| 1. |
- Golman, Klaes, et al.
(författare)
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13C-angiography.
- 2002
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Ingår i: Academic Radiology. - 1878-4046. ; 9:Suppl 2, s. 507-510
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Tidskriftsartikel (refereegranskat)
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| 2. |
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| 3. |
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| 4. |
- Kindlund, Bert, 1969, et al.
(författare)
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FOXP3-expressing CD4(+) T-cell numbers increase in areas of duodenal gastric metaplasia and are associated to CD4(+) T-cell aggregates in the duodenum of Helicobacter pylori-infected duodenal ulcer patients.
- 2009
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Ingår i: Helicobacter. - : Wiley. - 1523-5378 .- 1083-4389. ; 14:3, s. 192-201
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: We have previously demonstrated that Helicobacter pylori infection is associated with an increased number of CD4(+)CD25(high) regulatory T cells in the gastric and duodenal mucosa. In this study, we determined the number and localization of CD4(+) cells expressing the regulatory T-cell-specific transcription factor FOXP3 in the antrum and duodenum of duodenal ulcer patients, asymptomatic carriers, and uninfected individuals. We also determined gene expression levels of FOXP3 as well as anti- and proinflammatory cytokines before and after H. pylori eradication. METHODS: Cellular FOXP3 expression was studied by immunofluorescence and flow cytometry, and transcription levels of FOXP3, interleukin (IL)-10, transforming growth factor-beta, CD4, and interferon-gamma were analyzed by real-time reverse transcription-polymerase chain reaction. RESULTS: We found an increased (6-fold) frequency of CD4(+)FOXP3(+) T cells in H. pylori-infected gastric mucosa; interestingly 26% of these cells did not co-express CD25. The increase of FOXP3-expressing T cells in the antrum of infected individuals was dependent on the presence of H. pylori, since eradication therapy resulted in 4-fold lower levels of FOXP3 and IL-10 mRNA in the antrum. Furthermore, higher numbers of CD4(+)FOXP3(+) T cells were found in areas of duodenal gastric metaplasia in the duodenum of duodenal ulcer patients compared to duodenal gastric metaplasia of asymptomatic individuals and healthy mucosa in both patient groups. In duodenal ulcer patients, the CD4(+)FOXP3(+) T cells were more highly associated to aggregates in the duodenal mucosa. CONCLUSION: The numbers of CD4(+)FOXP3(+) T cells are increased and localized in CD4(+) T-cell aggregates in areas of duodenal gastric metaplasia in duodenal ulcer patients.
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| 5. |
- Anckarsäter, Henrik, 1966, et al.
(författare)
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Child neurodevelopmental and behavioural problems are intercorrelated and dimensionally distributed in the general population
- 2008
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Ingår i: The Open Psychiatry Journal. - : Bentham Science Publishers Ltd.. - 1874-3544. ; 2, s. 5-11
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Tidskriftsartikel (refereegranskat)abstract
- The Autism – Tics, AD/HD, and other Comorbidities inventory (A-TAC) is a comprehensive interview for evaluating problems related to autism spectrum disorders (ASD), tic disorders, attention-deficit/hyperactivity disorder (AD/HD), and common comorbid conditions in children and adolescents. A-TAC telephone interviews were administered to parents of 2,957 children aged nine- or twelve-years, representing one in each twin pair included in the population- based Child and Adolescent Twin Study in Sweden (CATSS). A total of 16.4% were screen-positive for one or several of the targeted disorder, 1.3% for ASD and 5.6% for AD/HD. All types of problems were more common among boys, with the exception of those related to “eating habits”. They were all dimensionally/continuously distributed, highly inter-correlated, and overlapped across types. They aggregated in three ba- sic factors corresponding to externalizing/disruptiveness, socio-communicative problems, and compulsiveness. Population-based data on problems in children thus challenge current categorical diagnostic definitions, calling for dimen- sional and complementary models of problem descriptions.
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| 6. |
- Andersson, Henrik, et al.
