SwePub - search: WFRF:(Hansen Sonja)

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1.	Abata, E., et al. (author) Study of energy response and resolution of the ATLAS barrel calorimeter to hadrons of energies from 20 to 350 GeV 2010 In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier. - 0168-9002 .- 1872-9576 .- 0167-5087. ; 621:1-3, s. 134-150 Journal article (peer-reviewed)abstract A fully instrumented slice of the ATLAS detector was exposed to test beams from the SPS (Super Proton Synchrotron) at CERN in 2004. In this paper, the results of the measurements of the response of the barrel calorimeter to hadrons with energies in the range 20-350 GeV and beam impact points and angles corresponding to pseudo-rapidity values in the range 0.2-0.65 are reported. The results are compared to the predictions of a simulation program using the Geant 4 toolkit. (C) 2010 Published by Elsevier B.V.
2.	Andersson-Marforio, Sonja, et al. (author) A survey of the physiotherapy treatment methods for infants hospitalised with acute airway infections in Sweden 2021 In: European Journal of Physiotherapy. - : Informa UK Limited. - 2167-9169 .- 2167-9177. ; 23:3, s. 149-156 Journal article (peer-reviewed)abstract Purpose: The purpose of this study was to investigate what treatment methods physiotherapists in Sweden use for infants 0–24 months hospitalised with acute breathing difficulties due to lower respiratory tract infections. Material and methods: We constructed an anonymous digital survey for paediatric physiotherapists in Sweden. It was distributed by e-mail and was posted on professional websites. Completed forms were obtained from all 21 counties in Sweden. Results: Eighty-eight physiotherapists replied and 52 worked with the target group. Different treatment methods were used, based on the situation and the individual’s symptom. The most common methods involved physical activity and change of the body position. Conclusions: A variety of treatment methods are used by the Swedish physiotherapists. The most commonly used are treatment methods involving frequent changes of the body position and stimulation to physical activity. Thus, the praxis in Sweden seem to differ from methods described in the literature. Methods are chosen depending on the symptoms of the patients. No differences in the choice of treatment methods were found regarding the physiotherapists’ background characteristics.
3.	Andersson-Marforio, Sonja, et al. (author) Physiotherapy interventions encouraging frequent changes of the body position and physical activity for infants hospitalised with bronchiolitis : an internal feasibility study of a randomised control trial 2022 In: Pilot and Feasibility Studies. - : Springer Science and Business Media LLC. - 2055-5784. ; 8, s. 1-10 Journal article (peer-reviewed)abstract BACKGROUND: The effect of a treatment that includes frequent changes of the body position for infants with bronchiolitis has not been evaluated, although it is often used in Swedish hospitals. Because of this, a randomised control trial (RCT) has begun with the aim to evaluate this treatment, comparing the effect of an individualised physiotherapy intervention, a non-individualised intervention, and standard care in a control group. The objective of this internal pilot study was to address uncertainties concerning the ongoing RCT and to determine whether the trial is feasible or not, possibly with adjustments to the protocol.METHODS: Descriptive analyses of the recruitment, retention, data supply for the primary end point, and the usability of the primary outcome measure in the full RCT were performed. A safety analysis was conducted by an independent analysis group.RESULTS: Ninety-one infants were included, 33 (36.3%), 28 (30.8%), and 30 (33.0%) in the respective allocation groups. Fifty-nine (64.8%) were boys. The median age was 2.5 (min-max 0.2-23.7) months. They remained in the study for a median of 46 hours (min-max 2-159). The recruitment rate was 19%. The data supply for the primary end point and for the primary outcome measure was lower than anticipated in the original sample size calculation. Difficulties concerning utilising the primary outcome measure were identified. The safety analysis detected no risks of harm related to participation in the study.CONCLUSIONS: It is feasible to continue the RCT with modifications of the analysis plan. Participation in the study was not associated with any safety risks.TRIAL REGISTRATION: ClinicalTrials.gov NCT03575091 . Registered 2 July 2018. Retrospectively registered.
