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- Hayes, A. B., et al.
(författare)
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Coulomb excitation of a Am-242 isomeric target: E2 and E3 strengths, rotational alignment, and collective enhancement
- 2010
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 82:4
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Tidskriftsartikel (refereegranskat)abstract
- A 98% pure Am-242m ( K = 5(-), t(1/2) = 141 years) isomeric target was Coulomb excited with a 170.5-MeV Ar-40 beam. The selectivity of Coulomb excitation, coupled with the sensitivity of Gammasphere plus CHICO, was sufficient to identify 46 new states up to spin 18h in at least four rotational bands; 11 of these new states lie in the isomer band, 13 in a previously unknown yrast K-pi = 6(-) rotational band, and 13 in a band tentatively identified as the predicted yrast K-pi = 5(+) band. The rotational bands based on the K-pi = 5- isomer and the 6(-) bandhead were populated by Coulomb excitation with unexpectedly equal cross sections. The gamma-ray yields are reproduced by Coulomb excitation calculations using a two-particle plus rotor model (PRM), implying nearly complete Delta K = 1 mixing of the two almost-degenerate rotational bands, but recovering the Alaga rule for the unperturbed states. The degeneracy of the 5(-) and 6(-) bands allows for precise determination of the mixing interaction strength V, which approaches the strong-mixing limit; this agrees with the 50% attenuation of the Coriolis matrix element assumed in the model calculations. The fractional admixture of the I-K(pi) = 6(6)(-) state in the nominal 6(5)(-) isomer band state is measured within the PRM as 45.6(-1.1)(+0.3)%. The E2 and M1 strengths coupling the 5(-) and 6(-) bands are enhanced significantly by the mixing, while E1 and E2 couplings to other low-K bands are not measurably enhanced. The yields of the 5(+) band are reproduced by an E3 strength of approximate to 15 W.u., competitive with the interband E2 strength. Alignments of the identified two-particle Nilsson states in Am-242 are compared with the single-particle alignments in Am-241.
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- Horst, SA, et al.
(författare)
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Prognostic value and therapeutic potential of TREM-1 in Streptococcus pyogenes- induced sepsis
- 2013
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Ingår i: Journal of innate immunity. - : S. Karger AG. - 1662-8128 .- 1662-811X. ; 5:6, s. 581-590
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Tidskriftsartikel (refereegranskat)abstract
- TREM-1 (triggering receptor expressed on myeloid cells) is a surface molecule expressed on neutrophils and macrophages which has been implicated in the amplification of inflammatory responses triggered during infection. In the present study, we have investigated the clinical significance of TREM-1 in <i>Streptococcus pyogenes</i>-induced severe sepsis in both experimentally infected mice as well as in patients with streptococcal toxic shock. We found that <i>S. pyogenes</i> induced a dose-dependent upregulation of TREM-1 in in vitro cultured phagocytic cells and in the organs of <i>S. pyogenes-</i>infected mice. Furthermore, we reported a positive correlation between serum levels of soluble TREM-1 (sTREM-1) and disease severity in infected patients as well as in experimentally infected mice. Hence, sTREM-1 may represent a useful surrogate marker for streptococcal sepsis. We found that modulation of TREM-1 by administration of the TREM-1 decoy receptor rTREM-1/Fc substantially attenuated the synthesis of inflammatory cytokines. More importantly, treatment of <i>S. pyogenes</i>-infected septic mice with rTREM-1/Fc or the synthetically produced conserved extracellular domain LP17 significantly improved disease outcome. In summary, our data suggest that TREM-1 may not only represent a valuable marker for <i>S. pyogenes</i> infection severity but it may also be an attractive target for the treatment of streptococcal sepsis.
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- Paul, E. S., et al.
(författare)
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High-spin yrast states in the gamma-soft nuclei Pr-135 and Ce-134
- 2011
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 84:4
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states have been studied in Pr-135(59), populated through the Cd-116(Na-23,4n) reaction at 115 MeV, using the Gammasphere gamma-ray spectrometer. The negative-parity yrast band has been significantly extended to spin similar to 45 (h) over bar and excitation energy 21.5 MeV, showing evidence for several rotational alignments. The positive-parity yrast band of Ce-135(58), populated through the p4n channel of this reaction, was also populated to spin similar to 38 (h) over bar and excitation energy 18 MeV. Cranking calculations indicate that these nuclei are soft with respect to the triaxiality parameter gamma and that several competing nuclear shapes occur at high spin.
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- Yang, SZ, et al.
(författare)
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Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons
- 2013
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Ingår i: Development (Cambridge, England). - : The Company of Biologists. - 1477-9129 .- 0950-1991. ; 140:22, s. 4554-4564
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Tidskriftsartikel (refereegranskat)abstract
- CXCL12/CXCR4 signaling has been reported to regulate three essential processes for the establishment of neural networks in different neuronal systems: neuronal migration, cell positioning and axon wiring. However, it is not known whether it regulates the development of A9-A10 tyrosine hydroxylase positive (TH+) midbrain dopaminergic (mDA) neurons. We report here that Cxcl12 is expressed in the meninges surrounding the ventral midbrain (VM), whereas CXCR4 is present in NURR1+ mDA precursors and mDA neurons from E10.5 to E14.5. CXCR4 is activated in NURR1+ cells as they migrate towards the meninges. Accordingly, VM meninges and CXCL12 promoted migration and neuritogenesis of TH+ cells in VM explants in a CXCR4-dependent manner. Moreover, in vivo electroporation of Cxcl12 at E12.5 in the basal plate resulted in lateral migration, whereas expression in the midline resulted in retention of TH+ cells in the IZ close to the midline. Analysis of Cxcr4-/- mice revealed the presence of VM TH+ cells with disoriented processes in the intermediate zone (IZ) at E11.5 and marginal zone (MZ) at E14. Consistently, pharmacological blockade of CXCR4 or genetic deletion of Cxcr4 resulted in an accumulation of TH+ cells in the lateral aspect of the IZ at E14, indicating that CXCR4 is required for the radial migration of mDA neurons in vivo. Altogether, our findings demonstrate that CXCL12/CXCR4 regulates the migration and orientation of processes in A9-A10 mDA neurons.
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