(författare)
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Constitutive dependence in finite-element modelling of crack closure during fatigue
- 2004
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Ingår i: Fatigue & Fracture of Engineering Materials & Structures. - : Wiley. - 1460-2695 .- 8756-758X. ; 27:2, s. 75-87
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Tidskriftsartikel (refereegranskat)abstract
- The influence of choice of constitutive relation on the prediction of crack-opening stress for fatigue cracks using the finite-element method is investigated and compared with experimental results. Two different experimentally obtained stress–strain relations for IN718 at 550 °C were used for fitting material parameters to the linear kinematic and the Bodner–Partom viscoplastic constitutive models. In addition, one reference material description and one Bodner–Partom with parameters fitted to both types of experiment was used, i.e., in total six constitutive descriptions. Experimental values for crack-opening stress were found by the potential drop method for the two load cases analyzed. Two different load cases, load control and displacement control, have been examined. It turns out that the correlation between experimental and analytical crack-opening stress vary significantly with material description, opening criteria in the simulation and load case. The investigation shows that care must be taken when choosing material description and opening criteria for crack propagation simulations.
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| 7. |
- Andersson, Malin E, 1978, et al.
(författare)
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Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease.
- 2007
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Ingår i: International journal of molecular medicine. - 1107-3756 .- 1791-244X. ; 20:2, s. 233-9
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Tidskriftsartikel (refereegranskat)abstract
- Kinesin is a microtubule-associated motor protein that transports Alzheimer-associated amyloid precursor protein (APP) in neurons. In animal models, impaired kinesin-mediated APP transport seems to enhance formation of the neurotoxic 42 amino acid fragment of beta-amyloid (A beta 42). In man, one study suggests that a polymorphism (rs8702, 56,836G>C) in the kinesin light chain 1 gene (KNS2) may affect the risk of Alzheimer's disease (AD). To further assess KNS2 as a susceptibility gene for AD we analyzed 802 patients with sporadic AD and 286 controls, 134 longitudinally followed patients with mild cognitive impairment (MCI) and 39 cognitively stable controls for the rs8702 polymorphism. The rs8702 polymorphism did not influence risk of AD (p=0.46). However, rs8702 interacted with APOE epsilon 4 carrier status in AD (p=0.006) and influenced cerebrospinal fluid levels of hyperphosphorylated tau in MCI patients who converted to AD during follow-up (p=0.018). These findings support earlier indications that genetic variability in the KNS2 gene may play a role during early stages of AD pathogenesis.
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| 8. |
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| 9. |
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| 10. |
- Balk, Lennart, et al.
(författare)
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Wild birds of declining European species are dying from a thiamine deficiency syndrome.
- 2009
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 106:29, s. 12001-12006
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Tidskriftsartikel (refereegranskat)abstract
- Wild birds of several species are dying in large numbers from an idiopathic paralytic disease in the Baltic Sea area. Here, we demonstrate strong relationships between this disease, breeding failure, and thiamine (vitamin B(1)) deficiency in eggs, pulli, and full-grown individuals. Thiamine is essential for vertebrates, and its diphosphorylated form functions as a cofactor for several life sustaining enzymes, whereas the triphosphorylated form is necessary for the functioning of neuronal membranes. Paralyzed individuals were remedied by thiamine treatment. Moreover, thiamine deficiency and detrimental effects on thiamine-dependent enzymes were demonstrated in the yolk, liver, and brain. We propose that the mortality and breeding failure are part of a thiamine deficiency syndrome, which may have contributed significantly to declines in many bird populations during the last decades.
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| 11. |
- Bengtsson, Jörgen, et al.
(författare)
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The influence of age on the distribution of morphine and morphine-3-glucuronide across the blood-brain barrier in sheep
- 2009
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Ingår i: British Journal of Pharmacology. - : Wiley. - 0007-1188 .- 1476-5381. ; 157:6, s. 1085-1096
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Tidskriftsartikel (refereegranskat)abstract
- Background and purpose The effect of age on the distribution of morphine and morphine-3-glucuronide (M3G) across the blood-brain barrier (BBB) was studied in a sheep model utilizing intracerebral microdialysis. The effect of neonatal asphyxia on brain drug distribution was also studied. Experimental approach Microdialysis probes were inserted into the cortex, striatum and blood of 11 lambs (127 gestation days) and six ewes. Morphine, 1 mg.kg(-1), was intravenously administered as a 10 min constant infusion. Microdialysis and blood samples were collected for up to 360 min and analysed using liquid chromatography-tandem mass spectrometry. The half-life, clearance, volume of distribution, unbound drug brain : blood distribution ratio (K(p,uu)) and unbound drug volume of distribution in brain (V(u,brain)) were estimated. Key results Morphine K(p,uu) was 1.19 and 1.89 for the sheep and premature lambs, respectively, indicating that active influx into the brain decreases with age. Induced asphyxia did not affect transport of morphine or M3G across the BBB. Morphine V(u,brain) measurements were higher in sheep than in premature lambs. The M3G K(p,uu) values were 0.27 and 0.17 in sheep and premature lambs, indicating a net efflux from the brain in both groups. Conclusions and implications The morphine K(p,uu) was above unity, indicating active transport into the brain; influx was significantly higher in premature lambs than in adult sheep. These results in sheep differ from those in humans, rats, mice and pigs where a net efflux of morphine from the brain is observed.