4.	Andersson-Marforio, Sonja, et al. (author) The effect of physiotherapy including frequent changes of body position and stimulation to physical activity for infants hospitalised with acute airway infections. Study protocol for a randomised controlled trial 2020 In: Trials. - : Springer Science and Business Media LLC. - 1745-6215. ; 21:1 Journal article (peer-reviewed)abstract Background: Every year, many infants are infected with the respiratory syncytial virus (RSV) or other agents and need hospitalisation due to bronchiolitis. The disease causes much suffering and high costs. Thus, it is important that the treatment methods are both effective and cost-efficient. The use of different physiotherapy treatment methods is debated, and not all methods are evaluated scientifically. The clinical praxis in Sweden that includes frequent changes of body position and stimulation to physical activity has not previously been evaluated. The aim of this clinical study is to evaluate this praxis. Methods: This study is a clinical two-centre individually randomised controlled trial (RCT) with three parallel groups. The participants will be randomly assigned to an individualised physiotherapy intervention, a non-individualised intervention, or a control group. All three groups will receive the standard care at the ward, and the two intervention groups will receive additional treatment, including different movements of the body. The primary outcome measure is a clinical index based on determinants for hospitalisation. Baseline assessments will be compared with the assessments after 24 h. The secondary outcome measures include vital signs, the parents' observations, time spent at the hospital ward, and referrals to an intensive care unit. We also want see if there is any immediate effect of the first intervention, after 20 min. Discussion: This study will add knowledge about the effect of two physiotherapy interventions that are commonly in use in Swedish hospitals for infants with bronchiolitis or other acute lower respiratory tract infections. Trial registration: ClinicalTrials.gov NCT03575091. Registered July 2, 2018 - retrospectively registered.
5.	Baltag, Alexandru, et al. (author) Logical Models of Informational Cascades 2013 In: Logic Across the University: Foundations and Applications. - 9781848901223 ; , s. 405-432 Book chapter (peer-reviewed)abstract In this paper, we investigate the social herding phenomenon known as informational cascades, in which sequential inter-agent communication might lead to epistemic failures at group level, despite availability of information that should be sufficient to track the truth. We model an example of a cascade, and check the correctness of the individual reasoning of each agent involved, using two alternative logical settings: an existing probabilistic dynamic epistemic logic, and our own novel logic for counting evidence. Based on this analysis, we conclude that cascades are not only likely to occur but are sometimes unavoidable by "rational" means: in some situations, the group’s inability to track the truth is the direct consequence of each agent’s rational attempt at individual truth-tracking. Moreover, our analysis shows that this is even so when rationality includes unbounded higher-order reasoning powers (about other agents’ minds and about the belief-formation-and-aggregation protocol, including an awareness of the very possibility of cascades), as well as when it includes simpler, non-Bayesian forms of heuristic reasoning (such as comparing the amount of evidence pieces).
6.	Benatar, Michael, et al. (author) Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial 2024 In: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 23:7, s. 687-699 Journal article (peer-reviewed)abstract Background: Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder leading to muscle weakness and respiratory failure. Arimoclomol, a heat-shock protein-70 (HSP70) co-inducer, is neuroprotective in animal models of amyotrophic lateral sclerosis, with multiple mechanisms of action, including clearance of protein aggregates, a pathological hallmark of sporadic and familial amyotrophic lateral sclerosis. We aimed to evaluate the safety and efficacy of arimoclomol in patients with amyotrophic lateral sclerosis.Methods: ORARIALS-01 was a multinational, randomised, double-blind, placebo-controlled, parallel-group trial done at 29 centres in 12 countries in Europe and North America. Patients were eligible if they were aged 18 years or older and met El Escorial criteria for clinically possible, probable, probable laboratory-supported, definite, or familial amyotrophic lateral sclerosis; had an ALS Functional Rating Scale-Revised score of 35 or more; and had slow vital capacity at 70% or more of the value predicted on the basis of the participant's age, height, and sex. Patients were randomly assigned (2:1) in blocks of 6, stratified by use of a stable dose of riluzole or no riluzole use, to receive oral arimoclomol citrate 1200 mg/day (400 mg three times per day) or placebo. The Randomisation sequence was computer generated centrally. Investigators, study personnel, and study participants were masked to treatment allocation. The primary outcome was the Combined