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Sökning: WFRF:(Guy Lionel PhD Docent 1980 ) > (2020)

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1.
  • Hugoson, Eric, et al. (författare)
  • miComplete : weighted quality evaluation of assembled microbial genomes
  • 2020
  • Ingår i: Bioinformatics. - : Oxford University Press (OUP). - 1367-4803 .- 1367-4811. ; 36:3, s. 936-937
  • Tidskriftsartikel (refereegranskat)abstract
    • SUMMARY: Metagenomics and single-cell genomics have revolutionized the study of microorganisms, increasing our knowledge of microbial genomic diversity by orders of magnitude. A major issue pertaining to metagenome-assembled genomes (MAGs) and single-cell amplified genomes (SAGs) is to estimate their completeness and redundancy. Most approaches rely on counting conserved gene markers. In miComplete, we introduce a weighting strategy, where we normalize the presence/absence of markers by their median distance to the next marker in a set of complete reference genomes. This approach alleviates biases introduced by the presence/absence of shorter DNA pieces containing many markers, e.g. ribosomal protein operons.AVAILABILITY AND IMPLEMENTATION: miComplete is written in Python 3 and released under GPLv3. Source code and documentation are available at https://bitbucket.org/evolegiolab/micomplete.SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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2.
  • Wang, Helen, et al. (författare)
  • Chlamydia psittaci in Fulmars on The Faroe Islands : A Causative Link to South American Psittacines Eight Decades After a Severe Epidemic
  • 2020
  • Ingår i: Microbes and infection. - : Elsevier BV. - 1286-4579 .- 1769-714X. ; 22:8, s. 356-359
  • Tidskriftsartikel (refereegranskat)abstract
    • A psittacosis epidemic linked to fulmar hunting occurred on the Faroe Islands in the 1930s. This study investigates a plausible explanation to the 20% human mortality in this outbreak. Phylogenetic analysis showed that C. psittaci isolated from fulmars were closely related to the highly virulent 6BC strains from psittacines and is compatible with an acquisition by fulmars of an ancestor of the 6BC clade in the 1930s. This supports the hypothesis that the outbreak on the Faroe Islands started after naïve fulmars acquired C. psittaci from infected dead parrots thrown overboard when shipped to Europe in the 1930s.
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