulator of the Swedish National Road and Transport Research Institute to compare seasonal tire types from three brands. An extraction method was developed for a coarse (>30 mu m) fraction of tire and road wear particles (TRWP), and a comprehensive physicochemical characterisation scheme applied to both TRWP and tire-tread, including microscopy, energy-dispersive X-ray spectroscopy and pyrolysis-GC/MS. Road simulator dusts and hand-picked TRWP showed differences in shape, numbers, and mass between tire types and brands, and between asphalt and cement concrete road surfaces. Contrary to accepted perceptions, tactile analyses revealed that firm-elastic TRWP comprised only a minor proportion of TRWP. Fragile and chemically distinct tire-road-derived particles, termed here sub-elastic TRWP, comprised 39-100% of TRWP. This finding raises urgent questions about overall TRWP classification and identification features, resistance to weathering, and environmental fate. At the same time, differences in TRWP generation between tire formulations, and road surfaces, show potential for controlling emissions to reduce global impacts.
  •  
47.
  • Williamson, Alice, et al. (författare)
  • Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
  • 2023
  • Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:6, s. 973-983
  • Tidskriftsartikel (refereegranskat)abstract
    • Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P < 5 × 10-8) not previously associated with postchallenge insulin resistance, eight of which were shown to share their genetic architecture with type 2 diabetes in colocalization analyses. We investigated candidate genes at a subset of associated loci in cultured cells and identified nine candidate genes newly implicated in the expression or trafficking of GLUT4, the key glucose transporter in postprandial glucose uptake in muscle and fat. By focusing on postprandial insulin resistance, we highlighted the mechanisms of action at type 2 diabetes loci that are not adequately captured by studies of fasting glycemic traits.
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