| 1. |
- Hellerström, Claes, et al.
(författare)
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Diabetes
- 2002
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Bok (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Henriksson, Marie, et al.
(författare)
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Importance of ERK1/2 in upregulation of endothelin type B receptors in cerebral arteries
- 2004
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Ingår i: British Journal of Pharmacology. - : Wiley. - 1476-5381 .- 0007-1188. ; 142:7, s. 1155-1161
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Tidskriftsartikel (refereegranskat)abstract
- 1 This study examines the importance of mitogen-activated protein kinases (MAPKs) in upregulation of endothelin type B (ETB) receptors. 2 Rat middle cerebral arteries (MCAs) were incubated for 24 h with or without kinase inhibitors. Vessel segments were mounted in myographs and the contractile responses to endothelin-1 (ET-1; ETA and ETB receptor agonist) and sarafotoxin 6c (S6c; ETB receptor agonist) were studied. We used real-time PCR to measure the receptor mRNA levels. An ELISA assay showed the activation of ERK1/2 kinases after 3 h. Immunohistochemistry revealed the presence of ETB receptors on the vessels. 3 After organ culture, S6c induced vasoconstriction. Incubation with the MEK/ERK inhibitors U0126 and SB386023 diminished the contractile response to S6c. The p38 MAPK inhibitor SB239063 did not affect the S6c-induced contraction. 4 The ET-1-induced vasoconstriction was increased after incubation with SB386023 or SB239063, while unaffected by U0126. 5 The ETB receptor mRNA levels were diminished by SB386023 and U0126. The ETA receptor mRNA levels were unaffected. 6 The levels of activated ERK1/2 kinases were significantly higher after 3 h of organ culture as compared to fresh vessels. 7 The level of ETB receptor protein on the smooth muscle cells of the MCA, visualised by immunohistochemistry, was somewhat diminished by SB386023. 8 Our results show that the ERK1/2 MAPK is important in the upregulation of contractile ETB receptors in MCA after organ culture. Since there is a similar upregulation in models of focal ischaemia and subarachnoid haemorrhage, this may be an important pathophysiological event.
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| 3. |
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| 4. |
- Henriksson, Widar, 1943-, et al.
(författare)
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The Swedish driving-license test : A summary of studies from the department of educational measurement
- 2004
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Since 1990, the Department of Educational Measurement at Umeå University has been commissioned to study the Swedish drivinglicense test by the Swedish National Road Administration, SNRA. Over the past few years several studies have been conducted in order to develop and improve the Swedish driving-license test. The focus of the majority of the studies has been the theory test. The aims of this paper were threefold: firstly to describe the development of the driver education and the driving-license test in Sweden during the past century; secondly, to summarize the findings of our research, which is related to important issues in test development; and finally, to make some suggestions for further research.
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| 5. |
- Perseius, Kent-Inge, et al.
(författare)
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Does dialectical behavioural therapy reduce treatment cost for patients with borderline personality disorder : A pilot study
- 2004
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Ingår i: Vård i Norden. - : Sykepleiernes Samarbeid i Norden,Northern Nurses Federation. - 0107-4083 .- 1890-4238. ; 24:2, s. 27-30
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Tidskriftsartikel (refereegranskat)abstract
- Objective: In order to assess costs - consequences of dialectal behavioural therapy (DBT) in suicidal women with borderline personality disorder (BPD), the present study takes advantage of pilot data collected during a training phase, in relation to a large scale randomised controlled trail (RCT). Method: Under a 18 month period, 22 suicidal women with BPD were treated with outpatient DBT, with focus on reducing parasuicidal behaviour. Outcome data collected retrospectively 12 months before therapy start, were compared to prospective data collected up to 18 months in therapy. The cost - analysis included direct health care costs only. Results & Conclusions: The results suggest that DBT may have a positive impact on treatment costs, which decreased significantly during the last 12 months in a 18 month therapy period. The reduction of costs is due to decrease in the number of psychiatric inpatient days. The conclusions that can be drawn from the results are, however, limited as the study was not made in RCT conditions and indirect costs to society were not assessed.
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| 6. |
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| 7. |
- Tsuchida, Hiroki, et al.
(författare)
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Gene expression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects.
- 2002
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Ingår i: Pflügers Archiv. - : Springer Science and Business Media LLC. - 0031-6768 .- 1432-2013. ; 445:1, s. 25-31
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Tidskriftsartikel (refereegranskat)abstract
- The gene of the p85alpha regulatory subunit of phosphatidylinositol (PI) 3-kinase gives rise to several splice variants. We hypothesized that the expression of p85alpha splice variants may be altered in skeletal muscle from subjects with type 2 diabetes mellitus. Skeletal muscle biopsies were obtained from nine type 2 diabetic and eight healthy men, matched for age, body mass index (BMI) and physical fitness. PI 3-kinase activity in skeletal muscle following in vitro insulin stimulation was reduced in subjects with type 2 diabetes. p85alpha mRNA was elevated fourfold in type 2 diabetic as compared to healthy control subjects ( P<0.05). p85alpha mRNA abundance was positively correlated with plasma insulin concentration ( P<0.01) and serum glucose concentration ( P<0.01). Despite this, protein levels of p85alpha, p55alpha, and the novel human p50alpha were not altered in type 2 diabetic subjects. Thus, although gene expression of full-length p85alpha is increased in skeletal muscle from type 2 diabetics, this is not reflected by increased protein levels. Therefore, defects in PI 3-kinase activity are likely due to impaired activation of the enzyme rather than changes in protein expression of the isoforms of the regulatory subunit.
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| 8. |
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| 9. |
- Wiberg, Marie, et al.
(författare)
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Metoder för kravgränssättning : En teoretisk granskning samt diskussion av lämplig metod för ett målrelaterat certifieringsprov av typ körkortsprovets teoriprov
- 2000
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The main purpose of this study was to consider standard setting in a theoretical perspective. The aim was to describe the method categories which are used to set a standard, and to examine which category is the most suitable for a criterion-referenced licensure test. Criterion-referenced tests are used to ascertain an examinee’s status with respect to a well-defined criterion. A licensure test is administrated at the end of an education and covers the whole course. Another purpose of the study was to examine which method, in the most suitable category of methods, should be used to set a standard on a criterion-referenced licensure test like the Swedish driving licence test. The study describes how the standards are set in the old and new Swedish theoretical driving licence tests. The criteria used to decide the most suitable method were technical adequacy and practicability, each defined in several ways, and some specific criteria since it is a licensure test. The theoretical examination showed that it is not possible to find one single method that is best in all possible situations. The conclusion was that either Informed Judgement or Iterative Angoff was the most preferable method for setting a standard on the Swedish driving licence test.
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