| 1. |
- Dunham, I, et al.
(författare)
-
The DNA sequence of human chromosome 22
- 1999
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 402:6761, s. 489-495
-
Tidskriftsartikel (refereegranskat)
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Bay, R. C., et al.
(författare)
-
The AMANDA neutrino telescope and the indirect search for dark matter : AMANDA Colaboration
- 1998
-
Ingår i: Physics reports. - : Elsevier. - 0370-1573 .- 1873-6270. ; 307:1-4, s. 243-252
-
Tidskriftsartikel (refereegranskat)abstract
- With an effective telescope area of order 104m2, a threshold of ~50GeV and a pointing accuracy of 2.5°, the AMANDA detector represents the first of a new generation of high energy neutrino telescopes, reaching a scale envisaged over 25 years ago. We describe its performance, focussing on the capability to detect halo dark matter particles via their annihilation into neutrinos.
|
|
| 6. |
- Wischnewski, R., et al.
(författare)
-
The AMANDA neutrino detector
- 1999
-
Ingår i: Nuclear physics B, Proceedings supplements. - : Elsevier. - 0920-5632 .- 1873-3832. ; 75:1-2, s. 412-414
-
Tidskriftsartikel (refereegranskat)abstract
- The first stage of the AMANDA High Energy Neutrino Detector at the South Pole, the 302 PMT array AMANDA-B with an expected effective area for TeV neutrinos of ∼ 104 m2, has been taking data since 1997. Progress with calibration, investigation of ice properties, as well as muon and neutrino data analysis are described. The next stage 20-string detector AMANDA-II with ∼800 PMTs will be completed in spring 2000.
|
|
| 7. |
- Andres, E., et al.
(författare)
-
AMANDA : Status, results and future
- 1999
-
Ingår i: Proceedings, 8th International Workshop, Venice, Italy, February 23-26, 1999. Vol. 1, 2. ; , s. 63-79
-
Konferensbidrag (refereegranskat)abstract
- We review the status of the AMANDA neutrino telescope. We present resultsobtained from the four-string prototype array AMANDA-B4 and describe themethods of track reconstruction and neutrino event separation. We give also firstresults of the analysis of the 10-string detector AMANDA-B10, in particular onatmospheric neutrinos and the search for magnetic monopoles. We sketch thefuture schedule on the way to a cube kilometer telescope at the South Pole,ICECUBE.
|
|
| 8. |
- Andrés, E. C., et al.
(författare)
-
The AMANDA neutrino telescope
- 1999
-
Ingår i: Nuclear physics B, Proceedings supplements. - 0920-5632 .- 1873-3832. ; 77:1-3, s. 474-485
-
Tidskriftsartikel (refereegranskat)abstract
- With an effective telescope area of order 104 m2 for TeV neutrinos, a threshold near ∼50 GeV and a pointing accuracy of 2.5 degrees per muon track, the AMANDA detector represents the first of a new generation of high energy neutrino telescopes, reaching a scale envisaged over 25 years ago. We describe early results on the calibration of natural deep ice as a particle detector as well as on AMANDA's performance as a neutrino telescope.
|
|
| 9. |
- Andrés, E., et al.
(författare)
-
Status of the AMANDA experiment
- 1999
-
Ingår i: Nuclear physics B, Proceedings supplements. - : Elsevier. - 0920-5632 .- 1873-3832. ; 70:1-3, s. 448-452
-
Tidskriftsartikel (refereegranskat)abstract
- The AMANDA high energy neutrino telescope has successfully been increased in size from four detector strings to ten detector strings during the 1996/1997 season. The first upward going muon-neutrino candidates have been reconstructed from the 1996 year's four-string data. Three new detector strings will be deployed during 1997/1998 to 2350 metres depth.
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
- Halzen, F., et al.
(författare)
-
From the first neutrino telescope, the antarctic muon and neutrino detector array AMANDA, to the IceCube observatory
- 1999
-
Ingår i: Proceedings of the 26th International Cosmic Ray Conference, August 17-25, 1999, Salt Lake City : Invited, Rapporteur, and Highlight Papers. - : American Institute of Physics (AIP). ; , s. 428-431
-
Konferensbidrag (refereegranskat)
|
|
| 13. |
- Varekamp, P R, et al.
