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| 2. |
- Alvåsen, Karin, et al.
(författare)
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Farm characteristics related to on-farm cow mortality in dairy herds: a questionnaire study
- 2014
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Ingår i: Animal. - 1751-7311 .- 1751-732X. ; 8, s. 1735-1742
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Tidskriftsartikel (refereegranskat)abstract
- Dairy cow mortality is an important animal welfare issue that also causes financial losses. The objective of this study was to identify farm characteristics and herd management practices associated with high on-farm cow mortality in Swedish dairy herds. A postal questionnaire was sent to farmers that had either high or low mortality rates for 3 consecutive years. The questionnaire consisted of five sections: 'About the farm', 'Milking and housing', 'Feeding', 'Routines' and 'Lame and sick cows'. A total of 145 questionnaires were returned (response rate = 33%). Ten of the 77 characteristics investigated met the inclusion criteria for multivariable analysis. The final logistic regression model included: herd size, breed, use of natural service bull, bedding improvement frequency and pasture system. Herds with Swedish Holstein as the predominant breed (odds ratio (OR) 22.9, 95% confidence interval (CI) 5.2 to 101.8) or with mixed breeds (OR 5.5, 95% CI 1.7 to 17.5) had a greater risk of being high mortality herds than herds that were predominantly Swedish Red (OR 1). Herds larger than 100 cows (OR 19.6, 95% CI 3.5 to 110.4) and herds with 50 to 99 cows (OR 13.8, 95% CI 3.2 to 60.6) had greater risk of mortality than herds numbering 35 to 50 cows (OR 1). Being a high mortality herd was also associated with having cows on exercise lots during the summer season (OR 3.6, 95% CI 1.3 to 9.9) compared with on pasture. A missing answer on the question of bedding improvement frequency was associated with high mortality herds. Overall, this study suggests that characteristics that are related to intensification of the dairy industry are also associated with high on-farm mortality of dairy cows.
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| 3. |
- Alvåsen, Karin, et al.
(författare)
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Herd-level risk factors associated with cow mortality in Swedish dairy herds
- 2012
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Ingår i: Journal of Dairy Science. - : American Dairy Science Association. - 0022-0302 .- 1525-3198. ; 95, s. 4352-4362
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Tidskriftsartikel (refereegranskat)abstract
- An increase in on-farm mortality (euthanasia and death) in dairy herds has been reported in several countries in the last decade. This does not only imply possible problems with animal welfare, but it also causes economic losses to the farmer. The objective of this study was to evaluate time trends in on-farm dairy cow mortality in Sweden and identify potential herd-level risk factors. Data were retrieved on all Swedish dairy herds enrolled in the milk recording scheme between 2002 and 2010. Herds with a herd size of <20 cows or a mortality rate (MR) of >40 dead or euthanized cows per 100 cow-years were excluded. Two different models were used: 1 multiple-year analysis, which included 6,898 herds during the period 2002 to 2010 and 1 single-year analysis including 4,252 herds for the year 2010, where other variables that were not present during the entire multiple year study were analyzed. The outcome variable was the number of euthanized and dead cows per year and season. A negative binomial regression model, adjusted for clustering within herd, was applied to both models. Fixed effects in the multiple-year analysis were breed, calving interval, herd size, milk yield, region, season, pasture period, and year. The fixed effects in the single-year analysis were breed, calving interval, conventional versus organic farming, herd size, housing system, milk yield, region, and season. The results demonstrated that MR gradually increased from 5.1 to 6.6 events per 100 cow-years during the study period. Swedish MR are consequently on par with, or even greater than, MR among dairy herds in other comparable countries. Higher mortality was associated with larger herd size, longer calving intervals, and herds that had Swedish Holstein as the predominant breed. Lower mortality was observed in herds with a higher herd average milk yield, during the fall and winter, and in organically managed herds. There were regional differences in mortality. An interaction between herd size and season was found in both models. Also, an interaction between housing system and milk yield was found in the single-year analysis. This first assessment of on-farm mortality in Swedish dairy herds confirmed that the MR has increased over the last few years. The study also identified some herd-level risk factors.
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| 4. |
- Alvåsen, Karin, et al.
(författare)
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On-farm mortality of cows in Swedish dairy herds
- 2011
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Ingår i: Annual meeting of the European Association for Animal Production. - 1382-6077. ; 17, s. 364-364
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Alvåsen, Karin, et al.