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| 12. |
- Blennow, Kaj, 1958, et al.
(författare)
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Evolution of Abeta42 and Abeta40 Levels and Abeta42/Abeta40 Ratio in Plasma during Progression of Alzheimer's Disease: A Multicenter Assessment.
- 2009
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Ingår i: The journal of nutrition, health & aging. - 1279-7707. ; 13:3, s. 205-8
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To better understand the seemingly contradictory plasma beta-amyloid (Abeta) results in Alzheimer's disease (AD) patients by using a newly developed plasma Abeta assay, the INNO-BIA plasma Abeta forms, in a multicenter study. Methods: A combined retrospective analysis of plasma Abeta isoforms on mild cognitive impairment (MCI) from three large cross-sectional studies involving 643 samples from the participating German and Swedish centers. Results: Detection modules based on two different amino (N)-terminal specific Abeta monoclonal antibodies demonstrated that Abeta in plasma could be reliable quantified using a sandwich immunoassay technology with high precision, even for low Abeta42 plasma concentrations. Abeta40 and Abeta42 concentrations varied consistently with the ApoE genotype, while the Abeta42/Abeta40 ratio did not. Irrespective of the decrease of the Abeta42/Abeta40 ratio with age and MMSE, this parameter was strongly associated with AD, as defined in this study by elevated hyperphosphorylated (P-tau181P) levels in cerebrospinal fluid (CSF). Conclusion: A highly robust assay for repeatedly measuring Abeta forms in plasma such as INNO-BIA plasma Abeta forms might be a useful tool in a future risk assessment of AD.
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| 13. |
- Boivie, Patrik, 1976-
(författare)
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Cerebrovascular accidents associated with aortic manipulation during cardiac surgery
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Despite the successful development in cardiac surgery, cerebrovascular accidents (CVA) remain a devastating complication. Aortic atherosclerosis has been identified as a major risk factor for CVA. The present thesis addresses this question in relation to aortic manipulation during cardiac surgery, being divided into a clinical (I-II) and an experimental part (III-V). Material and methods: Consecutive cardiac surgery cases (n=2641) were analyzed. Patients with CVA were extracted from a database designed to monitor clinical symptoms. Patient records were used to confirm clinical data and diagnosis. Subdivision was made into three groups: control subjects, immediate, and delayed CVA, being analyzed for neurological symptoms (I). Patients with CVA who also had been investigated with computer tomography (CT) (n=77) were further evaluated in terms of hemispheric and vascular distribution of lesions. The CT-findings were compared with CVA symptoms (II). An aortic perfusion model was developed using cadaver aorta onto which multiple cross-clamp manipulations were applied (III). Washout samples of perfusate were analyzed by computerized image processing and with subdivision into different particle spectra. The model was further developed with the introduction of intraluminal manipulation from cannula and intra-aortic filter (IV). A technique for macro-anatomic mapping of plaque distribution of cadaver thoracic aorta was developed (V). Variation in plaque density was analyzed in different anatomical segments, monitored by digital image analysis. Hazards associated with surgical manipulation were studied by superimposing cannulation and cross-clamp sites onto the aortic maps in a blinded fashion. Results: The incidence of immediate and delayed CVA was 3.0% and 0.9%, respectively. Aortic quality was a strongly associated with immediate but not delayed CVA. Left-sided symptoms of immediate CVA were significantly more frequent than of the contra-lateral side. Positive signs on CT were seen in 66% of the CVA patients. Right-hemispheric lesions were more frequent compared with the contra-lateral side and the middle-cerebral artery territory dominated. Aortic cross-clamping produced a substantial output of particulate matter. Manipulation by intra-aortic filter produced a significant washout of embolic particles that escaped the filter, although some particles were captured. Cannulation was an additional source of embolic material. In terms of plaque distribution was the anterior wall of the ascending part and arch of the aorta more affected than its posterior side. However, observing a plaque in the anterior wall of this aortic segment predicted to 83% a concomitant plaque in the posterior wall. Increased age correlated positively with plaque density. The theoretical chance of interfering with a plaque during cannulation and/or clamp positioning was 45.8%. Conclusions: Both CT scans and clinical symptoms confirmed that CVA after cardiac surgery had a right-hemispheric predominance. The perfusion model resulted in a profound output of material during cross-clamp maneuvers. The intra-aortic filter successfully collected particles but also generated embolic debris on its own. Aortic cannulation was an additional source of embolic debris. Plaques were frequently found in the cadaveric aorta, and there was a high risk of plaque interference during surgical manipulation. As expected, plaque density was age-dependent.