(författare)
-
Angle-resolved photoemission spectroscopy of the 1x1 ordered overlayers on iodine-saturated GaAs(001) and InAs(001)
- 1996
-
Ingår i: Surface Science. - : Elsevier BV. - 0039-6028 .- 1879-2758. ; 352, s. 387-390
-
Tidskriftsartikel (refereegranskat)abstract
- Angle-resolved valence band photoelectron spectra are collected from 1 X 1 ordered overlayers on I-2-saturated GaAs(001)-4 x 1, -c(2 X 8), and InAs(001)-c(8 x 2). A high-intensity dispersive surface state, located approximately 4.4 eV below the valence band maximum, is observed in each case. The state passes through an open lens in the projected bulk density of states and disperses symmetrically around the surface Brillouin zone edge. For all surfaces studied, the state is stronger when excited with the electric field polarized in the [110], as compared to the <(1)over bar 10>], azimuth. Since the state is independent of the termination of the initial surface, and since iodine bonds primarily to the outermost element, the state must result from delocalization of the electron states in the overlayer, and is not related to bonding with the substrate.
|
|
| 14. |
- Barwick, S. W., et al.
(författare)
-
Initial results from the AMANDA high-energy neutrino detector
- 1998
-
Ingår i: High-energy physics. Proceedings, 29th International Conference, ICHEP'98, Vancouver, Canada, July 23-29, 1998. Vol. 1, 2. ; , s. 1447-1452
-
Konferensbidrag (refereegranskat)
|
|
| 15. |
- Bay, RC, et al.
(författare)
-
The AMANDA neutrino telescope and the indirect search for dark matter
- 1998
-
Ingår i: PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS. - : ELSEVIER SCIENCE BV. - 0370-1573. ; 307:1-4, s. 243-252
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- With an effective telescope area of order 10(4) m(2), a threshold of similar to 50 GeV and a pointing accuracy of 2.5 degrees, the AMANDA detector represents the first of a new generation of high energy neutrino telescopes, reaching a scale envisaged over
|
|
| 16. |
- Berg, HE, et al.
(författare)
-
Lower limb skeletal muscle function after 6 wk of bed rest
- 1997
-
Ingår i: Journal of applied physiology (Bethesda, Md. : 1985). - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 82:1, s. 182-188
-
Tidskriftsartikel (refereegranskat)abstract
- Berg, H. E., L. Larsson, and P. A. Tesch. Lower limb skeletal muscle function after 6 wk of bed rest. J. Appl. Physiol. 82(1): 182–188, 1997.—Force, electromyographic (EMG) activity, muscle mass, and fiber characteristics were studied in seven healthy men before and after 6 wk of bed rest. Maximum voluntary isometric and concentric knee extensor torque decreased ( P < 0.05) uniformly across angular velocities by 25–30% after bed rest. Maximum quadricep rectified EMG decreased by 19 ± 23%, whereas submaximum (100-Nm isometric action) EMG increased by 44 ± 28%. Knee extensor muscle cross-sectional area (CSA), assessed by using magnetic resonance imaging, decreased by 14 ± 4%. Maximum torque per knee extensor CSA decreased by 13 ± 9%. Vastus lateralis fiber CSA decreased 18 ± 14%. Neither type I, IIA, and IIB fiber percentages nor their relative proportions of myosin heavy chain (MHC) isoforms were altered after bed rest. Because the decline in strength could not be entirely accounted for by decreased muscle CSA, it is suggested that the strength loss is also due to factors resulting in decreased neural input to muscle and/or reduced specific tension of muscle, as evidenced by a decreased torque/EMG ratio. Additionally, it is concluded that muscle unloading in humans does not induce important changes in fiber type or MHC composition or in vivo muscle contractile properties.
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
- Cui, H, et al.
