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- Kahn, Justine M., et al.
(författare)
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Subsequent neoplasms and late mortality in children undergoing allogeneic transplantation for nonmalignant diseases
- 2020
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Ingår i: Blood Advances. - : AMER SOC HEMATOLOGY. - 2473-9529 .- 2473-9537. ; 4:9, s. 2084-2094
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Tidskriftsartikel (refereegranskat)abstract
- We examined the risk of subsequent neoplasms (SNs) and late mortality in children and adolescents undergoing allogeneic hematopoietic cell transplantation (HCT) for nonmalignant diseases (NMDs). Weincluded 6028 patients (median age, 6 years; interquartile range, 1-11; range, <1 to 20) from the Center for International Blood and Marrow Transplant Research (1995-2012) registry. Standardized mortality ratios (SMRs) in 2-year survivors and standardized incidence ratios (SIRs) were calculated to compare mortality and SN rates with expected rates in the general population. Median follow-up of survivors was 7.8 years. Diagnoses included severe aplastic anemia (SAA; 24%), Fanconi anemia (FA; 10%), other marrow failure (6%), hemoglobinopathy (15%), immunodeficiency (23%), and metabolic/leukodystrophy syndrome (22%). Ten-year survival was 93% (95% confidence interval [95% CI], 92% to 94%; SMR, 4.2; 95% CI, 3.7-4.8). Seventy-one patients developed SNs (1.2%). Incidence was highest in FA (5.5%), SAA (1.1%), and other marrow failure syndromes (1.7%); for other NMDs, incidence was <1%. Hematologic (27%), oropharyngeal (25%), and skin cancers (13%) were most common. Leukemia risk was highest in the first 5 years posttransplantation; oropharyngeal, skin, liver, and thyroid tumors primarily occurred after 5 years. Despite a low number of SNs, patients had an 11-fold increased SN risk (SIR, 11; 95% CI, 8.9-13.9) compared with the general population. We report excellent long-term survival and low SN incidence in an international cohort of children undergoing HCT for NMDs. The risk of SN development was highest in patients with FA and marrow failure syndromes, highlighting the need for long-term posttransplantation surveillance in this population.
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| 2. |
- Uyama, Taichi, et al.
(författare)
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Atmospheric Characterization and Further Orbital Modeling of kappa Andromeda b
- 2020
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Ingår i: Astronomical Journal. - : American Astronomical Society. - 0004-6256 .- 1538-3881. ; 159:2
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Tidskriftsartikel (refereegranskat)abstract
- We present kappa Andromeda b's photometry and astrometry taken with Subaru/SCExAO+HiCIAO and Keck/NIRC2, combined with recently published SCExAO/CHARIS low-resolution spectroscopy and published thermal infrared photometry to further constrain the companion's atmospheric properties and orbit. The Y/Y-K colors of kappa And b are redder than field dwarfs, consistent with its youth and lower gravity. Empirical comparisons of its Y-band photometry and CHARIS spectrum to a large spectral library of isolated field dwarfs reaffirm the conclusion from Currie et al. that it likely has a low gravity but admit a wider range of most plausible spectral types (L0-L2). Our gravitational classification also suggests that the best-fit objects for kappa And b may have lower gravity than those previously reported. Atmospheric models lacking dust/clouds fail to reproduce its entire 1-4.7 mu m spectral energy distribution (SED), and cloudy atmosphere models with temperatures of similar to 1700-2000 K better match kappa And b data. Most well-fitting model comparisons favor 1700-1900 K, a surface gravity of log(g) similar to 4-4.5, and a radius of 1.3-1.6 R-Jup; the best-fit model (Drift-Phoenix) yields the coolest and lowest-gravity values: T-eff = 1700 K and log g = 4.0. An update to kappa And b's orbit with ExoSOFT using new astrometry spanning 7 yr reaffirms its high eccentricity (0.77 0.08). We consider a scenario where unseen companions are responsible for scattering kappa And b to a wide separation and high eccentricity. If three planets, including kappa And b, were born with coplanar orbits, and one of them was ejected by gravitational scattering, a potential inner companion with mass greater than or similar to 10 M-Jup could be located at less than or similar to 25 au.
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