(författare)
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Risk factors associated with on-farm mortality in Swedish dairy cows
- 2014
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Ingår i: Preventive Veterinary Medicine. - : Elsevier BV. - 0167-5877 .- 1873-1716. ; 117, s. 110-120
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Tidskriftsartikel (refereegranskat)abstract
- Dairy cow mortality (unassisted death and euthanasia) has increased, worldwide and in Sweden. On-farm mortality indicates suboptimal herd health or welfare and causes financial loss for the dairy producer. The objective of this study was to identify cow-level risk factors associated with on-farm cow mortality. Cows with at least one calving between 1 July 2008 and 30 June 2009 from herds enrolled in the Swedish official milk recording scheme with >40 cow-years were included. Each cow was followed from the day of calving until she calved again or left the herd (died, slaughtered or sold). The effects of potential risk factors on on-farm cow mortality were analysed using a Weibull proportional hazard model with a gamma distributed frailty effect common to cows within herd. The event of interest (failure) was euthanasia or unassisted death. An observation was right censored if the cow was slaughtered, sold, calved again or had an on-going lactation at 500 days after calving. The lactations were split into seasons (January to April, May to August and September to December) and at 30 and 100 days in milk in order to evaluate seasonal effects and the effect of disease in different lactation stages. Primiparous and multiparous cows were analysed separately. The highest hazards for both primiparous and multiparous cows were found for traumatic events and diseases, both in the lactation stage in which the cow died and in the preceding stage. The hazard was higher in early lactation and lower in 2nd parity compared to higher parities. Increased age at first calving (for primiparous cows), calving between January and April, dystocia and stillbirth also increased the mortality hazard. Differences were also found between breeds, between milk production parameters at first test milking and between management types. The results from this study show the importance of good management and preventive health actions, especially around calving, to avoid mortality in dairy cows. (C) 2014 Elsevier B.V. All rights reserved.
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| 9. |
- Jonsson, Eva Lindell, et al.
(författare)
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Effect of radiotherapy on expression of hyaluronan and EGFR and presence of mast cells in squamous cell carcinoma of the head and neck
- 2012
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Ingår i: ONCOL LETT. - : Spandidos Publications. - 1792-1074 .- 1792-1082. ; 4:6, s. 1177-1182
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Tidskriftsartikel (refereegranskat)abstract
- Head and neck squamous cell carcinoma is a common form of cancer, and despite improvements in treatment during the last decades, survival rates have not significantly increased. There is therefore a need to better understand how these tumours and the adjacent tissues react to radiotherapy, the most common type of treatment for this group of tumours. In order to improve this understanding, the expression of hyaluronan (HA) and epidermal growth factor receptor (EGFR) and the presence of mast cells were mapped before and after radiotherapy using immunohistochemistry. The results showed HA and EGFR to have similar expression patterns in tumour tissue and histologically normal squamous epithelium prior to radiotherapy. Following radiotherapy, EGFR increased in histologically normal epithelium. An increased number of mast cells were also observed as a result of radiotherapy. No expression of EGFR was observed in the connective tissue either prior to or following radiotherapy.
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| 10. |
- Sjöblom-Hallén, A, et al.
(författare)
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Gene expression profiling identifies STAT3 as a novel pathway for immunomodulation by cholera toxin adjuvant.
- 2010
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Ingår i: Mucosal immunology. - : Elsevier BV. - 1935-3456 .- 1933-0219. ; 3:4, s. 374-386
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Tidskriftsartikel (refereegranskat)abstract
- Earlier studies have reported on both proinflammatory and anti-inflammatory activities of cholera toxin (CT). As CT is a powerful adjuvant, we were interested in identifying genes with a possible involvement in these functions. A global gene expression analysis in mouse B cells showed that CT regulated <100 annotated genes, which encoded transcription factors, G proteins, cell-cycle regulators, and immunoregulating molecules. Interestingly, CT regulated the expression of the signal transducer and activator of transcription (STAT)3 gene and influenced the level and activation of both isoforms STAT3alpha and STAT3beta, in vitro in a B-cell line and in Peyer's patch (PP) B cells and in vivo in freshly isolated splenic B cells from CT-treated mice. This effect was cAMP dependent and was not seen with CTB. B cells pre-exposed to CT were significantly more susceptible to the activation of STAT3 by interleukin (IL)-6 and IL-10. This exerted a stronger inhibitory effect of IL-10 on lipopolysaccharide (LPS)-stimulated B-cell proliferation and cytokine production (IL-6). Moreover, IgG1 and IgA production induced by LPS and IL-10 were enhanced by the addition of CT to cultures of PP or splenic B cells. This is the first study to provide a molecular mechanism that can reconcile previous findings of proinflammatory and anti-inflammatory effects by CT adjuvant.Mucosal Immunology advance online publication 7 April 2010. doi:10.1038/mi.2010.16.
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| 11. |
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Studies in Industrial Renewal : Coping with Changing Contexts
- 2011. - 200
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- The purpose of this book is to provide a picture of ongoing research at Mälardalen University in order to create a point of departure for future research on industrial renewal. Many aspects of industrial renewal are dealt with by the researchers who contributed to this book. Some of them focus on functional aspects such as distribution channels and management accounting and control. Others deal with broad perspectives such as strategies and entrepreneurship, and still others consider specific empirical fields such as the institutions of society, and the energy sector.Our exposition identifies a need for further research into classical problems such as how to best exploit new ideas in established firms, as well as how to infuse new approaches and attitudes into going concerns, the role of the characteristics of industrial networks, geographical distance, the labour market, and the institutions of society in such renewal processes, and the need for more in-depth process research in order to further develop theory and practice.
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