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| 14. |
- Boström, Fredrik, et al.
(författare)
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Cerebrospinal fluid total tau is associated with shorter survival in dementia with Lewy bodies.
- 2009
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Ingår i: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 28:4, s. 314-9
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Tidskriftsartikel (refereegranskat)abstract
- A pathology typical of dementia with Lewy bodies (DLB) has been demonstrated to increase mortality to a greater extent than the pathology of Alzheimer's disease (AD). However, mortality in DLB has also been shown to increase with concomitant AD pathology. Furthermore, in a recent publication, we showed that there is a robust and specific increase in CSF calcium and magnesium in DLB patients compared to both AD patients and controls. Thus, in order to explore the influence of CSF AD markers and trace element concentrations on mortality in DLB, we undertook a longitudinal prospective study of 47 clinically diagnosed DLB patients and 157 AD patients as well as 49 healthy volunteers. Both AD and DLB patients showed an increased mortality compared to the healthy controls (relative risk: 10 and 8, respectively; p < 0.001). Increased levels of CSF total tau were associated with increased mortality among the DLB patients (p < 0.05), but not among the AD patients or controls. Gender, age, MMSE score, Abeta42 concentration and phosphorylated tau, and CSF trace element concentrations did not influence survival in the obtained models.
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| 15. |
- Boström, Fredrik, et al.
(författare)
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CSF Mg and Ca as diagnostic markers for dementia with Lewy bodies.
- 2008
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Ingår i: Neurobiology of aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 30:8, s. 1265-1271
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Tidskriftsartikel (refereegranskat)abstract
- Accumulating evidence implicates a role for altered metal homeostasis in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). However, few investigations have addressed this issue in dementia with Lewy bodies (DLB). The aim of the present study was to investigate metal concentrations in cerebrospinal fluid (CSF) and plasma from patients with DLB and other neurodegenerative disorders. To that end, CSF and plasma samples were collected from 29 patients with DLB, 174 patients with AD, 90 patients with AD with minor vascular components, and 51 healthy volunteers. Total concentrations of Mg, Ca, Mn, Fe, Cu, Zn, Rb, Sr, and Cs were determined using mass spectrometry. Patients with DLB had elevated Ca and Mg levels in CSF and Mg levels in plasma as compared to all other groups (p<0.001). Furthermore, a combination of CSF-Mg and CSF-Ca could distinguish DLB from AD with a sensitivity of 93% and a specificity of 85%. Cu levels in both CSF and plasma tended to be higher in DLB compared to the other groups, but these trends failed to reach significance after correction for multiple comparisons. Mn, Fe, Zn, Rb, and Sr concentration in CSF or plasma were similar in all groups. The observed elevations of CSF-Mg, CSF-Ca and CSF-Cu may contribute to or be associated with the neurodegenerative process in DLB. Furthermore, determination of CSF-Mg and CSF-Ca concentration may be a valuable tool in distinguishing DLB from AD.
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| 16. |
- Brinkmalm-Westman, Ann, 1966, et al.
(författare)
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Proteomics/peptidomics tools to find CSF biomarkers for neurodegenerative diseases.