(författare)
-
Inactivation of H19, an imprinted and putative tumor repressor gene, is a preneoplastic event during Wilms' tumorigenesis
- 1997
-
Ingår i: Cancer Research. ; 57:20, s. 4469-4473
-
Tidskriftsartikel (refereegranskat)abstract
- Genetic evidence shows that the parent of origin-dependent expression patterns of the Igf2 and H19 genes is coordinated in mouse, such that H19 controls the activity of Igf2 in cis. Equally compelling evidence for a similar situation in humans is absent, although the frequently observed activation of the maternal IGF2 allele (ie., loss of imprinting) in Wilms' tumors has been attributed to the silencing of the maternal H19 locus. We show here that loss of H19 activity is generally a preneoplastic event, which may be linked with an overgrowth lesion that has been proposed to be permissive for tumor formation. Although our results document one instance in which a postneoplastic loss of H19 activity correlates with loss of IGF2 imprinting at the cellular level, it appears that inactivation of H19 is more generally independent of loss of imprinting of IGF2, at least in our specimens. Our results imply that inactivation of H19 correlates with blastema overgrowth and can be independent of a regulatory role with respect to IGF2 imprinting status in cis.
|
|
| 22. |
|
|
| 23. |
- Farde, L, et al.
(författare)
-
PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man
- 1996
-
Ingår i: Dementia (Basel, Switzerland). - : S. Karger AG. - 1013-7424. ; 7:4, s. 187-195
-
Tidskriftsartikel (refereegranskat)abstract
- Xanomeline, a substituted TZTP, is a new M<sub>1</sub> selective muscarinic agonist in clinical trials for Alzheimer''s disease. The brain uptake of [<sup>11</sup>C]xanomeline and the analog [<sup>11</sup>C]butylthio-TZTP was examined by positron emission tomography (PET). Radioactivity accumulated most markedly in the neocortex and the striatum. Pharmacological characterization in vitro and in cynomolgus monkeys in vivo by PET indicated specific [<sup>11</sup>C]butylthio-TZTP binding to muscarinic receptors and to sigma-1 recognition sites. More than 5% of the radioactivity was in the human brain 5 min after i.v. injection of [<sup>11</sup>C]xanomeline or [<sup>11</sup>C]butylthio-TZTP. This high brain uptake may be clinically advantageous in the sense that substituted TZTP may induce central muscarinic agonist effects at a dose level for which there is a low risk of peripheral side-effects.
|
|
| 24. |
|
|
| 25. |
- GLANT, TT, et al.
(författare)
-
CARTILAGE - DISCUSSION
- 1995
-
Ingår i: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. - 0300-9742. ; , s. 63-63
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
|
|
| 26. |
|
|
| 27. |
|
|
| 28. |
|
|
| 29. |
- He, X., et al.
(författare)
-
The gene encoding vitamin K-dependent anticoagulant protein C is expressed in human male reproductive tissues
- 1995
-
Ingår i: Journal of Histochemistry and Cytochemistry. - : SAGE Publications. - 0022-1554 .- 1551-5044. ; 43:6, s. 563-570
-
Tidskriftsartikel (refereegranskat)abstract
- Protein C is a vitamin K-dependent protein circulating in plasma as a zymogen to an anticoagulant serine protease. After its activation, protein C cleaves and inactivates coagulation factors Va and VIIIa. Human protein C is synthesized in liver and undergoes extensive post-translational modification during its synthesis. Recently, the protein C inhibitor was demonstrated to be synthesized in several organs of the human male reproductive tract. Moreover, vitamin K-dependent protein S, which functions as a co-factor to activated protein C, was found to be synthesized in the Leydig cells of human testis. The aim of this study was to elucidate whether the protein C gene is also expressed in the male reproductive system. Specific immunostaining of protein C was found in Leydig cells of human testis, in the excretory epithelium of epididymis, and in some epithelial glands of the prostate, whereas no immunostaining was detected in seminal vesicles. Northern blotting and non-radioactive in situ hybridization demonstrated protein C mRNA in Leydig cells, in the excretory epithelium of epididymis, and in some of the epithelial glands of the prostate. The mRNA was distributed perinuclearly and the localization was in accordance with the specific immunostaining for protein C. The epithelium of epididymis was also found to contain both protein S mRNA and immunoreactivity. The demonstration of both protein C and protein S immunoreactivities, as well as their mRNAs, in male reproductive tissues suggests as yet unknown local functions for these proteins.
|
|
| 30. |
- He, Z Q, et al.