Assessment of Function and Survival (CAFS) rank score over 76 weeks of treatment. The primary outcome and safety were analysed in the modified intention-to-treat population. This trial is registered with ClinicalTrials.gov, NCT03491462, and is completed.Findings: Between July 31, 2018, and July 17, 2019, 287 patients were screened, 245 of whom were enrolled in the trial and randomly assigned. The modified intention-to-treat population comprised 239 patients (160 in the arimoclomol group and 79 in the placebo group): 151 (63%) were male and 88 (37%) were female; mean age was 57·6 years (SD 10·9). CAFS score over 76 weeks did not differ between groups (mean 0·51 [SD 0·29] in the arimoclomol group vs 0·49 [0·28] in the placebo group; p=0·62). Cliff's delta comparing the two groups was 0·039 (95% CI –0·116 to 0·194). Proportions of participants who died were similar between the treatment groups: 29 (18%) of 160 patients in the arimoclomol group and 18 (23%) of 79 patients in the placebo group. Most deaths were due to disease progression. The most common adverse events were gastrointestinal. Adverse events were more often deemed treatment-related in the arimoclomol group (104 [65%]) than in the placebo group (41 [52%]) and more often led to treatment discontinuation in the arimoclomol group (26 [16%]) than in the placebo group (four [5%]).Interpretation: Arimoclomol did not improve efficacy outcomes compared with placebo. Although available biomarker data are insufficient to preclude future strategies that target the HSP response, safety data suggest that a higher dose of arimoclomol would not have been tolerated.Funding: Orphazyme.
7.	Dahlberg, Anders, et al. (author) Den nya rödlistan har 746 svampar 2010 In: Svensk mykologisk tidskrift. - 1653-0357. ; 31:2, s. 37-47 Journal article (peer-reviewed)abstract The new Red List that was recently presented by the Swedish Species Information Centre (Gärdenfors 2010) includes 746 species of fungi considered to be threatened. Compared to the previous Red List published in 2005, 36 species have been down-listed whereas 150 species have been added, thus the list has increased by 114. The changes are above all due to increased knowledge of taxonomy, ecology and distribution. In the present paper members of the Species Specialist Group for Fungi 2006-2010 summarize the background and results of the red-listing process and present the habitats in which the red-listed species occur.
8.	Dahlberg, Anders, et al. (author) Svampar – Fungi 2010 In: Rödlistade arter i Sverige 2010 – The 2010 Red List of Swedish Species. - 9789188506351 ; , s. 231-246 Book chapter (other academic/artistic)
9.	Dovemark, Marianne, 1952, et al. (author) Deregulation, Privatisation and Marketisation of Nordic Comprehensive Education: Social Changes Reflected in Schooling 2018 In: Education Inquiry. - : Informa UK Limited. - 2000-4508. ; 9:1, s. 122-141 Journal article (peer-reviewed)abstract The Nordic countries are often perceived as a coherent group representing the Nordic model of welfare states, with a strong emphasis on the public provision of universal welfare and a strong concern with social equality. But today we see a change in the Nordic model as part of a global knowledge economy. The aim of this article is to examine education in the five Nordic countries utilising three dimensions of political change: deregulation, marketisation and privatisation. We also analyse the parallel changes in relation to segregation and differentiation in education. The analysis shows that the themes related to deregulation seem to show fairly similar patterns and structures in all contexts. The emerging differences were discovered mainly in the themes of marketisation and privatisation. Institutional segregation emerges in all Nordic countries to different extents along the lines of these three processes, and we observe a simultaneous social segregation and differentiation with an ambiguous connection to them. Based on these findings, the question of what is left of the “Nordic model” could be raised.
10.	Hansen, Jens Ulrik, et al. (author) A Logic-Based Approach to Pluralistic Ignorance 2014 In: Logic and Interactive RAtionality Yearbook 2012, Volume II. ; , s. 226-245 Book chapter (other academic/artistic)abstract “Pluralistic ignorance” is a phenomenon mainly studied in social psychology. Viewed as an epistemic phenomenon, one way to define it is as a situation where “no one believes, but everyone believes that everyone else believes”. In this paper various versions of pluralistic ignorance are formalized using epistemic/doxastic logic (based on plausibility models). The motive is twofold. Firstly, the formalizations are used to show that the various versions of pluralistic ignorance are all consistent, thus there is nothing in the phenomenon that necessarily goes against logic. Secondly, pluralistic ignorance, is on many occasions, assumed to be fragile. In this paper, however, it is shown that pluralistic ignorance need not be fragile to announcements of the agents’ beliefs. Hence, to dissolve pluralistic ignorance in general, something more than announcements of the subjective views of the agents is needed. Finally, suggestions to further research are outlined.