- 2009
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Ingår i: Frontiers in bioscience : a journal and virtual library. - : IMR Press. - 1093-4715. ; 14, s. 1793-806
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Forskningsöversikt (refereegranskat)abstract
- Neurodegenerative diseases are characterized by premature neuronal loss in specific brain regions. During the past decades our knowledge on molecular mechanisms underlying neurodegeneration has increased immensely and resulted in promising drug candidates that might slow down or even stop the neuronal loss. These advances have put a strong focus on the development of diagnostic tools for early or pre-clinical detection of the disorders. In this review we discuss our experience in the field of neuroproteomics/peptidomics, with special focus on biomarker discovery studies that have been performed on CSF samples from well-defined patient and control populations.
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| 17. |
- Buchhave, Peder, et al.
(författare)
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Elevated plasma levels of soluble CD40 in incipient Alzheimer's disease.
- 2009
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Ingår i: Neuroscience letters. - : Elsevier BV. - 0304-3940. ; 450:1, s. 56-9
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Tidskriftsartikel (refereegranskat)abstract
- CD40 is a member of the tumor necrosis factor receptor super-family and has been suggested to play a role in the metabolism of beta-amyloid (Abeta) in Alzheimer's disease (AD). However, the role of CD40-signalling in incipient AD has not yet been studied. We investigated the plasma levels of soluble CD40 (sCD40) and the soluble CD40 ligand (sCD40L) at baseline in 136 subjects with mild cognitive impairment (MCI) and 30 age-matched controls. Sixty of the 136 MCI cases converted to AD (MCI-AD) during a clinical follow-up period of 4-7 years. The baseline levels of sCD40, but not sCD40L, were elevated in MCI-AD cases when compared to age-matched controls (Mann-Whitney U-test, p=0.02). However, MCI patients who were cognitively stable or developed vascular dementia during follow-up did not have significantly increased levels of sCD40 or sCD40L when compared to controls. The levels of sCD40 correlated to decreased baseline performance on mini-mental state examination (MMSE) in both controls (r(s)=-0.37, p<0.05) and MCI-AD cases (r(s)=-0.29, p<0.05). Finally, the plasma levels of sCD40 correlated with the levels of soluble amyloid precursor protein-alpha (sAPP-alpha) (r(s)=0.28, p<0.01) and sAPP-beta (r(s)=0.23, p<0.05) in cerebrospinal fluid. In conclusion, CD40-signalling might play a role in the pathogenesis of early AD.
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| 18. |
- Buchhave, Peder, et al.
(författare)
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Longitudinal study of CSF biomarkers in patients with Alzheimer's disease.
- 2009
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Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 16:Suppl 3, s. 337-337
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The CSF biomarkers tau and Abeta42 can identify patients with AD, even during the preclinical stages. However, previous studies on longitudinal changes of tau and Abeta42 in individual patients with AD and elderly controls report somewhat inconsistent results. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the levels of tau and Abeta42 at baseline and after 1 year in 100 patients with AD. In a second cohort of 45 AD patients we measured the CSF biomarkers at baseline and after 2 years. Moreover, in 34 healthy elderly controls the CSF biomarkers were followed for 4 years. The baseline levels of tau were increased with >60% in AD patients compared to controls (p<0.001), while baseline Abeta42 levels were decreased with >50% (p<0.001). In the AD group followed for 2 years, tau increased with 16% compared to the baseline levels (p<0.05). However, the levels of tau were stable over 4 years in the controls. The levels of Abeta42 did not change significantly over time in any of the groups. In the patients with AD, tau was moderately associated with worse cognitive performance already at baseline (p<0.05). CONCLUSIONS/SIGNIFICANCE: Tau and Abeta42 in CSF seem to reflect the underlying disease state in both early and late stages of AD. The slight increase in tau over time observed in the patients with AD is modest when compared to the relatively large difference in absolute tau levels between AD patients and controls. Therefore, these markers maintain their usefulness as state markers over time and might serve as surrogate markers for treatment efficacy in clinical trials.
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| 19. |
- Caputa, Peter, et al.
