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- Falconer, D., et al.
(författare)
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New Air-interface Technologies and Deployment Concepts
- 2006
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Ingår i: Technologies for the Wireless Future: Wireless World Research Forum (WWRF). - Chichester, UK : John Wiley & Sons. - 0470029056 - 9780470029053 ; , s. 131-226
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Bradley, E. L., et al.
(författare)
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The BIOSAFEPAPER project for in vitro toxicity assessments : Preparation, detailed chemical characterisation and testing of extracts from paper and board samples
- 2008
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Ingår i: Food and Chemical Toxicology. - : Elsevier BV. - 0278-6915 .- 1873-6351. ; 46:7, s. 2498-2509
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Tidskriftsartikel (refereegranskat)abstract
- Nineteen food contact papers and boards and one non-food contact board were extracted following test protocols developed within European Union funded project BIOSAFEPAPER. The extraction media were either hot or cold water, 95% ethanol or Tenax, according to the end use of the sample. The extractable dry matter content of the samples varied from 1200 to 11,800 mg/kg (0.8-35.5 mg/dm2). According to GC-MS the main substances extracted into water were pulp-derived natural products such as fatty acids, resin acids, natural wood sterols and alkanols. Substances extracted into ethanol particularly, were diisopropylnaphthalenes, alkanes and phthalic acid esters. The non-food contact board showed the greatest number and highest concentrations of GC-MS detectable compounds. The extracts were subjected to a battery of in vitro toxicity tests measuring both acute and sublethal cytotoxicity and genotoxic effects. None of the water or Tenax extracts was positive in cytotoxicity or genotoxicity assays. The ethanol extract of the non-food contact board gave a positive response in the genotoxicity assays, and all four ethanol extracts gave positive response(s) in the cytotoxicity assays to some extent. These responses could not be pinpointed to any specific compound, although there appeared a correlation between the total amount of extractables and toxicity.
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| 6. |
- Nygård, K, et al.
(författare)
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Isotope quantum effects in the electron momentum density of water.
- 2007
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 126:15, s. 154508-
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Tidskriftsartikel (refereegranskat)abstract
- The isotope quantum effects in the ground-state electron momentum density of water are studied at temperatures ranging from 5 to 90 degrees C by combining Compton scattering experiments utilizing synchrotron radiation and computational analysis within density functional theory. We observe clear differences in the momentum density between normal and heavy water at room temperature, which are interpreted as predominantly reflecting intramolecular structural differences. The changes in the momentum density upon increasing the temperature are found to be larger for heavy than for normal water, which is attributed primarily to temperature-induced intramolecular structural effects. Both model computations and an ab initio approach qualitatively reproduce the changes in the momentum density as a function of temperature.
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| 7. |
- Valkonen, J., et al.
(författare)
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Formal Verification of Safety I&C System Designs : Two Nuclear Power Plant Related Applications
- 2008
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Ingår i: Proceedings Man-Technology-Organisation Session, Enlarged Halden Programme Group Meeting. - Norway : Institt for energiteknikk.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Instrumentation and control (I&C) systems play a crucial role in the operation of nuclear power plants(NPP) and other safety critical processes. An important change is the replacement of the old analogue I&Csystems with new digitalised ones. The programmable digital logic controllers enable more complicatedcontrol tasks than the old analogue systems and thus the validation of the control logic designs against safetyrequirements has become more important. In order to diminish the subjective component of the evaluationthere is a need to develop new formal verification methods. A promising approach is a method called modelchecking, which enables the complete verification of requirements when a finite state machine model of thesystem is available. The use of model checking to verify two nuclear power plant related systems isdescribed: an arc protection system and a reactor emergency cooling system. For the verification, it was alsonecessary to model the operation environment of the device and the larger system it is part of. Theenvironment models could be kept relatively simple, but it is important that the essential behaviour of theenvironment is covered. The reactor emergency cooling system is in use in an operating nuclear power plantand the arc protection system model included a typical realistic operation environment. The results showedthat it was possible to reliably verify the presence of desired behaviour as well as the absence of anundesired behaviour of the system. The possibility for complete verification makes model checking differentfrom simulation-based testing where only a number of selected scenarios can be simulated and one can neverbe sure that all the possible behaviour is covered. The challenges for future research are to develop morededicated methods for the verification of safety critical automation and safety critical embedded software.
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| 8. |
- Åkerblom, Hans, et al.
(författare)
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Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes : A pilot study
- 2005
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 48:5, s. 829-837
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Tidskriftsartikel (refereegranskat)abstract
- Aims/hypothesis: We aimed to assess the feasibility of a dietary intervention trial with weaning to hydrolysed formula in infants at increased risk of type 1 diabetes and to study the effect of the intervention on the emergence of diabetes-associated autoantibodies in early childhood. Methods: We studied 242 newborn infants who had a first-degree relative with type 1 diabetes and carried risk-associated HLA-DQB1 alleles. After exclusive breastfeeding, the infants underwent a double-blind, randomised pilot trial of either casein hydrolysate (Nutramigen, Mead Johnson) or conventional cow's milk-based formula until the age of 6-8 months. During a mean observation period of 4.7 years, autoantibodies to insulin, anti-glutamic acid decarboxylase and insulinoma-associated antigen-2 were measured by radiobinding assays, and islet cell antibodies (ICA) by immunofluorescence. Results: The feasibility of screening and identifying a cohort of first-degree relatives with HLA-conferred disease susceptibility, enrolling them in a dietary intervention trial and following them for seroconversion to autoantibody positivity is established. The cumulative incidence of autoantibodies was somewhat smaller in the casein hydrolysate vs control formula group, suggesting the need for a larger well-powered study. After adjustment for duration of study formula feeding, life-table analysis showed a significant protection by the intervention from positivity for ICA (p=0.02) and at least one autoantibody (p=0.03). Conclusions/interpretation: The present study provides the first evidence ever in man, despite its limited power, that it may be possible to manipulate spontaneous beta cell autoimmunity by dietary intervention in infancy. © Springer-Verlag 2005.
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