(författare)
-
As overlayer on GaAs(110) studied with photoemission
- 1995
-
Ingår i: Physical Review B Condensed Matter. - 0163-1829 .- 1095-3795. ; 52:23, s. 16602-16607
-
Tidskriftsartikel (refereegranskat)abstract
- As-terminated GaAs(110) surfaces were prepared on ex situ cleaved substrates by molecular-beam epitaxy. The surface stoichiometry was controlled by postgrowth As deposition. Photoemission from a surface covered with a monolayer As was investigated in detail using synchrotron radiation. Two different surface components were found in core-level spectra, which are interpreted as due to adatoms bonding to the surface anions and cations. In the valence-band spectra several surface states were identified, in analogy with previous reports on the isoelectronic Sb/GaAs(110) system. The polarization dependence is not the same, however, which leads us to the conclusion that the adlayer bonding mechanisms are different in the two cases.
|
|
| 31. |
- He, Z Q, et al.
(författare)
-
Band structure evolution in InAs overlayers on GaAs(110)
- 1996
-
Ingår i: Applied Surface Science. - 0169-4332 .- 1873-5584. ; 104, s. 608-614
-
Tidskriftsartikel (refereegranskat)abstract
- An angle-resolved photoemission study of MBE grown InAs/GaAs(110) hetero-structures was carried out to investigate the establishment of valence bands as a function of overlayer thickness. The valence band spectra were found to change gradually up to thicknesses well above 10 nm. The data are interpreted in terms of excitations within the overlayer from a combination of substrate and overlayer initial states, the former tailing into the overlayer.
|
|
| 32. |
|
|
| 33. |
|
|
| 34. |
|
|
| 35. |
|
|
| 36. |
|
|
| 37. |
- NAVIKAS, V, et al.
(författare)
-
Cytokine mRNA profiles in mononuclear cells in acute aseptic meningoencephalitis
- 1995
-
Ingår i: Infection and immunity. - : American Society for Microbiology. - 0019-9567 .- 1098-5522. ; 63:4, s. 1581-1586
-
Tidskriftsartikel (refereegranskat)abstract
- Cytokines are important modulators of inflammation and immune responses. Using in situ hybridization with radiolabelled cDNA oligonucleotide probes, we studied the expression of mRNA encoding the cytokines gamma interferon (IFN-gamma), interleukin 4 (IL-4), IL-6, IL-10, transforming growth factor beta (TGF-beta), tumor necrosis factor alpha (TNF-alpha), lymphotoxin, and perforin in mononuclear cells (MNC) from blood and cerebrospinal fluid (CSF) of patients with acute aseptic meningoencephalitis (AM) and from blood of healthy controls. Patients in the acute phase of AM had elevated numbers of IFN-gamma mRNA-expressing cells in the blood compared with that of controls and higher numbers of IFN-gamma mRNA-expressing cells in their CSF compared with that of convalescent-phase patients, which is in accordance with the antiviral effects of this cytokine. Upregulation of IL-4, IL-6, and IL-10 was found in convalescent-phase patients, which is consistent with the longstanding B-cell response found in AM. TGF-beta and perforin were upregulated in both stages of AM, while the numbers of blood and CSF MNC expressing cytokine mRNA of the TNF family (TNF-alpha and lymphotoxin) did not differ between patients with AM and controls. An even higher elevation in CSF was noticed for MNC expressing most of the cytokines, particularly IL-4 and TGF-beta, reflecting the autonomy of the immune response in the CSF. The definition of cytokine profiles in AM, a self-limiting and benign disease, provides a foundation for future comparisons with other infectious and inflammatory nervous system diseases.
|
|
| 38. |
|
|
| 39. |
|
|
| 40. |
|
|
| 41. |
|
|
| 42. |
|
|
| 43. |
|
|
| 44. |
|
|
| 45. |
|
|
| 46. |
|
|
