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- Dictor, Michael, et al.
(författare)
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Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.
- 2009
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Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 94:11, s. 1563-1568
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1. DESIGN AND METHODS: On hundred and seventy-two specimens were immunostained for the SOX11 N and C termini. Cyclin D1 was detected by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction; in situ hybridization for t(11;14) was applied when needed. RESULTS: Nuclear SOX11 was strongly expressed in most B and T-lymphoblastic leukemia/lymphomas and half of childhood Burkitt's lymphomas, but only weakly expressed in some hairy cell leukemias. Chronic lymphocytic leukemia/lymphoma, marginal zone, follicular and diffuse large B-cell lymphomas were negative for SOX11, as were all cases of intermediate Burkitt's lymphomas/diffuse large B-cell lymphoma, myeloma, Hodgkin's lymphomas and mature T-cell and NK/T-cell lymphomas. CONCLUSIONS: In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia.
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| 4. |
- Spangenberg, Elin, et al.
(författare)
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Effects of physical activity and group size on animal welfare in laboratory rats
- 2009
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Ingår i: Animal Welfare. - 0962-7286 .- 2054-1538. ; 18, s. 159-169
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate whether moderate physical activity and group size influence physical fitness, the level of social interactions in the home cage and rats' performance in the Elevated Plus Maze and a handling test. Forty-eight male Sprague Dawley rats were kept in groups of two, four or eight for seven weeks in cages adjusted to the group size. Home cage social interactions were studied during direct observations. Half of the number of rats from each cage were subjected to moderate exercise on a treadmill for five weeks. An exercise test was performed at the beginning and end of the experimental period, during which time lactate levels were analysed via blood sampling. Rats living in groups of four or eight performed better in the second exercise test; had more social interactions and showed more activity, open-arm entries and risk assessment in the Elevated Plus Maze test compared to rats living in pairs. The trained rats had lower blood lactate levels in the second exercise test lower bodyweight and plasma insulin levels and had a greater relative heart weight at the end of the study compared to control rats. In conclusion, rats kept in larger groups had more social interactions, a lower lactate response during exercise and showed less emotional reactivity. Moderate treadmill exercise resulted in the expected increase in the rats' physical fitness. The results show that both group size and physical activity are important factors for animal welfare,
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