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- Glimelius, B, et al.
(författare)
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The Swedish Council on Technology Assessment in Health Care (SBU) systematic overview of chemotherapy effects in some major tumour types--summary and conclusions
- 2001
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Ingår i: Acta oncologica (Stockholm, Sweden). - : Informa UK Limited. - 0284-186X. ; 40, s. 135-
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Forskningsöversikt (refereegranskat)abstract
- This report by The Swedish Council on Technology Assessment in Health Care (SBU) reviews, classifies, and grades the scientific literature on cancer chemotherapy in some major tumour types, describes the practice of chemotherapy in Sweden, compares practice with scientific knowledge, and analyses the costs and cost-effectiveness of chemotherapy. The report is intended primarily for decision-makers at various levels, both practitioners and administrators. It is also of interest for the medical profession. The extensive body of scientific literature was reviewed according to strict criteria that reflected the scientific weight of the literature. Sixteen experts representing different disciplines (oncology, surgery, internal medicine, health economy and quality of life research) participated in the literature review. Each section was discussed within the project group and was reviewed by at least one, but usually two international researchers. Additional input was provided by national experts representing different scientific disciplines. For the final evaluation to be as close to the objective truth as possible, a concerted effort was made to guarantee objectivity and thorough assessment of current knowledge about the effects of chemotherapy on the selected cancers. The tumour types selected for this assessment include firstly those types where three investigations had shown an increased use of chemotherapy in Sweden during the latest decade. These were non-small cell lung cancer (NSCLC), gastric cancer, pancreatic cancer, colorectal cancer and urinary bladder cancer. Secondly, the two tumour types comprising the greatest number of patients treated with chemotherapy in Sweden, breast cancer and haematological malignancies, were included. Among the haematological malignancies, the most prevalent ones, acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL), Hodgkin's disease (HD), aggressive non-Hodgkin's lymphoma (NHL) of the large B-cell type and indolent NHL of follicular type were evaluated. These constitute about 75%, of all haematological malignancies. Thirdly, ovarian cancer was included since chemotherapy has been extensively used and since, at the time of the planning of this overview, a group of very expensive drugs, the taxanes, had preliminarily shown promising results. A wealth of scientific literature has been published on cancer therapy. The review presented in this report is limited to scientific studies judged to be important for evaluating chemotherapy efficacy. Assessments of the content and quality of these studies, and a critical summary of the results in all stages of the selected tumours, have never before been attempted in this way. However, similar comprehensive overviews of certain stages of the tumours have previously been made. These overviews were also critically evaluated. Totally 1,496 studies involving 558,743 patients were reviewed. The survey of practice of chemotherapy use involved all departments of surgery, urology, gynaecology, internal medicine including haematologic units, pulmonary medicine and general and gynaecologic oncology at 16 hospitals in two health care regions in Sweden, covering 39% of the Swedish population. During the 4 weeks of the survey, all patients with the diagnoses concerned who received chemotherapy were registered. The study included 1,590 patients. The working group's general conclusions are summarised in the following points: The literature on the effects of chemotherapy is extensive. Chemotherapy has a well-documented role in the curative and palliative treatment of patients with several types of cancer. The use of chemotherapy is of utmost importance for the possibility of cure in certain tumour types. In other tumours, chemotherapy increases the possibility of cure when added to local and regional treatments, particularly surgery. In the instances of no possibility of cure, chemotherapy may to a variable extent improve both patient survival and well-being. In Sweden chemotherapy is largely used in accordance with that documented in the scientific literature. The extent of both over- and under-treatment seems to be limited but cannot be excluded at the individual patient level. The literature-based knowledge is scientifically of lower quality in the most chemotherapy sensitive tumours than in tumours showing more limited sensitivity. In the more sensitive tumours, positive effects on a symptomatic stage and survival were seen several decades ago. In those days, clinical treatment studies did not fulfil the current high quality requirements. Small life-prolonging effects of chemotherapy are sometimes very well documented in large, high quality scientific studies. Some of these s
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| 5. |
- Ballerini, L., et al.
(författare)
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How Do People Choose Meat?
- 2001
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Konferensbidrag (refereegranskat)abstract
- In this paper we present a survey carried out to understand the choice of
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| 9. |
- Högberg, Hans, et al.
(författare)
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Deposition of transition metal carbides and superlattices using C-60 as carbon source
- 2000
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Ingår i: JOURNAL OF THE ELECTROCHEMICAL SOCIETY. - 0013-4651. ; 147:9, s. 3361-3369
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Tidskriftsartikel (refereegranskat)abstract
- Thin films of TiC, VC, and NbC have been deposited on MgO(001) by coevaporation of the metals and C-60 It was found that these metals induced a decomposition of the C-60 molecule and that carbide films can be formed at a temperature as low as 100 degrees
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| 14. |
- Högberg, Thomas, 1947-, et al.
