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Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level

Wang, Fei (author)
BGI Shenzhen, BGI Qingdao, Qingdao Europe Adv Inst Life Sci, Lars Bolund Inst Regenerat Med, Qingdao, Peoples R China.;Aarhus Univ, Dept Biomed, Aarhus, Denmark.;BGI Shenzhen, Shenzhen, Peoples R China.
Ding, Peiwen (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China.
Liang, Xue (author)
Univ Copenhagen, Dept Biol, Copenhagen, Denmark.
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Ding, Xiangning (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China.
Brandt, Camilla Blunk (author)
Aarhus Univ, Dept Biomed, Aarhus, Denmark.;Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark.
Sjostedt, Evelina (author)
Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
Zhu, Jiacheng (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China.
Bolund, Saga (author)
Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
Zhang, Lijing (author)
BGI Shenzhen, Shenzhen, Peoples R China.;BGI Shenzhen, MGI, Shenzhen, Peoples R China.
de Rooij, Laura P. M. H. (author)
VIB, Ctr Canc Biol, Lab Angiogenesis & Vasc Metab, Leuven, Belgium.;Katholieke Univ Leuven, Leuven Canc Inst, Dept Oncol, Leuven, Belgium.,BGI Shenzhen, Shenzhen, Peoples R China.;Qingdao Univ, Coll Basic Med, Qingdao, Peoples R China.
Luo, Lihua (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China.
Wei, Yanan (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Qingdao Univ, Coll Basic Med, Qingdao, Peoples R China.
Zhao, Wandong (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Qingdao Univ, Coll Basic Med, Qingdao, Peoples R China.
Lv, Zhiyuan (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Qingdao Univ, Coll Basic Med, Qingdao, Peoples R China.
Hasko, Janos (author)
Aarhus Univ, Dept Biomed, Aarhus, Denmark.
Li, Runchu (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Qingdao Univ, Coll Basic Med, Qingdao, Peoples R China.
Qin, Qiuyu (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Qingdao Univ, Coll Basic Med, Qingdao, Peoples R China.
Jia, Yi (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Qingdao Univ, Coll Basic Med, Qingdao, Peoples R China.
Wu, Wendi (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Qingdao Univ, Coll Basic Med, Qingdao, Peoples R China.
Yuan, Yuting (author)
Binzhou Med Univ, Sch Basic Med Sci, Yantai, Peoples R China.
Pu, Mingyi (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Qingdao Univ, Coll Basic Med, Qingdao, Peoples R China.
Wang, Haoyu (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China.
Wu, Aiping (author)
Chinese Acad Med Sci, Peking Union Med Coll, Inst Syst Med, Beijing, Peoples R China.;Suzhou Inst Syst Med, Suzhou, Peoples R China.
Xie, Lin (author)
BGI Shenzhen, MGI, Shenzhen, Peoples R China.
Liu, Ping (author)
BGI Shenzhen, MGI, Shenzhen, Peoples R China.
Chen, Fang (author)
BGI Shenzhen, MGI, Shenzhen, Peoples R China.
Herold, Jacqueline (author)
Aarhus Univ, Dept Biomed, Aarhus, Denmark.
Kalucka, Joanna (author)
Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark.;Aarhus Univ, Aarhus Univ Adv Studies AIAS, Aarhus, Denmark.
Karlsson, Max (author)
KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden.
Zhang, Xiuqing (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China.
Helmig, Rikke Bek (author)
Aarhus Univ Hosp, Dept Obstet & Gynecol, Aarhus, Denmark.
Fagerberg, Linn (author)
KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden.
Lindskog, Cecilia (author)
Uppsala universitet,Institutionen för immunologi, genetik och patologi
Pontén, Fredrik (author)
Uppsala universitet,Institutionen för immunologi, genetik och patologi
Uhlén, Mathias (author)
KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.;KTH Royal Inst Technol, Sci Life Lab, Dept Prot Sci, Stockholm, Sweden.
Bolund, Lars (author)
BGI Shenzhen, BGI Qingdao, Qingdao Europe Adv Inst Life Sci, Lars Bolund Inst Regenerat Med, Qingdao, Peoples R China.;Aarhus Univ, Dept Biomed, Aarhus, Denmark.
Jessen, Niels (author)
Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark.
Jiang, Hui (author)
BGI Shenzhen, MGI, Shenzhen, Peoples R China.
Xu, Xun (author)
BGI Shenzhen, Shenzhen, Peoples R China.
Yang, Huanming (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, IBMC BGI Ctr,Canc Hosp,Zhejiang Canc Hosp, Hangzhou, Peoples R China.
Carmeliet, Peter (author)
Aarhus Univ, Dept Biomed, Aarhus, Denmark.;VIB, Ctr Canc Biol, Lab Angiogenesis & Vasc Metab, Leuven, Belgium.;Katholieke Univ Leuven, Leuven Canc Inst, Dept Oncol, Leuven, Belgium.;Khalifa Univ Sci & Technol, Ctr Biotechnol, Abu Dhabi, U Arab Emirates.
Mulder, Jan (author)
Karolinska Institutet,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
Chen, Dongsheng (author)
BGI Shenzhen, Shenzhen, Peoples R China.;Suzhou Inst Syst Med, Suzhou, Peoples R China.
Lin, Lin (author)
Aarhus Univ, Dept Biomed, Aarhus, Denmark.;Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark.
Luo, Yonglun (author)
BGI Shenzhen, BGI Qingdao, Qingdao Europe Adv Inst Life Sci, Lars Bolund Inst Regenerat Med, Qingdao, Peoples R China.;Aarhus Univ, Dept Biomed, Aarhus, Denmark.;BGI Shenzhen, Shenzhen, Peoples R China.;Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark.
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BGI Shenzhen, BGI Qingdao, Qingdao Europe Adv Inst Life Sci, Lars Bolund Inst Regenerat Med, Qingdao, Peoples R China;Aarhus Univ, Dept Biomed, Aarhus, Denmark.;BGI Shenzhen, Shenzhen, Peoples R China. BGI Shenzhen, Shenzhen, Peoples R China.;Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China. (creator_code:org_t)
2022-06-24
2022
English.
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 13:1
Related links:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Pigs are valuable large animal models for biomedical and genetic research, but insights into the tissue- and cell-type-specific transcriptome and heterogeneity remain limited. By leveraging single-cell RNA sequencing, we generate a multiple-organ single-cell transcriptomic map containing over 200,000 pig cells from 20 tissues/organs. We comprehensively characterize the heterogeneity of cells in tissues and identify 234 cell clusters, representing 58 major cell types. In-depth integrative analysis of endothelial cells reveals a high degree of heterogeneity. We identify several functionally distinct endothelial cell phenotypes, including an endothelial to mesenchymal transition subtype in adipose tissues. Intercellular communication analysis predicts tissue- and cell type-specific crosstalk between endothelial cells and other cell types through the VEGF, PDGF, TGF-beta, and BMP pathways. Regulon analysis of single-cell transcriptome of microglia in pig and 12 other species further identifies MEF2C as an evolutionally conserved regulon in the microglia. Our work describes the landscape of single-cell transcriptomes within diverse pig organs and identifies the heterogeneity of endothelial cells and evolutionally conserved regulon in microglia.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)

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