11.	Heid, Iris M, et al. (author) Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution 2010 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 949-960 Journal article (peer-reviewed)abstract Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
12.	Hvejsel, Ulla, et al. (author) Fiskerkonen på besøg på Sydhavn Station 2015 In: Sydhavn Station, Copenhagen. Artistic work (other academic/artistic)abstract Relocations of sculpture from the “finer” area in central Copenhagen to a new spot on the outskirts of town, and right next to the artist run exhibiton space Sydhavn Station. Next to this new placement of the sculpture we also mounted a large billboard on which the group of artists behind the exhibition space will show contemporary artistic takes on this older sculptural work.
13.	Kocsis, Otilia, et al. (author) SmartWork: Designing a Smart Age-Friendly Living and Working Environment for Office Workers 2019 In: 12TH ACM INTERNATIONAL CONFERENCE ON PERVASIVE TECHNOLOGIES RELATED TO ASSISTIVE ENVIRONMENTS (PETRA 2019). - New York, NY, USA : ASSOC COMPUTING MACHINERY. - 9781450362320 ; , s. 435-441 Conference paper (peer-reviewed)abstract Europe is being severely challenged by the ageing of the population, and although for well over a decade now is looking for strategies to effectively increase the labour force participation of older workers and reduce the rates of early retirement and labour market exit, the unemployment amongst older people remains particularly high. The design and realization of age-friendly living and working environments is a huge challenge that we have just only started to address as the number of older citizens who are and want to continue being active members of society and live independently is constantly increasing. This paper introduces the SmartWork project, which aims at building a worker-centric Artificial Intelligence system for work ability sustainability, integrating unobtrusive sensing and modelling of the worker state with a suite of novel services for context and worker-aware adaptive work support.
14.	Lefmann, Kim, et al. (author) Simulation of a suite of generic long-pulse neutron instruments to optimize the time structure of the European Spallation Source 2013 In: Review of Scientific Instruments. - : AIP Publishing. - 1089-7623 .- 0034-6748. ; 84:5 Journal article (peer-reviewed)abstract We here describe the result of simulations of 15 generic neutron instruments for the long-pulsed European Spallation Source. All instruments have been simulated for 20 different settings of the source time structure, corresponding to pulse lengths between 1 ms and 2 ms; and repetition frequencies between 10 Hz and 25 Hz. The relative change in performance with time structure is given for each instrument, and an unweighted average is calculated. The performance of the instrument suite is proportional to (a) the peak flux and (b) the duty cycle to a power of approximately 0.3. This information is an important input to determining the best accelerator parameters. In addition, we find that in our simple guide systems, most neutrons reaching the sample originate from the central 3-5 cm of the moderator. This result can be used as an input in later optimization of the moderator design. We discuss the relevance and validity of defining a single figure-of-merit for a full facility and compare with evaluations of the individual instrument classes. (C) 2013 AIP Publishing LLC.