(författare)
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An Extended Transition Energy Cost Model for Buses in Deep Submicron Technologies
- 2004
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Ingår i: Proceedings of the Power and Timing Modeling, Optimization and Simulation Conference, Santorini, Greece. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783540230953 - 9783540302056 ; , s. 849-858
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Konferensbidrag (refereegranskat)abstract
- In this paper we present and carefully analyze a transition energy cost model aimed for efficient power estimation of performance critical deep submicron buses. We derive an accurate transition energy cost matrix, scalable to buses of arbitrary bit width, which includes properties that closer capture effects present in high-performance VLSI buses. The proposed energy model is verified against Spectre simulations of an implementable bus, including drivers. The average discrepancy between results from Spectre and the suggested model is limited to 4.5% when fringing effects of edge wires is neglected. The proposed energy model can account for effects that limit potential energy savings from bus transition coding.
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| 20. |
- Eriksson, Henrik, 1973, et al.
(författare)
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Integrated Management Systems. Theoretical and practical implications.
- 2006
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Ingår i: Asian Journal on Quality. - : Emerald. - 1598-2688. ; 7:2, s. 69-82
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Tidskriftsartikel (refereegranskat)abstract
- Organisations worldwide strive to develop their management systems for business functions, ranging from quality and environment to safety, information security and social responsibility. During the latest decade a considerable amount of these efforts has been concentrated on introducing and applying standards such as the ISO 9001 and ISO 14001. The need for Integrated Management Systems (IMS) often arises as a result of decisions to implement Environmental Management Systems (EMS) and/or an occupational health and safety management system in addition to a Quality Management System (QMS) At the end of 2003, approximately 3200 organisations in Sweden had an ISO 9001 certificate, and approximately 3400 organisations had a certificate based on an EMS. Dealing with separate management systems and ensuring that they align with the organisation’s strategies and goals, has proved difficult. Owing to the large number of organisations certified according to multiple types of systems, an increasing number of organisations are establishing IMS. There are examples of companies, which chose to integrate EMS and QMS into a co-ordinated implementation approach, and although sparse, the research within this area indicates potential benefits of using an integrated approach. This paper presents both a theoretical and an empirical investigation with the aim to elucidate problems related to the integration of management systems. Furthermore, the paper will present recommendations for succeeding in such integrations and, hence, contributing to an increased understanding on how IMS should be designed and implemented.
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| 21. |
- Eriksson, Henrik, 1973, et al.
(författare)
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Kvalitetsutveckling är lönsamt
- 2002
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Ingår i: Kvalitetsmagasinet.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 22. |
- Eriksson, Henrik, 1973, et al.
(författare)
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The impact of TQM on financial performance
- 2003
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Ingår i: Measuring Business Excellence. - : Emerald. - 1368-3047. ; 7:1, s. 36-50
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Tidskriftsartikel (refereegranskat)abstract
- The question whether an adoption of total quality management (TQM) improves the financial performance has been discussed for several years. Various studies have been conducted to examine the impact of TQM on financial performance, but there is still disagreement concerning the effectiveness of TQM. This paper presents a study of Swedish quality award recipients, which are compared to branch indices and to identified competitors. The comparison concerns the development of different financial performance indicators. The study indicates that the award recipients as a group outperform the branch index and their identified competitors on most of the studied indictors.
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| 23. |
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| 24. |
- Eriksson-Zetterquist, Ulla, 1967, et al.
(författare)
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The dilemma with ICT in educational organisations
- 2002
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Ingår i: 6th International Research Conference Dilemmas Facing the Public Sector 4-6th September 2002 University of East London, England.
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Konferensbidrag (refereegranskat)
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| 25. |
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| 26. |
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| 27. |
- Hansson, Anders, et al.
(författare)
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On Methods for Gradient Estimation in IFT for MIMO Systems
- 2002
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Ingår i: Proceedings of 15th IFAC World Congress. - 9783902661746 ; , s. 1047-1047
-
Konferensbidrag (refereegranskat)abstract
- Iterative feedback tuning (IFT) is a model free control tuning method using closed loop experiments. For single-input single-output (SISO) systems only 2 or 3, depending on the controller structure, closed loop experiments are required. However for multivariable systems the number of experiments increase to a maximum of 1 + m times p, where m times p is the dimension of the controller. In this contribution several methods are proposed to reduce the experimental time by approximating the gradient of the cost function. The local convergence for a method which uses the same technique as in IFT for SISO systems is analyzed. It is shown that even if there are commutation errors due to the approximation method, the numerical optimization may still converge to the true optimum.
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| 28. |
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| 29. |
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| 30. |
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| 31. |
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| 32. |
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| 33. |
- Hansson, Henrik, et al.