(författare)
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A prospective population-based management program including primary surgery and postoperative risk assessment by means of DNA ploidy and histopathology. Adjuvant radiotherapy is not necessary for the majority of patients with FIGO stage I-II endometrial cancer
- 2004
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Ingår i: International Journal of Gynecological Cancer. - : BMJ. - 1048-891X .- 1525-1438. ; 14:3, s. 437-450
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Tidskriftsartikel (refereegranskat)abstract
- A management program for FIGO stage I-II nonserous, nonclear-cell adenocarcinomas was evaluated. Histopathology and DNA ploidy were used to estimate postoperatively the risk of progression or death of disease and to tailor treatment. The patient material was a population-based consecutive cohort of all women with endometrial cancer in the Southern Swedish Health Care Region diagnosed between June 1993 and June 1996 (n = 553). Of these, 335 were eligible for the management program. Patients estimated to be at low risk were treated by surgery only, while high-risk patients also received vaginal brachytherapy. A large low-risk group consisting of 84% (n = 283) of the patients with an estimated disease-specific 5-year survival of 96% (95% CI = 93-98%) was identified. The high-risk group (n = 52, 16%) showed a worse outcome with an 80% 5-year disease-specific survival (95% CI = 65-89%). The difference in survival between the groups was highly significant (P < 0.0001). Half of the progressions were distant in the high-risk group. Although there is a clear indication for adjuvant therapy for this group, locoregional radiotherapy could be expected to fail in cases with distant progression. Thus, effective systemic treatments need to be developed. Low-risk patients, constituting the majority (84%) of the patients, can be safely treated by surgery only.
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| 15. |
- Landstrlom, L., et al.
(författare)
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In situ monitoring of size distributions and characterization of nanoparticles during W ablation in N2 atmosphere
- 2003
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 94:3, s. 2011-2017
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Tidskriftsartikel (refereegranskat)abstract
- Amporphous WN0.3 nanoparticles were generated by pulsed excimer ablation of tungsten in a N2 ambient at atmospheric pressure. Size distributions and concentrations were monitored by dynamic mechanical analysis (DMA) and condensation particle counter (CPC) with different laser parameters and sport sizes. It was found that the fast desorptive part for which a thermal process for material removal was ruled out and the 'real' ablation gave rise to different types of size distributions.
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| 19. |
- Rieske, LK, et al.
(författare)
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Captures of male European pine sawflies (Hymenoptera : Diprionidae) in pheromone-baited traps in Kentucky
- 2001
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Ingår i: Journal of Entomological Science. - 0749-8004. ; 36:1, s. 67-73
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Tidskriftsartikel (refereegranskat)abstract
- Using sticky traps baited with (2S, 3S, 7S)-3,7-dimethyl-2-pentadecyl acetate, we assessed the seasonal and diurnal flight activity of the European pine sawfly, Neodiprion sertifer (Geoffrey), in Fayette, Madison, and Livingston counties in Kentucky. At each site, two replicates of individual sticky traps were baited and suspended about 1 m high and spaced at least 20 m apart. Trap catch was affected by site (P = 0.001). A total of 326 European pine sawfly males were captured at the Fayette Co. site during the period 18 September to 12 November, representing 7% of the season total. No males of this species were caught at the other sites. During peak flight activity (1 to 15 October), we monitored traps at 2.5-h intervals over 4 d to determine diurnal flight patterns. Flight activity began after 1100 h and ceased by 1830 h, and was significantly affected by time of day. European pine sawfly flight activity was greatest between 1330 and 1330 h. We captured over 5,200 male sawflies at all three sites, with peak activity occurring in May, July, September and October.
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- Wiklund, H, et al.
(författare)
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Somalis giving birth in Sweden : a challenge to culture and gender specific values and behaviours.
- 2000
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Ingår i: Midwifery. - : Elsevier BV. - 0266-6138 .- 1532-3099. ; 16:2, s. 105-15
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Tidskriftsartikel (refereegranskat)abstract
- The Somalis' experiences of childbirth in Sweden can be understood by using the theoretical concept of gender, rather than culture. Our own and other studies show that women and men may have different frames of reference in childbirth, where the women mainly focus on biological circumstances and the men on the social and cultural aspects of birth. The Somali couple were found to be vulnerably positioned, with the professionals having the important role of supporting and empowering Somali parents.
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