15.	Lindgren-Ciampi, Pontus (author) Purism and National Identity : The construction of language and national identity in Serbian and Bulgarian nineteenth-century purist discourse 2024 Doctoral thesis (other academic/artistic)abstract The aim of this thesis is to analyse how the Serbian and Bulgarian nineteenth-century intellectual elites constructed concepts of national identity in media-discourses on linguistic purity, as well as how these purist discourses were situated within their unique Balkan cultural-historical contexts. The dissertation places itself in the field of historical sociolinguistics which suggests a contextual approach to language change in the past and the discourses shaping them. Nevalainen (2015) has subsumed this approach under the integrationist notion of “layered simultaneity”. This notion implies that the meanings which a specific sociocultural community—the Balkan nineteenth-century intellectuals, in the case of this study—simultaneously produces in discourse, are always the outcome of an infinitely complex interplay of historical, social, political, ideological, and cultural contingencies, relations, and entanglements. The material examined in this study consists of fifteen Serbian and Bulgarian periodicals, four pamphlets, and one book. These publications were either originally published in the periodical press or constituted a vital part of debates that had been initiated in the periodical press. All were published in the period of the Serbian and Bulgarian ‘National Revivals’ (1804–1878) and represent platforms where the members of the expanding bourgeois public sphere debated the questions of purism, language, and national identity. The primary sources stretch from 1830 to 1874. This period was formative for the construction of complex and interacting sets of cultural practices and symbols which were intended to define the nation externally – in relation to other nations and unite it internally. According to the then prevailing Romanticist cultural ideology, language was the prime definer of cultural difference and the utmost expression of the unicity of a people.Purist discourses on language and national identity are always embedded in specific historical and cultural contexts and can hardly be understood without taking these dynamic frameworks into consideration. The broad picture that emerges from the results of this thesis shows that the convergences and divergences in the purist discourses of the Serbian and Bulgarian intellectual elites are dependent on several contextual factors. A convergent factor was the common starting point in the Pax Slavia Orthodoxa, where higher cultural meanings were defined by the ideology of the Orthodox churches. Yet, divergent were the historical and cultural contexts in which these elites entered into dialogue with the ideological paradigms of Enlightenment and Romanticism that to such and eminent degree shaped the cultural side of modern European nation-building.
16.	Marforio, Sonja Andersson, et al. (author) Frequent body position changes and physical activity as effective as standard care for infants hospitalised with acute respiratory infections - a randomised controlled trial 2023 In: Multidisciplinary Respiratory Medicine. - : PAGEPress Publications. - 1828-695X .- 2049-6958. ; 18 Journal article (peer-reviewed)abstract Background: No definite consensus has been reached yet on the best treatment strategy for the large group of infants hospitalised with bronchiolitis or pneumonia. Minimal handling is often recommended, although not evaluated scientifically. There is a need to evaluate the management, as the infants often are critically affected, and the costs for society are high. The aim of this RCT was to evaluate the most common physiotherapy intervention in Sweden for this patient group, including frequent changes in body position and stimulation of physical activity, compared to standard care. Methods: Infants 0-24 months old, without previous cardiac or respiratory diagnoses and born in gestational week 35+, were recruited in two Swedish hospitals. The participants (n=109) were randomised to either interventions in addition to standard care (intervention group) or to standard care alone (control group). The primary outcome measure was time to improvement. The secondary outcomes were immediate changes in oxygen saturation, heart rate and respiratory rate, time to improved general condition (parents' assessment), and lung complications. Results: The median time to improvement was 6 hours in both groups (p=0.54). The result was similar when we adjusted for age in months, sex, tobacco smoke exposure, heredity for asthma/atopic disease, and early stage of the infection (for those with RSV), p=0.69. Analyses of the immediate changes showed no significant differences either (p=0.49-0.89). Time to improved general condition was median 3 hours in the intervention group and 6 hours in the control group, p=0.76. No lung complications occurred. Conclusions: No statistically significant differences in outcomes were detected between the intervention group and the control group. Both strategies were found to be equally effective and safe, indicating that the current recommendation of minimal handling for these infants should be reconsidered. Furthermore, the findings suggest that this treatment can be safely continued.
17.	Nasiopoulou, Panagiota, et al. (author) Exploring preschool teachers’ professional profiles in Swedish preschool: a latent class analysis 2019 In: Early Child Development and Care. - : Informa UK Limited. - 0300-4430 .- 1476-8275. ; 189:8, s. 1306-1324 Journal article (peer-reviewed)abstract This article explores preschool teachers’ professional profiles in Sweden. Considering various educational policy reforms in Sweden the last decades, this study is grounded in interactionist perspectives and Bronfenbrenner’s bio-ecological model. A set of multiple professional indicators related to preschool teachers’ educational background, personal characteristics and their working context were analysed applying latent class analysis as a person-oriented approach. The sample consists of 698 preschool teachers across different preschools in 46 municipalities in Sweden. The analysis revealed two subgroups of preschool teachers’ professional profiles: (a) late educated (after the introduction of preschool curriculum in 1998) and (b) early educated (before the introduction of preschool curriculum in 1998). The pattern of graduation year, experience, continuous professional development and specified assignment in preschool was the most distinctive pattern across these profiles. Findings add to the ongoing debate on preschool teachers’ professionalization suggesting an alternative analytic approach examining multiple indicators characterizing preschool teachers’ professional profiles.