(författare)
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Critical Issues for e-Learning Telecenters in Sri Lanka and India
- 2009
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Ingår i: 23rd ICDE World Conference on Open Learning and Distance Education including the 2009 EADTU Annual Conference, to be held on 7-10 June 2009 in Maastricht, Netherlands..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 34. |
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| 35. |
- Hansson, Henrik, 1963-, et al.
(författare)
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Filtering of Scientific e-Content
- 2006
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Ingår i: World Wide Work. - Amesterdam : VU University Press. ; , s. 121-128
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 36. |
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| 37. |
- Hansson, Henrik, 1965
(författare)
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Förändring och överföring av kompetens inom ett industriföretag - ett komplext interaktivt ingenjörsarbete
- 2003
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Change and transfer of competence within an industrial company - complex and interactive engineering. This paper presents how transfer of knowledge and competence occurs in relation to a major organizational change. The particular setting of predominantly engineers as organizational players can be one explanation as to how structure sometimes is emphasized more than content. The theoretical issue in this paper is one of competence transfer and how competence is communicated through the interaction of people. Collective competence is a term used to se how this interaction creates organizational learning and development. The theoretical foundation is primarily symbolic interaction; however the paper is more of a case study than a theoretical argumentation. One issue that is has been focused is the structure of meetings, and it is a concurrent issue on the agenda. The reason for this is that the meeting structure in order to correspond with hierarchical levels as well as the task and need for information has create a formal structure of meetings to enable the concerned person to be able to attend the meetings needed. For a person with high hierarchical status as well as one with many tasks there is a meeting to go to every moment of the week. The task of competence and knowledge transfer has been an issue that has not been discussed in the sense one would think it has been. It has been in the background and the issues discussed and focused on, mostly as unspoken but very dominant agenda are of a more practical nature. The change has two major practical restrictions, group sizes should not exceed 10 persons and the whole setting for the change had to be set before summer vacation (in order to be able to move everybody´s office equipment etc). The official agenda, however, is that the work should be subject to more commonality, the efficiency should be increased and the balance between projects and line organization should be restored.
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| 38. |
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| 39. |
- Hansson, Henrik, 1965
(författare)
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Höganäs - en fallstudierapport om IT och skolan
- 2004
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This paper is the fourth of six case studies in a research project "The school and information- and communication technology (ICT)". This one is taking place in the mu-nicipality of Höganäs. The results from the study can be summarised as: A few enthusiasts driving the development of IT managing the hardware and software with scarce resources. The new technology introduced is making a difference, but the change is not a revolution but rather a slow evolution. The differences in competence and the subsequent specializa-tion of some teachers seem to be an unintended and inevitable consequence of the ICT introduction. The municipality claim to strive towards decentralization of the organization, however ICT seem to have an opposite effect. The continuity from the development can be interpreted in terms of careful development of infrastructure and competence. No radi-cal measures are taken but most investments are well thought over and implemented con-tinuously. Also the competences among the teachers are changing over time. A more inter-esting conclusion is that ICT has affected the long-term attitude and use of ICT. The pro-jects have exposed the community with possibilities as well as limitations and therefore the perception of ICT has changed within the school organization.
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- Hansson, Henrik, 1963-, et al.
(författare)
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Language filtering
- 2006
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Ingår i: World Wide Work. - : VU University Press.
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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- Hansson, Henrik, 1965, et al.
(författare)
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Skolan och informationstekniken - en fallstudie av grundskolan i Stenungsund
- 2003
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This paper is the first of six case studies in a research project "The school and information- and communication technology (ICT)". This one is taking place in the municipality of Stenungsund. The results from the study can be summarised as: Some enthusiasts driving the development work and producing star cases. They claim that the new technology introduced is making a difference, but the most important aspect is that new technology is triggering a development for pedagogical renewal. Technology also bears the potential for extended surveillance and control, which is not so much spoken about. The differences in competence and the subsequent specialization of some teachers seem to be an unintended and inevitable consequence of the ICT introduction. The municipality claim to strive towards decentralization of the organization, however ICT seem to have an opposite effect. The continuity from the projects can be interpreted in two ways. When there is no more money there is any development. A more interesting conclusion is that ICT has affected the long-term attitude and use of ICT. The projects have exposed the community with possibilities as well as limitations and therefore the perception of ICT has changed within the school organization.
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