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- Han, Tiantian, et al.
(författare)
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Room-temperature photoluminescence of doped 4H-SiC film grown on AlN/Si(100)
- 2007
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Ingår i: Applied Physics A. - : Springer Science and Business Media LLC. - 0947-8396 .- 1432-0630. ; 86:1, s. 145-149
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Tidskriftsartikel (refereegranskat)abstract
- Well-defined room-temperature photoluminescence (PL) was observed from 4H-SiC films on AlN/Si(100) complex substrates grown at temperatures below 1150 degrees C by the chemical vapor deposition method. The PL spectrum consists of three major emission peaks in the vicinities of 3.03, 3.17 and 3.37 eV. By the combination of experimental measurements and theoretical analysis, the origins of the PL emission peaks have been identified and associated with N donors, Al acceptors in the 4H-SiC films and the band-to-band transition between the second minimum of the conduction band and the top of valance band of the 4H-SiC. The room-temperature SiC PL can be much utilized for optoelectronic high-power, high-frequency and high-temperature applications in the ultraviolet spectral regime.
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- Hua, Dong, et al.
(författare)
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Small interfering RNA-directed targeting of toll-like receptor 4 inhibits human prostate cancer cell invasion, survival, and tumorigenicity
- 2009
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Ingår i: Molecular Immunology. - : Elsevier BV. - 0161-5890 .- 1872-9142. ; 46:15, s. 2876-2884
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Tidskriftsartikel (refereegranskat)abstract
- A major cause of tumor treatment failure is cancer cell metastasis. Toll-like receptor 4 (TLR4)-mediated signaling has been implicated in tumor cell invasion, survival, and metastasis in a variety of cancers. In this study, we investigated the biological roles of TLR4 in prostate metastatic cell invasion and survival, and the potential of gene silencing of TLR4 using small interfering RNA (siRNA) for treatment of cancer. In cultured human prostate cancer cell lines, TLR4 were higher PC3 and DU145 as compared with the poorly metastatic LNCaP indicating that up-regulation of TLR4 was positively correlated with metastasis of tumor cell. In the highly metastatic cancer cell PC3, gene silencing of TLR4 using siRNA significantly inhibited TLR4 mRNA expression and protein level. Knockdown of TLR4 in PC3 cells resulted in a dramatic reduction of tumor cell migration and invasion as indicated by a Matrigel invasion assay. Furthermore, TLR4 siRNA suppressed cell viability and ultimately caused the induction of apoptotic cell death. The effects were associated with abrogating TLR4-mediated signaling to downstream target molecules such as myeloid differentiation factor 88 (MyD88), adaptor-inducing IFN-beta (TRIF), and interferon regulatory factor-1 (IRF-1). In a mouse prostate cancer model, administration with the plasmid construct expressing siRNA for TLR4 obviously inhibited established tumor growth and survival. These studies revealed evidence of a multifaceted signaling network operating downstream of TLR4-mediated tumor cell invasion, proliferation, and survival. Thus, RNA interference-directed targeting of TLR4 may raise the potential of its application for cancer therapy.
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| 7. |
- Wang, Qin, et al.
(författare)
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Experimental Decoy-State Quantum Key Distribution with a Sub-Poissionian Heralded Single-Photon Source
- 2008
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 100:9, s. 090501-
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Tidskriftsartikel (refereegranskat)abstract
- We have experimentally demonstrated a decoy-state quantum key distribution scheme (QKD) with a heralded single-photon source based on parametric down-conversion. We used a one-way Bennett-Brassard 1984 protocol with a four states and one-detector phase-coding scheme, which is immune to recently proposed time-shift attacks, photon-number splitting attacks, and can also be proven to be secure against Trojan horse attacks and any other standard individual or coherent attacks. In principle, the setup can tolerate the highest losses or it can give the highest secure key generation rate under fixed losses compared with other practical schemes. This makes it a quite promising candidate for future quantum key distribution systems.
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| 8. |
- Wang, Qin, et al.
(författare)
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Robust decoy-state quantum key distribution with heralded single photon source
- 2008
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Ingår i: 2008 Conference On Lasers And Electro-Optics & Quantum Electronics And Laser Science Conference. - 9781557528599 ; , s. 3589-3590
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Konferensbidrag (refereegranskat)abstract
- We have experimentally demonstrated a decoy-state quantum key distribution scheme (QKD) with a heralded single-photon source based on parametric down-conversion. What we used is a one-way BB84 protocol with a four-state and one-detector phase-coding scheme.
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