18.	Pramling Samuelsson, Ingrid, 1946, et al. (author) Young children’s experience of aesthetics in preschool 2013 In: Nordisk Barnehageforskning. - 1890-9167. ; 6:31, s. 1-12 Journal article (peer-reviewed)abstract This article aims to investigate young children’s experience of aesthetic activities in preschool. The result is based on preschool teachers’ mapping during a two-week period of what toddlers (1.5 to 3.4 years) are offered or take initiatives themselves to, within the area of aesthetics. The 24 preschools where the mapping was done have been participating in a larger research project called, Children’s early learning. A current study of preschool as an environment for children’s learning (Sheridan, Pramling Samuelsson & Johansson, 2009). This means that we also had data on the quality of the participating preschools, based on ECERS (Harms & Clifford, 1980; Sheridan, 2007), which we linked to children’s experience in aesthetics. The result shows that there is a large variation between the amount and kind of aesthetic activities in preschool that young children can participate in.
19.	Sartelli, Massimo, et al. (author) Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action 2023 In: WORLD JOURNAL OF EMERGENCY SURGERY. - 1749-7922. ; 18:1 Research review (peer-reviewed)abstract Antibiotics are recognized widely for their benefits when used appropriately. However, they are often used inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component of universal healthcare, and it is a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive to develop new antibiotics due to scientific, regulatory, and financial barriers, further emphasizing the importance of appropriate antibiotic use. To address this issue, the Global Alliance for Infections in Surgery established an international multidisciplinary task force of 295 experts from 115 countries with different backgrounds. The task force developed a position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness of antimicrobial resistance and improving antibiotic prescribing practices worldwide. The statement outlined is 10 axioms, or "golden rules," for the appropriate use of antibiotics that all healthcare workers should consistently adhere in clinical practice.
20.	Seror, Raphaele, et al. (author) EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI): development of a consensus patient index for primary Sjogren's syndrome 2011 In: Annals of the Rheumatic Diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 70:6, s. 968-972 Journal article (peer-reviewed)abstract Objectives To develop a score for assessment of patients' symptoms in primary Sjogren's syndrome (SS): the EULAR SS Patient Reported Index (ESSPRI). Methods Dryness, pain, somatic and mental fatigue were identified as the main symptoms of patients with primary SS, in studies developing the Profile of Fatigue and Discomfort (PROFAD) and Sicca Symptoms Inventory (SSI). It was suspected that a single 0-10 numerical scale for each domain was sufficient to assess these symptoms. These four scales were gathered to form the ESSPRI. 230 patients, from 12 countries completed the ESSPRI, SSI and PROFAD questionnaires and a 0-10 patient global assessment (PGA). Correlations between each symptom and PGA were obtained. Multiple regression modelling, using PGA as 'gold standard' was used to select domains and estimate their weights. Results PGA had good correlation with dryness, limb pain, fatigue and mental fatigue (r=0.49-0.59, all p<0.0001), but correlated less well with individual dryness features. In multivariate analysis, dryness, limb pain and fatigue, but not mental fatigue, were significantly associated with PGA; weights derived from the regression were identical for these three domains. Thus, ESSPRI was redefined as the mean of the three scales: dryness, limb pain and fatigue. Lastly, ESSPRI significantly correlated with PGA (r=0.70), PROFAD (r=0.73) and SSI (r=0.66). Conclusion ESSPRI is a very simple index designed to measure patients' symptoms in primary SS. It has good construct validity and is well correlated with SSI and PROFAD. ESSPRI should now be validated for use as an outcome measure in clinical trials.
21.	Speliotes, Elizabeth K., et al. (author) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index 2010 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948 Journal article (peer-reviewed)abstract Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

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